Review
Biochemistry & Molecular Biology
Sean X. Gu, Sanjana Dayal
Summary: Aging is a major risk factor for various diseases, including cardiovascular disease. Reactive oxygen species and oxidative stress have been shown to play a role in age-related vascular diseases. Platelets, as key contributors in vascular disease progression, undergo oxidative changes that are associated with comorbid conditions such as diabetes, atherosclerosis, obesity, and cancer. Understanding the mechanistic links between oxidative stress and vascular diseases is crucial for developing targeted therapeutic strategies for age-associated vascular diseases.
Article
Biochemistry & Molecular Biology
Pin Gong, Xiaojuan Wang, Meng Liu, Mengrao Wang, Siyuan Wang, Yuxi Guo, Xiangna Chang, Wenjuan Yang, Xuefeng Chen, Fuxin Chen
Summary: This study evaluated the hypoglycemic effect of a novel polysaccharide from Lentinus edodes, named LNT-1, on mice with type 2 diabetes. The results showed that LNT-1 treatment improved the damage in diabetic mice, possibly by activating the Nrf2/HO-1 pathway. Metabolomics analysis also identified several metabolic pathways related to the occurrence of diabetes.
Article
Cardiac & Cardiovascular Systems
Kanika Jain, Tarun Tyagi, Jing Du, Xiaoyue Hu, Kanchi Patell, Kathleen A. Martin, John Hwa
Summary: This study reveals that activation of unfolded protein response (UPR) in anucleate platelets can be independent of genomic regulation, with selective induction specific to the source and severity of stress. Each UPR pathway plays a key role and can differentially modulate platelet activation pathways and phenotype.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Patrik Palacka, Anna Gvozdjakova, Zuzana Rausova, Jarmila Kucharska, Jan Slopovsky, Jana Obertova, Daniel Furka, Samuel Furka, Keshav K. Singh, Zuzana Sumbalova
Summary: This study found that patients with urothelial carcinoma (UC) have deficient platelet mitochondrial function, decreased antioxidant levels, and increased oxidative stress. These changes are consistent with cell metabolism reprogramming in UC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Karolina Siewiera, Magdalena Labieniec-Watala, Nina Wolska, Hassan Kassassir, Cezary Watala
Summary: Various factors, such as blood anticoagulants, platelet suspension media, and ADP stimulation, have been found to affect platelet mitochondrial respiration significantly. The method of platelet preparation may have a greater impact on mitochondrial respiration than platelet activation itself.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Brian Schnoor, Anne-Laure Papa
Summary: Lyophilized platelets, as a potential hemostatic agent, have long-term ambient storage capabilities and high biocompatibility, which make them a promising platform for drug delivery. The interactions between lyophilized platelets and fresh platelets have paradoxical effects on platelet adhesion and aggregation, which could have an impact for clinical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Immunology
Isaclaudia Gomes de Azevedo-Quintanilha, Mariana Macedo Campos, Ana Paula Teixeira Monteiro, Alessandra Dantas do Nascimento, Andrea Surrage Calheiros, Douglas Mathias Oliveira, Suelen Silva Gomes Dias, Vinicius Cardoso Soares, Julia da Cunha Santos, Isabel Tavares, Thiago Moreno Lopes Souza, Eugenio D. Hottz, Fernando A. Bozza, Patricia T. Bozza
Summary: Chikungunya fever, transmitted by mosquitoes, is a viral disease characterized by symptoms such as fever and joint pain. This study found that the infection leads to platelet activation, suggesting their involvement in immune processes and inflammatory amplification.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Layla Van Doren, Nga Nguyen, Christopher Garzia, Elizabeth K. Fletcher, Ryan Stevenson, David Jaramillo, Athan Kuliopulos, Lidija Covic
Summary: 12-LOX-derived 12(S)-HETE stimulates GPR31-Gi signaling pathways to enhance platelet activation and arterial thrombosis. Inhibition of this pathway with GPR310 provides protective effects against platelet aggregation and thrombosis without affecting hemostasis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Immunology
Patrice Cunningham, Christian A. Unger, Emma A. Patton, Akyla Aiken, Alea Browne, Ella James, Ahmed K. Aladhami, Marion C. Hope, Brandon N. Vanderveen, Thomas D. Cardaci, E. Angela Murphy, Reilly T. Enos, Kandy T. Velazquez
Summary: This study investigated the immunopathogenesis of cancer cachexia using the Apc(Min/+) mouse model. The study revealed an elevated platelet count prior to the development of cachexia in the mice, as well as increased expression of certain markers in the skeletal muscle. Behavioral and metabolic phenotype analysis showed decreased physical activity in the pre-cachectic mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Pema Raj, Karen Sayfee, Liping Yu, Ali Sabra, Champa Wijekoon, Lovemore Malunga, Sijo Joseph Thandapilly, Thomas Netticadan
Summary: Oats are considered a functional food that can prevent or manage chronic diseases like hypertension. In this study, the cardiovascular benefits of an oat beta-glucan extract were examined in male and female spontaneously hypertensive rats (SHRs) in combination with an anti-hypertensive medication called hydrochlorothiazide. The results showed that the beta-glucan extract, either alone or in combination with hydrochlorothiazide, could effectively prevent high blood pressure, cardiac dysfunction, and oxidative stress in the SHRs.
Article
Nutrition & Dietetics
Xuan Wang, Yuting Ji, Dekui Jin, Jingyi Qi, Xuening Hou, Wenting Zhao, Shuaishuai Zhou, Chengying Zhang, Yongting Luo, Peng An, Junjie Luo
Summary: In this study, it was found that beta-glucan can prevent Doxorubicin-induced cardiotoxicity. Doxorubicin reduces the ATP production capacity of the heart and increases oxidative stress, while beta-glucan can restore heart function and reduce oxidative stress.
Article
Biochemistry & Molecular Biology
Karolina Siewiera, Magdalena Labieniec-Watala, Hassan Kassassir, Nina Wolska, Dawid Polak, Cezary Watala
Summary: The study found that prolonged exposure of blood platelets to high concentrations of glucose in diabetes can lead to increased mitochondrial respiration, but this is not the main reason for abnormal platelet functioning. Additionally, metformin was not able to inhibit platelet activation under in vitro conditions, indicating that its beneficial effect on the coagulation system in vivo may be related to other mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Manuella Caux, Rana Mansour, Jean-Marie Xuereb, Gaetan Chicanne, Julien Viaud, Alicia Vauclard, Frederic Boal, Bernard Payrastre, Helene Tronchere, Sonia Severin
Summary: This study demonstrates that PIKfyve and its lipid products PtdIns5P and PtdIns(3,5)P-2 play crucial roles in regulating granule integrity in both megakaryocytes and platelets. Inhibition of PIKfyve leads to impaired granule integrity, affecting platelet aggregation and thrombus formation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jianfeng Shi, Renyang Tong, Meng Zhou, Yu Gao, Yichao Zhao, Yifan Chen, Wenhua Liu, Gaoxiang Li, Dong Lu, Guofeng Meng, Liuhua Hu, Ancai Yuan, Xiyuan Lu, Jun Pu
Summary: The study revealed that the circadian protein Rev-erb alpha is functionally expressed in platelets and enhances platelet activation and thrombus formation. This suggests that Rev-erb alpha could be a promising therapeutic target for managing thrombosis-related cardiovascular diseases.
EUROPEAN HEART JOURNAL
(2022)
Article
Multidisciplinary Sciences
Lacey Johnson, Pearl Lei, Lauren Waters, Matthew P. Padula, Denese C. Marks
Summary: The aim of this study was to define the phenotype of in vitro generated platelet subpopulations and identify the subpopulations present in cryopreserved components. The study found that cryopreserved platelets contained procoagulant platelets and a novel population that did not align with the phenotype of aggregatory or apoptotic subpopulations.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Angela Dziedzic, Joanna Saluk-Bijak, Elzbieta Miller, Marcin Niemcewicz, Michal Bijak
Summary: The study found that infection with the novel coronavirus may have serious consequences for patients with multiple sclerosis, potentially leading to neurodegenerative diseases such as demyelination. Infection with the novel coronavirus can trigger cytokine storm syndrome, increasing the risk of developing acute cerebrovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Natalia Cichon, Angela Dziedzic, Leslaw Gorniak, Elzbieta Miller, Michal Bijak, Michal Starosta, Joanna Saluk-Bijak
Summary: Age-related cognitive decline can be improved through proper diet, comprehensive nutrition, and a healthy lifestyle. The effectiveness in preventing dementia is particularly important before symptoms appear, and the impact of diet and nutrition on cognitive function can be continuously observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sylwia Pietrasik, Angela Dziedzic, Elzbieta Miller, Michal Starosta, Joanna Saluk-Bijak
Summary: Multiple sclerosis is a neurodegenerative disease with a variable course, often characterized by alternating periods of exacerbation and stabilization. Distinguishing between subtypes early can lead to faster implementation of appropriate treatment. Research suggests circulating microRNAs may be valuable for MS diagnosis and predicting disease subtype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sylwia Pietrasik, Natalia Cichon, Michal Bijak, Leslaw Gorniak, Joanna Saluk-Bijak
Summary: Neuroplasticity plays a crucial role in the treatment of central nervous system (CNS) disorders, and marine carotenoids, abundant in the aquatic environment, have antioxidant and neuroprotective effects that can promote neuronal recovery and enhancement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Rafal Szelenberger, Michal Seweryn Karbownik, Michal Kacprzak, Karina Maciak, Michal Bijak, Marzenna Zielinska, Piotr Czarny, Tomasz Sliwinski, Joanna Saluk-Bijak
Summary: Transcriptome analysis is an important method to understand the genetic basis of disease pathogenesis, with microRNAs playing a key role in post-transcriptional gene expression regulation. In this study, platelet microRNA profiles were used to identify potential biomarkers for acute coronary syndrome (ACS), with eight overexpressed microRNAs associated with platelet function. A combined model using miR-142-3p and aspartate transaminase showed high sensitivity and specificity in differentiating study groups. Cluster analysis revealed two groups of microRNAs regulated by different biological factors, potentially linked to platelet physiological processes and interactions with the vascular environment. This research contributes to a better understanding of the role of platelet microRNAs in ACS pathophysiology and risk modeling.
Review
Cell Biology
Paulina Wigner, Michal Bijak, Joanna Saluk-Bijak
Summary: Nephrolithiasis ranks third in prevalence among urological diseases, with the increasing incidence likely attributed to unhealthy dietary and lifestyle changes in developed countries. Oxalate urolithiasis, making up about 80% of cases, poses the highest risk of recurrence. Frequent relapses lead to severe complications and high treatment costs.
Article
Biochemistry & Molecular Biology
Angela Dziedzic, Rafal Szelenberger, Michal Kacprzak, Piotr Czarny, Ewelina Synowiec, Joanna Saluk-Bijak, Tomasz Sliwinski, Marzenna Zielinska, Michal Bijak
Summary: The pathophysiology of atherosclerosis and acute coronary syndrome (ACS) is related to interactions between immune cells, endothelium, and blood platelets. Excessive immune activation and ACS incidence are linked, and augmented expression of pro-inflammatory genes from peripheral blood cells may be a crucial genetic factor in ACS pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Paulina Wigner, Michal Bijak, Joanna Saluk-Bijak
Summary: Bladder cancer is the most common tumor of the urinary system, and despite anticancer therapies, it has a high recurrence risk. In addition to smoking, occupational exposure, and genetic factors, diet quality may also influence the development of bladder cancer. Adequate consumption of fruits such as pomegranates and cranberries can reduce the risk of bladder cancer.
Review
Medicine, General & Internal
Lidia Wlodarczyk, Natalia Cichon, Joanna Saluk-Bijak, Michal Bijak, Agata Majos, Elzbieta Miller
Summary: Stroke, as a leading cause of disability, poses challenges to the healthcare system and society. Recent studies focus on stroke recovery, particularly angiogenesis and neuroplasticity. Neuroimaging techniques offer indirect descriptions and quantifiable indicators of these processes and therapeutic responses, enabling personalized treatment interventions and novel rehabilitation strategies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Michal Starosta, Natalia Cichon, Joanna Saluk-Bijak, Elzbieta Miller
Summary: This review examines the current evidence of the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in post-stroke rehabilitation and discusses the effects of different stimulation types on motor function, cognitive function, depression, and aphasia. The findings suggest that rTMS is safe and can modulate cortical excitability to improve overall performance. However, the methodological problem of conducting double-blinding studies in stroke rehabilitation research is highlighted.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Rafal Szelenberger, Michal Seweryn Karbownik, Michal Kacprzak, Ewelina Synowiec, Sylwia Michlewska, Michal Bijak, Marzenna Zielinska, Alina Olender, Joanna Saluk-Bijak
Summary: This study aims to detect potential changes at the molecular level in platelet surface receptors that could be of potential importance in the occurrence of Acute Coronary Syndrome. The results show that the P2Y12 receptor is expressed more frequently among patients, and there are quantitative changes in other platelet receptors important in platelet activation at the genetic level.
Article
Biochemistry & Molecular Biology
Rafal Szelenberger, Pawel Jozwiak, Michal Kacprzak, Michal Bijak, Marzenna Zielinska, Alina Olender, Joanna Saluk-Bijak
Summary: Proteomic analysis based on mass spectrometry is a powerful tool for identifying proteins and their characteristics. Dysregulation in platelet protein expression in patients with acute coronary syndrome (ACS) may be associated with an increased risk of thrombotic events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Angela Dziedzic, Joanna Saluk
Summary: The gut-brain axis plays a vital role in connecting the intestine microflora with the nervous, immune, and endocrine systems. Studies have shown that alterations in the gut-brain axis may contribute to the pathogenesis of multiple sclerosis (MS), and probiotic supplementation could potentially benefit the disease course.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Radoslaw Grebowski, Joanna Saluk, Michal Bijak, Janusz Szemraj, Paulina Wigner
Summary: Bladder cancer is the 10th most common form of cancer globally, and chronic inflammation may play a role in its development and progression. This study aimed to investigate the association between selected single nucleotide polymorphisms (SNPs) in IL-6 and IL-8 genes and bladder cancer development, as well as the impact of bladder cancer on the expression and methylation of IL-6 and IL-8 promoters in PBMCs. The study found no association between the studied SNPs and bladder cancer occurrence. However, bladder cancer patients had decreased IL-6 and IL-8 mRNA expression levels and higher methylation status of the IL-6 promoter compared to controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Klaudia Marek, Natalia Cichon, Joanna Saluk-Bijak, Michal Bijak, Elzbieta Miller
Summary: Hypovitaminosis D is a serious public health problem, and maintaining normal serum vitamin D levels can improve cardiovascular health and reduce stroke risk. Vitamin D also influences brain development, immune modulation, and brain neuroplasticity. Further research is needed to explore the effects of vitamin D supplementation on stroke survivors' rehabilitation outcomes and prevention.