Article
Hematology
Sanne Bakker, Johanna Louise I. Burggraaf, Marieke J. H. A. Kruip, Felix J. M. van der Meer, Willem M. Lijfering, Nienke van Rein
Summary: Selective serotonin reuptake inhibitors (SSRIs) may increase the risk of major bleeding, particularly for CYP2C9-inhibiting SSRIs, by affecting platelet function and VKA metabolism. The use of SSRIs is associated with an increased risk of a high INR, indicating potential bleeding complications.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Elli Anna Kotsailidi, Catherine Gagnon, Lucy Johnson, Abdul Barmak Basir, Alexandra Tsigarida
Summary: This retrospective study evaluated the association between the use of selective serotonin reuptake inhibitors (SSRIs) and changes in peri-implant marginal bone levels. The results showed a significant correlation between SSRI use and marginal bone loss around dental implants.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vera Sovkova, Karolina Vocetkova, Vera Hedvicakova, Veronika Hefka Blahnova, Matej Buzgo, Evzen Amler, Eva Filova
Summary: The study found that different components of platelet concentrates have varying effects on cells: groups containing plasma had higher levels of growth factors, while groups containing platelet proteins had higher levels of chemokines and growth factors. The synergic effect of plasma and platelet proteins plays a crucial role in cell proliferation and viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
George M. Anderson, Christine M. Ramsey, Kevin G. Lynch, Joel Gelernter, David W. Oslin
Summary: This study investigated the distribution of baseline platelet serotonin (5-HT) levels in depression patients seeking treatment and defined subgroups based on drug exposure. The bioeffect of 5-HT reuptake inhibitors (SRIs) and the relationship between demographic variables and platelet 5-HT concentration were also assessed. Data from a cross-sectional study of 1433 Veterans Administration (VA) patients were analyzed, revealing a bimodal distribution of platelet 5-HT levels and significant differences in population, sex, and age.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Soon H. Yang, Charles F. Seifert
Summary: The use of serotonergic antidepressants (SADs) during the perioperative period is associated with an increased risk of bleeding in patients undergoing orthopedic surgery. Patients on SADs had a higher percentage of requiring transfusion and a longer hospital stay compared to those not on SADs.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Jakob Christensen, Betina B. Trabjerg, Yuelian Sun, Julie Werenberg Dreier
Summary: This study examined the association between maternal antidepressant prescription during pregnancy and standardized test scores among Danish schoolchildren. Results showed that children born to mothers filling antidepressant prescriptions during pregnancy had significantly lower math test scores but no significant difference in language test scores compared to children whose mothers did not fill antidepressant prescriptions. The difference in math scores was small and of uncertain clinical importance, suggesting the need to balance the findings against the benefits of treating maternal depression during pregnancy.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Oncology
Naiqi Zhang, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: This population-based cohort study suggests that the use of SSRIs is associated with a reduced risk of CRC among individuals with a family history of CRC. The decreased risk of CRC showed a non-linear, dose-dependent pattern. Furthermore, the use of SSRIs was strongly associated with advanced-stage CRC rather than early-stage CRC.
Review
Chemistry, Analytical
Ilona Oledzka, Alina Plenis, Piotr Kowalski, Tomasz Baczek, Anna Roszkowska
Summary: The pharmacotherapy of depression relies on different types of antidepressants, with SSRIs being the most commonly used first-line treatment. There is a growing demand for fast and accurate methods to monitor SSRI levels during depression therapy. Recent efforts have focused on developing instrumental methods that enable lower detection limits, better quantitation, and separation of multiple analytes, resulting in more reliable and selective determination of SSRIs. However, the preparation of biological samples for analysis remains a bottleneck in most analytical procedures. This review discusses recent advancements in methods for preparing various conventional and non-conventional complex biological matrices for precise determination of SSRI levels, as well as the advantages, challenges, and potential applications of these developed methodologies in clinical studies.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Joseph Grech, Melissa Victoria Chan, Chinedu Ochin, Amber Lachapelle, Florian Thibord, Zoe Schneider, Bongani Brian Nkambule, Paul Charles John Armstrong, Catherine Wallace de Melendez, Katherine L. Tucker, Mahdi Garelnabi, Timothy David Warner, Ming-Huei Chen, Andrew Danner Johnson
Summary: Depression is associated with cardiovascular disease, and platelet reactivity is related to the use of antidepressants, especially those affecting serotonin.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Anesthesiology
Li Wang, Joshua Tobe, Emily Au, Cody Tran, Jane Jomy, Yvgeniy Oparin, Rachel J. Couban, James Paul
Summary: The systematic review and meta-analysis found that SSRIs and SNRIs as adjuncts for postoperative pain management significantly reduced postoperative pain, opioid consumption, and improved patient satisfaction without increasing adverse events compared with placebo. SSRIs tend to be less effective than SNRIs, but the effects of SSRIs remain inconclusive due to limited evidence.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Clinical Neurology
Shuzhe Zhou, Qinhong Ma, Yiwei Lou, Xiaozhen Lv, Hongjun Tian, Jing Wei, Kerang Zhang, Gang Zhu, Qiaoling Chen, Tianmei Si, Gang Wang, Xueyi Wang, Nan Zhang, Yu Huang, Qi Liu, Xin Yu
Summary: This study utilized machine learning models to explore baseline variables for predicting the 8-week treatment outcome of patients with MDD receiving SSRIs. Results showed that neurocognitive functions and anxiety symptoms were important predictors, with SVM achieving an accuracy of 74.49% and sensitivity and specificity of 0.899 and 0.422, respectively.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
Avital Fischer, Hedy S. Rennert, Gad Rennert
Summary: The study found that the use of SSRIs before and after breast cancer diagnosis is associated with increased mortality in breast cancer patients. Research is needed to further understand the mechanisms behind this association.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Surapon Nochaiwong, Chidchanok Ruengorn, Ratanaporn Awiphan, Chatree Chai-Adisaksopha, Apichat Tantraworasin, Chabaphai Phosuya, Penkarn Kanjanarat, Wilaiwan Chongruksut, Manish M. Sood, Kednapa Thavorn
Summary: This systematic review and meta-analysis found that the use of serotonin reuptake inhibitor (SRI) antidepressants in patients receiving antithrombotic therapy is associated with a higher risk of bleeding complications, including major bleeding, gastrointestinal bleeding, and any bleeding events. The risk is elevated among individuals receiving anticoagulants or antiplatelet therapy. Caution should be exercised in co-prescribing SRIs with antithrombotic therapy due to safety concerns regarding bleeding risks.
ANNALS OF MEDICINE
(2022)
Article
Psychiatry
Fredrik Hieronymus, Alexander Lisinski, Elias Eriksson, Soren Dinesen Ostergaard
Summary: This study analyzed patient-level data to assess the relationship between antidepressant side effects and HDRS-17 ratings, finding that some HDRS-17 items are associated with common antidepressant side effects, potentially leading to an underestimation of antidepressant efficacy.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Kinsley Tate, Brenna Kirk, Alisia Tseng, Abigail Ulffers, Karen Litwa
Summary: The developing prenatal brain is sensitive to environmental disturbances, with factors like pharmaceuticals potentially affecting synapse formation and increasing the risk of neurodevelopmental abnormalities. However, there is still a lack of research on how specific environmental factors impact the developing neural circuitry of the human brain. Recent studies show that the selective serotonin reuptake inhibitor fluoxetine can acutely alter synaptic function in developing neural circuits, but the effects are not long-lasting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)