Article
Cell & Tissue Engineering
Chun-Wei Chen, Linda Zhang, Ravi Dutta, Abhishek Niroula, Peter G. Miller, Christopher J. Gibson, Alexander G. Bick, Jaime M. Reyes, Yi-Tang Lee, Ayala Tovy, Tianpeng Gu, Sarah Waldvogel, Yi-Hung Chen, Bryan J. Venters, Pierre-Olivier Esteve, Sriharsa Pradhan, Michael-Christopher Keogh, Pradeep Natarajan, Koichi Takahashi, Adam S. Sperling, Margaret A. Goodell
Summary: This study describes the context and mechanisms leading to the enrichment of hematopoietic stem cells (HSCs) with SRCAP mutations. The authors demonstrate that SRCAP mutations confer a selective advantage in both human cells and mice, resulting in lymphoid-biased expansion. These findings provide new insight into the functional impact of genetic variants promoting stem cell competition in the hematopoietic system.
Review
Biochemistry & Molecular Biology
Charles J. Dorman
Summary: Transcription is a noisy and stochastic process that leads to variations in physiology among genetically identical cells due to transcription bursting and failure to remove accumulated supercoils in DNA. The relaxation of these supercoils is performed by type II topoisomerases, but interference with their action can disrupt transcription and lead to phenotypic outliers such as antibiotic-tolerant persister cells. This interference can also drive physiological diversity in the bacterial population as an important epigenetic factor.
MOLECULAR MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Purboja Purkayastha, Kavya Pendyala, Ayush S. Saxena, Hesamedin Hakimjavadi, Srikar Chamala, Purushottam Dixit, Charles F. Baer, Tanmay P. Lele
Summary: The study investigated the effects of substrate stiffness on the growth and phenotypic plasticity of mouse fibroblasts, revealing that soft-selected lines showed reverse plasticity compared to the ancestral pattern. The changes were driven by genetic evolution and not phenotypic plasticity alone, with distinct transcriptional architectures related to mechanotransduction and proliferation contributing to the phenotypic outcomes in the selected populations.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Plant Sciences
J. Steen Hoyer, Olivia W. Wilkins, Aanandi Munshi, Emma Wiese, Divya Dubey, Savannah Renard, Karoline Rosendal Harto Mortensen, Anna E. Dye, Ignazio Carbone, Siobain Duffy, Jose Trinidad Ascencio-Ibanez
Summary: This study found that mutations in the cabbage leaf curl virus occur rapidly and have the potential to change the majority consensus sequence within the virus population. Additionally, the virus may undergo convergent evolution in different parts of its genome.
PHYTOBIOMES JOURNAL
(2022)
Article
Neurosciences
Zachary Beine, Zimei Wang, Pantelis Tsoulfas, Murray G. Blackmore
Summary: This study analyzed neurons projecting from the brain to the spinal cord in mice, identifying 14 transcriptionally distinct cell types and marker genes. The findings provide insights into the molecular characteristics and physiological functions of supraspinal cell populations.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Dermatology
Peter S. Nyasulu, Jacques L. Tamuzi
Summary: Skin manifestations related to COVID-19 in African populations vary by country and severity, with multisystem inflammatory syndrome (MIS) being the primary manifestation. Different dermatological lesions, including MIS, erythema multiforme-like, livedoid, vesicular or varicella-like rashes, urticarial, maculopapular or morbilliform rashes, and chilblain-like or pernio-like rashes, were observed. MIS cases accounted for 47.5% of cases in published African studies. Early onset rash may allow for the diagnosis of MIS within 2-7 days. Advanced age, obesity, diabetes, cardiovascular disease, HIV, tuberculosis, asthma, atopic disease, underweight, malnutrition, and malignancy were associated with COVID-19 cutaneous manifestations in African populations.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Microbiology
Zishan K. Siddiqui, Mihir Chaudhary, Matthew L. Robinson, Anna B. McCall, Ria Peralta, Rogette Esteve, Charles W. Callahan, Yukari C. Manabe, James D. Campbell, J. Kristie Johnson, Maryam Elhabashy, Melinda Kantsiper, James R. Ficke
Summary: The BinaxNOW rapid antigen COVID-19 test showed a sensitivity of 87% in symptomatic individuals and 71% in asymptomatic individuals. This performance may help expedite isolation decisions or referrals for time-sensitive monoclonal antibody treatment in communities where timely COVID PCR tests are unavailable.
MICROBIOLOGY SPECTRUM
(2021)
Review
Immunology
Damian Perez-Mazliah, Francis M. Ndungu, Racheal Aye, Jean Langhorne
IMMUNOLOGICAL REVIEWS
(2020)
Article
Biochemistry & Molecular Biology
Elie Hammam, Guruprasad Ananda, Ameya Sinha, Christine Scheidig-Benatar, Mylene Bohec, Peter R. Preiser, Peter C. Dedon, Artur Scherf, Shruthi S. Vembar
NUCLEIC ACIDS RESEARCH
(2020)
Article
Microbiology
Alok Tanala Patra, Tejashri Hingamire, Meenakshi A. Belekar, Aoli Xiong, Gowtham Subramanian, Zbynek Bozdech, Peter Preiser, Dhanasekaran Shanmugam, Rajesh Chandramohanadas
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Cell Biology
Karthigayan Gunalan, Xiaohong Gao, Sally Shu Lin Yap, Soak Kuan Lai, Andrea Ravasio, Sundar Ganesan, Hoi Yeung Li, Peter R. Preiser
CELLULAR MICROBIOLOGY
(2020)
Article
Engineering, Electrical & Electronic
Shaomeng Wang, Chuanshi Yang, Peter Preiser, Yuanjin Zheng
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2020)
Article
Chemistry, Analytical
Clement Yuen, Xiaohong Gao, James Jia Ming Yong, Prem Prakash, Chalapathy Raja Shobana, Perera Adhikarige Taniya Kaushalya, Yuemei Luo, Yanru Bai, Chun Yang, Peter R. Preiser, Quan Liu
Summary: The chip based on SERS technology is developed for field diagnosis of malaria, requiring only a small amount of water and blood sample. It is cost-effective and easy to use, with high sensitivity and accuracy in detecting hemozoin concentrations in the blood of malaria patients.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Infectious Diseases
Ria Lassauniere, Charlotta Polacek, Jannik Fonager, Marc Bennedbaek, Lasse Boding, Morten Rasmussen, Anders Fomsgaard
Summary: Several factors may account for the recent increased spread of the SARS-CoV-2 Delta sub-lineage AY.4.2 in the United Kingdom, Romania, Poland, and Denmark. The study found that neutralization of AY.4.2 was comparable to other circulating Delta lineages or sub-lineages, while the variant B.1.617.2 with E484K mutation showed a significant more than 4-fold reduction in neutralization, highlighting the importance of monitoring strains with this mutation.
Article
Microbiology
Thomas Bruun Rasmussen, Jannik Fonager, Charlotte Svaerke Jorgensen, Ria Lassauniere, Anne Sofie Hammer, Michelle Lauge Quaade, Anette Boklund, Louise Lohse, Bertel Strandbygaard, Morten Rasmussen, Thomas Yssing Michaelsen, Sten Mortensen, Anders Fomsgaard, Graham J. Belsham, Anette Botner
Summary: In a farm with around 15,000 animals, a majority of tested mink became infected with SARS-CoV-2 and remained seropositive even after free-testing. After the second round of infection, the animals showed significantly higher levels of anti-SARS-CoV-2 antibodies in their serum samples.
Editorial Material
Infectious Diseases
Jannik Fonager, Marc Bennedbaek, Peter Bager, Jan Wohlfahrt, Kirsten Maren Ellegaard, Anna Cacilia Ingham, Sofie Marie Edslev, Marc Stegger, Raphael Niklaus Sieber, Ria Lassauniere, Anders Fomsgaard, Troels Lillebaek, Christina Wiid Svarrer, Frederik Trier Moller, Camilla Holten Moller, Rebecca Legarth, Thomas Vognbjerg Sydenham, Kat Steinke, Sarah Juel Paulsen, Jose Alfredo Samaniego Castruita, Uffe Vest Schneider, Christian Hojte Schouw, Xiaohui Chen Nielsen, Maria Overvad, Rikke Thoft Nielsen, Rasmus L. Marvig, Martin Schou Pedersen, Lene Nielsen, Line Lynge Nilsson, Jonas Bybjerg-Grauholm, Irene Harder Tarpgaard, Tine Snejbjerg Ebsen, Janni Uyen Hoa Lam, Vithiagaran Gunalan, Morten Rasmussen
Article
Multidisciplinary Sciences
Frederik Plesner Lyngse, Kare Molbak, Matt Denwood, Lasse Engbo Christiansen, Camilla Holten Moller, Morten Rasmussen, Arieh Sierra Cohen, Marc Stegger, Jannik Fonager, Raphael Niklaus Sieber, Kirsten Maren Ellegaard, Claus Nielsen, Carsten Thure Kirkeby
Summary: Vaccines not only reduce susceptibility to infection, but also the infectiousness of breakthrough infections. Danish national data shows that the vaccine effectiveness against susceptibility to infection is estimated to be 61% when the primary case is unvaccinated, and the vaccine effectiveness against infectiousness is estimated to be 31% when the household contact is unvaccinated. Additionally, unvaccinated secondary cases have a three-fold higher viral load compared to fully vaccinated secondary cases with breakthrough infections.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Hoi Lok Cheng, Sing Mei Lim, Huan Jia, Ming Wei Chen, Say Yong Ng, Xiaohong Gao, Jyoti Somani, Sharmila Sengupta, Dousabel M. Y. Tay, Patrina W. L. Chua, R. Abirami, Sharon Y. H. Ling, Megan E. McBee, Barnaby E. Young, Hadley D. Sikes, Peter R. Preiser
Summary: The study demonstrates significant heterogeneity in nAb responses to SARS-CoV-2 variants after vaccination, suggesting a more personalized vaccination approach may be more suitable.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Paneeraq Noahsen, Louise Lohmann Fabers, Silvia Isidor, Jannik Fonagers, Morten Rasmussens, Hansen L. Henrik
Summary: Greenland implemented strict measures to control the COVID-19 pandemic and successfully contained the virus before the vaccination rollout. After vaccination, the number of confirmed cases increased, but the overall mortality rate remained low.
Article
Engineering, Electrical & Electronic
Wensong Wang, Zesheng Zheng, Chuanshi Yang, Zhongyuan Fang, Shaomeng Wang, Clement Yuen, Kai Tang, Quan Liu, Peter Preiser, Yuanjin Zheng
Summary: In this study, the PA-SAW sensing and detection system is proposed to detect the ring-stage malaria parasite by generating PA signal from red blood cells and converting it into an electrical signal for analysis. The system showed excellent potential in the early diagnosis of malaria parasite at low concentration levels.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Article
Infectious Diseases
Laura Espenhain, Tjede Funk, Maria Overvad, Sofie Marie Edslev, Jannik Fonager, Anna Cacilia Ingham, Morten Rasmussen, Sarah Leth Madsen, Caroline Hjorth Espersen, Raphael N. Sieber, Marc Stegger, Vithiagaran Gunalan, Bartlomiej Wilkowski, Nicolai Balle Larsen, Rebecca Legarth, Arieh Sierra Cohen, Finn Nielsen, Janni Uyen Hoa Lam, Kjetil Erdogan Lavik, Marianne Karakis, Katja Spiess, Ellinor Marving, Christian Nielsen, Christina Wiid Svarrer, Jonas Bybjerg-Grauholm, Stefan Schytte Olsen, Anders Jensen, Tyra Grove Krause, Luise Muller
Summary: By December 9, 2021, Denmark has identified 785 cases of the SARS-CoV-2 Omicron variant. Most cases were fully vaccinated or had a booster dose, and the majority reported symptoms and were infected in Denmark. Some cases could not be linked to previous cases, suggesting widespread community transmission. Nine cases were hospitalized, with one in intensive care, and there have been no deaths reported.
Article
Immunology
Anne Sofie Hammer, Michelle Lauge Quaade, Thomas Bruun Rasmussen, Jannik Fonager, Morten Rasmussen, Karin Mundbjerg, Louise Lohse, Bertel Strandbygaard, Charlotte Svaerke Jorgensen, Alonzo Alfaro-Nunez, Maiken Worsoe Rosenstierne, Anette Boklund, Tariq Halasa, Anders Fomsgaard, Graham J. Belsham, Anette Botner
Summary: Novel virus variants in farmed mink in Denmark were found to subsequently appear in the local human community, highlighting the potential for interspecies transmission of the virus.
EMERGING INFECTIOUS DISEASES
(2021)