Article
Optics
Soocheol Kim, Jin Hwa Ryu, Hoesung Yang, Kyuwon Han, Hyunseok Kim, Kwangsoo Cho, Soyoung Park, Sang Gi Hong, Kangbok Lee
Summary: This paper presents a spectrometer-based surface plasmon resonance imaging (SPRi) technique without mechanical scanning. A polarized broadband light source illuminates an object via a gold-coated prism, and the reflected light is spatially modulated by a digital mirror device (DMD) and measured with a spectrometer. Reflectance spectral images are reconstructed using the Hadamard transform (HT), and a refractive index (RI) map is visualized by analyzing the resonance peak shift at each image pixel. The method is demonstrated to have high resolution, sensitivity, and dynamic detection range, with experimental results validating the simulations.
Article
Chemistry, Analytical
Shimeng Chen, Yun Liu, Qingxu Yu, Wei Peng
Summary: A novel SPR biosensing approach with low LOD, high sensitivity, and extensive applicability was introduced in this study. By optimizing the SPR sensor structure and employing a self-referencing sensing strategy, the low LOD of 0.2 fM was achieved.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Analytical
Hasan Kurt, Parsa Pishva, Zeki Semih Pehlivan, Elif Gul Arsoy, Qandeel Saleem, Mustafa Kemal Bayaz, Meral Yuce
Summary: Nanoplasmonic biosensing holds great promise in meeting the demands of the global health industry, offering advantages such as low cost, high sensitivity, real-time detection, and miniaturization. By discussing nanostructure design, material selection, and nanofabrication methods, this review highlights the wide range of clinically relevant applications of nanoplasmonic biosensors, along with the challenges and proposed strategies for clinical translation.
ANALYTICA CHIMICA ACTA
(2021)
Article
Materials Science, Multidisciplinary
Chenglong Zhang, Yicheng Chen, Hongyi Tang, Zhi-mei Qi
Summary: This work presents the preparation and application of an ultrathin nanoporous gold film for biochemical sensing. Large-area UTNPG films with a thickness of less than 15 nm were successfully prepared on conventional Au-SPR chips. The UTNPG-m-SPR sensor showed higher sensitivity, lower detection limit, wider dynamic detection range, and faster response time compared to the Au-SPR sensor. This study demonstrates a new method for improving the performance of conventional SPR biochemical sensors using large-area UTNPG films.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Aline dos Santos Almeida, Dario A. Bahamon, Nuno M. R. Peres, Christiano J. S. de Matos
Summary: The use of graphene in surface plasmon resonance sensors has advantages such as protecting the film and increasing sensitivity. However, the role of single and few layers of graphene in sensitivity enhancement was critically examined, and it was found that only the isotropic layer model provides significant sensitivity increases.
Article
Biophysics
Tianping Xu, Zhaoxin Geng
Summary: Due to the lower sensitivity of LSPR biosensors compared to other sensors, researchers have explored various methods to improve performance, including structural, material, and interface modifications. These efforts are expected to expand the applications of LSPR biosensing technology.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Shimeng Chen, Shuwen Chu, Yongxin Song, Haojun Wu, Yun Liu, Wei Peng
Summary: Binding behaviors of proteins play a crucial role in biochemistry applications. This paper presents a label-free sensing approach based on a near-infrared surface plasmon resonance sensing chip modified with a graphene-gold surface architecture. The method demonstrates enhanced sensitivity and detection capability through the use of graphene and successfully detects human immunoglobulin G.
ANALYTICA CHIMICA ACTA
(2022)
Article
Optics
Zhen Tian, Yicun Yao, Jinhui Yuan, Liqiang Zhang, Nan-kuang Chen, Yanqing Zhang, Minghong Wang, Qiang Wu
Summary: A post-chemical etching process for a tapered seven-core fiber (TSCF) is proposed and demonstrated to effectively adjust the mode profiles and improve the figure of merit (FOM) of the fiber. The experimental results show a significant enhancement in FOM, reaching 1431.36 1/RIU, compared to the TSCF without etching.
Review
Chemistry, Multidisciplinary
Dong Liu, Can Xue
Summary: Plasmonic photocatalysis is a promising approach for solar energy transformation, which can enhance photocatalytic efficiency by optimizing the composition, spacing, and orientation of metal nanostructures. Integrating metal nanostructures with semiconductor photocatalysts can accelerate exciton generation and separation, thus improving photocatalytic efficiency.
ADVANCED MATERIALS
(2021)
Article
Optics
Can Li, Jinjuan Gao, Muhammad Shafi, Runcheng Liu, Zhipeng Zha, Dejun Feng, Mei Liu, Xuejian Du, Weiwei Yue, Shouzhen Jiang
Summary: The study developed an optical fiber surface plasmon resonance biosensor for measuring DNA hybridization kinetics, with high sensitivity and resolution, suitable for medical diagnostics and clinical applications.
PHOTONICS RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Qifa Wang, Liping Hou, Chenyang Li, Hailin Zhou, Xuetao Gan, Kaihui Liu, Fajun Xiao, Jianlin Zhao
Summary: In this study, a plasmonic nanocavity sensor is proposed, which enhances the interaction between the local field and the surrounding medium by coupling the nanocavity and the metal film, thereby improving sensitivity and figure of merit.
Article
Physics, Applied
Yundong Liu, Hailiang Chen
Summary: The study proposed a dual-polarized photonic crystal fiber sensor based on SPR for measuring the refractive indexes of liquids in the range of 1.36-1.42, achieving dual-polarized detection through external SPR effect, with maximum RI sensitivities of 15,900 nm RIU-1 and 16,900 nm RIU-1, respectively.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Materials Science, Multidisciplinary
Chongzhen Li, Zhiquan Li, Shiliang Guo, Xin Li, Qiufan Cheng, Shuhan Meng
Summary: This study investigates the application of BiFeO3 film in enhancing the sensitivity of SPR biosensors, achieving the highest sensitivity through structural adjustments. The results demonstrate that BiFeO3 film as a supporting material can effectively enhance the SPR effect, showing promising potential applications in the field of biosensors.
Article
Chemistry, Analytical
Meng-Qi He, Yongjian Ai, Wanting Hu, Xiaomeng Jia, Lei Wu, Mingyu Ding, Qionglin Liang
Summary: By using DNA as an etching agent, it is possible to control the morphology and optical properties of plasmonic nanoparticles, while also introducing fluorescence properties. This strategy allows for precise tuning of localized surface plasmon resonance (LSPR) and fluorescence-composited dual-mode signals.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Shun Li, Zhicheng Zhao, Maosong Liu, Xinbo Liu, Wei Huang, Shikuan Sun, Yinhua Jiang, Yong Liu, Jianming Zhang, Zuotai Zhang
Summary: In this study, a novel heterostructured piezo-photocatalyst was developed by decorating plasmonic Au nanoparticles on piezoelectric AgNbO3 nanocubes. The significantly enhanced photocatalytic performance of the optimized nanocomposites can be attributed to the synergetic coupling of localized surface plasmon resonance (SPR) effect and piezotronic effect, which facilitate the extraction of energetic hot electrons from AuNPs to the AgNbO3 driven by the mechanical vibration induced piezo-potential near the heterojunction.
Article
Optics
Harry Miyosi Silalahi, Yu-Hsuan Tsai, Kuang-Li Lee, Pei-Kuen Wei, Chia-Yi Huang
Summary: This study presents a simple design for shifting the resonance wavelength of silver nanoslits using an EWOD cell, demonstrating the ability to shift the resonance wavelength by moving a droplet with an electric field. The wavelength shift of 135 nm can be achieved by adjusting the electric field, making it suitable for high-performance electro-optical devices.
Article
Engineering, Electrical & Electronic
Yi-Hsin Tai, Shu-Cheng Lo, Ya-Lun Ho, Jean-Jacques Delaunay, Pei-Kuen Wei
Summary: This work introduces a sensitive handheld refractometer using a tapered fiber tip and multimode fiber, which is capable of measuring the refractive index of surrounding solutions to determine properties of various liquids. The sensor demonstrates high resolution under specific conditions and can handle hand-held vibrations and environmental disturbances.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Devi Wahyuningtyas, Wen-Hao Chen, Ruei-Yu He, Yung-An Huang, Chia-Kang Tsao, Yu-Jung He, Chu-Yi Yu, Po-Chao Lu, Yu-Cai Chen, Sheng-Hann Wang, Ka Chon Ng, Bryan Po-Wen Chen, Pei-Kuen Wei, Jiun-Jie Shie, Chun-Hong Kuo, Y. Henry Sun, Joseph Jen-Tse Huang
Summary: The researchers designed and synthesized a polyglutamine-specific gold nanoparticle complex that targeted mHtt and alleviated its toxicity. The complex was able to disassociate fibrillary aggregates from polyQ peptides and reduce beta-sheet content in a concentration-dependent manner. Additionally, the complex was shown to penetrate cells, bind to cytosolic mHtt proteins, dissociate mHtt inclusions, reduce mHtt oligomers, and ameliorate mHtt-induced toxicity, suggesting potential therapeutic strategies against Huntington's disease.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biophysics
Han-Yun Hsieh, Ray Chang, Yung-Yu Huang, Po-Han Juan, Hidetoshi Tahara, Kuan-Yi Lee, Di Ngoc Kha Vo, Ming-Han Tsai, Pei-Kuen Wei, Horn-Jiunn Sheen, Yu-Jui Fan
Summary: This study successfully detected the DNA sequence of LMP1 using a combination of microfluidic PCR and gold nanoslit-based SPR sensor, achieving rapid and accurate analytical procedures, as well as enhancing the detection efficiency of DNA extracted from EBV-positive cells.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Yi-Hsin Tai, Shu-Cheng Lo, Kevin Montagne, Po-Cheng Tsai, Cheng-Chieh Liao, Sheng-Hann Wang, Iuan-Sheau Chin, Di Xing, Ya-Lun Ho, Nien-Tsu Huang, Pei-Kuen Wei, Jean-Jacques Delaunay
Summary: An osmium-coated lensed fiber probe and a silver-coated black silicon substrate were used to generate a dielectrophoretic force for trapping and detecting bacteria. By controlling the frequency of the AC voltage, bacteria concentration could be rapidly identified by recording the Raman peak variation.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Polymer Science
Yi-Jung Lu, Han-Yun Hsieh, Wen-Chang Kuo, Pei-Kuen Wei, Horn-Jiunn Sheen, Hidetoshi Tahara, Te-Wei Chiu, Yu-Jui Fan
Summary: The study proposed a multiplex detection system by integrating LSPR sensing array and microfluidic channels, proving successful in detecting different targets in parallel channels.
Article
Biotechnology & Applied Microbiology
Sheng-Hann Wang, Chia-Wen Kuo, Shu-Cheng Lo, Wing Kiu Yeung, Ting-Wei Chang, Pei-Kuen Wei
Summary: In this study, a spectral image contrast-based flow digital nanoplasmon-metry method was developed to amplify and quickly detect the peak shift signal of gold nanoparticles (AuNPs) by comparing the scattering image brightness in two neighboring wavelength bands near the local surface plasmon resonance (LSPR) peak. The method provides an ultrahigh signal-to-noise ratio and has a lower sample volume requirement compared to conventional LSPR immunoassays. It demonstrates high sensitivity, selectivity, and a broad dynamic detection range.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Cheng-Chuan Chen, Shu-Cheng Lo, Pei-Kuen Wei
Summary: Label-free detection of mercuric ions in aqueous solutions was achieved using capped gold nanoslit arrays combined with electrochemical sensing technique. The system showed high sensitivity and selectivity towards Hg2+ ions, with a detection range from 100 μM to 10 nM and a detection limit of 1 μM. The developed system has the potential to be applied in detecting various chemicals and biomolecules.
Article
Nanoscience & Nanotechnology
Chia-Wen Kuo, Sheng-Hann Wang, Shu-Cheng Lo, Wei-Han Yong, Ya-Lun Ho, Jean-Jacques Delaunay, Wan-Shao Tsai, Pei-Kuen Wei
Summary: The study proposes a method for sensitive detection of small molecules by coupling image dipoles of gold nanoparticles with Fano resonance of capped gold nanoslits. The coupling mechanism was verified through calculations and experiments, showing potential for detecting low concentrations of small molecules. This resonant coupling significantly pushes the sensitivity boundary, with the detection limit reported to be 3 orders of magnitude lower than prism-based SPR.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Environmental
Prakhar Dutta, Ting-Yu Su, An-Ying Fu, Mei-Chi Chang, Yu-Jie Guo, I-Jung Tsai, Pei-Kuen Wei, Yu-Sheng Chang, Ching-Yu Lin, Yu-Jui Fan
Summary: In this study, a portable solar-powered centrifuge was developed to provide access to centrifugation in remote areas. The device showed high yield and plasma purity in a short time, and can be used for various purposes. The integration of smartphone reader and nanoplamonic chip allows for evaluation of autoantibodies through image analysis. The device can operate under different conditions with minimal energy requirement, making it suitable for areas without electricity.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Optics
Yi-Ru Li, Kuang-Li Lee, Kuan-Ming Chen, Yun Cheng Lu, Pin Chieh Wu, Sy-Hann Chen, Jiun-Haw Lee, Pei-Kuen Wei
Summary: This paper proposes a measurement method for sensitive and label-free detection of virus-like particles (VLPs) using color images of nanoplasmonic sensing chips. The experimental results show that the image contrast method has good linearity and can achieve direct detection of SARS-CoV-2 VLPs in a short period of time.
Article
Chemistry, Analytical
Han-Yun Hsieh, Jia-Xian Luo, Yi-Hong Shen, Shu-Cheng Lo, Yi-Chiung Hsu, Hidetoshi Tahara, Yu-Jui Fan, Pei-Kuen Wei, Horn-Jiunn Sheen
Summary: This study developed a rapid and highly sensitive EBV screening method using a nanofluidic preconcentrator integrated with a nanoslit Fano resonance biosensor to detect latent membrane protein 1 (LMP1) for EBV diagnosis. Through nanoimprinting and aluminum deposition, a low-cost nanoslit plasmonic sensing chip was mass-produced, achieving a limit of detection of 100 pg/ml and a sensing range of 100 pg/ml to 10 μg/ml.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Optics
Shu-cheng Lo, Chia-wei Lee, Ruey-lin Chern, Pei-kuen Wei
Summary: In this work, high-performance surface plasmonic sensors using gold nanostructures and Bragg photonic structures are presented. The hybrid Tamm-plasmon mode, resulting from the Fano coupling between higher order Tatum plasmon states and Bloch-wave surface plasmon polariton on the gold nanoslit array, demonstrates high surface sensitivity and resonant quality. The experimental results show that the hybrid mode has significantly higher sensitivity and better signal-to-noise ratios in biomolecular interaction measurement.
Article
Chemistry, Analytical
Shu-Cheng Lo, Shao-Sian Li, Wen-Fai Yang, Kuang-Chong Wu, Pei-Kuen Wei, Horn-Jiunn Sheen, Yu-Jui Fan
Summary: This paper presents a new micro/nanostructure co-hot embossing technique for the integration of gold-capped nanostructures as localized surface plasmon resonance (SPR) sensors into a microfluidic channel. The advantage of this technique is that it eliminates the need for alignment between the SPR sensors and the microfluidic channel during bonding. The integrated SPR sensor and microfluidic channel were characterized, and the sensitivity of the SPR sensor to refractive index was determined using different concentrations of glycerol solutions. The SPR sensor was also used for quantifying latent membrane protein (LMP-1) by modifying anti-LMP-1 on its surface, and a calibration curve was created using different concentrations of LMP-1 samples.
Article
Biochemical Research Methods
Shih-En Chou, Kuang-Li Lee, Pei-Kuen Wei, Ji-Yen Cheng
Summary: Metastasis, a common complication of cancer, can be controlled by regulating cell adhesion. New technologies and strategies, such as metal-based nanoslit surface plasmon resonance (SPR) and scanner-based cell adhesion kinetic examination (CAKE) systems, provide new approaches for drug screening in cancer treatment.
