Article
Multidisciplinary Sciences
Giulia Dottorini, Thomas Yssing Michaelsen, Sergey Kucheryavskiy, Kasper Skytte Andersen, Jannie Munk Kristensen, Miriam Peces, Dorottya Sarolta Wagner, Marta Nierychlo, Per Halkjaer Nielsen
Summary: The study quantified the impact of immigration on bacterial communities in wastewater treatment plants by analyzing the species level in 11 Danish full-scale activated sludge plants. It revealed that the microbial communities in wastewater treatment plants were strongly controlled by the source community and could be quantitatively predicted by considering immigration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Environmental
Takahiro Kubo, Diogo Verissimo, Shinya Uryu, Taro Mieno, Douglas MacMillan
Summary: Online crowdfunding can help address financial shortfalls in environmental conservation, but factors influencing success are complex. Campaign topics, marketing strategies, and competition all play a role in determining the success of crowdfunding efforts.
Article
Multidisciplinary Sciences
Lei Rao, Bing Zhou, Raphael Serruya, Arieh Moussaieff, Lior Sinai, Sigal Ben-Yehuda
Summary: Bacterial spores can remain dormant for years and then revive by metabolizing glutamate and producing ATP, a process influenced by the metabolic enzyme RocG and the initial developmental phase of spore formation.
Article
Multidisciplinary Sciences
Predrag Popovic, Olivier Devauchelle, Anais Abramian, Eric Lajeunesse
Summary: By studying laboratory rivers, we found that the balance between fluid stress, gravity, and cross-stream diffusion determines the shape and sediment flux of rivers. Rivers are restricted to exist near the threshold of sediment motion, and can widen to transport more sediment as total sediment discharge increases. The way sediment is transported in the flow depends on the state of sediment transport.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Yan Zhao, Shanshan Mo, Lanlan Yu, Xiaolu Li, Yun Hao, Wenbo Zhang, Qi Zhang, Ping Wang, Xiangdong Wang, Chenxuan Wang, Luo Zhang
Summary: The crystalline state of a protein is correlated with its potency to induce inflammation.
Article
Chemistry, Multidisciplinary
Lijun Thayyil Raju, Olga Koshkina, Huanshu Tan, Andreas Riedinger, Katharina Landfester, Detlef Lohse, Xuehua Zhang
Summary: Our study demonstrates that the size of colloidal particles determines the shape of supraparticles. By comparing supraparticles made of different sized silica particles and mixtures of small and large particles, we found that colloidal particles form a flexible shell at the rapidly moving interfaces of evaporating droplets.
Article
Multidisciplinary Sciences
Florian M. Gartner, Isabella R. Graf, Erwin Frey
Summary: The time complexity of nonequilibrium self-assembly processes is characterized and different assembly scenarios are identified with distinct degrees of complexity. Optimal control strategies are determined. An efficient irreversible scheme for artificial self-assembly of nanostructures is proposed.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Materials Science, Multidisciplinary
Guannan Zu, Yunfei Yang, Hongyi Li, Juan Wang, Yonghong Fu, Xinxin Wang, Wenyuan Zhou, Jinshu Wang
Summary: Wearable flexible devices require advanced lithium-ion batteries (LIBs) for energy supply, thus promoting the development of self-assembled, binder-free, film-type anodes with the advantage of no additives, strong binding force and low contact resistance. 2H phase molybdenum disulfide (2H-MoS2) has been attracting much attention due to its high practical capacity and graphene-like structure. However, few interests are paid to the compactness design inside the in-situ grown MoS2 film on bendable matrices, leading to poor structure stability and low volumetric capacity.
MATERIALS CHARACTERIZATION
(2023)
Article
Chemistry, Physical
Gurvinder Singh, Hesamodin Jami, Pooria Lesani, Shubhayan Bhattacharya, Yogambha Ramaswamy, Prem B. Bisht, Hala Zreiqat
Summary: Understanding surface processes is crucial in producing reproducibly stellated or branched gold nanoparticles with precise control. By tuning reaction variables, such as reduction rate and molecules/ions density, various shapes of thermodynamically stabilized and kinetic gold nanoparticles can be obtained. High temperature stability and self-assembly abilities of these nanoparticles have been studied, showing potential for advanced applications.
Article
Environmental Sciences
Ziyang Dong, Yuxin Ma, Mengwen Yu, Yufei Cai, Yingluo Chen, Junwei Wu, Fang Ma, Baolan Hu
Summary: This study aimed to investigate the impact of two siderophores specific for Ca. Brocadia and Ca. Kuenenia on the assembly, interaction mode, and stability of the anammox community. Siderophores improved the stability of the anammox community by reducing vulnerability and altering the assembly pattern and succession speed. The affinity of different siderophore-Fe with bacterial membrane receptors influenced community reconstruction, with Ca. Brocadia and Ca. Kuenenia exhibiting high affinity with enterobactin-Fe and putrebactin-Fe, respectively.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Physical
Alexandra Mavridi-Printezi, Arianna Menichetti, Lucia Ferrazzano, Marco Montalti
Summary: A simple supramolecular charge-transfer adduct is formed during the formation of synthetic melanin, and its stability can be determined using a simple association model.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Physical
Alexandra Mavridi-Printezi, Arianna Menichetti, Lucia Ferrazzano, Marco Montalti
Summary: This study demonstrates that a small fraction of dopamine is oxidized to form a supramolecular charge-transfer adduct during the formation of synthetic melanin, which exhibits similar optical properties to melanin materials in the red-NIR region. The adduct can easily disassemble upon dilution, indicating the reversibility of the process.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Mathematics
Fucheng Liao, Hao Xie
Summary: This paper investigates the construction method of pandiagonal magic cube and proposes a simple way to construct it. By designing a set of orthogonal pandiagonal Latin cubes, the corresponding order pandiagonal magic cube can be constructed. The paper also provides algebraic conditions and strict theoretical proof for the orthogonality of universal diagonal Latin cubes. It is shown that at least 6(n!)(3) pandiagonal magic cubes of order n can be formed through a pandiagonal Latin cube, and the method is easy to implement by computer program.
Article
Chemistry, Multidisciplinary
Jiehui Xue, Ning Zheng, Wenyu Zhao, Xia Cao, Zhong Lin Wang
Summary: SRC-TENG is a self-powered generator based on the principle of frictional electricity generation, capable of powering LEDs and charging commercial capacitors. It can be used as a self-powered sensor in smart toys and track the movement trajectory of a Rubik cube during recovery.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Physical
Ming Zhou, Hongsen Wang, Lihua Zhang, Can Li, Amar Kumbhar, Hector D. Abruna, Jiye Fang
Summary: Surface-structure engineering is an effective strategy to optimize the energy conversion performance of nanocatalysts. In this study, the crystallographic facets of ultra-small CuMn2O4 spinel nanocatalysts were controlled through a colloidal synthesis approach to improve the electrocatalytic activity and durability for oxygen reduction reaction (ORR). The {101} facet-exposed CuMn2O4 nano-octahedra showed higher electrocatalytic activity and better durability compared to their spherical counterparts.
Article
Engineering, Biomedical
Arijit Ghosh, Yizhang Liu, Dmitri Artemov, David H. Gracias
Summary: The study optimized the magnetic dipole moment of untethered thermally responsive grippers for efficient coupling to external magnetic resonance (MR) fields. Gripper encapsulation in a millimeter sized wax pellet reduces friction with surrounding tissue and enables MR Navigation (MRN) of a 700 μm sized microgripper within narrow channels in tissue phantoms and in an ex vivo porcine esophagus. The results provide convincing proof-of-concept evidence that it is possible to sequentially image, move, and guide a submillimeter functional microsurgical tool in tissue conduits using a commercial preclinical MR system, which is an important step towards the clinical translation of untethered microtools in combination with prior demonstrations of physiologically responsive in vivo biopsy.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
David H. Gracias
Summary: Integrated nanotechnology 2.0 focuses on the design, fabrication, and assembly of nanostructured devices that could significantly impact human life through artificial intelligence, smart medicine, and robotics. This article outlines a few examples, principles, and perspectives.
IEEE NANOTECHNOLOGY MAGAZINE
(2022)
Article
Chemistry, Multidisciplinary
Debadrita Paria, Kam Sang Kwok, Piyush Raj, Peng Zheng, David H. Gracias, Ishan Barman
Summary: The study reports a large-scale and label-free testing platform that combines surface-enhanced Raman spectroscopy and machine learning for rapid and accurate detection of SARS-CoV-2. The technique can not only distinguish between different types of viruses, but also detect virus signatures in human saliva without additional sample preparation.
Article
Chemistry, Multidisciplinary
Gayatri J. Pahapale, Jiaxiang Tao, Milos Nikolic, Sammy Gao, Giuliano Scarcelli, Sean X. Sun, Lewis H. Romer, David H. Gracias
Summary: Precise spatial organization of multicellular structures plays a vital role in biological processes. This study uncovers a new mode of self-organization of endothelial cells guided by the combined effects of stiffness and geometry, independent of protein or chemical patterning.
Article
Multidisciplinary Sciences
Qi Huang, Bohao Tang, July Carolina Romero, Yuqian Yang, Saifeldeen Khalil Elsayed, Gayatri Pahapale, Tien-Jung Lee, Itzy E. Morales Pantoja, Fang Han, Cynthia Berlinicke, Terry Xiang, Mallory Solazzo, Thomas Hartung, Zhao Qin, Brian S. Caffo, Lena Smirnova, David H. Gracias
Summary: Researchers have developed miniaturized wafer-integrated caps with multiple electrodes (MEAs) for electrical recording in brain organoids. These MEAs have the ability to adapt to organoids of different sizes through mechanics simulations, and can record electrophysiological data for up to 4 weeks.
Article
Chemistry, Multidisciplinary
Arijit Ghosh, Wangqu Liu, Ling Li, Gayatri J. Pahapale, Si Young Choi, Liyi Xu, Qi Huang, Ruili Zhang, Zijian Zhong, Florin M. Selaru, David H. Gracias
Summary: This study describes autonomous microinjectors that can efficiently deliver macromolecular drugs, such as insulin, to the systemic circulation via the gastrointestinal tract. In vitro studies showed that these microinjectors can penetrate the gastrointestinal mucosa and in vivo experiments in rats demonstrated successful release of insulin.
Article
Robotics
Aishwarya Pantula, Bibekananda Datta, Yupin Shi, Margaret Wang, Jiayu Liu, Siming Deng, Noah J. Cowan, Thao D. Nguyen, David H. Gracias
Summary: This study demonstrates a mechanism for using thermoresponsive hydrogels to enable gel crawlers to move unidirectionally, achieving successful results in experiments. This mechanism holds potential for application to other shape-changing locomotors.
Review
Computer Science, Artificial Intelligence
Itzy Morales E. Pantoja, Lena Smirnova, Alysson R. Muotri, Karl J. Wahlin, Jeffrey Kahn, J. Lomax Boyd, David H. Gracias, Timothy D. Harris, Tzahi Cohen-Karni, Brain S. Caffo, Alexander S. Szalay, Fang Han, Donald J. Zack, Ralph Etienne-Cummings, Akwasi Akwaboah, July Carolina Romero, Dowlette-Mary Alam El Din, Jesse D. Plotkin, Barton L. Paulhamus, Erik C. Johnson, Frederic Gilbert, J. Lowry Curley, Ben Cappiello, Jens C. Schwamborn, Eric J. Hill, Paul Roach, Daniel Tornero, Caroline Krall, Rheinallt Parri, Fenna Sille, Andre Levchenko, Rabih E. Jabbour, Brett J. Kagan, Cynthia A. Berlinicke, Qi Huang, Alexandra Maertens, Kathrin Herrmann, Katya Tsaioun, Raha Dastgheyb, Christa Whelan Habela, Joshua T. Vogelstein, Thomas Hartung
Summary: The brain is a powerful computation system with efficient processing and adaptability. Advances in stem cell technology have led to the development of three-dimensional brain organoids that better mimic human brain functionality. Organoid Intelligence aims to use these capabilities for biocomputing and synthetic intelligence. Understanding how learning changes organoid connectivity can shed light on cognition in the human brain.
FRONTIERS IN ARTIFICIAL INTELLIGENCE
(2023)
Article
Chemistry, Multidisciplinary
Kam Sang Kwok, Yi Zuo, Soo Jin Choi, Gayatri J. Pahapale, Luo Gu, David H. Gracias
Summary: Lithographic nanopatterning techniques have been widely used in electronics and optics, but their application in nanobio interfaces is limited by cytotoxicity and 2D features. This article presents a biocompatible and cost-effective transfer process using nanoimprint lithography and alginate hydrogel to create flexible and degradable transfer layers. Biotransfer printing of the nanopattern arrays on live cells and animal brains demonstrates high pattern fidelity and cell viability. This method has great potential in advancing bionics, biosensing, and biohybrid tissue interfaces.
Correction
Multidisciplinary Sciences
Anum Glasgow, Helen T. Hobbs, Zion R. Perry, Malcolm L. Wells, Susan Marqusee, Tanja Kortemme
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Joshua Fern, Ruohong Shi, Yixin Liu, Yan Xiong, David H. Gracias, Rebecca Schulman
Summary: The development of biomolecular stimuli-responsive hydrogels is crucial for various applications such as biomimetic structures, soft robots, tissue engineering, and drug delivery. DNA polymerization gels, composed of polymer gel backbones with DNA duplex crosslinks, can be swollen through strand displacement using hairpin-shaped DNA strands. By adjusting the design and concentration of DNA crosslinks, the DNA hairpin triggers, and the ionic strength of the solution, the swelling response of DNA polymerization gels can be finely tuned, providing a quantitative connection between biochemical reactions and macroscopic material behavior.
Article
Automation & Control Systems
Qi Huang, Tao Deng, Weinan Xu, ChangKyu Yoon, Zhao Qin, Yida Lin, Tengfei Li, Yuqian Yang, Michael Shen, Susanna M. Thon, Jacob B. Khurgin, David H. Gracias
Summary: This study demonstrates a scalable strategy for creating reversible self-folding structures using a negative epoxy photoresist. Complex structures and functional devices are achieved, including integrated gold electrodes for enhanced photoresponse and 3D angle sensitive detection. This work provides a comprehensive framework for the rational design and scalable fabrication of complex 3D optical and electronic devices through the folding of 2D monolayer graphene.
ADVANCED INTELLIGENT SYSTEMS
(2023)
Review
Pharmacology & Pharmacy
Wangqu Liu, Soo Jin Choi, Derosh George, Ling Li, Zijian Zhong, Ruili Zhang, Si Young Choi, Florin M. Selaru, David H. Gracias
Summary: Recent studies show that the deployment of tether-free and shape-changing devices, especially at sub-mm scales, could greatly improve the diagnosis and treatment of GI diseases such as cancer, IBD, and IBS. These devices have the potential to enhance treatment efficacy, reduce costs, and increase medication compliance. The article discusses the challenges and possibilities associated with ensuring safe, reliable, and autonomous operation of these smart devices.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Meeting Abstract
Urology & Nephrology
Ridwan Alam, Wangqu Liu, Ezra Baraban, Brian Matlaga, Andres Matoso, David Gracias, Jared Winoker
JOURNAL OF UROLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Ling Li, Arijit Ghosh, Wangqu Liu, Gayatri Pahapale, Brian Choi, Liyi Xu, Qi Huang, David H. Gracias, Florin M. Selaru