Article
Multidisciplinary Sciences
Yu-Hee Kim, Hyun-Ji Lee, Kyung-Ah Cho, So-Youn Woo, Kyung-Ha Ryu
Summary: This study found that conditioned medium obtained from human tonsil-derived MSCs (T-MSC CM) can inhibit adipocyte differentiation by regulating glucocorticoid signal transduction, thereby reducing obesity. The experiments showed that T-MSC CM can attenuate early-stage adipocyte differentiation and protect mice from the negative effects induced by glucocorticoid treatment. Additionally, T-MSC CM enhances megakaryocyte differentiation and protects blood platelet counts.
Article
Engineering, Biomedical
Zhifa Wang, Leng Han, Tianyu Sun, Weijian Wang, Xiao Li, Buling Wu
Summary: Cell sheet techniques are widely used in bone engineering, and this study successfully induced bidiretionally differentiated ADSCs to form ADSC sheet-EPC complexes for bone regeneration. The complexes demonstrated dense and well-vascularized new bone tissue, showing promising results for repairing bone defects.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Cell Biology
Yuan Liu, Christina Holmes
Summary: This review explores the tissue regeneration potential of EVs isolated from bone marrow and adipose tissue, the two most common clinical sources of adult MSCs, focusing on their angiogenic, osteogenic, and immunomodulatory potentials. Other important issues in the development of MSC-derived EV based therapies are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Ejaz R. Dar, Mudasir B. Gugjoo, Moien Javaid, Shahid Hussain, Mujeeb R. Fazili, Kuldeep Dhama, Taha Alqahtani, Ali M. Alqahtani, Riaz A. Shah, Talha Bin Emran
Summary: The study evaluates the influence of ambient temperature, donor physiological status, and tissue source on sheep mesenchymal stem cells. Results show that adipose tissue-derived MSCs from full term pregnant female sheep exhibit higher potential for proliferation and differentiation compared to male sheep-derived MSCs. Cryopreserved MSCs have similar characteristics to fresh cells. Therefore, it is important to consider tissue type and donor physiological status when applying MSCs in clinical settings.
Article
Critical Care Medicine
Jennifer A. Munley, Lauren S. Kelly, Gwendolyn S. Gillies, Kolenkode B. Kannan, Erick E. Pons, Letitia E. Bible, Philip A. Efron, Alicia M. Mohr
Summary: Severe trauma disrupts bone marrow function, resulting in persistent anemia and immunosuppression. Exosomes, which are extracellular vesicles, have been implicated in various diseases and cellular functions. This study investigates the effects of trauma plasma-derived exosomes on bone marrow hematopoiesis and explores the potential mechanisms underlying the altered bone marrow function after severe trauma.
Article
Genetics & Heredity
Weite Li, Shulei Wen, Jiahan Wu, Bin Zeng, Ting Chen, Junyi Luo, Gang Shu, Song-bo Wang, Yongliang Zhang, Qianyun Xi
Summary: The study revealed that skeletal muscle-derived exosomes can inhibit adipogenesis of porcine preadipocytes, with certain microRNAs enriched in lipid-related metabolism processes. These findings provide a fundamental resource for understanding the detailed functions of exosomes in the skeletal muscle-adipose crosstalk and the potential relationship between skeletal muscle atrophy and obesity.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Ivan J. Vechetti, Bailey D. Peck, Yuan Wen, R. Grace Walton, Taylor R. Valentino, Alexander P. Alimov, Cory M. Dungan, Douglas W. Van Pelt, Ferdinand von Walden, Bjorn Alkner, Charlotte A. Peterson, John J. McCarthy
Summary: Regular physical activity may improve health by releasing factors from skeletal muscle through extracellular vesicles (EVs) containing miR-1, promoting adipose tissue metabolic adaptations. EVs are preferentially taken up by eWAT, enhancing adrenergic signaling and lipolysis, ultimately benefiting overall health.
Article
Surgery
Helen Xun, Pooja Yesantharao, Leila Musavi, Amy Quan, Sinan Xiang, Jose C. Alonso-Escalante, Howard Wang, Markus Tammia, Aysel Cetinkaya-Fisgin, W. P. Andrew Lee, Gerald Brandacher, Anand Kumar, Joseph Lopez
Summary: This study demonstrated the efficacy of Schwann cell-like cells differentiated from muscle-derived stem cells in improving nerve regeneration and muscle function after nerve trauma. Both induced MDSCs and MDSCs reduced denervation muscle atrophy and improved functional outcomes after upper extremity nerve trauma in rodents.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Maria Yoshida, Ayumu Nakashima, Naoki Ishiuchi, Kisho Miyasako, Keisuke Morimoto, Yoshiki Tanaka, Kensuke Sasaki, Satoshi Maeda, Takao Masaki
Summary: Both adipose-derived and bone marrow-derived mesenchymal stem cells (ADSCs and BMSCs) can suppress renal fibrosis, with ADSCs showing a stronger effect under serum-containing culture conditions. However, ADSC infusion in mice may lead to a higher death rate from pulmonary embolism. Therefore, the selection of ADSCs or BMSCs for clinical applications should consider the target disease and culture method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Wen Zhang, Jian Zhang, Hua Huang
Summary: Exosomes derived from adipose tissue and bone marrow mesenchymal stem cells (MSCs) can reduce oxidative stress and inflammation, improve kidney function and structure, and protect against lipopolysaccharide-induced acute kidney injury (AKI).
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell & Tissue Engineering
Noriyuki Ogawa, Tetsuya Imamura, Tomonori Minagawa, Teruyuki Ogawa, Osamu Ishizuka
Summary: By using tissue engineering and regenerative techniques, a bilayered adipose-derived mesenchymal cell (AMC)-gelatin sheet was successfully fabricated and transplanted into rabbits to replace surgically excised ureteral segments, showing promising potential for ureteral repair.
TISSUE ENGINEERING PART A
(2022)
Article
Cell Biology
Muhammad Ashraf, Srinivas M. Tipparaju, Joung Woul Kim, Wanling Xuan
Summary: The failure of muscle repair in aging may lead to muscle mass loss. Muscle progenitor cells (MPCs) were generated from human iPSC cell lines using small molecules. It was found that ITGA4, heavily expressed in Givi-MPCs, plays a role in directing MPC migration to the injury site.
Article
Immunology
Tirumalai Rangasamy, Laxman Ghimire, Liliang Jin, John Le, Sivakumar Periasamy, Sagar Paudel, Shanshan Cai, Samithamby Jeyaseelan
Summary: The study demonstrates the potential immunomodulatory, antibacterial, and therapeutic effects of Sca-1(+) LMSCs in treating pneumonia caused by K. pneumoniae. These cells inhibit bacterial growth, enhance bacterial clearance, and improve survival in infected mice.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Aoxuan Zhu, Na Liu, Yujia Shang, Yonghuan Zhen, Yang An
Summary: This review provides insights into the potential mechanism of adipose stem cell-derived exosomes (ASC-exos) in muscle regeneration. The authors discuss various signaling pathways, such as Wnt, MAPK, PI3K/Akt, and JAK/STAT, and how ASC-exos contribute to different stages of skeletal muscle regeneration through these pathways.
CHINESE MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Rishi Man Chugh, Payel Bhanja, Ximena Diaz Olea, Fang Tao, Kealan Schroeder, Ryan Zitter, Tanu Arora, Harsh Pathak, Bruce F. Kimler, Andrew K. Godwin, John M. Perry, Subhrajit Saha
Summary: The study showed that myeloid committed progenitor cells derived from human peripheral blood mononuclear cells can mitigate radiation-induced bone marrow toxicity and improve survival in mice, offering a natural polypharmacy solution against complex injury processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)