Review
Cell Biology
Gilberto Jaramillo-Rangel, Maria-de-Lourdes Chavez-Briones, Adriana Ancer-Arellano, Marta Ortega-Martinez
Summary: Nestin expression in lung cancer leads to an aggressive phenotype and resistance to chemotherapy and radiation treatments, while also potentially being involved in the pathogenesis of some non-cancer-related lung diseases. Additionally, nestin-positive cells may play a role in lung homeostasis and be capable of generating various types of lung tissues.
Article
Oncology
Victoria Menendez, Jose L. Solorzano, Sara Fernandez, Carlos Montalban, Juan F. Garcia
Summary: This article reviews the important immune populations in the cHL tumor microenvironment, focusing on their integrative functional signatures. The cHL microenvironment plays a significant role in tumor cell survival. HRS cells promote their survival through intrinsic and extrinsic alterations, leading to immunosuppression. cHL is proving to be an ideal model for studying immune checkpoint blockade, with druggable key signaling pathways identified. Additionally, numerous biomarkers for predicting treatment response await further validation.
Article
Oncology
Nick A. Kuburich, Petra den Hollander, Jordan T. Pietz, Sendurai A. Mani
Summary: The cytoskeleton is crucial for maintaining the integrity of epithelial cells. During the epithelial-mesenchymal transition, cytokeratin-positive epithelial cells begin to express vimentin. This transition induces stem cell properties and drives tumor metastasis, chemoresistance, and relapse.
SEMINARS IN CANCER BIOLOGY
(2022)
Editorial Material
Hematology
Georg Stary
Summary: In this study published in Blood, van Halteren et al have identified an immune cell signature that is associated with the onset of acute graft-versus-host disease (aGVHD) and the response to first- and second-line therapy.(1)
Review
Biochemistry & Molecular Biology
Mark Bates, Bashir M. Mohamed, Mark P. Ward, Tanya E. Kelly, Roisin O'Connor, Victoria Malone, Robert Brooks, Doug Brooks, Stavros Selemidis, Cara Martin, Sharon O'Toole, John J. O'Leary
Summary: This review provides an overview of circulating tumour cells (CTCs), which are highly lethal cancer cells and play a crucial role in cancer metastasis. CTCs have clinical utility as diagnostic, prognostic, and therapeutic targets. However, their complex biology and the challenges involved in their isolation and identification hinder their clinical translation. CTCs are capable of forming microemboli composed of diverse populations, which interact with other circulating cells and may increase their malignant potential. These microemboli represent a prognostically important subset, but the presence of phenotypic gradients adds complexity to the situation.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Chemistry, Physical
Min Soo Kim, Raju Thota, Muhammad A. Abbas, Jin Ho Bang
Summary: Nanostructuring is crucial for synthesizing highly active electrocatalysts, but faces challenges in scalability and complexity. A thermal route utilizing hot H2S gas is demonstrated to transform poor oxide electrocatalysts into highly active ones, showing simplicity and scalability after only 10 minutes of treatment.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2021)
Review
Public, Environmental & Occupational Health
Mary N. Woessner, Alexander Tacey, Ariella Levinger-Limor, Alexandra G. Parker, Pazit Levinger, Itamar Levinger
Summary: Throughout history, technological advances have made daily activities more efficient, but have also led to increased sedentary behavior and a rise in chronic conditions related to obesity. Despite longer life expectancy, people are living with poorer physical function and reduced quality of life due to these factors. Discussing how technology influences sedentary behavior, this review proposes utilizing technology to encourage greater engagement in physical activity.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Green & Sustainable Science & Technology
James Cock, Daniel Jimenez, Hugo Dorado, Thomas Oberthur
Summary: This study explores the potential of using operations research (OR) with farmer-supplied data and machine learning (ML) to improve crop management in developing countries. The information provided by farmers includes yield, crop management practices, and growth environment details. The study utilizes two analytical approaches: benchmarking crop performance against farmers' practices and establishing relatively homogenous environmental conditions (HECs) to identify effective management practices. The combination of OR and ML can provide useful guidelines for crop management, even with relatively crude production data from individual farms. However, caution must be exercised to avoid extrapolation to circumstances not covered by the original datasets.
CURRENT OPINION IN ENVIRONMENTAL SUSTAINABILITY
(2023)
Editorial Material
Cell Biology
Nadine Martin, Anda Huna, David Bernard
Summary: Cellular senescence plays a critical role in various physiological and pathological contexts. Recent studies have highlighted the dual effects that eliminating senescent endothelial cells can have on health span. This raises questions about the current development of senolytics as a therapeutic strategy.
TRENDS IN CELL BIOLOGY
(2021)
Editorial Material
Chemistry, Physical
Jason Keonhag Lee, Aimy Bazylak
Summary: The impact of bubbles on electrolysis is detrimental, but researchers have found a way to minimize overpotentials by controlling the microstructure of electrodes in a photoelectrochemical cell.
Editorial Material
Neurosciences
Gabrielle M. Mey, Tara M. DeSilva
Summary: In this study, Sun et al. demonstrate the role of EndoMT in triggering breakdown of the blood-CNS barrier in the pathogenesis of multiple sclerosis.
Article
Business
Aaron M. Garvey, TaeWoo Kim, Adam Duhachek
Summary: This research explores the influence of artificial intelligence (AI) and human marketing agents on consumer responses to negative and positive offers. When faced with offers that are worse than expected, consumers are more willing to accept AI agents, whereas for offers that are better than expected, consumers prefer human agents. The study also found that marketers can anthropomorphize AI agents to strengthen consumer perception of their intentions and receive recognition for better offers while mitigating blame for worse offers.
JOURNAL OF MARKETING
(2023)
Review
Immunology
Ewan R. A. Ross, Andrew Devitt, Jill R. R. Johnson
Summary: Macrophages play critical roles in sterile inflammation and autoimmune diseases, particularly in the pathophysiology of diseases like rheumatoid arthritis. Imbalance in macrophage homeostasis contributes to chronic inflammation, and therapeutic strategies targeting macrophage plasticity are being explored. Apoptotic cell-derived extracellular vesicles may play a role in regulating macrophage phenotype and are a potential target for new therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Christopher M. Snyder, Saar I. Gill
Summary: In religious philosophy, karma represents the long-term impact of past and present actions. Macrophages, versatile cells in health and disease, play a significant role in cancer. They typically support tumor growth and suppress anti-tumor immunity. Efforts to modify the behavior of tumor-associated macrophages (TAM) for therapeutic purposes have not yet been successful. However, genetic engineering of macrophages shows promise in redirecting their functions for the treatment of cancer.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Psychology, Multidisciplinary
Qinglin Zhao, Wenxia Zhou
Summary: The ambivalent leader-follower relationship can have positive or negative influences, depending on the degree of ambivalence, support from the third party, and the integrative complexity of the follower.
FRONTIERS IN PSYCHOLOGY
(2021)