Article
Biochemistry & Molecular Biology
Bo Bae Lee, Hyeonju Woo, Min Kyung Lee, SeoJung Youn, Sumin Lee, Jae-Seok Roe, Soo Young Lee, TaeSoo Kim
Summary: Chromatin-based regulation of internal cryptic promoters is mediated by core promoter strength as well as transcription elongation factors.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Cell Biology
Dong-Hyuk Heo, Krzysztof Kus, Pawel Grzechnik, Sue Mei Tan-Wong, Adrien Birot, Tea Kecman, Soren Nielsen, Nikolay Zenkin, Lidia Vasiljeva
Summary: Phosphorylation of the RNA polymerase II C-terminal domain Y1S2P3T4S5P6S7 consensus sequence is crucial for coordinating key events in transcription, and its dysregulation can lead to defects in transcription and RNA processing. The histone deacetylase activity of the fission yeast Hos2/Set3 complex has been found to play a significant role in suppressing cryptic initiation of antisense transcription, particularly when RNA polymerase II phosphorylation is dysregulated. Loss of Hos2 or Set3, combined with the absence of Ssu72 phosphatase, results in a synergistic increase in antisense transcription globally and higher sensitivity to genotoxic agents.
Article
Biochemistry & Molecular Biology
Chao Dong, Liwei An, Cheng-han Yu, Michael S. Y. Huen
Summary: The DYRK1B kinase plays a crucial role in maintaining rDNA stability, nucleolar reorganization, and inhibition of rRNA synthesis. Inhibition of DYRK1B results in sustained nucleolar transcription, hypersensitivity to DSBs at rDNA arrays, and requirement for DSB repair and rDNA copy number maintenance. These findings highlight the importance of DYRK1B as a key signaling intermediate in coordinating DSB repair and rDNA transcriptional activities within the nucleolus.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Fangyu Song, Wenshuo Zhang, Xiaohui Li, Xiaoqing Chen, Xuejun Yuan, Mingjin Jiang, Yunhe Zhao, Qingxin Liu, Zizhang Zhou
Summary: The main cause of high mortality in cancer patients is tumor metastasis, and exploring the underlying mechanism of tumor metastasis is important for clinical treatments. This study identifies the transcription factor Apt/FSBP as a suppressor for tumor metastasis, providing it as a potential drug target for tumor treatment.
Article
Cell Biology
Marek M. Drozdz, Ashley S. Doane, Rached Alkallas, Garrett Desman, Rohan Bareja, Michael Reilly, Jakyung Bang, Maftuna Yusupova, Jaewon You, Zuhal Eraslan, Jenny Z. Wang, Akanksha Verma, Kelsey Aguirre, Elsbeth Kane, Ian R. Watson, Olivier Elemento, Elena Piskounova, Taha Merghoub, Jonathan H. Zippin
Summary: Nuclear cAMP microdomains can activate a tumor-suppressive pathway in a broad range of cancers by inhibiting the key effector protein YAP of the Hippo pathway.
Article
Cell Biology
Jianming Zhang, Jing Zhang, Zhongmao Fu, Yuan Zhang, Zai Luo, Pengshan Zhang, Yitian Xu, Chen Huang
Summary: Accumulating evidence suggests that downregulation of carbohydrate response element binding protein (CHREBP) is associated with gastric cancer (GC) development and progression. CHREBP acts as an independent diagnostic marker of GC and its downregulation promotes cell proliferation and inhibits apoptosis. Furthermore, CHREBP transcriptionally inhibits cyclin D1 expression in GC cells, suggesting its involvement in GC growth and apoptosis through targeting the cyclin D1-Rb-E2F1 pathway.
CELL DEATH DISCOVERY
(2022)
Article
Plant Sciences
Fisun G. Celikel, Qingchun Zhang, Yanlong Zhang, Michael S. Reid, Cai-Zhong Jiang
Summary: Application of thidiazuron on potted rose plants effectively inhibits leaf yellowing, resulting in compact plants with shorter shoots and thicker internodes. Thidiazuron likely modulates cell architecture and suppresses the expression of gibberellic acid biosynthesis genes, leading to altered plant growth responses. Ethylene production by plants is stimulated by thidiazuron, but inhibitors of ethylene biosynthesis or action do not affect the plant's response to thidiazuron.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Medicine, General & Internal
Deying Liu, Yan Huang, Chensihan Huang, Shunyu Yang, Xueyun Wei, Peizhen Zhang, Dan Guo, Jiayang Lin, Bingyan Xu, Changwei Li, Hua He, Jiang He, Shiqun Liu, Linna Shi, Yaoming Xue, Huijie Zhang
Summary: Among patients with obesity, a regimen of time-restricted eating was not more beneficial with regard to reduction in body weight, body fat, or metabolic risk factors than daily calorie restriction.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Seongmoon Jo, Sang Hee Im, Dongryul Seo, Hayeon Ryu, Sung Hoon Kim, Dawoon Baek, Ahreum Baek, Sung-Rae Cho
Summary: The study found that low-frequency rMS treatment can suppress the progression of neuroblastoma by downregulating the Wnt/β-catenin signaling pathway. This suggests that low-frequency rMS treatment may be a potential therapeutic strategy for tumor suppression.
BIOELECTROCHEMISTRY
(2022)
Article
Oncology
Xianliang Yang, Youjia Xu, Chao Jiang, Ziping Ma, Linguang Jin
Summary: Verteporfin (VP) inhibits tumor progression in osteosarcoma by downregulating the expression of YAP1 and TEAD1. Additionally, VP can modulate the effects on osteosarcoma by suppressing CYR61 expression.
Article
Cell Biology
Shenglin Gao, Lei Gao, Simin Wang, Xiaokai Shi, Chuang Yue, Shuzhang Wei, Li Zuo, Lifeng Zhang, Xihu Qin
Summary: Clear cell renal cell carcinoma (ccRCC) is a common malignant cancer in East Asia with high incidence and mortality rates. ATF3 expression is decreased in ccRCC and overexpression of ATF3 can inhibit tumor growth through the EGFR/AKT/GSK3 signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Shikun Yang, Wei Jiang, Wenjie Yang, Chao Yang, Xinchen Yang, Keyan Chen, Yuanchang Hu, Gefenqiang Shen, Ling Lu, Feng Cheng, Feng Zhang, Jianhua Rao, Xuehao Wang
Summary: miR-1224 is commonly downregulated in HCC and associated with poor clinicopathologic features and short overall survival. Its expression is modulated by CpG islands methylation, and it inhibits HCC cell proliferation by repressing YAP signaling pathway. The feedback loop between miR-1224 and CREB may represent a promising target for HCC treatment.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biotechnology & Applied Microbiology
Wen Ye, Yachao Cui, Jian Rong, Wenlin Huang, Zhousan Zheng, Anqi Li, Yingchang Li
Summary: The expression of MCPIP1 is reduced in colorectal cancer tissues and is associated with poor prognosis. MCPIP1 exerts its anti-cancer effect by suppressing the NF-κB signaling pathway, making it a potential treatment option.
CANCER GENE THERAPY
(2023)
Article
Agronomy
Wang Chuxin, Zhu Chengchao, Zhou Yu, Xiong Min, Wang Jindong, Bai Huang, Lu Chenya, Zhang Changquan, Liu Qiaoquan, Li Qianfeng
Summary: A novel and unique OsbZIP transcription factor OsbZIP09 was identified, which functions as a brake of the ABA pathway to attenuate the inhibitory effect of ABA on rice seed germination via dual strategies. It directly enhances the expression of ABA catabolism gene ABA8ox1 and inhibits the expression of the LEA3 gene to reduce ABA accumulation and alleviate the suppressive effect of ABA on seed germination, respectively.
Article
Energy & Fuels
Xu Fang, Longhua Hu, Xiaolei Zhang, Richard K. K. Yuen
Summary: This paper investigates the flame morphological characteristics of diffusion combustion in cross-wind with or without near-wall constraint. The flame height is higher and flame tilt angle is lower in near-wall condition, while flame horizontal length shows a complex trend with increasing cross-wind speed.
Review
Hematology
Denis F. Noubouossie, Brandi N. Reeves, Brian D. Strahl, Nigel S. Key
Article
Genetics & Heredity
Mary Leatham-Jensen, Christopher M. Uyehara, Brian D. Strahl, A. Gregory Matera, Robert J. Duronio, Daniel J. McKay
Article
Biochemistry & Molecular Biology
Katherine I. Albanese, Mackenzie W. Krone, Christopher J. Petell, Madison M. Parker, Brian D. Strahl, Eric M. Brustad, Marcey L. Waters
ACS CHEMICAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Hashem A. Meriesh, Andrew M. Lerner, Mahesh B. Chandrasekharan, Brian D. Strahl
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Anne-Marie W. Turner, Raghuvar Dronamraju, Frances Potjewyd, Katherine S. James, Daniel K. Winecoff, Jennifer L. Kirchherr, Nancie M. Archin, Edward P. Browne, Brian D. Strahl, David M. Margolis, Lindsey James
ACS INFECTIOUS DISEASES
(2020)
News Item
Biochemistry & Molecular Biology
Kanishk Jain, Brian D. Strahl
Summary: High-throughput biochemical and biological analyses of disease-associated histone mutations reveal key residues in globular cores that affect chromatin remodeling, nucleosome stability, and stem cell pluripotency.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andrew R. Yoblinski, Seoyoung Chung, Sophie B. Robinson, Kaitlyn E. Forester, Brian D. Strahl, Raghuvar Dronamraju
Summary: In yeast cells, Dma1 and Dma2 work redundantly and catalytically to maintain genome stability, influencing the choice of repair pathways. They localize to transcribed regions of the genome and increase in abundance after DNA damage.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Paul Enriquez, Krzysztof Krajewski, Brian D. Strahl, Scott B. Rothbart, Robert H. Dowen, Robert B. Rose
Summary: This study explores the function of Bromodomains in SWI/SNF chromatin-remodeling complexes, demonstrating the recognition of acetylated lysine 14 on histones by the SMARCA4 BD. The findings suggest essential roles for the SWI/SNF bromodomain in vivo and reveal potential redundancy in epigenetic readers regulating chromatin remodeling. Implications include the development of small-molecule BD inhibitors for cancer and disease treatment.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Jibo Zhang, Aakanksha Gundu, Brian D. Strahl
Summary: In this study, Zhang et al. investigate how transcription programs rapidly adjust to changing metabolic and cellular cues, with a focus on the role of the Yaf9 component in maintaining timely transcription of metabolic genes across the yeast metabolic cycle. They find that Yaf9 recruits chromatin regulatory complexes to deposit H2A.Z and acetylate H4, promoting transcriptional initiation during the oxidative phase. These findings suggest a dynamic chromatin and transcription initiation factor signature is necessary for proper regulation of metabolic gene transcription during the yeast metabolic cycle, with unique regulatory mechanisms at distinct metabolic states.
GENES & DEVELOPMENT
(2021)
Article
Biology
Christopher J. Petell, Kathyrn Randene, Michael Pappas, Diego Sandoval, Brian D. Strahl, Joseph S. Harrison, Joshua P. Steimel
Summary: The METRIS assay leverages the concept of friction to measure protein-protein interaction affinities, offering high resolution and sensitivity. It allows for the measurement of a wide range of affinities with a small amount of reagents, providing new insights into epigenetic recognition.
Article
Genetics & Heredity
Aaron T. Crain, Stephen Klusza, Robin L. Armstrong, Priscila Santa Rosa, Brenda R. S. Temple, Brian D. Strahl, Daniel J. McKay, A. Gregory Matera, Robert J. Duronio
Summary: KMT5A and Set8 enzymes have functional conservation in Drosophila development, and the N-terminal domain of Set8 has a specific role in eye development, which is distinct from H4K20me1.
Editorial Material
Cell Biology
Kanishk Jain, Brian D. Strahl
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Letter
Cell Biology
Zhenzhen Chen, Taylor Lundy, Zhongliang Zhu, Victoria E. Hoskins, Jiahai Zhang, Xuebiao Yao, Brian D. Strahl, Chao Xu
Correction
Cell Biology
Zhenzhen Chen, Taylor Lundy, Zhongliang Zhu, Victoria E. E. Hoskins, Jiahai Zhang, Xuebiao Yao, Brian D. D. Strahl, Chao Xu
Article
Multidisciplinary Sciences
Adam H. Tencer, Khan L. Cox, Gregory M. Wright, Yi Zhang, Christopher J. Petell, Brianna J. Klein, Brian D. Strahl, Joshua C. Black, Michael G. Poirier, Tatiana G. Kutateladze
NATURE COMMUNICATIONS
(2020)