Article
Immunology
Vincenzo Torraca, Dominik Brokatzky, Sydney L. Miles, Charlotte E. Chong, P. Malaka De Silva, Stephen Baker, Claire Jenkins, Kathryn E. Holt, Kate S. Baker, Serge Mostowy
Summary: Shigella, including specific serotypes, can establish persistent infection in the zebrafish model. The O-antigen plays a crucial role in this process, and the serotype-associated effects observed in humans are also observed in zebrafish.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Jing-Jing Nie, Ya-Ya Pian, Ji-Hong Hu, Guo-Qing Fan, Lv-Tao Zeng, Qiu-Geng Ouyang, Zhen-Xiang Gao, Zhen Liu, Chen-Chen Wang, Qian Liu, Jian-Ping Cai
Summary: Acute infection induced by Shigella flexneri causes increased RNA oxidative damage in various tissues (liver, spleen, and brain) and an increase of the urinary metabolite 8-oxo-Gsn. Urinary 8-oxo-Gsn may serve as a useful biomarker for evaluating the severity and prognosis of infection.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Ines Abatedaga, Barbara Perez Mora, Marisel Tuttobene, Gabriela Muller, Daiana Biancotti, Claudio D. Borsarelli, Lorena Valle, Maria A. Mussi
Summary: This study characterized the BLUF photoreceptors in A. nosocomialis and found that they have idiosyncratic characteristics compared to the previously characterized A. baumannii BlsA, including temperature-dependency and expression patterns. The results contribute to broadening our knowledge of the BLUF family.
Article
Immunology
Li-guo Ding, Guang-kun Han, Xin-you Wang, Ru-han Sun, Yong-yao Yu, Zhen Xu
Summary: This study investigated the composition of the teleost gallbladder microbiota and its potential role in mucosal immunity. The results showed that the gallbladder microbiome was similar to the gut microbiota. Infection induced inflammation and disrupted microbial homeostasis in the gallbladder. Beneficial bacteria from the Lactobacillales order increased in abundance in the bile microbial community, while the structure of the Mycoplasmatales order in the gut microbial community changed significantly.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Gina M. Borgo, Thomas P. Burke, Cuong J. Tran, Nicholas T. N. Lo, Patrik Engstrom, Matthew D. Welch
Summary: This study identified a phospholipase enzyme in Rickettsia bacteria that plays an important role in the invasion and spread of infection by helping the bacteria escape from host cell vacuoles, preventing targeting by autophagy, and promoting bacterial motility and spread to other cells.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Timothy French, Johannes Steffen, Albert Glas, Lisa Osbelt, Till Strowig, Bjoern H. Schott, Thomas Schueler, Ildiko Rita Dunay
Summary: This study compared the differences between oral and intraperitoneal infection routes of Toxoplasma gondii in terms of acute and chronic infection stages. It was found that intraperitoneal infection resulted in a more severe infection process and inflammatory response in the central nervous system (CNS), while oral infection led to persistent intestinal inflammation and dysbiosis. Furthermore, intraperitoneal infection also affected neuronal function and synaptic connectivity in the CNS.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Ophthalmology
Shilpa Das, Sunita Chaurasia, Savitri Sharma, Sujata Das
Summary: With the increasing use of lamellar keratoplasty for selective corneal tissue replacement, the risk of infections, especially Candida species, postoperatively is a concern. Most infections occur within 2 months after surgery, with a high percentage due to donor to host transmission. Strict aseptic measures and drug susceptibility testing are crucial in preventing and treating these infections.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Cell Biology
Nicholas J. First, Katelyn M. Parrish, Amparo Martinez-Perez, Africa Gonzalez-Fernandez, Sushma Bharrhan, Matthew Woolard, James B. Mclachlan, Rona S. Scott, Jian Wang, Monica C. Gestal
Summary: This study reveals the important role of eosinophils in Bordetella bronchiseptica infection. Eosinophils are involved in the immune response through their interaction with B/T cells and the formation of iBALT. Furthermore, XCL1 is found to be critical for the formation of iBALT, suggesting a novel role for eosinophils in adaptive immunity.
Article
Anatomy & Morphology
Jonathan M. Chan, Katrina H. Worthy, Marcello G. P. Rosa, David H. Reser, Nafiseh Atapour
Summary: Lesions in the primary visual cortex result in significant volume loss in the lateral pulvinar nucleus, but do not lead to obvious neuronal degeneration. Unlike the geniculocortical pathway, the pulvinar pathway appears to be largely spared from the severe long-term effects of V1 lesions, possibly due to its more divergent connectivity pattern with the visual cortex.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Biology
Tanya L. Nowland, Roy N. Kirkwood, Valeria A. Torok, Kate J. Plush, Mary D. Barton
Summary: The study revealed that initial microbial colonisation had occurred in the spiral colon of piglets before birth, with higher diversity in suckling piglets and less evenness in stillborn piglets. Colostrum consumption influenced microbial community richness, highlighting the importance of immediate post-natal environment and colostrum in shaping microbial colonisation.
Review
Immunology
Holly O'Flanagan, Mohammed Siddiq, Carrie Llewellyn, Daniel Richardson
Summary: There is an increasing presence of antimicrobial resistant strains of Shigella in men who have sex with men, limiting the options for treatment. More research is needed to develop alternative strategies for controlling shigella in this population.
INTERNATIONAL JOURNAL OF STD & AIDS
(2023)
Article
Immunology
Christina M. Newman, Alice F. Tarantal, Michele L. Martinez, Heather A. Simmons, Terry K. Morgan, Xiankun Zeng, Jenna R. Rosinski, Mason I. Bliss, Ellie K. Bohm, Dawn M. Dudley, Matthew T. Aliota, Thomas C. Friedrich, Christopher J. Miller, David H. O'Connor
Summary: The study conducted on three rhesus macaques challenged with ZIKV through sexual transmission indicates that sexual transmission of ZIKV may represent an underappreciated risk of pregnancy loss during early gestation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aleksandar R. Zivkovic, Karsten Schmidt, Stefan Hofer, Thorsten Brenner, Markus A. Weigand, Sebastian O. Decker
Summary: This study aimed to investigate the involvement of non-neuronal AChE activity in sepsis and evaluate its association with disease severity and clinical outcomes. The results showed that AChE activity remained stable for 7 days and decreased at 28 days. However, there was no correlation between initial AChE activity and inflammatory biomarkers, disease severity scores, ICU stay, or hospital stay.
Article
Multidisciplinary Sciences
Gi Uk Jeong, Hyung-Jun Kwon, Wern Hann Ng, Xiang Liu, Hyun Woo Moon, Gun Young Yoon, Hye Jin Shin, In-Chul Lee, Zheng Lung Ling, Alanna G. Spiteri, Nicholas J. C. King, Adam Taylor, Ji Soo Chae, Chonsaeng Kim, Dae-Gyun Ahn, Kyun-Do Kim, Young Bae Ryu, Seong-Jun Kim, Suresh Mahalingam, Young-Chan Kwon
Summary: This study demonstrates that SARS-CoV-2 can infect the eyes and cause retinal inflammation in transgenic mice and Syrian hamster models. The virus can also spread from the lungs to the brain and eyes through neuronal pathways. These findings contribute to a better understanding of viral transmission and clinical characteristics of SARS-CoV-2 and can aid in improving COVID-19 control procedures.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Sahar EL Hadad, Maha Alsolami, Alia Aldahlawi, Jehan Alrahimi, Fatemah Basingab, Shahira Hassoubah, Hani Alothaid
Summary: The study found that the Streptococcus thermophilus probiotic has significant immunomodulatory effects in preventing colon cancer, reducing the expression levels of cancer-related genes and altering cytokine levels in mouse serum.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Philippe Aubert, Elena Oleynikova, Hina Rizvi, Marieme Ndjim, Catherine Le Berre-Scoul, Pierre Antoine Grohard, Julien Chevalier, Jean-Pierre Segain, Gwenola Le Drean, Michel Neunlist, Helene Boudin
Article
Immunology
Marion Rincel, Philippe Aubert, Julien Chevalier, Pierre-Antoine Grohard, Lilian Basso, Camille Monchaux de Oliveira, Jean Christophe Helbling, Elodie Levy, Gregoire Chevalier, Marion Leboyer, Gerard Eberl, Sophie Laye, Lucile Capuron, Nathalie Vergnolle, Michel Neunlist, Helene Boudin, Patricia Lepage, Muriel Darnaudery
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Chemistry, Medicinal
Philippe Aubert, Isabelle Guinobert, Claude Blondeau, Valerie Bardot, Isabelle Ripoche, Pierre Chalard, Michel Neunlist
JOURNAL OF MEDICINAL FOOD
(2019)
Article
Anatomy & Morphology
Bettina Pretterklieber, Maria Hader, Niels Hammer, Galyna Pryymachuk, Felicitas Proels, Franziska Vielmuth, Miriam Barnerssoi, Sebastian Cotofana, Amanda Custozzo, Imke Weyers, Thilo Wedel, Philipp Arnold, Christoph Rahner, Magdalena Mueller-Gerbl, Michael L. Pretterklieber
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2020)
Letter
Gastroenterology & Hepatology
Yuk Lung Wong, Lars Hummitzsch, Ingmar Lautenschlaeger, Karina Zitta, Thilo Wedel, Francois Cossais, Clemens Schafmayer, Thomas Becker, Rouven Berndt, Matthias Gruenewald, Norbert Weiler, Markus Steinfath, Martin Albrecht
Article
Surgery
Michael Anapolski, Ibrahim Alkatout, Thilo Wedel, Dimriitos Panayotopoulos, Stefan Soltesz, Sven Schiermeier, Thomas Papathemelis, Gunter K. Noe
Summary: This study discussed three different options for laparoscopic access to the retropubic space, providing an algorithm for selecting the most appropriate route based on the patient's surgical history and accompanying interventions. Understanding various access routes allows for tailored surgical procedures to individual patient circumstances.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2021)
Article
Surgery
Johannes Ackermann, Thilo Wedel, Heiko Hagedorn, Nicolai Maass, Liselotte Mettler, Tillmann Heinze, Ibrahim Alkatout
Summary: The study demonstrated the technical feasibility and didactic effectiveness of laparoscopic training courses using ethanol-glycerol-lysoformin embalmed body donors. Participants rated high benefits of the course to their daily routine, especially correlated with the use of body donors and the ability to train laparoscopic dissections.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Biochemistry & Molecular Biology
Aglae Herbreteau, Philippe Aubert, Mikael Croyal, Philippe Naveilhan, Stephanie Billon-Crossouard, Michel Neunlist, Yves Delneste, Dominique Couez, Laetitia Aymeric
Summary: The brain-gut axis is a bidirectional functional connection between the brain and gut, which is associated with gastrointestinal diseases and tumor progression. Using a glioma model, antibiotic treatment was shown to delay mouse death and alter the proportion of cells in brain tumors.
Article
Gastroenterology & Hepatology
Thilo Wedel, Marvin Heimke, Jordan Fletcher, Danilo Miskovic, Stefan Benz, Sigmar Stelzner, Tillmann Heinze
Summary: This study determined the optimal surgical dissection planes for right hemicolectomy with complete mesocolic excision (CME) based on anatomical studies. Using clear anatomical terms instead of confusing eponyms to describe the retrocolic fascial system and surgical planes for CME can improve surgical accuracy.
COLORECTAL DISEASE
(2023)
Letter
Gastroenterology & Hepatology
Thilo Wedel, Marcos Gomez Ruiz, Samson Tou, Sigmar Stelzner, Klaus E. Matzel
COLORECTAL DISEASE
(2023)
Article
Clinical Neurology
Antoine Philippe Fournier, Erwan Baudron, Isabelle Wagnon, Philippe Aubert, Denis Vivien, Michel Neunlist, Isabelle Bardou, Fabian Docagne
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Amelie Le, Amandine Selle, Philippe Aubert, Carole Brosseau, Emilie Durieu, Thibauld Oullier, Michel Neunlist, Marie Bodinier, Malvyne Rolli-Derkinderen
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Raphael Bodin, Vincent Paille, Thibauld Oullier, Tony Durand, Philippe Aubert, Catherine Le Berre-Scoul, Philippe Hulin, Michel Neunlist, Moustapha Cisse
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)