Article
Plant Sciences
Paulo Victor R. Souza, Vanessa G. F. C. Martins, Maria do Socorro S. Chagas, Carla J. J. Moragas-Tellis, Maria D. D. Behrens, Davyson L. L. Moreira
Summary: Anthocyanidins are natural compounds responsible for the color of foods and seed dispersal. A method was developed to quantify 3D-anth compound in plant extracts, using Arrabidaea chica Verlot as an example. The method was validated and can be used for quality control and evaluation of 3D-anth in plant extracts with chemical ecology interest.
Correction
Multidisciplinary Sciences
Changfa Wang, Haijing Li, Yu Guo, Jinming Huang, Yan Sun, Jiumeng Min, Jinpeng Wang, Xiaodong Fang, Zicheng Zhao, Shuai Wang, Yanlin Zhang, Qingfeng Liu, Qiang Jiang, Xiuge Wang, Yijun Guo, Chunhong Yang, Yinchao Wang, Fang Tian, Guilong Zhuang, Yanna Fan, Qican Gao, Yuhua Li, Zhihua Ju, Jianbin Li, Rongling Li, Minghai Hou, Guiwen Yang, Guiqin Liu, Wenqiang Liu, Jiao Guo, Shanshan Pan, Guangyi Fan, Wei Zhang, Ruitao Zhang, Jie Yu, Xinhao Zhang, Qi Yin, Chuanliang Ji, Yuanchun Jin, Guidong Yue, Mei Liu, Jiake Xu, Shimin Liu, Jordi Jordana, Antonia Noce, Marcel Amills, Dong Dong Wu, Shuaicheng Li, Xiangshan Zhou, Jifeng Zhong
Summary: The paper has been corrected.
NATURE COMMUNICATIONS
(2021)
Article
Agronomy
Mozhgan Abtahi, Aghafakhr Mirlohi, Ehsan Ataii, Mohammad R. Sabzalian, Parisa Jafari
Summary: The inheritance of seed color in flax is primarily determined by the maternal genotype, while flower color is controlled by three loci B-1, B-2, and C'. Different epistatic interactions between these loci contribute to the expression of different flower colors.
Article
Genetics & Heredity
Andrey D. Manakhov, Maria Y. Mintseva, Tatiana V. Andreeva, Pavel A. Filimonov, Alexey A. Onokhov, Irina E. Chernova, Sergey N. Kashtanov, Evgeny I. Rogaev
Summary: The discovery of a genetic mutation causing pastel fur color in sables provides valuable insights for tracking and improving fur traits in sables.
Article
Plant Sciences
Ruifang Gao, Taotao Han, Hongwei Xun, Xiangsheng Zeng, Penghui Li, Yueqing Li, Yanan Wang, Yan Shao, Xin Cheng, Xianzhong Feng, Jian Zhao, Li Wang, Xiang Gao
Summary: The study identified two key regulators, GmMYBA2 and GmMYBR, in the control of soybean seed coat pigmentation. GmMYBA2 functions as an activator of anthocyanin biosynthetic genes, while GmMYBR acts as a repressor. These regulators may form a feedback loop to finely tune seed coat coloration.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Polymer Science
Shijian Wu, Mark Mintel, Baran Teoman, Stephanie Jensen, Andrei Potanin
Summary: In this study, we propose a rapid and cost-effective computer vision approach using Python to quantify the prevalent gloppiness phenomenon observed in complex fluids and gels. We found that rheology measurements from commercial shear rheometers provide some hints, but do not strongly correlate with the extent of gloppiness. To measure the gloppiness level of laboratory-produced shower gel samples, we used the rupture time of jetting flow and found a significant correlation with data from the technical insight panelist team. While fully comprehending the gloppiness phenomenon remains complex, the Python-based computer vision technique utilizing jetting flow offers a promising, efficient, and affordable solution for assessing the degree of gloppiness in the industry.
Article
Multidisciplinary Sciences
Najiya S. K. Meethal, Deepmala Mazumdar, Sergii Morshchavka, Jasper Robben, J. van der Steen, Ronnie George, Johan J. M. Pel
Summary: This study developed a novel method for parametrization of the Pupillary Light Reflex using a haploscope-based pupillometer, and evaluated the influence of iris color on PLR. The results showed significant differences in PLR parameters between light and dark iris groups, and the potential of the proposed system in detecting pupil abnormalities in neuro-ophthalmic diseases.
SCIENTIFIC REPORTS
(2021)
Article
Computer Science, Information Systems
Jinbao Zhang, Xia Li, Yao Yao, Ye Hong, Jialyu He, Zhangwei Jiang, Jianchao Sun
Summary: The Traj2Vec method and random forest model can accurately quantify the semantic vectors of residents' trajectories and effectively classify mixed urban land use. The study shows that Shenzhen has a high degree of mixed urban land use at the street block scale, emphasizing that urban planning should focus on mixed land use to reduce residents' travel distances, lower energy consumption, and make cities more compact.
INTERNATIONAL JOURNAL OF GEOGRAPHICAL INFORMATION SCIENCE
(2021)
Article
Computer Science, Information Systems
Jeahan Jung, Minseok Choi
Summary: Polynomial chaos (PC) is an efficient method for uncertainty quantification, but it is limited by assumptions of mutual independence and exact knowledge of distribution. We propose a new data-driven method for dealing with correlated multivariate random variables, transforming them into independent random variables using singular value decomposition. The transformed variables can be used to construct a PC basis for building a surrogate model, and when combined with ANOVA, it can accurately quantify high-dimensional uncertainties with fewer simulations compared to Monte Carlo method.
Article
Biochemistry & Molecular Biology
Alejandro Garcia, Lucia Talavera-Mateo, M. Estrella Santamaria
Summary: Trichomes are hair-like appendages on plant epidermis that act as a protective barrier. We propose a new method based on machine learning for quantifying trichomes, which is fast, accessible, and adaptable to different plant species.
Article
Biochemical Research Methods
Jaskaran Singh, Yingzhou Edward Pan, Shunmoogum A. Patten
Summary: This study developed an ImageJ macro called NMJ Analyser to automatically and unbiasedly analyze the structural morphology of neuromuscular junctions in zebrafish. The macro can extract and quantify terminal structures from zebrafish images, providing valuable insights for the study of neuromuscular diseases and developmental neurobiology.
Article
Biochemistry & Molecular Biology
Maria Narciso, Jorge Otero, Daniel Navajas, Ramon Farre, Isaac Almendros, Nuria Gavara
Summary: A new image processing algorithm has been developed for quantitative analysis of DNA content in (de)cellularized tissues, offering a faster, simpler, and more comprehensive alternative to traditional methods. This method can be applied to both native and decellularized tissues, providing a means to quantify DNA content and assess decellularization procedures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Weijian Ding, Kexin Ma, Amy E. Childress
Summary: This study introduces a novel method to quantify the compaction of membranes under low pressure by combining electrical impedance spectroscopy with dynamic mechanical analysis. Results indicate that the initial instant compaction contributes more to total compaction than subsequent instant compaction. The method shows promise for detecting and predicting performance and fatigue of water treatment membranes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2023)
Article
Multidisciplinary Sciences
Charlotte Burup Kristensen, Katrine Aagaard Myhr, Frederik Fasth Grund, Niels Vejlstrup, Christian Hassager, Raj Mattu, Rasmus Mogelvang
Summary: Increased left ventricular mass is a strong predictor for adverse cardiovascular events. Conventional echocardiographic methods have limited reproducibility and accuracy, while our novel method shows better reproducibility and accuracy.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Civil
Qiaoqiao Li, Junju Zhou, Wenyue Zou, Xi Zhao, Peng Huang, Lanying Wang, Wei Shi, Xiaoyan Ma, Yaru Zhao, Dongxiang Xue, Jiao Dou, Wei Wei, Guofeng Zhu
Summary: By using the tributary-comparison method, this study conducted empirical research in the upper reaches of the Shiyang River in the eastern area of Qilian Mountain. The results showed a transition from hydrological humidification to aridification in tributaries at the annual and seasonal scales, with human activities reducing hydrological drought duration and enhancing intensity. The method can be applied in areas with varying human activity levels, providing a useful supplement to existing research methods.
JOURNAL OF HYDROLOGY
(2021)
Article
Obstetrics & Gynecology
John Mark P. Pabona, Alexander F. Burnett, Dustin M. Brown, Charles M. Quick, Frank A. Simmen, Maria Theresa E. Montales, Shi J. Liu, Tyler Rose, Iad Alhallak, Eric R. Siegel, Rosalia C. M. Simmen
REPRODUCTIVE SCIENCES
(2020)
Article
Oncology
Valentina K. Todorova, Eric R. Siegel, Yihong Kaufmann, Asangi Kumarapeli, Aaron Owen, Jeanne Y. Wei, Issam Makhoul, V. Suzanne Klimberg
TRANSLATIONAL ONCOLOGY
(2020)
Article
Hematology
Juan C. Ramos, Joseph A. Sparano, Amy Chadburn, Erin G. Reid, Richard F. Ambinder, Eric R. Siegel, Page C. Moore, Paul G. Rubinstein, Christine M. Durand, Ethel Cesarman, David Aboulafia, Robert Baiocchi, Lee Ratner, Lawrence Kaplan, Adam A. Capoferri, Jeannette Y. Lee, Ronald Mitsuyasu, Ariela Noy
Article
Developmental Biology
Hari Eswaran, Chrystal Lau, Pam Murphy, Eric R. Siegel, Hubert Preissl, Curtis Lowery
Summary: This study tracked the development trajectory of fetal auditory and visual evoked responses in high-risk pregnancies, showing a decrease in latency with gestational age progression. There was a significant difference in detection rates between male and female fetuses, but this difference was not reflected in latency values or sensory modality. Factors affecting response detectability included intervening layers of adipose tissue and an increase in maternal body mass index.
DEVELOPMENTAL PSYCHOBIOLOGY
(2021)
Article
Orthopedics
Jeffrey B. Stambough, Ryan Hui, Eric R. Siegel, Paul K. Edwards, C. Lowry Barnes, Simon C. Mears
Summary: This study reviewed preoperative and postoperative narcotic prescriptions for 438 consecutive TJA patients using the state's mandatory opioid prescription monitoring program. Patients who underwent total hip arthroplasty, were aged 65 or older, and had Medicare coverage were more likely to receive fewer post-discharge narcotic refills. Patients with higher satisfaction tended to consume less overall opioids when needing a refill.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Biochemical Research Methods
Mikyung Han, J. Alex Watts, Azemat Jamshidi-Parsian, Urooba Nadeem, Eric R. Siegel, Vladimir P. Zharov, Ekaterina I. Galanzha
Summary: Blood liquid biopsy is commonly used to detect markers of metastatic tumors, but the utility of lymphatic markers remains largely unexplored. This study introduces lymph liquid biopsy to detect stem-like CTCs in lymph samples, highlighting the significance of the lymphatic pathway in metastasis development. Integration of lymph and blood liquid biopsies showed promise for diagnosis and prognosis of early metastasis.
Article
Orthopedics
Kaleb B. Smithson, Sean G. Parham, Simon C. Mears, Eric R. Siegel, Lee Crawley, Brant C. Sachleben
Summary: Approximately 14.6% of patients transferred to a pediatric Level 1 trauma center for isolated orthopedic injuries underwent no surgery or fracture reductions and were discharged directly home. In particular, isolated tibia fractures were more frequently treated without reduction or surgery. Telemedicine consultation for these specific injury types may limit unnecessary and costly transfers to a Level 1 pediatric trauma hospital in the future.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Oncology
Sina Dadgar, Joel Rodriguez Troncoso, Eric R. Siegel, Natalie M. Curry, Robert J. Griffin, Ruud P. M. Dings, Narasimhan Rajaram
Summary: In this study, changes in hemoglobin oxygen saturation (sO(2)) in tumor xenografts from two head and neck squamous cell carcinoma cell lines during radiation therapy were monitored. The sO(2) in treatment-responsive UM-SCC-22B tumors immediately increased post-radiation, while in the relatively radiation-resistant UM-SCC-47 tumors, sO(2) increased after each radiation dose, possibly due to HIF-1 expression.
Article
Engineering, Biomedical
D. Escalona-Vargas, E. R. Siegel, S. Oliphant, H. Eswaran
Summary: This study used a non-invasive and novel magnetomyography (MMG) technique to record and characterize the activity of levator ani muscles (LAM) during pregnancy and postpartum. The results showed changes in amplitude and spectral parameters of LAM activity during postpartum. This study provides a new method for studying the changes in LAM activity during pregnancy and postpartum.
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2022)
Article
Surgery
Yihong Kaufmann, Stephanie D. Byrum, Alison A. Acott, Eric R. Siegel, Charity L. Washam, V. Suzanne Klimberg, Anne T. Mancino
Summary: Protein profiling in tears can distinguish patients with and without colon lesions.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Bernice Nounamo, Fariba Jousheghany, Eric Robb Siegel, Steven R. R. Post, Thomas Kelly, Soldano Ferrone, Thomas Kieber-Emmons, Behjatolah Monzavi-Karbassi
Summary: The study demonstrated that anti-CSPG4 monoclonal antibodies exhibit anti-tumor activity and therapeutic potential for breast cancer treatment. The specificity and importance of glycan contribution to the binding of specific anti-CSPG4 antibodies to tumor cells were investigated. The mAb VT68.2 displayed strong binding to a carbohydrate-mimicking peptide (CMP) and showed a higher affinity for certain glycans. Furthermore, VT68.2 inhibited cancer cell migration, suggesting its potential as a less toxic therapeutic approach targeting tumor-specific glyco-peptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Alan P. Baltz, Eric R. Siegel, Arif H. Kamal, Robert Siegel, Mary May Kozlik, Stephanie T. S. Crist, Issam Makhoul, ASCO Quality Publications Task Force
Summary: The American Society for Clinical Oncology released the Choosing Wisely list in 2012, advising against the use of certain imaging procedures for staging early-stage breast cancer. A study was conducted to assess the impact of these guidelines on inappropriate staging imaging among early-stage breast cancer patients.
JCO ONCOLOGY PRACTICE
(2023)
Article
Physiology
Luis Mercado, Diana Escalona-Vargas, Sarah Blossom, Eric R. Siegel, Julie R. Whittington, Hubert Preissl, Kaitlyn Walden, Hari Eswaran
Summary: The study found that maternal pregestational diabetes has an effect on the fetal autonomic nervous system (ANS), which can be assessed using non-invasive fetal magnetocardiography. There were differences in the frequency domain of fetal heart rate variability (fHRV) and heart rate-movement coupling in fetuses of pregestational diabetic mothers compared to non-diabetics. However, the effect on fHRV related to fetal ANS and sympathovagal balance was not as conclusive as observed in neonates of pregestational diabetic mothers.
PHYSIOLOGICAL REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Stefania Bellone, Blair McNamara, Levent Mutlu, Cem Demirkiran, Tobias Max Philipp Hartwich, Justin Harold, Yang Yang-Hartwich, Eric R. Siegel, Alessandro D. Santin
Summary: The use of personalized circulating tumor DNA markers can potentially detect residual tumors and early recurrences in patients with uterine serous carcinoma and carcinosarcomas, leading to earlier treatment and changing clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Lauren C. Morehead, Sarita Garg, Katherine F. Wallis, Camila C. Simoes, Eric R. Siegel, Alan J. Tackett, Isabelle R. Miousse
Summary: The study found that restricting methionine in the diet increased the expression of MHC-I and PD-L1 in colorectal cancer cells, as well as the expression of STING and interferon. This led to a better response to immune checkpoint inhibitors in a mouse model of colorectal cancer.