Article
Neurosciences
Elias Gebara, Olivia Zanoletti, Sriparna Ghosal, Jocelyn Grosse, Bernard L. Schneider, Graham Knott, Simone Astori, Carmen Sandi
Summary: The research suggests that the mitochondrial GTPase MFN2 in the NAc plays a crucial role in regulating anxiety and depression-like behaviors by impacting mitochondrial and MSN structure and function. Viral MFN2 overexpression in the NAc can reverse these behavioral and neuronal phenotypes changes.
BIOLOGICAL PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Adalberto Merighi, Laura Lossi
Summary: In addition to protein processing, the endoplasmic reticulum (ER) also plays roles in lipid synthesis, molecular transfers, and Ca2+ homeostasis. Proper protein folding and modification in the ER require molecular chaperones and a favorable environment. Disruption in ER conditions or chaperone capacity can lead to the unfolded protein response (UPR), triggering autophagy and potentially causing cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Cell Biology
Marijn Kuijpers, Volker Haucke
Summary: The role of macroautophagy/autophagy in neurons and the physiological substrates in healthy neurons are still largely unknown. Research has shown that loss of neuronal autophagy can affect neurotransmission and calcium homeostasis in axonal and synaptic regions.
Article
Plant Sciences
Maria De Benedictis, Antonia Gallo, Danilo Migoni, Paride Papadia, Pietro Roversi, Angelo Santino
Summary: We studied the response of Arabidopsis thaliana to chronic and temporary Cd2+ stress, finding that Cd2+ induces ER stress and unfolded protein response (UPR) through the bZIP60 arm. The UPR activation is concentration- or time-dependent and leads to the activation of ER stress marker genes. Severe Cd2+ stress triggers programmed cell death (PCD) through NAC089 activation. The Atbzip28/bzip60 double mutant shows reduced UPR and PCD, as well as enhanced Cd2+ tolerance, possibly due to increased brassinosteroids signaling.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Microbiology
Veronica Garrido-Bazan, Jesus Aguirre
Summary: The dynamin-like protein DnmA and its receptor FisA play essential roles in H2O2-induced mitochondrial division in Aspergillus nidulans. Lack of DnmA or FisA results in fewer spontaneous mitochondrial constrictions, which are significantly increased by H2O2 or CCCP. H2O2 causes transient constrictions while CCCP induces irreversible alterations in mitochondrial filaments.
Article
Neurosciences
Yi Li, Shuizhen Shi, Fan Xia, Chao Shan, Yonju Ha, Jing Zou, Awadalkareem Adam, Ming Zhang, Tian Wang, Hua Liu, Pei-Yong Shi, Wenbo Zhang
Summary: Research suggests that ZIKV infection causes damage to the neurons and blood vessels in the retina, leading to inflammation and cell apoptosis, resulting in retinal abnormalities. The use of the preventive drug NITD008 may help to block ZIKV-induced retinal abnormalities, but the use of a live-attenuated ZIKV vaccine candidate may potentially induce them. This study established a new mouse model, providing a direct link between ZIKV and retinal lesions, laying the foundation for further investigation into the mechanisms of ZIKV-induced retinopathy and the development of effective treatments.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Neurosciences
Alexandre Bouron
Summary: The endoplasmic reticulum (ER) is the primary storage compartment for calcium (Ca2+) in eukaryotic cells. Ca2+ is mobilized from the ER through store-operated Ca2+ channels (SOCCs), leading to a store-operated Ca2+ entry (SOCE) that has been extensively studied in non-excitable cells. The presence of this Ca2+ entry route in neurons has been a subject of debate, but experimental evidence suggests that SOCE can be generated by the recruitment of Ca2+ from neuronal ER Ca2+ stores. This review summarizes the main supporting studies and explores the molecular composition, expression, pharmacological properties, and physiological relevance of neuronal SOCCs.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Cell Biology
Nannan Tan, Tianhua Liu, Xiaoping Wang, Mingyan Shao, Miao Zhang, Weili Li, Guanjing Ling, Jinchi Jiang, Qiyan Wang, Jing Li, Chun Li, Wei Wang, Yong Wang
Summary: FUNDC1, as a receptor of mitophagy, plays a crucial role in maintaining mitochondrial function and clearance, protein folding, iron metabolism, and the interaction with endoplasmic reticulum. Studies have also shown that FUNDC1 is associated with the progression of ischemic diseases, cancer, and metabolic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Joana aniani Sa-Pessoa, Sara Lopez-Montesino, Kornelia Przybyszewska, Isabel Rodriguez-Escudero, Helina Marshall, Adelia Ova, Gunnar N. Schroeder, Peter Barabas, Maria Molina, Tim Curtis, Victor J. Cid, Jose A. Bengoechea
Summary: The trans-kingdom antimicrobial T6SS effector VgrG4 from Klebsiella pneumoniae can manipulate eukaryotic cells by altering the mitochondrial network. VgrG4 colocalizes with the endoplasmic reticulum protein mitofusin 2. VgrG4 induces the transfer of calcium from the endoplasmic reticulum to the mitochondria, activating the regulator of mitochondrial fission, Drp1, resulting in mitochondrial network fragmentation.
NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Li Ma, Sirao Hai, Chenlong Wang, Chuangjiang Chen, Sajid Ur Rahman, Chang Zhao, Mansoor Ahmed Bazai, Shibin Feng, Xichun Wang
Summary: This study aimed to investigate the molecular mechanism of Zearalenone (ZEA)-induced dysfunction of mitochondria-associated endoplasmic reticulum membranes (MAM) in piglet Sertoli cells (SCs) through the endoplasmic reticulum stress (ERS) pathway. The results showed that ZEA damaged cell viability, disrupted MAM structure, and altered protein expression of various markers related to MAM function. The inhibition of ERS reduced the cytotoxicity of ZEA and restored the normal function of MAM in SCs.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Multidisciplinary Sciences
Hakjoo Lee, Tae Jin Lee, Chad A. Galloway, Wenbo Zhi, Wei Xiao, Karen L. de Mesy Bentley, Ashok Sharma, Yong Teng, Hiromi Sesaki, Yisang Yoon
Summary: This study reveals that OPA1 is dispensable in the liver and its deletion induces a mitohormesis response that protects the liver from drug toxicity and enhances liver resilience.
NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Zhaoqi He, Peng Shen, Lianjun Feng, Haoyang Hao, Yuhong He, Guyue Fan, Zhuoyu Liu, Kun Zhu, Yiqi Wang, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu, Jiacheng Wu
Summary: Cadmium-induced liver toxicity is associated with ferroptosis, which is involved in oxidative stress, autophagy, and endoplasmic reticulum stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cell & Tissue Engineering
Malgorzata Zatyka, Tatiana R. Rosenstock, Congxin Sun, Adina M. Palhegyi, Georgina W. Hughes, Samuel Lara-Reyna, Dewi Astuti, Alessandro di Maio, Axel Sciauvaud, Miriam E. Korsgen, Vesna Stanulovic, Gamze Kocak, Malgorzata Rak, Sandra Pourtoy-Brasselet, Katherine Winter, Thiago Varga, Margot Jarrige, Helene Polveche, Joao Correia, Eva-Maria Frickel, Maarten Hoogenkamp, Douglas G. Ward, Laetitia Aubry, Timothy Barrett, Sovan Sarkar
Summary: Wolfram syndrome (WS) is a rare early-onset neurodegenerative disease that is associated with mitochondrial abnormalities. The loss of interaction between WFS1 and VDAC1 in WS cells can compromise mitochondrial function, but restoring WFS1 levels can improve mitochondrial function and network. Therefore, targeting WFS1 or modulating mitochondrial function may provide a therapeutic intervention for WS and similar diseases.
Article
Pharmacology & Pharmacy
Acacia White, Rohan Umesh Parekh, Drew Theobald, Pranaya Pakala, Ariel Lynn Myers, Rukiyah Van Dross, Srinivas Sriramula
Summary: Activation of kinin B1 receptor (B1R) is found to contribute to the development of endoplasmic reticulum stress (ER stress) and the initiation of unfolded protein response (UPR) in neurons, making it a key factor in the ER stress pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Julie Bas, Trang Nguyen, Germain Gillet
Summary: Bcl-2 family proteins, known for their role in regulating apoptosis, also have non-canonical functions in the CNS. Bcl-xL, a close homolog of Bcl-2, plays a crucial role in neuronal development, promoting ATP generation in mitochondria and contributing to synaptic transmission without causing cell death. Understanding the roles of cell death machinery in neurons may have important clinical implications for degenerative diseases and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ana R. Inacio, Yawei Liu, Bettina H. Clausen, Martina Svensson, Krzysztof Kucharz, Yiyi Yang, Totte Stankovich, Reza Khorooshi, Kate L. Lambertsen, Shohreh Issazadeh-Navikas, Tomas Deierborg
JOURNAL OF NEUROINFLAMMATION
(2015)
Article
Endocrinology & Metabolism
Krzysztof Kucharz, Ida Sondergaard Rasmussen, Anders Bach, Kristian Stromgaard, Martin Lauritzen
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Article
Clinical Neurology
Krzysztof Kucharz, Martin Lauritzen
Article
Endocrinology & Metabolism
Krzysztof Kucharz, Tadeusz Wieloch, Hakan Toresson
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2011)
Article
Neurosciences
Krzysztof Kucharz, Tadeusz Wieloch, Hakan Toresson
JOURNAL OF NEUROSCIENCE RESEARCH
(2011)
Article
Neurosciences
Ai Na Ng, Morten Krogh, Hakan Toresson
JOURNAL OF NEUROSCIENCE RESEARCH
(2011)
Article
Neurosciences
Ai Na Ng, Hakan Toresson
Article
Neurosciences
Ai Na Ng, Andrew J. Doherty, Paul J. Lombroso, Nigel J. Emptage, Graham L. Collingridge
Article
Microbiology
Crystal Woodard, Meir Shamay, Gangling Liao, Jian Zhu, Ai Na Ng, Renfeng Li, Rob Newman, Hee-Sool Rho, Jianfei Hu, Jun Wan, Jiang Qian, Heng Zhu, S. Diane Hayward
Article
Clinical Neurology
K. Kucharz, T. Wieloch, H. Toresson
TRANSLATIONAL STROKE RESEARCH
(2013)
Article
Cell Biology
Thomas M. Sanderson, Clarrisa A. Bradley, John Georgiou, Yun Hwa Hong, Ai Na Ng, Yeseul Lee, Hee-Dae Kim, Doyeon Kim, Mascia Amici, Gi Hoon Son, Min Zhuo, Kyungjin Kim, Bong-Kiun Kaang, Sang Jeong Kim, Graham L. Collingridge
Article
Biology
Mette Mathiesen Janiurek, Rana Soylu-Kucharz, Christina Christoffersen, Krzysztof Kucharz, Martin Lauritzen
Article
Pharmacology & Pharmacy
Mie Kristensen, Krzysztof Kucharz, Eduardo Felipe Alves Fernandes, Kristian Stromgaard, Morten Schallburg Nielsen, Hans Christian Cederberg Helms, Anders Bach, Malte Ulrikkaholm Tofte-Hansen, Blanca Irene Aldana Garcia, Martin Lauritzen, Birger Brodin
Article
Multidisciplinary Sciences
Krzysztof Kucharz, Kasper Kristensen, Kasper Bendix Johnsen, Mette Aagaard Lund, Micael Lonstrup, Torben Moos, Thomas Lars Andresen, Martin Johannes Lauritzen
Summary: Limited understanding of interactions between nanoparticle drug carriers and the blood-brain barrier underlies many translational failures in treatments of brain disorders. Here the authors use two-photon microscopy in mice to characterize the receptor-mediated transcytosis of nanoparticles at all steps of delivery from the blood to the brain in vivo.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Thomas M. Sanderson, Liam T. Ralph, Mascia Amici, Ai Na Ng, Bong-Kiun Kaang, Min Zhuo, Sang Jeong Kim, John Georgiou, Graham L. Collingridge
Summary: In hippocampal area CA1, mGluR-LTD can be expressed by a decrease in neurotransmitter release probability or a change in postsynaptic AMPA receptor number. The determinant of expression locus is still unknown. Using different concentrations of DHPG, we found that low concentration DHPG induces presynaptic LTD that requires NMDA receptor co-activation, while high concentration DHPG induces postsynaptic LTD that is independent of NMDA receptor activation. Our results reveal an unexpected complexity to mGluR-mediated synaptic plasticity in the hippocampus.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2022)