Article
Neurosciences
Harish M. Kawade, Sanjay N. Awathale, Nishikant K. Subhedar, Dadasaheb M. Kokare
Summary: This study investigates the role of NPS in modulating the VTA-AcbSh circuit in fear extinction. The results suggest that intra-VTA administration of NPS prior to fear extinction training can enhance fear extinction learning and memory.
Article
Neurosciences
Stacey L. Robinson, Todd E. Thiele
Summary: Somatostatin (SST), a neuropeptide expressed in the central nervous system, has gained attention for its role in modulating alcohol use disorders and neuropsychiatric disorders. This study examines the role of SST in the central nucleus of the amygdala (CeA) in binge ethanol intake, using a mouse model.
Article
Behavioral Sciences
William J. Giardino, Matthew B. Pomrenze
Summary: The intricate relationship between sleep, emotional arousal, and neural circuits presents a significant challenge in understanding the impact of sleep quality on emotional responses. Investigating these interrelated factors can provide crucial insights into improving psychiatric treatments and global psychological wellbeing.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Ying-Liang Larry Lai, Kuan Chen, Tzu-Wei Lee, Chao-Wei Tso, Hui-Hsien Lin, Li-Wei Kuo, Cheng-Yu Chen, Hua-Shan Liu
Summary: The study revealed significant differences in the associations between APOE-epsilon 4 and cholinergic structural changes among subjects with different levels of cognitive impairment, reflecting impaired brain function underlying neurocognitive degeneration in AD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Chemistry, Medicinal
Allison Zarkin, Rajwana Jahan, Rajendra Uprety, Yanan Zhang, Charles McElhinny, Rodney Snyder, Elaine Gay, Gabriel Jewula, Heather Bool, Stewart D. Clark, Scott Runyon
Summary: Activation of the NPS receptor system has various physiological effects, while a newly discovered compound, 14b, demonstrates potent NPS receptor antagonist activity by effectively blocking NPS-induced locomotor activity in mice. This compound shows potential for further exploration of the pharmacological functions of the NPS receptor system.
Article
Endocrinology & Metabolism
Louise E. Atkinson, Ciaran J. McCoy, Bethany A. Crooks, Fiona M. McKay, Paul McVeigh, Darrin McKenzie, Allister Irvine, John Harrington, Bruce A. Rosa, Makedonka Mitreva, Nikki J. Marks, Aaron G. Maule, Angela Mousley
Summary: Nematode parasites pose threats to human health and global food security, with the frontline anthelmintic drugs facing resistance. The complexity of nematode neuropeptide signaling pathways offers potential new drug targets for parasite control. Recent advancements in 'omics' technologies provide opportunities for in silico identification and prioritization of targets for anthelmintic discovery pipelines.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Celia Garau, Xiaobin Liu, Girolamo' Calo, Stefan Schulz, Rainer K. Reinscheid
Summary: Evaluation of stimulus salience is crucial for organisms to prioritize important information, prepare responses, and form valuable memories. This study reveals the importance of neuropeptide S (NPS) signaling in the paraventricular nucleus of the thalamus (PVT) in stimulus salience encoding. Manipulation of NPS activity in the PVT modulates the salience of low-intensity stimuli and affects fear extinction and novel object memory formation.
Article
Neurosciences
Sahana Kribakaran, Paola Odriozola, Emily M. Cohodes, Sarah McCauley, Sadie J. Zacharek, H. R. Hodges, Jason T. Haberman, Jasmyne C. Pierre, Dylan G. Gee
Summary: Exposure to trauma can increase the risk of anxiety and PTSD. Research has shown that safety signal learning can effectively reduce fear responses among individuals with trauma exposure, but the neural mechanisms are still unclear. At the neural level, individuals with higher levels of trauma exposure showed lower brain activation during SSL, suggesting sensitivity to trauma exposure.
NEUROBIOLOGY OF STRESS
(2022)
Article
Multidisciplinary Sciences
Yuting Cui, Xiaodan Huang, Pengcheng Huang, Lu Huang, Zhao Feng, Xinkuan Xiang, Xinfeng Chen, Anan Li, Chaoran Ren, Haohong Li
Summary: This study reveals the important role of the basal forebrain-lateral habenula circuit in the pathophysiology of depression. Chronic activation of the circuit leads to depressive-like behaviors, while inhibition of the circuit alleviates stress-induced depressive phenotype.
Review
Neurosciences
Michael D. Murphy, Elizabeth A. Heller
Summary: This review examines the acute and chronic regulation of the dorsal striatum epigenome by stress and stimulants. Findings suggest that stress and stimulant exposure regulate the epigenome through DNA methylation, transposable element activity, and histone post-translational modifications, leading to impaired neuronal function and activity.
TRENDS IN NEUROSCIENCES
(2022)
Review
Neurosciences
Aaron Limoges, Hector E. Yarur, Hugo A. Tejeda
Summary: This article reviews the role of the Dyn/KOR system in regulating amygdala circuitry and its implications in emotional and stress-related behaviors. The study highlights the need for future research to further understand the impact of the Dyn/KOR system on amygdala-related behaviors and suggests that targeting this system could offer novel approaches for treating neuropsychiatric disorders.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2022)
Article
Cell Biology
Chen-Liang Zhang, Yi-Zhang Lin, Qi Wu, Chenxu Yan, Matthew Wai-Kin Wong, Fan Zeng, Ping Zhu, Kelsey Bowes, Kailun Lee, Xuan Zhang, Zhi-Yuan Song, Shu Lin, Yan-Chuan Shi
Summary: Chronic high salt intake is a leading cause of hypertension. This study demonstrates that high salt intake results in downregulation of NPY expression in the hypothalamic Arc and upregulation of BDNF and vasopressin expression in the PVN, leading to the development of hypertension.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Neurosciences
Yu-Feng Shao, Can Wang, Xiao-Ping Rao, Hua-Dong Wang, Yan-Li Ren, Jing Li, Chao-Yu Dong, Jun-Fan Xie, Xing-Wen Yang, Fu-Qiang Xu, Yi-Ping Hou
Summary: Neuropeptide S (NPS) acts by activating its cognate receptor (NPSR) in the posterior medial amygdala to attenuate defensive and risk assessment behaviors induced by alarm pheromones in mice.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Polymer Science
Yajun Ren, ZhuanZhuan Zhang, Wenlong Xia, Qifeng Zhou, Xiaofeng Song
Summary: A novel copolymer PCL(PMVS-s-PAA)-PCL-PTMG-PCL-(PMVS-s-PAA)-PCL was devised as an additive to endow PLLA with water-responsive shape memory capability. The incorporated PLLA showed excellent shape fixation and recovery ratios, as well as remarkable toughness. This new material has great potential applications in medical and biomimetic fields.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Nutrition & Dietetics
Yermek Rakhat, Kentaro Kaneko, Lei Wang, Wanxin Han, Yutaka Seino, Daisuke Yabe, Toshihiko Yada
Summary: d-allulose can suppress hunger-associated feeding and inhibit hunger-promoting neurons in the hypothalamic arcuate nucleus.
Article
Anatomy & Morphology
Anil Annamneedi, Guersel Caliskan, Sabrina Mueller, Dirk Montag, Eike Budinger, Frank Angenstein, Anna Fejtova, Wolfgang Tischmeyer, Eckart D. Gundelfinger, Oliver Stork
BRAIN STRUCTURE & FUNCTION
(2018)
Article
Neurosciences
Lejla Colic, Meng Li, Liliana Ramona Demenescu, Shija Li, Iris Mueller, Anni Richter, Gusalija Behnisch, Constanze I. Seidenbecher, Oliver Speck, Bjoern H. Schott, Oliver Stork, Martin Walter
JOURNAL OF NEUROSCIENCE
(2018)
Article
Behavioral Sciences
Guersel Caliskan, Oliver Stork
NEUROBIOLOGY OF LEARNING AND MEMORY
(2018)
Article
Neurosciences
Marina Mikhaylova, Julia Baer, Bas van Bommel, Philipp Schaetzle, PingAn YuanXiang, Rajeev Raman, Johannes Hradsky, Anja Konietzny, Egor Y. Loktionov, Pasham Parameshwar Reddy, Jeffrey Lopez-Rojas, Christina Spilker, Oliver Kobler, Syed Ahsan Raza, Oliver Stork, Casper C. Hoogenraad, Michael R. Kreutz
Article
Neurosciences
Yunus E. Demiray, Kati Rehberg, Stefanie Kliche, Oliver Stork
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Review
Biochemistry & Molecular Biology
Gal Richter-Levin, Oliver Stork, Mathias V. Schmidt
MOLECULAR PSYCHIATRY
(2019)
Review
Neurosciences
Guersel Caliskan, Oliver Stork
PSYCHOPHARMACOLOGY
(2019)
Article
Immunology
Natalie Waldt, Anke Seifert, Yunus Emre Demiray, Eric Devroe, Benjamin E. Turk, Peter Reichardt, Charlie Mix, Annegret Reinhold, Christian Freund, Andreas J. Mueller, Burkhart Schraven, Oliver Stork, Stefanie Kliche
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Anatomy & Morphology
Elena Martinez-Rodriguez, Ana Martin-Sanchez, Simona Coviello, Cristina Foiani, Emre Kul, Oliver Stork, Fernando Martinez-Garcia, Juan Nacher, Enrique Lanuza, Monica Santos, Carmen Agustin-Pavon
BRAIN STRUCTURE & FUNCTION
(2019)
Article
Neurosciences
Sebastian Ivens, Guersel Caliskan, Ismini Papageorgiou, Tiziana Cesetti, Ansgar Malich, Oliver Kann, Uwe Heinemann, Oliver Stork, Anne Albrecht
Article
Multidisciplinary Sciences
Z. Ardi, A. Richter-Levin, L. Xu, X. Cao, H. Volkmer, O. Stork, G. Richter-Levin
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Stav Regev-Tsur, Yunus Emre Demiray, Kuldeep Tripathi, Oliver Stork, Gal Richter-Levin, Anne Albrecht
NEUROBIOLOGY OF DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Anil Annamneedi, Miguel del Angel, Eckart D. Gundelfinger, Oliver Stork, Gursel Caliskan
Summary: Bassoon, an active zone organizer protein, plays a crucial role in coordinating various functions at the presynaptic active zone. The absence of Bassoon in forebrain glutamatergic synapses leads to developmental disturbances in the dentate gyrus and may affect signaling pathways related to TrkB and neurogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Anne Albrecht, Iris Mueller, Alice Weiglein, Evangelia Pollali, Gursel Caliskan, Oliver Stork
Summary: Remembering food location is crucial for survival. Under stress, rodents and humans shift their strategy from hippocampus-dependent spatial strategies to striatum-mediated stimulus-based strategies. The dorsal dentate gyrus (dDG) in the hippocampus was identified as a crucial hub for mediating stress effects on strategy choices, highlighting its importance in spatial and non-spatial foraging strategies.
NEUROBIOLOGY OF STRESS
(2022)
Article
Neurosciences
Emre Kul, Oliver Stork
Summary: This study explored the effectiveness of nutritional trehalose supplementation in ameliorating symptoms in a mouse model of Fragile X-associated tremor/ataxia syndrome (FXTAS). The results showed that trehalose supplementation improved the formation of intracellular inclusions and motor deficiencies in the mouse model, suggesting its potential for early stage FXTAS treatment.
NUTRITIONAL NEUROSCIENCE
(2023)