Article
Polymer Science
Yi-Jung Lu, Han-Yun Hsieh, Wen-Chang Kuo, Pei-Kuen Wei, Horn-Jiunn Sheen, Hidetoshi Tahara, Te-Wei Chiu, Yu-Jui Fan
Summary: The study proposed a multiplex detection system by integrating LSPR sensing array and microfluidic channels, proving successful in detecting different targets in parallel channels.
Article
Chemistry, Multidisciplinary
Mengdi Lu, Wei Peng, Ming Lin, Fang Wang, Yang Zhang
Summary: A self-assembled templating technique using block copolymer layer was proposed for LSPR sensors, resulting in a high uniformity and density of gold nanoparticle monolayer. The performance in LSPR resonance wavelength and refractive index sensitivity significantly improved compared to conventional techniques, with a notable decrease in detection limit.
Article
Biophysics
Tomas Springer, Zdenek Krejcik, Jiri Homola
Summary: A novel and extremely sensitive label-free optical biosensor-based assay for the detection of miRNAs has been proposed, which enhances specific sensor response while suppressing non-specific binding interference. The assay has been successfully applied to detect miRNAs related to myelodysplastic syndromes in blood plasma, achieving a low detection limit and enabling multiplexed miRNA detection.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Yichao Xu, Meng Xiong, Hui Yan
Summary: A low-cost, portable, and reusable optical fiber-based LSPR biosensor for detecting ZEN was developed in this study, showing good sensitivity, selectivity, and potential for on-site ZEN monitoring.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Analytical
Maria Simone Soares, Miguel Vidal, Nuno F. Santos, Florinda M. Costa, Carlos Marques, Sonia O. Pereira, Catia Leitao
Summary: The evolution of optical fiber technology has revolutionized various fields, especially in the field of biosensing. Different optical fiber configurations and biofunctionalization strategies affect the manufacturing complexity, cost, and performance of optical fiber immunosensors. Current research trends mainly focus on the application of technologies such as EW, SPR, LSPR, as well as the research and optimization of optical fiber configurations.
Article
Spectroscopy
Hyeong-Min Kim, Jae-Hyoung Park, Seung-Ki Lee
Summary: FO LSPR sensors are limited by the small area of the substrate, and enhancing interactions between plasmonic nanostructures can improve sensor sensitivity. By using dimers, the interaction between light and nanostructures is effectively increased, resulting in improved performance of the FO LSPR sensors.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Chemistry, Analytical
Muyang Li, Ragini Singh, Yiran Wang, Carlos Marques, Bingyuan Zhang, Santosh Kumar
Summary: This article concisely summarizes the current advancements in novel nanomaterial-based optical fiber biosensors and highlights the wide application of optical and biological properties of nanomaterials in biosensing. By enhancing sensitivity, limit of detection, specificity, response time, and signal-to-noise ratio, nanomaterials improve the performance of fiber optic biosensors.
Article
Chemistry, Analytical
Thakshila Liyanage, Meimei Lai, Gymama Slaughter
Summary: We have developed a novel label-free ultrasensitive tapered optical fiber plasmonic biosensor that can successfully detect a panel of microRNAs with good selectivity. The biosensor showed high refractive index sensitivity and achieved a limit of detection between 103 aM and 261 aM for the microRNA panel. It also demonstrated successful detection of clinically relevant concentrations of microRNAs in human serum with a LOD between 1.097 fM and 1.220 fM. This approach could potentially broaden the applications of biosensors for detecting and quantifying large arrays of microRNAs.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Analytical
Davide Capelli, Viviana Scognamiglio, Roberta Montanari
Summary: In the modern era, the Surface Plasmon Resonance (SPR) technology has emerged as a successful method for rapid and accurate analyses. It provides real-time measurement of interactions with high sensitivity and without the need for labels. This technology has gained popularity in various fields, including life sciences, pharmaceutics, agrifood, and environmental monitoring of harmful substances. This article examines the recent advances in SPR technology, discusses the available instrumentation, their advantages and limitations, future trends, and analyzes case studies.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Xiaoyong Chen, Pin Xu, Wenwei Lin, Jin Jiang, Hang Qu, Xuehao Hu, Jinghua Sun, Yukun Cui
Summary: This study proposes a plasmonic titled fiber Bragg grating biosensor for the detection of breast cancer cells. Experimental results demonstrate that the biosensor has good detection performance, capable of detecting low concentrations of breast cancer cells in a short period of time. The sensor has a simple structure, easy manufacturing process, making it a promising choice for future cancer cell detection.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Chemistry, Analytical
Yu-Chun Lu, Bin-Hao Chen, Tung-Yuan Yung, Yu-Chih Tzeng, Chia-Yi Fang, Ren-Jei Chung, Po-Tuan Chen
Summary: The study presents a novel approach using nano-diamonds on a gold nano-slit array for surface plasmon resonance (SPR) biosensing. Covalently bound nano-diamonds shift the extraordinary transmission (EOT) spectrum and can be used to quantify the number of molecules attached. The use of 35 nm nano-diamonds enhances signal responses and allows for detection at lower analyte concentrations, making it suitable for biochip technology applications.
Article
Chemistry, Analytical
Jinghan Zhang, Xinming Mai, Xueming Hong, Yuzhi Chen, Xuejin Li
Summary: We propose a portable and user-friendly optical fiber sensing platform for rapid glucose detection based on surface plasmon resonance (SPR) sensing and enzymatic reaction. The platform allows for specific detection of different levels of urine glucose concentrations with high sensitivity. It offers a simple and fast operation, making it suitable for the detection of food additives and medical immunoassays.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Shimeng Chen, Yun Liu, Qingxu Yu, Wei Peng
Summary: A novel SPR biosensing approach with low LOD, high sensitivity, and extensive applicability was introduced in this study. By optimizing the SPR sensor structure and employing a self-referencing sensing strategy, the low LOD of 0.2 fM was achieved.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Physics, Applied
Weiqi He, Weina Zhang, Jiantian Zhang, Peng Yu, Pu Liu, Guowei Yang, Hongxiang Lei
Summary: Utilizing flexible dielectric material polylactic acid (PLA) doped with high refractive index quantum dots (QDs) as the substrate, a nanowire RI sensor capable of high sensitivity and the highest FOM under white light source is fabricated, showing great potential for biological applications.
APPLIED PHYSICS LETTERS
(2021)
Article
Chemistry, Analytical
Like Li, Ya-nan Zhang, Wanlu Zheng, Xuegang Li, Yong Zhao
Summary: This study proposes an optical fiber SPR biosensor based on a sandwich model with gold nanoparticles amplification for high sensitivity DNA hybridization detection. The experimental results show a log-linear response in the DNA concentration range of 1 pM-10 nM with high sensitivity and detection limit.
Article
Chemistry, Analytical
Alberto Rico-Yuste, Rahma Abouhany, Javier L. Urraca, Ana B. Descalzo, Guillermo Orellana, Maria C. Moreno-Bondi
Summary: In this study, porous molecularly imprinted polymer (MIP) microspheres doped with Eu(III) were prepared for selective and fast analysis of TeA in rice extracts. The sensor showed a linear response to TeA in a wide concentration range under optimized conditions, with low detection limit. The MIP-based optosensor exhibited high selectivity towards TeA without cross-recognition of other mycotoxins.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Editorial Material
Biochemical Research Methods
Maria C. Moreno-Bondi, Elena Benito-Pena
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Biochemical Research Methods
Riikka Peltomaa, Rodrigo Barderas, Elena Benito-Pena, Maria C. Moreno-Bondi
Summary: Recombinant antibodies are expected to have a high growth rate in the future due to their versatility and beneficial characteristics compared to monoclonal and polyclonal antibodies. Despite challenges, recombinant antibodies show potential for sensitive, selective, and rapid detection of food contaminants in food analysis.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Alvaro Luque-Uria, Riikka Peltomaa, Tarja K. Nevanen, Henri O. Arola, Kristiina Iljin, Elena Benito-Pena, Maria C. Moreno-Bondi
Summary: In this study, cyclic peptides that mimic the behavior of the immunosuppressant drug mycophenolic acid (MPA) were developed using a phage-displayed peptide library. A recombinant fusion protein containing the peptide sequence and a bioluminescent enzyme, NanoLuc, was created for use as a tracer in competitive immunoassays. The bioluminescent sensor showed good selectivity towards MPA, with a detection limit of 0.26 ng mL(-1) and an IC50 of 2.9 +/- 0.5 ng mL(-1), and was successfully applied to the analysis of clinical samples.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Fernando Pradanas-Gonzalez, Gerardo Alvarez-Rivera, Elena Benito-Pena, Fernando Navarro-Villoslada, Alejandro Cifuentes, Miguel Herrero, Maria Cruz Moreno-Bondi
Summary: Edible insects are becoming increasingly popular worldwide due to their high-quality protein content, but the lack of regulation poses safety concerns. A study developed an environmentally friendly analytical method to detect mycotoxins in insect-based food products, demonstrating high extraction efficiency and accuracy.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Polymer Science
Jose Quilez-Alburquerque, Ana B. Descalzo, Maria C. Moreno-Bondi, Guillermo Orellana
Summary: Tenuazonic acid, a common fungal mycotoxin in food, can cause allergic reactions. A novel trifunctional ruthenium(II)-bipyridyl complex has been engineered for rapid and selective detection of TeA. This nanocomposite shows fast response time and low detection limits for real-time monitoring.
Article
Chemistry, Analytical
Lidia N. Gomez-Arribas, Augusto Juste-Dolz, Riikka Peltomaa, David Gimenez-Romero, Sergi Morais, Rodrigo Barderas, Carmen Cuadrado, Angel Maquieira, Elena Benito-Pena, Maria C. Moreno-Bondi
Summary: Phage display technology has become a powerful tool for antibody discovery, selecting specific binders for a given antigen from combinatorial libraries. High-affinity VH antibody fragments identified as PHA binders (with apparent association constants ranging from 108 to 1010 M^-1) through QCM-D measurements and PCA, enable evaluation and identification of clone clusters with similar binding characteristics and molecular interaction mechanisms with capabilities beyond conventional techniques.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Physical
Carlos Angulo Barrios
Summary: This study investigated a surface plasmon resonance biosensor based on a graphene nanoribbon array in a microfluidic flow cell operating in a flow-over format. The optical response and performance of the biosensor were analyzed in terms of the limit of detection, which was found to be optimized by specific values of the fill fraction. Fabrication issues were also discussed, with implications for the design and implementation of SPR biosensors using nanopatterned 2D materials.
Article
Chemistry, Analytical
Carlos Angulo Barrios
Summary: This article demonstrates a low-cost, smartphone-based optical diffraction grating refractometer. It operates based on the dependence of the diffraction efficiency of a DVD grating on the surrounding refractive index, without the need for additional optical accessories.
Editorial Material
Chemistry, Analytical
Maria C. Moreno-Bondi, X. Chris Le, Jennifer A. Field, Susan D. Richardson, Xing-Fang Li, Miriam L. Diamond, Xiangdong Li, Paul D. Goring
ANALYTICAL CHEMISTRY
(2022)
Editorial Material
Engineering, Environmental
Maria C. Moreno-Bondi, X. Chris Le, Jennifer A. Field, Susan D. Richardson, Xing-Fang Li, Miriam L. Diamond, Xiangdong Li, Paul D. Goring
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Editorial Material
Chemistry, Multidisciplinary
Maria C. Moreno-Bondi, X. Chris Le, Jennifer A. Field, Susan D. Richardson, Xing-Fang Li, Miriam L. Diamond, Xiangdong Li, Paul D. Goring
Article
Chemistry, Analytical
Elena Benito-Pena, Maria C. Moreno-Bondi, Bettina Glahn-Martinez, Giacomo Lucchesi, Fernando Pradanas-Gonzalez, Ana Isabel Manzano, Angeles Canales, Gabriella Caminati
Summary: This study utilized FKBP1A as an alternative to antibodies for biosensing purposes, specifically for monitoring the immunosuppressant drug FK506. The method demonstrated good selectivity and accuracy in determining the drug in blood samples from organ transplant patients.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Carlos Angulo Barrios, Teona Mirea, Miguel Huerga Represa
Summary: We present a self-referenced refractive index optical sensor utilizing Au nanoislands. The device consists of randomly distributed Au nanoislands on a planar SiO2/metal Fabry-Perot cavity. Experimental and theoretical studies reveal that the spectral response of the sensor is due to a combination of localized surface plasmon resonance (LSPR) and the lowest-order anti-symmetric resonance of the Fabry-Perot cavity. This self-referenced sensor provides high sensitivity to refractive index variations of different fluids while maintaining a stable reference signal. The proposed sensor has a spectral sensitivity of 212 nm/RIU and an intensity sensitivity of 4.9 RIU-1, making it a promising candidate for compact biosensing optical platforms.
Review
Chemistry, Analytical
Riikka Peltomaa, Elena Benito-Pena, Hans H. Gorris, Maria C. Moreno-Bondi
Summary: The application of biosensing technology, using elements such as upconversion nanoparticles, has revolutionized food safety and quality monitoring by enabling rapid and accurate detection of harmful contaminants in food.
