Review
Surgery
Stephanie Nemir, Summer E. Hanson, Carrie K. Chu
Summary: Autologous fat grafting is widely used in plastic surgery for various applications, and despite issues with incomplete and unpredictable graft survival, using evidence to guide surgical decisions can maximize success.
AESTHETIC SURGERY JOURNAL
(2021)
Review
Medicine, General & Internal
Filippo Migliorini, Francesco Cuozzo, Ernesto Torsiello, Filippo Spiezia, Francesco Oliva, Nicola Maffulli
Summary: The study compared the morbidity and pain, blood loss, and complications between RIA and ICBG for obtaining bone grafts, finding that RIA may result in more blood loss but with less morbidity and complications, making it a potential alternative source for bone grafting.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Shenzhen Gao, Baixue Lu, Rong Zhou, Weicheng Gao
Summary: Autologous fat grafting is a common surgical procedure in plastic and cosmetic surgery, but complications such as fat necrosis, calcification, and fat embolism are challenging areas of current research. Fat necrosis, a common complication after fat grafting, directly affects both surgical outcomes and survival rates. In recent years, researchers from various countries have made significant progress in understanding the mechanisms of fat necrosis through clinical and basic studies. We summarize recent research advancements on fat necrosis to provide a theoretical basis for reducing its occurrence.
Review
Surgery
B. J. Langridge, S. Jasionowska, H. Khan, L. Awad, B. R. H. Turner, J. Varghese, P. E. M. Butler
Summary: This systematic review examines the processing methods of autologous fat grafting and evaluates the long-term patient outcomes. The results suggest that processing the fat through washing and filtration, especially when combined with commercial devices, leads to better long-term outcomes compared to centrifugation and decantation methods. In facial fat grafting, ASC enrichment methods and commercial devices seem to have superior long-term volume retention.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Review
Surgery
Nicholas A. Vernice, Wooram F. Jung, Grant G. Black, Michele Demetres, David M. Otterburn
Summary: Although the optimal technique for fat grafting in breast reconstruction remains elusive, this systematic review suggests that active closed wash and filtration (ACWF) systems offer higher fat volumes in less time, with decreased rates of suboptimal outcomes and revisions. Further large-scale, randomized trials are needed to confirm these findings.
AESTHETIC SURGERY JOURNAL
(2023)
Review
Oncology
Rodrigo Goncalves, Bruna Salani Mota, Bruno Sobreira-Lima, Marcos Desiderio Ricci, Jose Maria Soares Jr, Alexandre Mendonca Munhoz, Edmund Chada Baracat, Jose Roberto Filassi
Summary: This study provides a systematic review and meta-analysis on the oncological safety of autologous fat grafting (AFG) for breast reconstruction. The results indicate that AFG is a safe technique that does not affect overall survival, disease-free survival, or local recurrence for patients who have undergone breast cancer surgery.
Article
Polymer Science
Kristin Oskarsdotter, Catherine T. Nordgard, Peter Apelgren, Karin Saljo, Anita A. Solbu, Edwin Eliasson, Sanna Samfors, Henriette E. M. Saetrang, Lise Cathrine Asdahl, Eric M. Thompson, Christofer Troedsson, Stina Simonsson, Berit L. Strand, Paul Gatenholm, Lars Kolby
Summary: This study aimed to compare the effects of different crosslinking methods on autologous fat grafting. It was found that ex situ crosslinking using 3D bioprinting was more effective in maintaining the shape stability of the grafts, while in situ crosslinking, although improving fat cell distribution and survival, had poorer shape retention.
Review
Surgery
Allison J. Seitz, Malke Asaad, Summer E. Hanson, Charles E. Butler, Rene D. Largo
Summary: Autologous fat grafting is commonly used in aesthetic and reconstructive procedures, but its safety in oncologic patients is a growing concern. Adipose-derived stem cells in the adipose tissue may promote tumor cell proliferation, but clinical studies have yielded conflicting results, necessitating further research for clarification.
AESTHETIC SURGERY JOURNAL
(2021)
Article
Surgery
Nicolas S. Dhooghe, Sebastiaan Maes, Bernard Depypere, Karel E. Y. Claes, Renaat Coopman, Bela Kubat, Michel H. Piette, Stan Monstrey
Summary: This study raises awareness of the potentially lethal complication of cerebral microfat embolism after facial fat grafting. It provides evidence of permanent monocular blindness and neurologic symptoms as the main complications. The study also highlights the importance of preventive measures due to the lack of effective treatment options.
AESTHETIC SURGERY JOURNAL
(2022)
Review
Biotechnology & Applied Microbiology
Gretel S. Major, Jeremy W. Simcock, Tim B. F. Wood, Khoon S. Lim
Summary: Autologous fat grafting shows promise in repairing soft tissue deformities, but engineered solutions are needed to improve adipose tissue survival due to high resorption rates. Advances in material development and biofabrication have laid the foundation for functional adipose tissue constructs, but a balance is required between clinically feasible delivery and enhanced graft structural integrity. A new approach that combines clinical and research objectives can assist in developing mature adipose tissue constructs with controlled spatial arrangement and increased potential for neovascularization.
TRENDS IN BIOTECHNOLOGY
(2022)
Review
Oncology
Ricardo Tukiama, Rene A. C. Vieira, Ed C. R. Moura, Ana G. C. Oliveira, Gil Facina, Gustavo Zucca-Matthes, Joao N. Neto, Caio M. B. de Oliveira, Plinio da Cunha Leal
Summary: This systematic review and meta-analysis investigated whether fat grafting increases the risk of locoregional recurrence in patients formerly treated for breast cancer. The analysis found no statistically significant difference in disease recurrence between the lipofilling group and the control group among 4247 subjects.
Review
Surgery
Teri N. Moak, Trina G. Ebersole, Damini Tandon, Marissa Tenenbaum
Summary: Autologous fat grafting, after undergoing multiple modifications, has become the standard of care for reconstruction and cosmetic enhancement of the breast and face. Increasing evidence suggests positive outcomes for patient and surgeon satisfaction, as well as overall aesthetic appearance.
AESTHETIC SURGERY JOURNAL
(2021)
Review
Surgery
Yujie Chen, Guangxue Li
Summary: This study evaluated the safety and effectiveness of autologous fat grafting for breast reconstruction after radiotherapy. Results showed that autologous fat grafting does not increase complications or tumor recurrence risk, with high patient satisfaction rates. Autologous fat grafting effectively corrects breast deformities caused by breast-conserving therapy and radiotherapy without increasing tumor recurrence.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Surgery
Surinder Kaur, J. Peter Rubin, Jeffrey Gusenoff, Catherine A. Sommers, Meghana G. Shamsunder, Keith M. Hume, Babak J. Mehrara
Summary: The GRAFT registry, launched in 2015, aims to collect prospective data on autologous fat transfer procedures in order to determine complication rates and establish safe practices. The data collected from 7052 procedures show low complication rates overall, but with higher rates observed for fat grafting to the breast and buttocks compared to other areas. Oil cysts and infections were the most common complications for breast fat grafting, while seroma and palpable mass were most common for buttock fat grafting.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Surgery
Maurice Y. Nahabedian
Summary: Autologous fat grafting is widely accepted and routinely performed in breast augmentation and reconstruction, with small-volume grafting being more predictable than large-volume grafting. This article aims to review outcomes of large-volume and megavolume fat grafting in breast augmentation and reconstruction.
AESTHETIC SURGERY JOURNAL
(2021)