Article
Biochemistry & Molecular Biology
Laura Rullo, Francesca Felicia Caputi, Loredana Maria Losapio, Camilla Morosini, Luca Posa, Donatella Canistro, Fabio Vivarelli, Patrizia Romualdi, Sanzio Candeletti
Summary: This study investigated the impact of morphine, buprenorphine, and tapentadol on intracellular reactive oxygen species levels, superoxide dismutase activity/gene expression, as well as beta 2 and beta 5 subunit proteasome activity/biosynthesis in SH-SY5Y cells. The results showed that these opioids differently altered ROS production, SOD activity/biosynthesis, and proteasome activity/biosynthesis. The findings suggest that the differences in these cellular processes may contribute to the occurrence of opioid-related side effects.
Article
Biochemistry & Molecular Biology
Lucie Valek, Irmgard Tegeder
Summary: Knockdown of nucleoredoxin (NXN) in neuronal cells leads to increased proliferation, elevated basal respiratory rates, and a similar relative change in oxygen consumption compared to control cells under mitochondrial stressors. Moreover, NXN-deficient cells show increased expression of redox-sensitive heat shock proteins and autophagy markers, indicating higher levels of self-renewal and autophagy.
Article
Neurosciences
Xin Huang, Xinyue Yan, Gang Chen, Yue Feng, Yuying Bai, Peng Yan, Jianghua Lai, Shuguang Wei
Summary: This study aims to clarify the role of opioid receptors in morphine-induced ferroptosis and investigate the role of NRF2 in morphine-induced ferroptosis. The results showed that morphine can induce ferroptosis in a dose-dependent manner, and GPX4 may be involved in this process. Additionally, NRF2 was found to promote morphine-induced ferroptosis, possibly due to increased p62-related insufficient autophagy.
PSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zahra Madadi, Shiva Akbari-Birgani, Saeed Mohammadi, Mitra Khademy, Seyed Asadollah Mousavi
Summary: Neuroblastoma is a common malignant tumor in infants and young children, with differentiation-inducing potential. The activation of caspase-9 plays a crucial role in the differentiation process of human neuroblastoma cells, promoting a change in cell morphology and protein expression.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elda Chiaino, Matteo Micucci, Roberta Budriesi, Laura Beatrice Mattioli, Carla Marzetti, Maddalena Corsini, Maria Frosini
Summary: Natural compound PRES, composed of extracts from Olea europaea L. leaves and Hibiscus sabdariffa L. flowers, showed potential in decreasing viability of neuroblastoma cells through ROS-mediated apoptosis. The mixture exhibited a synergistic effect compared to individual extracts of Olea europaea L. leaves and Hibiscus sabdariffa L. flowers.
Article
Food Science & Technology
Carmen Rodriguez-Rivera, Maria Dolores Perez-Carrion, Lucia Casariego Olavarria, Luis F. Alguacil, Maria Jose Polanco Mora, Carmen Gonzalez-Martin
Summary: Food-related disorders are on the rise in developed societies, with a growing focus on the psychological component of these disorders. Research has shown that overnourishment with high-fat diets and perinatal undernourishment in mice are associated with increased motivation toward food intake. The protein clusterin (CLU) is overexpressed in the nucleus accumbens of over-fed rats and those suffering from chronic undernutrition, and its increase has been observed in obese patients with food addiction, suggesting its implication in this eating disorder.
FOOD & NUTRITION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ami Oguro, Kenta Fujita, Yasuhiro Ishihara, Megumi Yamamoto, Takeshi Yamazaki
Summary: DHA can suppress the neurotoxicity induced by MeHg, possibly by further inducing antioxidant genes to inhibit the production of ROS caused by MeHg and by inhibiting the generation of 19,20-DHDP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Andrila E. Collins, Tarek M. Saleh, Bettina E. Kalisch
Summary: This study aimed to assess the cytoprotective effects of the novel antioxidant compound VANL-100 in a cellular model of beta-amyloid (A beta)-induced toxicity. The results demonstrate that VANL-100 significantly attenuated A beta-induced cell death, indicating its cytoprotective effects against A beta-induced toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Carlos Villaorduna, Mariano Mendoza-Carlos, Manuel Chuyma, Jhon Aviles, Ayda Avalos-Diaz, Ronald Lozano-Reategui, Juan Garcia-Ruiz, Nadia Panduro-Tenazoa, Jessy Vargas, Ysabel Moran-Quintanilla, Jose-Luis Rodriguez
Summary: Ipconazole, an antifungal agrochemical, poses a hazard to human, animal, and environmental health due to its widespread use in agriculture and easy accumulation in the environment. Our study investigated the cytotoxic effects of ipconazole on SH-SY5Y neuroblastoma cells, revealing a dose-dependent reduction in cell viability, increased ROS production, and induction of cell death. These findings suggest that ipconazole exposure may contribute to neurotoxicity or neurodegeneration.
Article
Biochemistry & Molecular Biology
Muganti Rajah Kumar, Swee Keong Yeap, Han Chung Lee, Nurul Elyani Mohamad, Muhammad Nazirul Mubin Aziz, Melati Khalid, Mas Jaffri Masarudin, Adam Thean Chor Leow, Janna Ong Abdullah, Noorjahan Banu Alitheen
Summary: The study found that Kefir B in kefir water exhibited the highest antioxidant and anti-apoptotic activities, providing significant cell protection and maintaining cellular morphology. The results suggest that kefir water can exert its antioxidative, anti-apoptotic, and neuroprotective effects through upregulating enzymes like SOD and catalase.
Article
Neurosciences
Seda Onder, Lawrence M. Schopfer, Wei Jiang, Ozden Tacal, Oksana Lockridge
Summary: It has been found that SH-SY5Y cells express active AChE and BChE, but these proteins do not mature into glycosylated tetramers.
Article
Biochemistry & Molecular Biology
Renata Perlikowska, Joana Silva, Celso Alves, Patricia Susano, Rui Pedrosa
Summary: This study investigates the neuroprotective properties of four naturally occurring peptides. The results show that endomorphin-1 and endomorphin-2 can inhibit neuronal cell death induced by 6-hydroxydopamine, reducing mitochondrial membrane potential and Caspase-3 activity. Meanwhile, rubiscolin-6 shows antioxidant potential and can recover neurotoxicity by reducing reactive oxygen species levels and improving mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Xin Wang, Hongfei Ni, Wenping Xu, Bing Wu, Te Xie, Cheng Zhang, Jiagao Cheng, Zhong Li, Liming Tao, Yang Zhang
Summary: Difenoconazole exhibits neurotoxicity at the cellular level, causing cell apoptosis and DNA damage, and adversely affecting cell function.
Article
Neurosciences
Lei Wang, Kunliang Lu, Xingyue Lou, Shenghui Zhang, Wenxin Song, Ranran Li, Lujing Geng, Binfeng Cheng
Summary: This study found that astaxanthin (AST) significantly enhanced cell survival, suppressed apoptosis and oxidative stress in a Parkinson's disease (PD) model. It also improved behavioral disorders and protected dopaminergic neurons in the substantia nigra pars compacta (SNpc). The neuroprotective effects of AST were mediated through the inhibition of MAPK signaling.
BRAIN RESEARCH BULLETIN
(2023)
Article
Biology
Jason C. Sang, Eric Hidari, Georg Meisl, Rohan T. Ranasinghe, Maria Grazia Spillantini, David Klenerman
Summary: Researchers found that cells respond to disruption of protein homeostasis by alpha-synuclein seeds primarily by secreting nanoscopic aggregates. This mechanism may represent an important protective response by cells to protein aggregation.
COMMUNICATIONS BIOLOGY
(2021)
Article
Neurosciences
Nisrine Kamoun, Geraldine Gazzo, Yannick Goumon, Virginie Andry, Ipek Yalcin, Pierrick Poisbeau
Summary: Neuropathic pain is often accompanied by anxiety and major depressive disorders, impacting the patient experience significantly. Etifoxine, a non-benzodiazepine anxiolytic, has shown promising potential in relieving both sensory and emotional components of neuropathic pain through GABAergic mechanisms. The therapeutic effects of Etifoxine include sustained relief from mechanical allodynia, alleviation of ongoing pain aversiveness, and mitigation of anxiodepressive-like consequences of neuropathic pain. Additionally, Etifoxine's neuroprotective and analgesic actions have been demonstrated in preclinical studies.
Article
Neurosciences
Jerome Wahis, Angel Baudon, Ferdinand Althammer, Damien Kerspern, Stephanie Goyon, Daisuke Hagiwara, Arthur Lefevre, Lara Barteczko, Benjamin Boury-Jamot, Benjamin Bellanger, Marios Abatis, Miriam Da Silva Gouveia, Diego Benusiglio, Marina Eliava, Andrei Rozov, Ivan Weinsanto, Hanna Sophie Knobloch-Bollmann, Matthew K. Kirchner, Ranjan K. Roy, Hong Wang, Marie Pertin, Perrine Inquimbert, Claudia Pitzer, Jan Siemens, Yannick Goumon, Benjamin Boutrel, Christophe Maurice Lamy, Isabelle Decosterd, Jean-Yves Chatton, Nathalie Rouach, W. Scott Young, Javier E. Stern, Pierrick Poisbeau, Ron Stoop, Pascal Darbon, Valery Grinevich, Alexandre Charlet
Summary: This study reveals a morphologically distinct subpopulation of astrocytes expressing OT receptors in the central amygdala of mice and rats, mediating the anxiolytic and positive reinforcement effects of OT. It challenges the traditional belief that OT exclusively acts on neurons, highlighting the essential role of astrocytes in modulating emotional states under normal and chronic pain conditions.
NATURE NEUROSCIENCE
(2021)
Article
Anesthesiology
Baptiste Letellier, Melanie Kremer, Lea J. Becker, Virginie Andry, Yannick Goumon, Quentin Leboulleux, Pierre Hener, Perrine Inquimbert, Nolwenn Couqueberg, Elisabeth Waltisperger, Ipek Yalcin, Franck Mouthon, Marine Droguerre, Mathieu Charveriat, Michel Barrot
Summary: The connexin inhibitor mefloquine potentiates the therapeutic effect of amitriptyline in neuropathic pain by modulating noradrenergic descending pathways and recruiting alpha(2) adrenoceptors. In addition, another connexin blocker, carbenoxolone, also improves the action of amitriptyline. Furthermore, in vitro studies suggest that mefloquine may also directly act on serotonin transporters and adenosine receptors A(1) and A(2A), but drugs targeting these other pathways failed to amplify the action of amitriptyline.
Article
Cell Biology
Valerie Jolivel, Susana Brun, Fabien Biname, Jeremie Benyounes, Omar Taleb, Dominique Bagnard, Jerome De Seze, Christine Patte-Mensah, Ayikoe-Guy Mensah-Nyagan
Summary: Research has shown that the neurosteroid allopregnanolone (ALLO) has a direct impact on the morphology and phagocytic function of microglial cells, potentially contributing to the development of effective strategies against neurological disorders.
Article
Behavioral Sciences
David de Sa Nogueira, Romain Bourdy, Dominique Filliol, Gaelle Awad, Virginie Andry, Yannick Goumon, Mary C. Olmstead, Katia Befort
Summary: This study found that bingeing on sucrose alters the endocannabinoid system in reward-related areas, exacerbating the effects of CB1R antagonist on sucrose reward. The results broaden our understanding of neural alterations associated with binge eating and demonstrate the important role of CB1R mechanisms in reward processing.
Article
Nutrition & Dietetics
Romain Bourdy, Alexandra Hertz, Dominique Filliol, Virginie Andry, Yannick Goumon, Jorge Mendoza, Mary C. Olmstead, Katia Befort
Summary: The study showed that excessive consumption of high-calorie palatable food is often driven by pleasure rather than metabolic need, leading to issues such as obesity and eating disorders, which are mainly related to the role of dopamine and the endocannabinoid system in the brain. By observing the behavior and gene expression in rats during a free-choice high-fat and high-sugar diet experiment, the research confirmed this association.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Cell Biology
Thomas T. Tapmeier, Nilufer Rahmioglu, Jianghai Lin, Bianca De Leo, Maik Obendorf, Muthuswamy Raveendran, Oliver M. Fischer, Cemsel Bafligil, Manman Guo, Ronald Alan Harris, Holger Hess-Stumpp, Alexis Laux-Biehlmann, Ernesto Lowy, Gerton Lunter, Jessica Malzahn, Nicholas G. Martin, Fernando O. Martinez, Sanjiv Manek, Stefanie Mesch, Grant W. Montgomery, Andrew P. Morris, Jens Nagel, Heather A. Simmons, Denise Brocklebank, Catherine Shang, Susan Treloar, Graham Wells, Christian M. Becker, Udo Oppermann, Thomas M. Zollner, Stephen H. Kennedy, Joseph W. Kemnitz, Jeffrey Rogers, Krina T. Zondervan
Summary: Genetic analyses identified a significant association between the NPSR1 gene and endometriosis, suggesting the NPSR1/NPS system as a genetically validated, nonhormonal target for the treatment of endometriosis, particularly in stage III/IV disease.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Florian Gabel, Volodya Hovhannisyan, Virginie Andry, Yannick Goumon
Summary: This study found that female mice have weaker morphine antinociception and faster induction of tolerance than males. Additionally, female mice have higher levels of M3G in the blood and pain-related CNS regions than male mice, while lower levels of morphine were observed in these regions. These differences are mainly attributed to morphine metabolism in pain-related CNS regions.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Laura Streit, Sophie Moog, Sylvain Hugel, Marion Rame, Emeline Tanguy, Virginie Andry, Herbert A. Schmid, Laurent Brunaud, Florence Bihain, Claire Nomine-Criqui, Yannick Goumon, Stephanie Lacomme, Sandra Lomazzi, Michel Vix, Didier Mutter, Nicolas Vitale, Stephane Ory, Stephane Gasman
Summary: NETs like pheochromocytoma can cause severe symptoms and life-threatening conditions. Treatment with somatostatin analogues may help inhibit the secretion of catecholamines. The study found that SOM230 could effectively inhibit catecholamine secretion and be considered a potential anti-secretory treatment for patients with pheochromocytoma.
Article
Neurosciences
David De Sa Nogueira, Romain Bourdy, Rafael Alcala-Vida, Dominique Filliol, Virginie Andry, Yannick Goumon, Jean Zwiller, Pascal Romieu, Karine Merienne, Mary C. Olmstead, Katia Befort
Summary: This study investigated the long-term adaptations induced by cocaine self-administration, including transcriptional modifications and associated epigenetic processes. The results suggest that the endogenous cannabinoid system may play a role in this process, and highlight the key role of the hippocampus in cocaine-induced plasticity.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Neurosciences
Florian Gabel, Volodya Hovhannisyan, Abdel-Karim Berkati, Yannick Goumon
Summary: Morphine metabolism leads to the production of two main metabolites, M3G and M6G, with different biological activities. M6G produces potent analgesia, while M3G induces excitation and reduces analgesic effects. The receptor(s) on which M3G acts remain unclear and controversial.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Laura Durieux, Karine Herbeaux, Christopher Borcuk, Cecile Hildenbrand, Virginie Andry, Yannick Goumon, Alexandra Barbelivien, Chantal Mathis, Demian Bataglia, Monique Majchrzak, Lucas Lecourtier
Summary: Upon stress exposure, a network of structures including the medial prefrontal cortex, amygdala, hippocampus, hypothalamus, monoaminergic systems, and periaqueductal gray are engaged to provide adequate responses and restore homeostasis. The lateral habenula (LHb), a structure connected to prefrontal cortical areas, amygdala, and hippocampus, acts as a main modulator of the monoaminergic systems and is activated during stress exposure. This study confirms the involvement of LHb in the stress response network and explores its functional interactions with other key structures.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Immunology
Francis Schneider, Pierrick Le Borgne, Jean-Etienne Herbrecht, Francois Danion, Morgane Solis, Sophie Helle, Cosette Betscha, Raphael Clere-Jehl, Francois Lefebvre, Vincent Castelain, Yannick Goumon, Marie-Helene Metz-Boutigue
Summary: Neuroendocrine cells release Catestatin (CST) from Chromogranin A (CgA) to regulate stress responses, and COVID patients with higher plasma CST levels may have an increased risk of in-hospital mortality. The study suggests that plasma CST could be a potential biomarker for predicting outcomes in COVID patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Albin A. Bernardin, Sarah Colombani, Antoine Rousselot, Virginie Andry, Yannick Goumon, Helene Delanoe-Ayari, Come Pasqualin, Bernard Brugg, Etienne D. Jacotot, Jean-Luc Pasquie, Alain Lacampagne, Albano C. Meli
Summary: This study presents an innovative neuro-cardiac organ-on-chip model to study the neuro-cardiac junction (NCJ) and understand the mechanisms involved in its establishment. The model successfully recapitulates the structural and functional properties of the NCJ and allows for the evaluation of the interaction between the heart and brain, as well as the impact of drugs on a reconstructed human neuro-cardiac system.
Article
Multidisciplinary Sciences
Adam J. Davenport, Ioana Neagoe, Nico Braeuer, Markus Koch, Andrea Rotgeri, Jens Nagel, Alexis Laux-Biehlmann, Frederic Machet, Anne-Marie Coelho, Susan Boyce, Nikisha Carty, Mark J. Gemkow, Stephen D. Hess, Thomas M. Zollner, Oliver M. Fischer
Summary: ATP-dependent P2X3 receptors play a crucial role in nerve sensitization, pain pathways, and cough. The development of eliapixant, a highly potent and selective P2X3 receptor antagonist, shows promising results in reducing inflammatory pain and neurogenic inflammation, suggesting potential benefits for disorders associated with hypersensitive nerve fibers, such as endometriosis.
SCIENTIFIC REPORTS
(2021)