Article
Biochemistry & Molecular Biology
Alex Vargas, Gustavo Garcia, Kathryn Rivara, Kathryn Woodburn, Louis Edward Clemens, Scott I. I. Simon
Summary: Diabetes mellitus is a chronic disease that leads to diabetic foot ulcers due to compromised innate immune system. The excessive blood glucose in diabetes increases inflammatory mediators, promoting cellular senescence and reducing antimicrobial activity in dermal tissue. The designed host defense peptide RP557, derived from naturally occurring antimicrobial peptides, can disrupt biofilms and promote wound healing. In this study, RP557 application effectively stopped bacterial growth in MRSA infected wounds of diabetic mice and accelerated wound closure. These findings demonstrate the effectiveness of RP557 in eliminating biofilm infections and restoring wound healing capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Emergency Medicine
Shizhao Ji, Xiaobin Liu, Jie Huang, Junmin Bao, Zhaohong Chen, Chunmao Han, Daifeng Hao, Jingsong Hong, Dahai Hu, Yufeng Jiang, Shang Ju, Hongye Li, Zongyu Li, Guangping Liang, Yan Liu, Gaoxing Luo, Guozhong Lv, Xingwu Ran, Zhongmin Shi, Juyu Tang, Aiping Wang, Guangyi Wang, Jiangning Wang, Xin Wang, Bing Wen, Jun Wu, Hailin Xu, Maojin Xu, Xiaofei Ye, Liangxi Yuan, Yi Zhang, Shichu Xiao, Zhaofan Xia
Summary: As China becomes an aging society, the incidence of diabetes and diabetic foot is increasing, making it a major health concern. Negative pressure wound therapy (NPWT) has shown great progress in the treatment of diabetic foot wounds, but irregular application can lead to complications. The consensus aims to provide clinicians with standardized treatment schemes for diabetic foot cases based on evidence-based practice.
Review
Biochemistry & Molecular Biology
Maria Figueres-Onate, Rebeca Sanchez-Gonzalez, Laura Lopez-Mascaraque
Summary: Understanding the strategies used to study cell lineages in the brain and their role in deciphering functional clonal relationships among neural cells; future perspectives will focus on studying cell heterogeneity and the origins of different cell lineages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Engineering, Biomedical
Chunping Wen, Yan Zhang, Luogen Lai, Xuan Zhang, Yijun Liu, Qiuyan Guo, Rujue Peng, Yating Gao, Xufei Zhang, Yan He, Shan Xu, Dan Qiao, Pengwu Zheng, Qingshan Pan, Wufu Zhu
Summary: This study presents a new multifunctional nanosheet with dual enzyme loading, photothermal enhancement effect, and targeting ability for the treatment of infected diabetic wounds. The nanosheet demonstrates improved antibacterial performance and wound repair capability both in vitro and in vivo.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cell & Tissue Engineering
Yu Xin, Peng Xu, Xiangsheng Wang, Yunsheng Chen, Zheng Zhang, Yixin Zhang
Summary: Combining hFDSPC-CM with HA showed superior wound healing effects for diabetic wounds, promoting proliferation and migration of epidermal cells and fibroblasts, leading to ECM deposition and remodeling, and reducing inflammation.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Zhoufeng Wang, Zhe Li, Kun Zhou, Chengdi Wang, Lili Jiang, Li Zhang, Ying Yang, Wenxin Luo, Wenliang Qiao, Gang Wang, Yinyun Ni, Shuiping Dai, Tingting Guo, Guiyi Ji, Minjie Xu, Yiying Liu, Zhixi Su, Guowei Che, Weimin Li
Summary: This study analyzed the composition and progression of LUAD in patient samples using single-cell RNA-seq and multiplex imaging, revealing a potential transcriptional divergence from alveolar type 2 cells. The research identified a group of cells resembling AT2 cells in LUAD progression and detected upregulated genes related to energy metabolism and ribosome synthesis in early stages of LUAD. Potential biomarkers including MDK and TIMP1 were identified for understanding LUAD pathogenesis, shedding light on the transcriptional signatures of distinct histologic stages of LUAD progression that may facilitate early diagnosis.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Xiong Luo, Lei Zhang, Yiping Luo, Zhuyun Cai, Hua Zeng, Tianlong Wang, Zhiqing Liu, Yixing Chen, Xuexin Sheng, Aquino Ernesto da Graca Mandlate, Zifei Zhou, Feng Chen, Longpo Zheng
Summary: The treatment of diabetic wounds is a major challenge in clinical practice. A new charge-driven self-assembled microsphere hydrogel scaffold (SMHS) has been developed, which combines black phosphorus (BP)-contained chitosan methacryloyl (CS) microspheres with positive charge and basic fibroblast growth factor-contained hyaluronic acid methacryloyl (HA) microspheres with negative charge. The SMHS has injectable characteristics due to weak charge attraction among microspheres. The SMHS with near-infrared (NIR) irradiation (SMHS+NIR) shows promising results in promoting cell proliferation, angiogenesis, and wound healing in diabetic rat skin wounds.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhiguo Li, Xiaotong Fan, Zheng Luo, Xian Jun Loh, Yedong Ma, Enyi Ye, Yun-Long Wu, Chaobin He, Zibiao Li
Summary: The authors developed a multifunctional nanoenzyme-chitosan hydrogel complex to improve the microenvironment of diabetic wounds and provide continuous oxygen delivery. By reducing glucose and reactive oxygen species concentrations and promoting cell proliferation, migration, and angiogenesis, the complex significantly accelerated diabetic wound healing.
Article
Engineering, Biomedical
Haijun Shen, Chun Zhang, Ye Meng, Yi Qiao, Yane Ma, Jialing Chen, Xiaona Wang, Lei Pan
Summary: By incorporating deferoxamine and copper sulfide nanoparticles into a biomimetic hydrogel, this study aims to simultaneously fulfill the essential requirements for effective diabetic wound healing, including promoting cell adhesion and migration, stimulating angiogenesis, and effectively eradicating drug-resistant bacteria.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Alexander Roth, Akshay Krishnakumar, Robyn R. R. McCain, Murali Kanaan Maruthamuthu, MacKenzie McIntosh, Yue Xiang Chen, Abigail D. D. Cox, Amber S. S. Jannasch, Juliane Nguyen, Mohamed N. N. Seleem, Rahim Rahimi
Summary: Recent studies have demonstrated that combining gaseous ozone and antibiotics through portable systems is a promising approach to eradicating antibiotic-resistant Gram-negative bacteria in wound infections. An optimized combination delivery of 4 mg/h of ozone and 200 μg/cm2 of topical antibiotics was found to effectively eliminate bacteria in just 6 hours, with minimal cytotoxicity to human fibroblast cells. Furthermore, in vivo studies on pig models showed no signs of adverse effects even after 5 days of continuous administration.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Engineering, Biomedical
Tao Xiang, Qianru Guo, Lianghao Jia, Tianyu Yin, Wei Huang, Xinyu Zhang, Shaobing Zhou
Summary: This review discusses the application of intelligent hydrogels with multifunctional capacities in the healing of diabetic wounds. These hydrogels can dynamically respond to the microenvironment and accelerate wound healing through various ways, including stimuli-responsiveness, injectable self-healing, shape-memory, conductive and real-time monitoring properties. Antibacterial, anti-inflammatory, immunomodulatory, antioxidant and pro-angiogenic strategies are combined with the hydrogels based on the microenvironment of diabetic wounds. This review aims to provide guidelines for fabricating hydrogels for diabetic wound healing and explore the role of intelligent hydrogels in the therapeutic processes.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Multidisciplinary Sciences
Xitiz Chamling, Alyssa Kallman, Weixiang Fang, Cynthia A. Berlinicke, Joseph L. Mertz, Prajwal Devkota, Itzy E. Morales Pantoja, Matthew D. Smith, Zhicheng Ji, Calvin Chang, Aniruddha Kaushik, Liben Chen, Katharine A. Whartenby, Peter A. Calabresi, Hai-Quan Mao, Hongkai Ji, Tza-Huei Wang, Donald J. Zack
Summary: The study reveals significant transcriptional heterogeneity of human oligodendrocyte progenitor cells (hOPCs) and identifies a potential cytokine-responsive hOPC subset, as well as candidate regulatory genes/networks that define the identity of these sub-populations.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Jinghuan Huang, Muyu Yu, Wenjing Yin, Bo Liang, Ang Li, Jingfeng Li, Xiaolin Li, Shichang Zhao, Fang Liu
Summary: This study combines exosome therapy and RNAi therapy through an engineering approach for the treatment of diabetic chronic wounds. The engineered miR-31 exosomes are shown to be an effective therapeutic agent for promoting diabetic wound healing by enhancing angiogenesis, fibrogenesis, and reepithelization.
BIOACTIVE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Wei Zhu, Ya-Qin Liu, Pei Liu, Jun Cao, Ai-Guo Shen, Paul K. Chu
Summary: A smart hydrogel dressing capable of consuming blood glucose and generating antibacterial agents is designed to promote wound healing. The hydrogel degrades glucose to produce hydrogen peroxide and gluconic acid, supporting a chemodynamic reaction that kills bacteria. Additionally, it can convert near infrared light into heat for photothermal therapy. This multifunctional hydrogel has great potential in the treatment of diabetic wounds.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Tian Zhang, Xin Cheng, Jingya Xiu, Min Liu, Siyi Liu, Bowen Zhang, Qi Miao, Dongyun Cun, Chunrong Yang, Kexin Li, Jiulong Zhang, Xiuli Zhao
Summary: A pH-responsive injectable hydrogel with curcumin and magnesium-based micromotors was developed for the treatment of diabetic chronic wounds. The hydrogel exhibited excellent antibacterial properties, antioxidative performance, and biocompatibility. In vivo experiments showed that the hydrogel promoted wound closure and tissue regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Critical Care Medicine
Matthew J. Gotlin, William Catalano, Jamie P. Levine, Kenneth A. Egol
Summary: The method of skin closure and post-operative wound management is crucial in orthopedic surgery, especially with the increasing importance of surgical site infection as a healthcare metric. Understanding the physiology of wound healing and factors affecting healing potential is essential to minimize complications. The goal of skin closure techniques is to promote rapid healing with minimal risk of infection and dehiscence. Knowledge of closure materials, techniques, dressings, and local therapies is important for optimizing wound healing.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Surgery
Daniel Boczar, Ricardo Rodriguez Colon, Lavinia Anzai, David A. Daar, Bachar F. Chaya, Jorge Trilles, Jamie P. Levine, Adam S. Jacobson
Summary: In microvascular free flap for head and neck reconstruction, there is no significant difference in postoperative complications and venous congestion between flaps with 1 and 2 venous anastomoses.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Article
Medicine, Research & Experimental
Jorge Trilles, Bachar F. Chaya, David A. Daar, Lavinia Anzai, Daniel Boczar, Ricardo Rodriguez Colon, David L. Hirsch, Adam S. Jacobson, Jamie P. Levine
Summary: This retrospective study compared the outcomes of single-barrel and double-barrel fibula flaps in mandibular reconstruction for head and neck defects. The results showed that double-barrel reconstruction did not increase postoperative morbidity or duration of hospital stay compared to single-barrel reconstruction. Additionally, double-barrel reconstruction was associated with higher odds of successful primary dental implantation.
Article
Surgery
David A. Daar, Lavinia M. Anzai, Neil M. Vranis, Michael L. Schulster, Jordan D. Frey, Min Jun, Lee C. Zhao, Jamie P. Levine
Summary: This study describes a minimally-invasive technique for robotic deep inferior epigastric artery perforator (DIEP) flap harvest and presents data from four patients who underwent a total of seven robotic-assisted DIEP flap operations. The results demonstrate the feasibility and safety of this technique.
Editorial Material
Urology & Nephrology
Brian W. Chao, Nabeel A. Shakir, Grace S. Hyun, Jamie P. Levine, Lee C. Zhao
Summary: Robotic-assisted testicular autotransplantation is a feasible and effective management option for solitary intra-abdominal testis. The procedure preserves testicular endocrine function and eliminates the need for intraoperative testicular biopsy.
Article
Dentistry, Oral Surgery & Medicine
David A. Daar, David J. Byun, Karl Spuhler, Lavinia Anzai, Lukasz Witek, David Barbee, Kenneth S. Hu, Jamie P. Levine, Adam S. Jacobson
Summary: Computerized surgical planning (CSP) is crucial in osseous reconstruction of head and neck cancer defects, but the impact of CSP-designed titanium plating systems on radiation therapy remains unclear, and there may be an underreported risk of osteoradionecrosis (ORN) and local recurrence.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Oncology
David J. Byun, David A. Daar, Karl Spuhler, Lavinia Anzai, Lukasz Witek, David Barbee, Adam S. Jacobson, Jamie P. Levine, Kenneth S. Hu
PRACTICAL RADIATION ONCOLOGY
(2022)
Article
Surgery
Carter J. Boyd, Kshipra Hemal, Sruthi Ramesh, Jonathan M. Bekisz, Ara A. Salibian, Vishal Thanik, Jamie P. Levine, Mihye Choi, Nolan S. Karp
Summary: This study aimed to quantify the impact of the COVID-19 pandemic on breast cancer screening, treatment, and reconstruction at a medical institution in New York City. The results showed a decline in mammography, oncologic breast surgeries, and breast reconstruction in 2020, but a rebound in 2021. Changes in the types of reconstruction were also noted.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Surgery
Elie P. Ramly, Allyson R. Alfonso, Zoe P. Berman, Gustave K. Diep, Jonathan L. Bass, Louis W. Catalano, Daniel J. Ceradini, Mihye Choi, Oriana D. Cohen, Roberto L. Flores, Alyssa R. Golas, Jacques H. Hacquebord, Jamie P. Levine, Pierre B. Saadeh, Sheel Sharma, David A. Staffenberg, Vishal D. Thanik, Allison Rojas, G. Leslie Bernstein, Bruce E. Gelb, Eduardo D. Rodriguez
Summary: This study presents the first successful combined full face and bilateral hand transplant, marking a new milestone in plastic and reconstructive surgery for patients with otherwise irremediable injuries. The patient was approaching functional independence at 8 months postoperatively, with significantly improved range of motion, motor power, and sensation of the face and hand allografts.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Clinical Neurology
Nora C. Kim, Eytan Raz, Maksim Shapiro, Howard A. Riina, Peter K. Nelson, Jamie P. Levine, Erez Nossek
Summary: This article describes a case of using a salvage direct bypass technique in a patient with recurrent symptomatic hemorrhagic moyamoya disease after failed indirect bypass. The strategy, approach, and technical nuances of this unique case have implications for revascularization options.
WORLD NEUROSURGERY
(2022)
Editorial Material
Clinical Neurology
Joseph Haynes, Mikel Sadek, Eytan Raz, Jamie Levine, Maksim Shapiro, Nader Delavari, Howard A. Riina, Peter Kim Nelson, Albert Favate, Erez Nossek
OPERATIVE NEUROSURGERY
(2022)
Article
Surgery
William J. Rifkin, David A. Daar, Courtney N. Cripps, Ginger Mars, Lee C. Zhao, Jamie P. Levine, Rachel Bluebond-Langner
Summary: This study presents a standardized postoperative protocol for gender-affirming phalloplasty and emphasizes the importance of postoperative care. The results show that following this protocol can reduce complications, accelerate recovery, shorten length of stay, and improve patient satisfaction.
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2022)
Article
Surgery
Hani Y. Nasr, Jamie P. Levine, Ernest S. Chiu
Summary: Liposuction is generally safe, but there are rare life-threatening complications. Clinicians should be vigilant of symptoms like shortness of breath, chest pain, and abdominal pain after liposuction.
ANNALS OF PLASTIC SURGERY
(2022)
Article
Surgery
Oriana Cohen, Kerry A. Morrison, Adam Jacobson, Jamie Levine, David A. Staffenberg
Summary: This study presents the technical considerations and details of mandibular reconstruction using virtual surgical planning and a vascularized free fibula flap in a 10-year-old boy with agnathia-otocephaly complex, a rare and often fatal condition. Virtual surgical planning was utilized to plan the reconstruction of the mandibular symphysis and bilateral body segments, along with the use of bilateral costochondral grafts for the rami. This is the first application of virtual surgical planning for mandibular reconstruction in a pediatric patient with severe agnathia-otocephaly complex.
JOURNAL OF CRANIOFACIAL SURGERY
(2023)
Letter
Surgery
Ian T. T. Nolan, Neil M. M. Vranis, Jamie P. P. Levine