Article
Immunology
Zhen Cao, Silong Mu, Maihuan Wang, Yun Zhang, Guijun Zou, Xinpu Yuan, Yun Huang, Siwang Yu, Jinming Zhang, Chaojun Zhang
Summary: Intestinal ischemia-reperfusion (I/R) injury disrupts the intestinal barrier composed of tight junction proteins, leading to the entry of bacteria and endotoxins into the bloodstream and causing distant organ damage. This study investigated the role of succinate, an intermediate product of the tricarboxylic acid cycle, in intestinal I/R injury, and found that pretreatment with succinate reduced tissue damage, necroptosis, and inflammation. The protective effect of succinate was associated with the upregulation of the inflammatory protein KLF4 and was diminished after inhibition of KLF4.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Yang Lyu, Yimin Chen
Summary: Digested human colostrum significantly reduces IL-8 production in human intestinal epithelial cells stimulated with LPS and TNF. However, individual colostrum samples exhibit wide variance in their ability to suppress inflammation and cytotoxicity.
Article
Chemistry, Multidisciplinary
Qi-xiang Mei, Jun-hui Hu, Ze-hua Huang, Jun-jie Fan, Chun-lan Huang, Ying-ying Lu, Xing-peng Wang, Yue Zeng
Summary: Severe acute pancreatitis (SAP) is a severe acute abdominal disease, and recent evidence suggests that maintaining intestinal homeostasis is crucial for managing this condition. Chitosan oligosaccharides (COS) with antioxidant properties have shown promising therapeutic effects in treating inflammatory diseases. This study demonstrated that COS administration alleviated the severity of SAP by reducing inflammation, oxidative stress, and restoring intestinal homeostasis, indicating its potential as a prebiotic agent for SAP treatment.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Gastroenterology & Hepatology
Bianca Crifo, Wallace K. MacNaughton
Summary: This article reviews the emerging evidence that mediators and innate immune cells play key roles in mucosal healing and resolution of chronic inflammation in the colon. It suggests that understanding the dual mechanisms of these mediators and cells may aid in the development of drugs for treating inflammatory bowel diseases (IBD).
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Biophysics
Yuto Kai
Summary: The finger-like shape of villi tightens regulation of shedding-cell ages, allowing epithelial cells to shed at around the same age to limit early shedding or prolonged stay in the epithelium. Computational simulations and mechanical conditions support the important roles of villi in the homeostatic maintenance of the small intestine and the applicability of this approach to tissues with collective cell movement.
BIOPHYSICAL JOURNAL
(2021)
Article
Agriculture, Dairy & Animal Science
Sudan Meng, Yongsheng An, Yuexin Wang, Shuai Wang, Hongwei Wang, Qi Shao, Mengying Dou, Lei He, Cai Zhang
Summary: This study demonstrates that tea polyphenols have protective effects against heat-stress-induced damage in bovine intestinal epithelial cells, by alleviating oxidative stress and inflammatory responses.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Man Guo, Daoqi Shen, Yiqi Su, Jiarui Xu, Shuan Zhao, Weidong Zhang, Yaqiong Wang, Wuhua Jiang, Jialin Wang, Xuemei Geng, Xiaoqiang Ding, Xialian Xu
Summary: Adherens junctions between tubular epithelial cells are disrupted in renal ischemia/reperfusion injury, and shedding of SDC-1 may play a key role in this process. Inhibiting SDC-1 shedding can alleviate the destruction of cell adherens junctions.
Article
Biochemistry & Molecular Biology
Jiao Lu, Menghao Wang, Yucheng Chen, Hua Song, Diguang Wen, Jianfei Tu, Yuan Guo, Zuojin Liu
Summary: The study aimed to investigate the role of NAMPT in liver ischemia-reperfusion injury (IRI). The results showed that NAMPT was upregulated in IRI, and treatment with the NAMPT inhibitor FK866 improved IRI and suppressed inflammation. Further mechanistic studies revealed that FK866 inhibited NAMPT activity, leading to decreased NAD+ levels and activity of NAD+-dependent enzymes, including PARP1, which in turn inhibited macrophage M1 polarization by reducing the expression of CD86, iNOS, TNF-alpha, and IL-1β. In conclusion, NAMPT can regulate macrophage polarization through NAD+/PARP1 to ameliorate liver injury, and FK866-mediated NAMPT blockade may serve as a therapeutic approach in liver IRI.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Food Science & Technology
Veronika Skockova, Ondrej Vasicek, Eliska Sychrova, Iva Sovadinova, Pavel Babica, Lenka Sindlerova
Summary: Freshwater cyanobacterial harmful blooms (CyanoHABs) can produce toxic compounds, including lipopolysaccharides (LPSs). The gastrointestinal tract can be exposed to these LPSs through contaminated water, but their effects on intestinal cells are not yet clear.
Review
Biochemistry & Molecular Biology
Shafaque Rahman, Mohammed Ghiboub, Joanne M. Donkers, Evita van de Steeg, Eric A. F. van Tol, Theodorus B. M. Hakvoort, Wouter J. de Jonge
Summary: Research on intestinal function models helps to understand intestinal physiology and functions in health and disease states. However, the translation to human in vivo situation remains problematic due to the failure of these models to fully reflect the complex in vivo environment. Although traditional models are still in use, more sophisticated intestinal models have been developed in recent years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Amanda Croasdell Lucchini, Naomi N. Gachanja, Adriano G. Rossi, David A. Dorward, Christopher D. Lucas
Summary: Respiratory diseases are characterized by epithelial injury, airway inflammation, defective tissue repair, and airway remodeling, with the lung having the capacity to repair and replace damaged cells in response to injury. Airway epithelial cells play a key role in maintaining lung homeostasis and host defense, orchestrating the resolution of inflammation and initiating tissue repair. Understanding the mechanisms of intercellular communication, including growth factors, extracellular vesicles, and cytokines, will identify potential cells, mediators, and interactions for therapeutic targeting.
Article
Immunology
Yuanyuan Wu, Zinah D. Zwaini, Nigel J. Brunskill, Xinyue Zhang, Hui Wang, Ravinder Chana, Cordula M. Stover, Bin Yang
Summary: The study showed that mice lacking Properdin exhibited more severe renal injury during the repair phase post IR, with Properdin playing a crucial role in optimizing damaged cells and regulating phagocytic ability to effectively clear apoptotic cells and reduce inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Anna Marei Grages, Nicole Verhaar, Christiane Pfarrer, Gerhard Breves, Marion Burmester, Stephan Neudeck, Sabine Kastner
Summary: This study compared two experimental models, low flow and no flow, to characterize the development of intestinal injury in horses. The results showed that the no flow model produced more consistent intestinal damage compared to the low flow model.
Article
Microbiology
Audrey Chong, Kendal G. Cooper, Laszlo Kari, Olof R. Nilsson, Chad Hillman, Brittany A. Fleming, Qinlu Wang, Vinod Nair, Olivia Steele-Mortimer
Summary: In this study, self-destructing Salmonella was used to investigate the role of cytosolic bacteria in infection, revealing that cytosolic Salmonella plays an essential role in fecal shedding during infection.
CELL HOST & MICROBE
(2021)
Article
Neurosciences
Yunwei Shi, Xinyi Chen, Jiaxing Liu, Xingjuan Fan, Ying Jin, Jingxiao Gu, Jiale Liang, Xinmiao Liang, Caiping Wang
Summary: Isoquercetin has been identified as a neuroprotective agent against ischemic stroke, showing the potential to suppress inflammatory response and improve cell recovery in rats with cerebral ischemia/reperfusion injury. The study suggests that targeting the TLR4 and C5aR1-mediated cAMP/PKA/I-kappa B/NF-kappa B signaling pathway may provide a promising therapeutic strategy for ischemic stroke.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Pediatrics
Kelly M. A. Dreuning, Rinse W. Barendsen, A. S. Paul van Trotsenburg, Jos W. R. Twisk, Christien Sleeboom, L. W. Ernest van Heurn, Joep P. M. Derikx
JOURNAL OF PEDIATRIC SURGERY
(2020)
Article
Pediatrics
Dominique Catherine Olthof, Sophie Reemst, Christian Sleeboom, C. F. Kuijper, Joost van Schuppen, J. P. M. Derikx, R. R. Gorter
Summary: The study demonstrates that the diagnostic accuracy of ultrasound for detecting underlying congenital abnormalities requiring surgery for umbilical discharge in pediatric population is limited, even with experienced pediatric radiologists. The sensitivity of ultrasound is 71.1% and specificity is 72.2%, indicating room for improvement in diagnostic capabilities for this condition.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Letter
Pediatrics
Kelly M. A. Dreuning, A. S. Paul van Trotsenburg, L. W. Ernest van Heurn, Joep P. M. Derikx
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Sofia el Manouni el Hassani, Hendrik J. Niemarkt, Joep P. M. Derikx, Daniel J. C. Berkhout, Andrea E. Ballon, Margot de Graaf, Willem P. de Boode, Veerle Cossey, Christian V. Hulzebos, Anton H. van Kaam, Boris W. Kramer, Richard A. van Lingen, Daniel C. Vijlbrief, Mirjam M. van Weissenbruch, Marc A. Benninga, Nanne K. H. de Boer, Tim G. J. de Meij
Summary: Lower gestational age, early clinical onset, and no maternal corticosteroids administration are predictors for surgical NEC. Low serum bicarbonate in the 3 days prior clinical onset and patent ductus arteriosus for which ibuprofen was administered predict surgical NEC.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Pediatrics
Laurens D. Eeftinck Schattenkerk, Gijsbert D. Musters, David J. Nijssen, Wouter J. de Jonge, Ralph de Vries, L. W. Ernest van Heurn, Joep P. M. Derikx
Summary: This study aggregated the incidence of different surgical site infections in infants who underwent surgery for abdominal birth defects, finding that complications like wound infection, wound dehiscence, and anastomotic leakage varied among different birth defects.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Review
Endocrinology & Metabolism
Annabel S. Zaat, Joep P. M. Derikx, Nitash Zwaveling-Soonawala, A. S. Paul van Trotsenburg, Christiaan F. Mooij
Summary: A systematic review shows that thyroidectomy is a safe treatment option for pediatric GD patients. Only a minority of patients may experience transient and benign morbidities, with hypocalcemia being the most common transient postoperative morbidity. Permanent postoperative morbidities are relatively rare.
EUROPEAN THYROID JOURNAL
(2021)
Review
Pediatrics
Francesco Morini, Kelly M. A. Dreuning, Maarten J. H. Janssen Lok, Tomas Wester, Joep P. M. Derikx, Florian Friedmacher, Hiromu Miyake, Haitao Zhu, Luca Pio, Martin Lacher, Stefania Sgro, Augusto Zani, Simon Eaton, L. W. Ernest van Heurn, Agostino Pierro
Summary: This study evaluated the evidence on pediatric inguinal hernia repair and compiled recommendations on six topics including surgical approach, timing, and anesthesia technique. Results suggest that laparoscopic repair may be beneficial for children with bilateral hernia, while preterm infants may benefit from regional anesthesia and delayed surgery. Evidence for other topics was less conclusive.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Pediatrics
Froukje A. Feenstra, Sara J. Kuik, Joep P. M. Derikx, M. Rebecca Heiner-Fokkema, Elisabeth M. W. Kooi, Arend F. Bos, Jan B. F. Hulscher
Summary: The study found that plasma citrulline levels gradually decreased in the first 48 hours after the onset of necrotizing enterocolitis (NEC), indicating ongoing intestinal injury. In survivors, measuring citrulline levels in the first 24 hours after NEC onset may provide an indication of intestinal recovery rate.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Laurens D. Eeftinck Schattenkerk, Gijsbert D. Musters, S. E. Le Coultre, Wouter J. de Jonge, L. W. Ernest van Heurn, Joep Pm Derikx
Summary: This study identified the incidence of incisional hernia following abdominal surgery in infants to be 5.2%. High risk diseases included necrotizing enterocolitis, gastroschisis, and omphalocele. Risk factors for incisional hernia included wound infection, preterm birth, and history of stoma.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Review
Pediatrics
Sanne Maat, Kelly Dreuning, Stefi Nordkamp, Wim van Gemert, Jos Twisk, Ruben Visschers, Ernst van Heurn, Joep Derikx
Summary: This systematic review compared different laparoscopic techniques for repairing pediatric inguinal hernias and found that single-port extra-corporeal closure had a lower recurrence rate and shorter operative time compared to intra-corporeal purse-string suture closing technique. Other outcome measures were inconclusive due to substantial heterogeneity.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Danielle Roorda, Jaap Oosterlaan, Ernest van Heurn, Joep P. M. Derikx
Summary: This study found a relatively low incidence of HAEC in patients with Hirschsprung disease, with preoperative and postoperative rates of 8% and 21% respectively. The median HAEC free interval after surgery was 226 days, with a decline in incidence over follow-up. No specific patient or clinical characteristics were associated with the risk of postoperative HAEC.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Review
Nutrition & Dietetics
Ilse H. de Lange, Charlotte van Gorp, Laurens D. Eeftinck Schattenkerk, Wim G. van Gemert, Joep P. M. Derikx, Tim G. A. M. Wolfs
Summary: This article summarizes the pathogenesis of necrotizing enterocolitis (NEC), highlighting the immaturity of the intestinal immune system in preterm infants and abnormal microbial colonization as key factors. Enteral feeding is considered an important factor influencing NEC pathogenesis, with bioactive components in breast milk being effective in preventing NEC.
Article
Pediatrics
Danielle Roorda, Jaap Oosterlaan, Ernest van Heurn, Joep Derikx
Summary: This retrospective study evaluated the effectiveness of BT injections in treating obstructive defecation problems in patients with Hirschsprung disease. The findings showed that BT injections can effectively improve symptoms with mild adverse effects.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Kelly M. A. Dreuning, Joep P. M. Derikx, Johan E. van Limbergen, Frea Kruisinga, Ilan J. N. Koppen
Summary: The infant with chylous ascites was unexpectedly found during surgery for bilateral inguinal hernia repair. With treatment and monitoring, the condition was controlled and the symptoms disappeared, allowing the child to successfully transition to regular feeding.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2021)
Article
Pediatrics
Fenne A. I. M. van den Bunder, Jan Hein Allema, Marc A. Benninga, Ivo de Blaauw, Tim van de Brug, Marcel den Dulk, Jan B. F. Hulscher, Claudia M. G. Keyzer-Dekker, Marieke J. Witvliet, Ernest L. W. van Heurn, Joep P. M. Derikx
Summary: The study found that the average incidence of IHPS in the Netherlands is 1.28 per 1,000 livebirths, with no changing trend or seasonal variation in incidence observed.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2021)