Review
Infectious Diseases
Anthony D. Bai, Carson Kl Lo, Adam S. Komorowski, Mallika Suresh, Kevin Guo, Akhil Garg, Pranav Tandon, Julien Senecal, Olivier Del Corpo, Isabella Stefanova, Clare Fogarty, Guillaume Butler-Laporte, Emily G. McDonald, Matthew P. Cheng, Andrew M. Morris, Mark Loeb, Todd C. Lee
Summary: This study compared the mortality rates of Staphylococcus aureus bacteremia in low- and middle-income countries versus high-income countries, finding that middle-income countries had significantly higher in-hospital mortality rates than high-income countries. It is important to note the low representation of low-income countries in related research, highlighting the need for further studies in these countries to better understand the differences in mortality rates.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Felicia Ruffin, Michael Dagher, Lawrence P. Park, Lisa Wanda, Jonathan Hill-Rorie, Michael Mohnasky, Julia Marshall, Maria Souli, Paul Lantos, Batu K. Sharma-Kuinkel, Stacey A. Maskarinec, Emily M. Eichenberger, Charles Muiruri, Brittney Broadnax, Vance G. Fowler
Summary: The study found that Black and White patients with Staphylococcus aureus bacteremia had similar outcomes, despite differences in age, diabetes, and hemodialysis dependence. The results highlight the need for further research on the reasons behind the disparities.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Petros Ioannou, Maria Zacharioudaki, Despoina Spentzouri, Antonia Koutoulakou, Konstantinos Kitsos-Kalyvianakis, Christoforos Chontos, Stamatis Karakonstantis, Sofia Maraki, George Samonis, Diamantis P. Kofteridis
Summary: This study retrospectively evaluated a cohort of SAB patients hospitalized in Heraklion, Greece, and identified factors independently associated with mortality. The study found that female gender, older age, severe sepsis, and MRSA infection were positively associated with in-hospital mortality. The study also emphasized the urgency of improving antimicrobial stewardship, involving infectious diseases physicians, providing education and training, and creating and implementing local guidelines.
Article
Immunology
Anita J. Campbell, Laila S. Al Yazidi, Linny K. Phuong, Clare Leung, Emma J. Best, Rachel H. Webb, Lesley Voss, Eugene Athan, Philip N. Britton, Penelope A. Bryant, Coen T. Butters, Jonathan R. Carapetis, Natasha S. Ching, Geoffrey W. Coombs, Denise Daley, Joshua Francis, Te-Yu Hung, Shakeel Mowlaboccus, Clare Nourse, Samar Ojaimi, Alex Tai, Nan Vasilunas, Brendan McMullan, Christopher C. Blyth, Asha C. Bowen
Summary: The ISAIAH study in Australia and New Zealand identified a high incidence of Staphylococcus aureus bacteremia in children hospitalized, with necrotizing pneumonia and multifocal infection being predictors of mortality for the first time in a pediatric setting. Consultation with infectious diseases specialists was found to be protective, highlighting the need to reevaluate pediatric vancomycin trough targets and limit unnecessary empiric vancomycin exposure to reduce poor outcomes and nephrotoxicity.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Anthony D. Bai, Carson K. L. Lo, Adam S. Komorowski, Mallika Suresh, Kevin Guo, Akhil Garg, Pranav Tandon, Julien Senecal, Olivier Del Corpo, Isabella Stefanova, Clare Fogarty, Guillaume Butler-Laporte, Emily G. McDonald, Matthew P. Cheng, Andrew M. Morris, Mark Loeb, Todd C. Lee
Summary: The mortality rate of Staphylococcus aureus bacteremia has decreased over the past three decades, but one in four patients still die within three months. Methicillin-resistant Staphylococcus aureus infection is associated with a higher mortality rate, while more recent time periods have shown lower mortality rates.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Immunology
Si-Ho Kim, Minji Jeon, Sukbin Jang, Seok Jun Mun
Summary: This study evaluated the effects of treatment response and bacteremia duration on mortality in patients with persistent Staphylococcus aureus bacteremia. The results showed that Pitt bacteremia score at treatment day 4 was strongly associated with 30-day in-hospital mortality, while defervescence and bacteremia duration were not independent factors.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Immunology
Seong-Ho Choi, Michael Dagher, Felicia Ruffin, Lawrence P. Park, Batu K. Sharma-Kuinkel, Maria Souli, Alison M. Morse, Emily M. Eichenberger, Lauren Hale, Celia Kohler, Bobby Warren, Brenda Hansen, Felix Mba Medie, Lauren M. McIntyre, Vance G. Fowler
Summary: This study identified several risk factors for R-SAB, with the highest risk observed among black hemodialysis patients. Higher levels of RANTES in R-SAB compared to matched controls suggest a need for further investigation.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Ari Meliyanti, Desy Rusmawatiningtyas, Firdian Makrufardi, Eggi Arguni
Summary: This study aimed to identify factors associated with mortality in pediatric pneumonia, and found that bacteremia and underweight were predictors of mortality for pediatric patients with pneumonia who were supported by mechanical ventilation. Comparing these findings with other centers is necessary.
Article
Infectious Diseases
Itziar Diego-Yague, Alberto Mora-Vargas, Jose Manuel Vazquez-Comendador, Beatriz Santamarina-Alcantud, Ana Fernandez-Cruz, Elena Munez-Rubio, Andrea Gutierrez-Villanueva, Isabel Sanchez-Romero, Victor Moreno-Torres, Antonio Ramos-Martinez, Jorge Calderon-Parra
Summary: Oral sequential therapy (OST) in uncomplicated Staphylococcus aureus bacteraemia (SAB) is found to be safe and effective, reducing mortality and microbiological failure.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Medicine, General & Internal
Benjamin Lefevre, Antoine Legoff, Mathilde Boutrou, Francois Goehringer, Willy Ngueyon-Sime, Catherine Chirouze, Matthieu Revest, Veronique Vernet Garnier, Xavier Duval, Francois Delahaye, Vincent Le Moing, Christine Selton-Suty, Laura Filippetti, Bruno Hoen, Nelly Agrinier
Summary: This study aimed to search for new potential prognostic factors and assess their prognostic value in Staphylococcus aureus infective endocarditis (SaIE). The study identified three potential SaIE prognostic factors: the prior use of non-steroidal anti-inflammatory drugs, the non-performance of valve surgery when indicated, and the decrease of vegetation size on antibiotic treatment.
FRONTIERS IN MEDICINE
(2022)
Review
Microbiology
Bahman Mirzaei, Ryhaneh Babaei, Habib Zeighami, Maryam Dadar, Ali Soltani
Summary: This mini-review discusses the recent progress in vaccine development, immunogenicity, and therapeutic features of some S. aureus macromolecules as putative vaccine candidates against S. aureus-related infections. Based on the reviewed experiments, multivalent vaccines could prevent diseases caused by this bacterium and enhance the prevention chance of S. aureus infections.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Nabil Ahmed, Abdel Hadi Khderat, Alaa Sarsour, Ameed Taher, Ahmad Hammoudi, Zakaria Hamdan, Zaher Nazzal
Summary: This study examined the incidence, epidemiological characteristics, and mortality rate of COVID-19 among maintenance dialysis patients in Palestine. The study found a notably high incidence of COVID-19 among dialysis patients, particularly among those on hemodialysis. High rates of hospitalization, ICU admission, intubation, and death were observed. Age, gender, smoking, diabetes, and the use of central venous catheters for hemodialysis were identified as predictive factors for COVID-19-related mortality. Strict infection control measures and promotion of home dialysis are necessary to reduce the risk of infection.
ANNALS OF MEDICINE
(2022)
Article
Immunology
Anthony D. Bai, Carson K. L. Lo, Adam S. Komorowski, Mallika Suresh, Kevin Guo, Akhil Garg, Pranav Tandon, Julien Senecal, Olivier Del Corpo, Isabella Stefanova, Clare Fogarty, Guillaume Butler-Laporte, Emily G. McDonald, Matthew P. Cheng, Andrew M. Morris, Mark Loeb, Todd C. Lee
Summary: In the case of Staphylococcus aureus bacteremia, mortality rates in randomized controlled trials (RCTs) are consistently lower than in observational studies, likely due to the stringent eligibility criteria and exclusion of early deaths in RCTs. Clinicians should consider the potential for lower treatment efficacy when applying RCT results to bedside care.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Pharmacology & Pharmacy
Nicola J. Stagg, Paula Katavolos, Kirsten Achilles Poon, Shelly Zhong, Nina Ljumanovic, Amrita Kamath, Hao Cai, Montserrat Carrasco-Triguero, Wendy Halpern
Summary: The THIOMABTM antibody antibiotic conjugate (TAC) successfully delivers an antibiotic to bacteria using a bacterial-wall specific antibody, providing a safer and more effective treatment option for invasive S. aureus infections.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Putri Amelia, Najib Advani, Aman B. Pulungan, Mulyadi M. Djer, Badriul Hegar, Yogi Prawira, Rubiana Sukardi
Summary: This study evaluated the predictive factors of mortality after the Blalock-Taussig (BT) shunt procedure in Indonesia. The study included 197 children who underwent the procedure, and the in-hospital mortality rate was 20.8%. The predictors of mortality identified through multivariate analysis were weight <4.25 kg and emergency procedures.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Infectious Diseases
Husain Poonawala, Narender Kumar, Sharon J. Peacock
INFECTION GENETICS AND EVOLUTION
(2020)
Letter
Infectious Diseases
Direk Limmathurotsakul, Jonathan A. T. Sandoe, David C. Barrett, Michael Corley, Li Yang Hsu, Marc Mendelson, Peter Collignon, Ramanan Laxminarayan, Sharon J. Peacock, Philip Howard
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2020)
Article
Infectious Diseases
Narender Kumar, Kathy E. Raven, Beth Blane, Danielle Leek, Nicholas M. Brown, Eugene Bragin, Paul A. Rhodes, Julian Parkhill, Sharon J. Peacock
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2020)
Review
Infectious Diseases
Ramanan Laxminarayan, Thomas Van Boeckel, Isabel Frost, Samuel Kariuki, Ejaz Ahmed Khan, Direk Limmathurotsakul, D. G. Joakim Larsson, Gabriel Levy-Hara, Marc Mendelson, Kevin Outterson, Sharon J. Peacock, Yong-Guan Zhu
LANCET INFECTIOUS DISEASES
(2020)
Article
Microbiology
Aishwarya Krishna, Bing Liu, Sharon J. Peacock, Sivaramesh Wigneshweraraj
Article
Infectious Diseases
Sharif A. Ismail, Catherine Huntley, Nathan Post, Samuel Rigby, Madhumita Shrotri, Sarah V. Williams, Sharon J. Peacock
Summary: POCTs like FebriDx show potential in distinguishing viral from bacterial infections in patients with influenza-like illnesses, but their performance may be affected by factors such as low COVID-19 case numbers and co-circulating viral respiratory infections. Reliable SARS CoV2-specific POCTs are likely to be preferred due to their greater specificity.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2021)
Article
Microbiology
Theodore Gouliouris, Francesc Coll, Catherine Ludden, Beth Blane, Kathy E. Raven, Plamena Naydenova, Charles Crawley, Mili Estee Torok, David A. Enoch, Nicholas M. Brown, Ewan M. Harrison, Julian Parkhill, Sharon J. Peacock
Summary: Longitudinal genomic surveillance of Enterococcus faecium carriage, environmental contamination, and transmission within a defined patient cohort revealed high endemicity of a hospital-adapted E. faecium lineage.
NATURE MICROBIOLOGY
(2021)
Article
Infectious Diseases
Cherry Lim, Viriya Hantrakun, Nittaya Teerawattanasook, Pramot Srisamang, Prapit Teparrukkul, Nithima Sumpradit, Paul Turner, Nicholas Pj Day, Ben S. Cooper, Sharon J. Peacock, Direk Limmathurotsakul
Summary: The impact of low blood culture utilization rate on estimated proportions and incidence rates of antimicrobial-resistant infections is significant, especially for bacteria like Escherichia coli and Klebsiella pneumoniae. The timing of blood culture collection during parenteral antibiotic treatment also plays a significant role in the development of antibiotic resistance.
JOURNAL OF INFECTION
(2021)
Review
Multidisciplinary Sciences
Madhumita Shrotri, May C. I. van Schalkwyk, Nathan Post, Danielle Eddy, Catherine Huntley, David Leeman, Samuel Rigby, Sarah V. Williams, William H. Bermingham, Paul Kellam, John Maher, Adrian M. Shields, Gayatri Amirthalingam, Sharon J. Peacock, Sharif A. Ismail
Summary: The study found that COVID-19 patients exhibit T cell lymphopenia, which is positively correlated with disease severity, duration of RNA positivity, and non-survival. Those with severe or critical disease tend to develop more robust, virus-specific T cell responses. Cross-reactive T cell responses have been demonstrated in unexposed and uninfected adults, but their significance for protection and susceptibility remains unclear.
Article
Multidisciplinary Sciences
Kathy E. Raven, Sophia T. Girgis, Asha Akram, Beth Blane, Danielle Leek, Nicholas Brown, Sharon J. Peacock
Summary: The study introduces a universal protocol for simultaneous DNA extraction and sequencing of multiple bacterial species, demonstrating high reproducibility and effectiveness. The addition of lysozyme and lysostaphin together proved to be essential for generating sufficient DNA across all 20 tested species, supporting low-volume and rapid turnaround time for local clinical microbiology laboratories.
SCIENTIFIC REPORTS
(2021)
Article
Biology
William L. Hamilton, Gerry Tonkin-Hill, Emily R. Smith, Dinesh Aggarwal, Charlotte J. Houldcroft, Ben Warne, Luke W. Meredith, Myra Hosmillo, Aminu S. Jahun, Martin D. Curran, Surendra Parmar, Laura G. Caller, Sarah L. Caddy, Fahad A. Khokhar, Anna Yakovleva, Grant Hall, Theresa Feltwell, Malte L. Pinckert, Iliana Georgana, Yasmin Chaudhry, Colin S. Brown, Sonia Goncalves, Roberto Amato, Ewan M. Harrison, Nicholas M. Brown, Mathew A. Beale, Michael Spencer Chapman, David K. Jackson, Ian Johnston, Alex Alderton, John Sillitoe, Cordelia Langford, Gordon Dougan, Sharon J. Peacock, Dominic P. Kwiatowski, Ian G. Goodfellow, M. Estee Torok
Summary: COVID-19 poses significant challenges in care homes due to high mortality rates and varied patterns of viral transmission. Limiting viral spread within care homes is crucial to reducing COVID-19 mortality in this population.
Article
Microbiology
Nipa Thammasonthijarern, Nathamon Kosoltanapiwat, Warisa Nuprasert, Pichamon Sittikul, Pimolpachr Sriburin, Wirichada Pan-ngum, Pannamas Maneekan, Somboon Hataiyusuk, Weerawan Hattasingh, Janjira Thaipadungpanit, Supawat Chatchen
Summary: Hand, foot, and mouth disease (HFMD) is a contagious illness that affects millions of children every year in the Asia-Pacific region. A school closure policy for HFMD outbreaks has been implemented in Thailand based on guidelines from the Department of Disease Control, although evidence supporting this policy is lacking. Molecular genetic techniques have been used to study the spread of HFMD in school settings, confirming the benefit of accurate data to support control measures.
Article
Virology
Pichamon Sittikul, Elizabeth M. Batty, Prasert Yodsawat, Jiratchaya Nuanpirom, Nathamon Kosoltanapiwat, Unitsa Sangket, Supawat Chatchen, Nicholas P. J. Day, Janjira Thaipadungpanit
Summary: Human enterovirus causes various clinical manifestations and enterovirus A71 and coxsackievirus are significant causes of hand-foot-mouth disease (HFMD), especially in children aged from birth to five years old. Molecular tools are used to investigate human enteroviruses circulating among kindergarten students and identify genotype variants causing HFMD epidemics. In this study, EV-A71 and coxsackievirus clusters were identified among symptomatic and asymptomatic cases in kindergartens in Bangkok, Thailand, and viral transmission was discovered between closely related clones.
Article
Genetics & Heredity
Jaime Brizuela, Rattagan Kajeekul, Thomas J. Roodsant, Athita Riwload, Parichart Boueroy, Auttapong Pattanapongpaibool, Janjira Thaipadungpanit, Piroon Jenjaroenpun, Thidathip Wongsurawat, Elizabeth M. Batty, Boas C. L. van der Putten, Constance Schultsz, Anusak Kerdsin
Summary: In March 2021, an outbreak of severe Streptococcus suis infections occurred in Nakhon Ratchasima province, Thailand, resulting in 19 confirmed cases and two deaths. The outbreak was traced back to a raw pork dish consumed by 241 people during a Buddhist ceremony. Whole genome sequencing revealed that the outbreak was caused by a novel sequence type strain of S. suis with antibiotic resistance.
MICROBIAL GENOMICS
(2023)
Article
Infectious Diseases
Fardosa Dahir Omar, Weerapong Phumratanaprapin, Udomsak Silachamroon, Borimas Hanboonkunupakarn, Natthida Sriboonvorakul, Janjira Thaipadungpanit, Wirichada Pan-ngum
Summary: Tropical acute febrile illness (TAFI) is a common cause of acute kidney injury (AKI). This study aimed to determine the prevalence, clinical characteristics, and outcomes of AKI associated with TAFI. Among 1019 TAFI patients, 6.8% were classified as AKI cases. The AKI group showed abnormal signs, symptoms, and laboratory results, with a higher mortality rate compared to the non-AKI group.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)