Article
Cell & Tissue Engineering
Zhihong Chen, Liyong Liu, Yunhua Chen, Minjie Liu, Andy Peng Xiang, Chunhua Deng, Mei Hua Jiang
Summary: Postn plays an important role in bladder urothelial regeneration by inducing Wnt4 upregulation and AKT signaling activation, leading to urothelial stem cell proliferation. It also promotes resident macrophage proliferation and polarization to a pro-regenerative phenotype. Injectable P-GelMA granular hydrogel can deliver recombinant POSTN into the bladder and alleviate interstitial cystitis symptoms.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Tsubasa Ochiai, Yuka Sasaki, Chieko Yokoyama, Hiroshi Kuwata, Shuntaro Hara
Summary: The study revealed that PTGIS-derived PGI(2)-IP signaling exacerbated CP-induced bladder inflammatory reactions, while Ptgis deficiency or treatment with an IP selective antagonist could suppress CP-induced bladder inflammation and hemorrhagic cystitis, thus relieving nociceptive behavior.
Article
Pharmacology & Pharmacy
Shiori Kawasaki, Masahiko Soga, Yusuke Sakurai, Isamu Nanchi, Miyuki Yamamoto, Sunao Imai, Tatsuya Takahashi, Naoki Tsuno, Toshiyuki Asaki, Yasuhide Morioka, Masahide Fujita
Summary: The study suggests the involvement of TRPV4 in bladder pain in a mouse cystitis model, indicating that a TRPV4 antagonist may be useful for patients with irritable bladder pain such as those with interstitial cystitis/painful bladder syndrome.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Virology
Alperen Aksakal, Bugra Kerget, Ferhan Kerget, Seda Askin
Summary: The study revealed the correlation between serum migration inhibitory factor (MIF) level and disease severity in COVID-19, with higher MIF levels potentially indicating a more severe condition. MIF levels can serve as an important predictive indicator for early disease prognosis in COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Chemistry, Multidisciplinary
Maryam Fatima, Irfan Anjum, Aamir Abdullah, Shaun Zshaan Abid, Muhammad Nasir Hayat Malik
Summary: The study demonstrates the protective effect of boswellic acids on cyclophosphamide-induced cystitis in rats, indicating their potential as therapeutic alternatives for cystitis. Boswellic acids exhibit antioxidant and anti-inflammatory properties, reducing urothelial damage and inflammation.
Article
Biochemistry & Molecular Biology
Juan Cai, Lin Huang, Hongri Tang, Hongling Xu, Lingjun Wang, Minghui Zheng, Hongsong Yu, Hui Liu
Summary: The MIF produced by Thelazia callipaeda can induce M2-like macrophage polarization through TLR4-mediated activation of the PI3K-Akt pathway, potentially aiding in disrupting the host immune system.
Article
Biochemistry & Molecular Biology
Jia-Fong Jhang, Yung-Hsiang Hsu, Han-Chen Ho, Yuan-Hong Jiang, Cheng-Ling Lee, Wan-Ru Yu, Hann-Chorng Kuo
Summary: This study evaluated the clinical significance of urinary bladder wall thickening on CT in IC/BPS patients, finding a correlation between bladder CT findings and clinical phenotypes and histopathological findings, helping to differentiate bladder-centered IC/BPS.
Article
Biochemistry & Molecular Biology
Mauro Vasella, Stefan Wolf, Eamon C. Francis, Gerrit Grieb, Pablo Pfister, Gregory Reid, Juergen Bernhagen, Nicole Lindenblatt, Epameinondas Gousopoulos, Bong-Sung Kim
Summary: Lipedema is a chronic disorder mainly affecting women, with an unknown etiology. Recent research suggests that the accumulation and polarization of macrophages may be involved in lipedema. This study provides evidence for the potential involvement of the MIF family, specifically the MIF-1-CD74 axis, in lipedema.
Article
Medicine, Research & Experimental
Merve Denizalti, Irfan Anjum, Gul Simsek, Sevgen Celik Onder, Nezahat Tugba Durlu-Kandilci
Summary: This study investigates the expression and effects of protease activated receptors (PARs) in interstitial cystitis/bladder pain syndrome (IC/BPS). Results show that PAR1 and PAR2 are expressed in rat bladder, and trypsin-induced contractions are potentiated in CYP-induced cystitis. PAR2 is identified as the main PAR subtype involved in IC/BPS. IP3 and Ca2+ sensitization are found to play important roles in cystitis pathology.
Article
Biochemistry & Molecular Biology
Ji Ae Kim, Ye Young Kim, Seung Hak Lee, Chul Jung, Mi Hee Kim, Dae Yul Kim
Summary: The macrophage migration inhibitory factor (MIF) exerts a neuroprotective effect, facilitating neurological recovery and protecting brain tissue from ischemic injury in an in vivo model of ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Irfan Saima, Irfan Anjum, Saima Najm, Kashif Barkat, Hiba-Allah A. Nafidi, Yousef A. Bin Jardan, Mohammed Bourhia
Summary: This study evaluated the protective effect of caftaric acid against cyclophosphamide-induced interstitial cystitis (IC) in female Sprague Dawley rats. Caftaric acid significantly decreased inflammation, increased antioxidant capacity, and inhibited bladder overactivity. These findings suggest that caftaric acid has potential as an adjuvant agent in cyclophosphamide-based chemotherapy treatments for IC.
Article
Oncology
Benjamin L. Woolbright, Ganeshkumar Rajendran, Erika Abbott, Austin Martin, Sarah Amalraj, Katie Dennis, Xiaogang Li, Joshua Warrick, John A. Taylor
Summary: MIF2 functions similarly to MIF1 in promoting bladder cancer development and progression, partly through CD74. Dual inhibition of MIF homologs is more effective in reducing tumor burden in bladder cancer compared to single inhibition of MIF1.
JOURNAL OF PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuxin Zhang, Zhonglong Liu, Kexin Wang, Shenji Lu, Shuai Fan, Lili Xu, Bin Cai
Summary: This study revealed the role of MIF and TGF-β1 in post-traumatic joint contracture, showing that MIF can enhance TGF-β1 production in fibroblasts through MAPK signaling, leading to fibroblast function changes and joint capsule fibrosis. Further investigation into this mechanism may lead to potential therapeutic targets for PTJC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Urology & Nephrology
Rehab Sabri Abdelrahman, Eman Mohamad El Nashar, Mansour Abdullah Alghamdi, Khulood Mohammed Al-Khater, Reham Ismail Taha
Summary: This study aimed to investigate the effect of Vinpocetine on cyclophosphamide-induced cystitis and found that Vinpocetine could alleviate inflammation and protect the bladder.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Fisheries
Zhengshi Zhang, Xiucong Hu, Qianying Diao, Panpan Zhang, Ying Wu, Zhenjie Cao, Yongcan Zhou, Chunsheng Liu, Yun Sun
Summary: In this study, a macrophage migration inhibitory factor (TroMIF) was identified from golden pompano and its function was analyzed. TroMIF showed high similarity with other known MIF sequences and was most closely related to large yellow croaker. TroMIF was highly expressed in the liver and head kidney and its expression was up-regulated after E. tarda infection. In vitro experiments showed that rTroMIF could inhibit the migration of lymphocytes and macrophages and enhance macrophage phagocytic activity. Furthermore, rTroMIF increased the expression levels of pro-inflammatory cytokines and had enzymatic redox activity. Overexpression of TroMIF enhanced the ability to resist E. tarda infection, while knockdown of TroMIF expression increased the bacterial load. These results suggest that TroMIF plays an important role in antibacterial immunity.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)