期刊
PLOS ONE
卷 3, 期 12, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0004039
关键词
-
资金
- Centocor, Inc
- Canadian Institutes for Health Research
- Wolfe and Gita Churg Foundation
Bone morphogenic protein (BMP)-7 is a member of the BMP family which are structurally and functionally related, and part of the TGF beta super family of growth factors. BMP-7 has been reported to inhibit renal fibrosis and TGF beta 1-induced epithelial-mesenchymal transition (EMT), in part through negative interactions with TGF beta 1 induced Smad 2/3 activation. We utilized in vivo bleomycin-induced fibrosis models in the skin and lung to determine the potential therapeutic effect of BMP-7. We then determined the effect of BMP-7 on TGF beta 1-induced EMT in lung epithelial cells and collagen production by human lung fibroblasts. We show that BMP-7 did not affect bleomycin-induced fibrosis in either the lung or skin in vivo; had no effect on expression of pro-fibrotic genes by human lung fibroblasts, either at rest or following exposure to TGF beta 1; and did not modulate TGF beta 1-induced EMT in human lung epithelial cells. Taken together our data indicates that BMP-7 has no antifibrotic effect in lung or skin fibrosis either in vivo or in vitro. This suggests that the therapeutic options for BMP-7 may be confined to the renal compartment.
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