☆ 4.6 Article

Sex-Differential Effect on Infant Mortality of Oral Polio Vaccine Administered with BCG at Birth in Guinea-Bissau. A Natural Experiment

PLOS ONE (2008)

获取全文
添加到收藏夹

期刊

PLOS ONE
卷 3, 期 12, 页码 -

出版社

PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0004056

关键词

-

类别

Multidisciplinary Sciences

资金

  1. EU [ICA4-CT-2002-10053]
  2. Danish Medical Research Council
  3. University of Copenhagen
  4. March of Dimes
  5. Ville Heise Foundation
  6. DANIDA
  7. Danish National Research Foundation
  8. Novo Nordisk Foundation [research professorship]

向作者/读者索取更多资源

Protocol

社区支持

Reagent

社区支持

Background: The policy to provide oral polio vaccine (OPV) at birth was introduced in low-income countries to increase coverage. The effect of OPV at birth on overall child mortality was never studied. During a trial of vitamin A supplementation (VAS) at birth in Guinea-Bissau, OPV was not available during several periods. We took advantage of this natural experiment to test the effect on mortality of receiving OPV at birth. Methodology: Between 2002 and 2004, the VAS trial randomised normal-birth-weight infants to 50,000 IU VAS or placebo administered with BCG. Provision of OPV at birth was not part of the trial, but we noted whether the infants received OPV or not. OPV was missing during several periods in 2004. We used Cox proportional hazards models to compute mortality rate ratios (MRR) of children who had received or not received OPV at birth. Principal Findings: A total of 962 (22.1%) of the 4345 enrolled children did not receive OPV at birth; 179 children died within the first year of life. Missing OPV at birth was associated with a tendency for decreased mortality (adjusted MRR=0.69 (95% CI = 0.46-1.03)), the effect being similar among recipients of VAS and placebo. There was a highly significant interaction between OPV at birth and sex (p = 0.006). Not receiving OPV at birth was associated with a weak tendency for increased mortality in girls (1.14 (0.70-1.89)) but significantly decreased mortality in boys (0.35 (0.18-0.71)). Conclusions: In our study OPV at birth had a sex-differential effect on mortality. Poliovirus is almost eradicated and OPV at birth contributes little to herd immunity. A randomised study of the effect of OPV at birth on overall mortality in both sexes is warranted.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Public, Environmental & Occupational Health

Understanding the child mortality decline in Guinea-Bissau: the role of population-level nutritional status measured by mid-upper arm circumference

Andreas Rieckmann, Ane Baerent Fisker, Christian Bjerregard oland, Sebastian Nielsen, Rasmus Wibaek, Tina Bonde Sorensen, Cesario Lourenco Martins, Christine Stabell Benn, Peter Aaby

Summary: Malnutrition is an important contributing factor to child mortality in Guinea-Bissau. Despite a significant decline in child mortality, changes in the mid-upper arm circumference (MUAC) distribution explain only a small portion of the decline. Understanding the driving factors of child mortality decline can inform future interventions.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2022)

添加到收藏夹
Article Immunology

Mortality Risk Among Frail Neonates and Maternal BCG Vaccine Scar Status: Observational Study From Guinea-Bissau

Frederik Schaltz-Buchholzer, Peter Aaby, Isaquel Silva, Ivan Monteiro, Tobias R. Kollmann, Nelly Amenyogbe, Morten Bjerregaard-Andersen, Christine Stabell Benn

Summary: This study suggests that maternal BCG vaccine may be associated with reduced overall NICU mortality rate in newborns.

JOURNAL OF INFECTIOUS DISEASES (2023)

添加到收藏夹
Article Obstetrics & Gynecology

Adverse pregnancy outcome disclosure and women's social networks: a qualitative multi-country study with implications for improved reporting in surveys

Doris Kwesiga, Leif Eriksson, Christopher Garimoi Orach, Charlotte Tawiah, Md Ali Imam, Ane B. Fisker, Yeetey Enuameh, Joy E. Lawn, Hannah Blencowe, Peter Waiswa, Hannah Bradby, Mats Malqvist

Summary: Disclosure of APOs within social networks in countries like Uganda, Ghana, Guinea-Bissau, and Bangladesh is a community concern, with key decision makers including men, spiritual leaders, and traditional leaders. Efforts to improve APOs reporting could benefit from guidance by the diffusion of innovation theory, emphasizing the importance of community role models in disseminating information. Health workers should adopt a more supportive response to APOs, like the social networks do, to encourage more bereaved women to seek care.

BMC PREGNANCY AND CHILDBIRTH (2022)

添加到收藏夹
Letter Allergy

Migration and allergic diseases: Findings from a population-based study in adults in Amsterdam, the Netherlands

Abena S. Amoah, Maria Prins, Elisabeth H. D. Bel, Wytske J. Fokkens, Aeilko H. Zwinderman, Maria Yazdanbakhsh, Anke H. Maitland-van der Zee, Ronald van Ree

ALLERGY (2022)

添加到收藏夹
Review Immunology

Stopping Oral Polio Vaccine (OPV) After Defeating Poliomyelitis in Low- and Middle-Income Countries: Harmful Unintended Consequences? Review of the Nonspecific Effects of OPV

Peter Aaby, Sebastian Nielsen, Ane B. Fisker, Line M. Pedersen, Paul Welaga, Syed M. A. Hanifi, Cesario L. Martins, Amabelia Rodrigues, Konstantin Chumakov, Christine S. Benn

Summary: Oral polio vaccine (OPV) has beneficial non-specific effects (NSEs) in reducing non-polio child mortality. OPV coadministered with diphtheria-tetanus-pertussis (DTP) vaccine is associated with lower mortality compared to DTP-only, while absence of OPV is associated with higher mortality. Early use of OPV also reduces infant mortality.

OPEN FORUM INFECTIOUS DISEASES (2022)

添加到收藏夹
Article Microbiology

Oral polio revaccination is associated with changes in gut and upper respiratory microbiomes of infants

Marcia Melo Medeiros, Anna Cacilia Ingham, Line Moller Nanque, Claudino Correia, Marc Stegger, Paal Skyt Andersen, Ane Baerent Fisker, Christine Stabell Benn, Miguel Lanaspa, Henrique Silveira, Patricia Abrantes

Summary: This study found that revaccination with oral polio vaccine (OPV) led to changes in the composition of gut and upper respiratory bacterial microbiotas in infants. Two months after revaccination, OPV-revaccinated infants had a more abundant and diversified microbiome with a reduced proportion of potentially pathogenic/opportunistic bacteria.

FRONTIERS IN MICROBIOLOGY (2022)

添加到收藏夹
Article Immunology

Oral Polio Vaccine to Mitigate the Risk of Illness and Mortality During the Coronavirus Disease 2019 Pandemic: A Cluster-Randomized Trial in Guinea-Bissau

Ane B. Fisker, Justiniano S. D. Martins, Line M. Nanque, Andreas M. Jensen, Elsi J. C. Ca, Sebastian Nielsen, Cesario L. Martins, Amabelia Rodrigues

Summary: In a cluster-randomised trial in Guinea-Bissau, the oral polio vaccine (OPV) showed no overall effect on morbidity/mortality, but did have around a 30% reduction in males and BCG scar-positive individuals. This study suggests that OPV may have beneficial nonspecific effects, especially in males.

OPEN FORUM INFECTIOUS DISEASES (2022)

添加到收藏夹
Editorial Material Medicine, General & Internal

Maximising the lessons learned from trial data after emergency use listing of a novel oral polio vaccine

Line M. Nanque, Ane Baerent Fisker

LANCET (2023)

添加到收藏夹
Article Public, Environmental & Occupational Health

Stillbirth and early neonatal mortality rates may be underestimated using recall information: A comparison of demographic surveillance methodologies

Andreas Moller Jensen, Sanne Marie Thysen, Oides Furtado, Claudino Correia, Stephane Helleringer, Jacob von Bornemann Hjelmborg, Ane Baerent Fisker

Summary: The objective of this study is to compare stillbirth and mortality estimates derived using two different methods: the method assuming full information and the prospective method. Child mortality and stillbirth rates may be underestimated in low-income countries due to incomplete reporting of child deaths. The study compares estimates based on complete information with estimates based on prospective data.

TROPICAL MEDICINE & INTERNATIONAL HEALTH (2023)

添加到收藏夹
Article Environmental Sciences

Predictors of serum- per- and polyfluoroalkyl substance (PFAS) concentrations among infants in Guinea-Bissau, West Africa

Marzanna Marianna Sorensen, Ane Baerent Fisker, Christine Dalgard, Kristoffer Jarlov Jensen, Flemming Nielsen, Christine Stabell Benn, Philippe Grandjean, Amalie Timmermann

Summary: The aim of this study was to identify predictors of infant serum-PFAS concentrations. The study found that the location of residence was the most important determinant of serum-PFAS concentrations among Guinea-Bissau infants, indicating a potential role of diet as affected by the global spread of PFAS, but further research is needed to explore reasons for the regional differences in PFAS exposure.

ENVIRONMENTAL RESEARCH (2023)

添加到收藏夹
Article Infectious Diseases

Overall effect of a campaign with measles vaccine on the composite outcome mortality or hospital admission: A cluster-randomized trial among children aged 9-59 months in rural Guinea-Bissau

Anshu Varma, Sanne M. Thysen, Justiniano S. D. Martins, Line M. Nanque, Aksel K. G. Jensen, Ane B. Fisker

Summary: A non-blinded cluster-randomized trial was conducted in rural Guinea-Bissau to evaluate the effect of measles vaccine campaigns (C-MV) targeting children aged 9-59 months. The study found that C-MV did not reduce overall mortality or hospital admission rates.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2023)

添加到收藏夹
Review Infectious Diseases

Measles vaccination and reduced child mortality: Prevention of immune amnesia or beneficial non-specific effects of measles vaccine?

Christine S. Benn, Peter Aaby

Summary: Measles vaccine may have beneficial effects beyond preventing measles infection, possibly due to measles-induced immune amnesia or beneficial non-specific immune training effects. Epidemiological studies support the hypothesis of immune amnesia, but there are also contradictory observations.

JOURNAL OF INFECTION (2023)

添加到收藏夹
Article Immunology

Using BCG Vaccine to Enhance Nonspecific Protection of Health Care Workers During the COVID-19 Pandemic: A Randomized Controlled Trial

Anne Marie Rosendahl Madsen, Frederik Schaltz-Buchholzer, Sebastian Nielsen, Thomas Benfield, Morten Bjerregaard-Andersen, Lars Skov Dalgaard, Christine Dam, Sisse Bolm Ditlev, Gulia Faizi, Mihnaz Azizi, Zainab Nadhim Hameed, Isik Somuncu Johansen, Poul-Erik Kofoed, Tyra Grove Krause, Gitte Schultz Kristensen, Ellen Christine Leth Loekkegaard, Christian Backer Mogensen, Libin Mohamed, Emilie Sundhaugen Oedegaard, Anne Ostenfeld, Marcus Kjaer Soerensen, Christian Wejse, Mihai G. Netea, Peter Aaby, Christine Stabell Benn

Summary: In a randomized clinical trial among Danish health care workers, BCG vaccination had no overall effect on absenteeism, COVID-19 incidence, hospitalization risk, or self-reported infectious diseases. BCG revaccination was associated with increased COVID-19 incidence, but reduced hospitalization risk.

JOURNAL OF INFECTIOUS DISEASES (2023)

添加到收藏夹
Article Public, Environmental & Occupational Health

Provider-mother interactions are associated with birth outcome misclassifications in household surveys: A case-control study in Guinea-Bissau

Sabine M. Damerow, Diana Yeung, Justiniano S. D. Martins, Ishaan Pathak, Yue Chu, Li Liu, Ane B. Fisker

Summary: A study in Guinea-Bissau found that inadequate communication between mothers and healthcare providers during childbirth is the main reason for misclassification of stillbirths and early neonatal deaths in household surveys. This misclassification leads to an overestimation of neonatal mortality.

JOURNAL OF GLOBAL HEALTH (2023)

添加到收藏夹
暂无数据
研讨会 海报 问题 讨论圈 基金 期刊 论文 科研社交 资讯集成 审稿人 关于我们 常见问题 移动App 隐私条款 使用条款
© Peeref 2019-2024. All rights reserved.