Article
Materials Science, Multidisciplinary
Ana C. Manjua, Joaquim M. S. Cabral, Carla A. M. Portugal, Frederico Castelo Ferreira
Summary: This study demonstrates the use of external magnetic fields to stimulate mesenchymal stromal cells (MSCs) and increase the production of vascular endothelial growth factor-A (VEGF-A). The magnetic stimulation significantly enhances MSCs angiogenic potential and guides their morphology and alignment, leading to an increase in new vessel formation in both in vitro and in vivo models. Ultimately, this research reveals the potential to manipulate cellular processes through short-term magnetic stimulation.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2021)
Article
Multidisciplinary Sciences
Ziqiang Zhang, Mengyu Zhang, Yingying Sun, Monan Li, Chenhao Chang, Weiqi Liu, Xuemin Zhu, Lan Wei, Fengyun Wen, Yumei Liu
Summary: Adipose derived stem cells (ADSCs) are used in regenerative medicine due to their availability and lack of controversy. However, the oxidative microenvironment can cause apoptosis of the transplanted cells. Resveratrol (Res) has been shown to improve the proliferation and nerve regeneration ability of ADSCs.
SCIENTIFIC REPORTS
(2023)
Article
Materials Science, Biomaterials
Tao Yang, Guangxu Li, Xifeng Li, Boyang Wei, Hengxian Su, Wenchao Liu, Shenquan Guo, Nan Yang, Tao Xu, Chuanzhi Duan
Summary: Previous research on tissue-engineered blood vessels mainly focused on one layer, neglecting the equal importance of both the intima and adventitia. This study developed a small-diameter graft that can gradually release growth factors and inhibitors to enhance tissue regeneration and remodeling in both layers.
REGENERATIVE BIOMATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Daniella Anthea Gomes, Anna Margaretha Joubert, Michelle Helen Visagie
Summary: This study investigated the effects of Papaverine (PPV) on cell migration and the expression of vascular endothelial growth factor (VEGF) and related proteins in cancer cells. The results showed that PPV can inhibit cell migration and influence the expression of VEGF B and VEGF R1 in MDA-MB-231, A549, and DU145 cells. These findings contribute to the understanding of the effects of phytomedicinal alkaloid compounds in cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Kuixiang Wang, Ziying Chen, Liang Jin, Lili Zhao, Libin Meng, Fanting Kong, Chenxin He, Fanlei Kong, Lingtao Zheng, Fang Liang
Summary: This study investigated the impact of LPS pretreated human adipose-derived MSCs on skin wound healing in diabetic rats. The findings revealed improvements in epithelialization and angiogenesis of diabetic wounds after LPS pre-MSCs treatment. Furthermore, LPS treatment led to increased cell viability, upregulation of VEGF and DNMT1 protein expression in MSCs. These results suggest that LPS pre-MSCs can promote wound repair and skin regeneration in the diabetic microenvironment.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Biochemistry & Molecular Biology
Anna Damanaki, Svenja Memmert, Marjan Nokhbehsaim, Ali Abedi, Birgit Rath-Deschner, Andressa Nogueira, James Deschner
Summary: The study found that obesity can negatively influence bone healing after periodontal treatment, and the application of regeneration-promoting molecules can partially compensate for this effect but not fully. Obesity may also inhibit the stimulatory effects of regeneration-promoting molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biophysics
Xuanbin Zhang, Haosen Wang, Zhixiu Hao
Summary: The proposed bone regeneration model integrates theories of angiogenesis to demonstrate the effects of oxygen tension on vascular endothelial growth factor during bone regeneration, as well as the growth and remodeling of vascular tissue under the influence of vascular endothelial growth factor and mechanical loading. This model illustrates the relationship between vascular tissue and bone regeneration.
JOURNAL OF BIOMECHANICS
(2021)
Article
Biotechnology & Applied Microbiology
Yan-ping Dai, Xiao-qin Gao
Summary: In this study, RNA interference was utilized to investigate the impact of arsenic poisoning on sperm function by targeting the VEGF gene expression in the epididymis. The results showed that silencing the VEGF gene could inhibit the activity of sperm hyaluronidase, providing a potential gene therapy target for male infertility caused by arsenic poisoning.
Article
Cell & Tissue Engineering
D. Johnson, A. Dunn, G. Haas, J. Madsen, J. Robinson, C. Tobo, N. Ziemkiewicz, A. Nagarapu, S. Shringarpure, K. Garg
Summary: The study found that biomimetic sponge treatment significantly improved muscle recovery in female rats with volumetric muscle loss (VML) injuries. This treatment achieved this by increasing contractile tissue deposition in the defect area and increasing cross-sectional area of specific types of muscle fibers.
EUROPEAN CELLS & MATERIALS
(2023)
Article
Medicine, General & Internal
Tayfun Bilgic, Umit Ince, Fehmi Narter
Summary: This study aimed to evaluate the effect of autologous omentum flaps on injured renal tissues in a rat model. The results showed that autologous omentum tissue can attenuate inflammation and granulation in kidney injuries. Additionally, the use of omental tissue to facilitate healing may lead to a more effective healing process and reduced fibrosis and tissue and function loss.
MILITARY MEDICAL RESEARCH
(2022)
Article
Engineering, Biomedical
Zhengchao Yuan, Dandan Sheng, Liping Jiang, Muhammad Shafiq, Atta ur Rehman Khan, Rashida Hashim, Yujie Chen, Baojie Li, Xianrui Xie, Jun Chen, Yosry Morsi, Xiumei Mo, Shiyi Chen
Summary: This study developed VEGF-binding aligned electrospun PCL/Gel scaffolds by incorporating BP sequence and demonstrated their potential in promoting ligament regeneration. The functionalized scaffolds accumulated VEGF, enhanced tubular formation of HUVECs and wound healing in vitro, and facilitated the regeneration of matured collagen in patellar ligament in vivo.
ACTA BIOMATERIALIA
(2022)
Article
Pharmacology & Pharmacy
Ravena P. do Nascimento, Livia B. de Jesus, Markley S. Oliveira-Junior, Aurea M. Almeida, Eduardo L. T. Moreira, Bruno D. Paredes, Jorge M. David, Bruno S. F. Souza, Maria de Fatima D. Costa, Arthur M. Butt, Victor Diogenes A. Silva, Silvia L. Costa
Summary: The study found that Agathisflavone can protect injured spinal cord tissue and exhibit therapeutic effects in a rat model of acute spinal cord injury. It also promotes neurogenesis and increases the expression of neurotrophins while reducing inflammation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Ali Hazrati, Kosar Malekpour, Sara Soudi, Seyed Mahmoud Hashemi
Summary: Liver tissue can be damaged by various factors, resulting in acute or chronic liver damage and potentially leading to serious conditions such as cirrhosis and liver carcinoma. Liver transplantation is the main treatment, but its limitations include a scarcity of donors, tissue rejection, immunosuppression, and high cost. Cell therapy, particularly using mesenchymal stem cells (MSCs), has gained attention as an alternative treatment due to their regenerative properties. However, MSC therapy also has limitations, and the use of MSC-derived extracellular vesicles (EVs) such as exosomes can provide a potential solution by promoting liver tissue repair and preventing disease progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Shady G. El-Sawah, Hanan M. Rashwan, Fayez Althobaiti, Adil Aldhahrani, Eman Fayad, El-Shaimaa Shabana, Ehab El-Hallous, Rehab M. Amen
Summary: This study aimed to investigate the potential benefits of adult mesenchymal stem cells (MSCs) on metabolic disturbances and tissue function defects in diabetic rats. The results showed that MSCs treatment significantly reduced hyperglycemia, normalized lipid fractions levels, and had hepato-renal protective effects in diabetic rats.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Liuhua Zhou, Tianli Yang, Feng Zhao, Kaiwei Song, Luwei Xu, Zhongle Xu, Changcheng Zhou, Zhiqiang Qin, Zheng Xu, Ran Wu, Hua Xu, Ruipeng Jia
Summary: This study evaluated the preventive effect of uncultured adipose derived stromal vascular fraction (SVF) on urethral fibrosis in a rat model of urethral stricture (US). The results demonstrated that SVF administration reduced the extent of urethral changes and fibrosis, as well as decreased the expression of collagen and TGF beta 1R, while increasing vascularization and the expression of VEGF and bFGF. Additionally, SVF exerted anti-inflammatory effects and modulated macrophage phenotype. These findings suggest that uncultured SVF has an inhibitory effect on stricture formation in the early stage of urethral fibrosis.
SCIENTIFIC REPORTS
(2022)
Article
Peripheral Vascular Disease
Nail Kahraman, Kadir K. Ozsin
Article
Chemistry, Physical
Cigdem Kip, Esin Akbay, Burcu Gokcal, Burge Okyay Savas, M. Ali Onur, Ali Tuncel
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2020)
Article
Peripheral Vascular Disease
Abdullah B. Balci, Umut S. Sanri, Kadir K. Ozsin, Ahmet B. Tatli, Ahmet F. Ozyazicioglu, Senol Yavuz
Summary: In this study comparing cyanoacrylate closure and radiofrequency ablation for incompetent great saphenous veins, both methods were found to be effective and reliable. However, patients in the cyanoacrylate closure group experienced a more comfortable postoperative period and returned to work earlier.
Article
Peripheral Vascular Disease
Nail Kahraman, Gunduz Yumun, Deniz Demir, Kadir K. ozsin, Sadik A. Sunbul, Arif Gucu, Ibrahim B. Seker, Buket ozyaprak, Senol Yavuz, Mehmet T. Goncu
Summary: Near Infrared (NIR) light can easily detect varicose veins that cannot be seen with the naked eye. Foam sclerotherapy guided by NIR light is an effective and safe treatment for residual varicose veins, particularly for female patients.
Article
Peripheral Vascular Disease
Nail Kahraman, Gunduz Yumun, Deniz Demir, Dursun Topal, Kadir Kaan Ozsin, Sadik Ahmet Sunbul, Temmuz Taner, Buket Ozyaprak, Mehmet Tugrul Goncu
Summary: This study aimed to calculate the predictive value of internal carotid wall thickness in computed tomography carotid angiography (CTA) for the success of modified carotid eversion endarterectomy (MCEE). The results showed that the thickness of the internal carotid artery (ICA) wall was associated with the success of MCEE and could help avoid serious complications.
Article
Cardiac & Cardiovascular Systems
Senol Yavuz, Kadir Kaan Ozsin, Umut Serhat Sanri, Faruk Toktas, Meral Ozsin, Cuneyt Eris
Summary: This study aimed to determine the relationship between HbA1c levels and the development of PoAF. The results showed that HbA1c levels were not an independent predictor of PoAF development, but high HbA1c levels may be a risk factor for the development of PoAF.
JOURNAL OF CARDIAC SURGERY
(2022)
Article
Peripheral Vascular Disease
Kadir K. Ozsin, Mesut Engin, Umut S. Sanri, Faruk Toktas, Nail Kahraman, Kagan Huysal, Yasemin Ustundag, Senol Yavuz
Summary: This study found that increased levels of adjusted ischemia-modified albumin (IMA) were associated with the presence and severity of peripheral artery disease (PAD). Adjusted-IMA values can be a valuable marker in the follow-up of clinical severity of PAD.
Article
Biology
Alp Yigit Ozdemir, Esin Akbay, Mehmet Ali Onur
Summary: The study compared the in vitro protective effects of γ-tocopherol and tocotrienol and found that both can prevent neurodegeneration and regulate calcium channel mechanisms in neurons. Additionally, they can reduce the accumulation of amyloid beta in the extracellular matrix. The protective effects of γ-tocopherol and tocotrienol vary at different time points.
TURKISH JOURNAL OF BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mesut Engin, Kadir Kaan Ozsin, Muhammed Savran, Orhan Guvenc, Senol Yavuz, Ahmet Fatih Ozyazicioglu
Summary: This study found that low PNI and high VAI were risk factors for PoAF.
BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
(2021)
Article
Biotechnology & Applied Microbiology
Senem citoglu, Ozlem Duyar Coskun, Le Duc Tung, Mehmet Ali Onur, Nguyen Thi Kim Thanh
Summary: The study synthesized superparamagnetic cubic iron oxide nanoparticles functionalized with meso-2,3-dimercaptosuccinic acid (DMSA) and investigated their cytotoxic effects on HeLa cells, showing slight toxicity at certain concentrations. This is the first study to examine the cytotoxic effects and hyperthermia performance of DMSA-coated cubic IONPs on HeLa cells.
Article
Cardiac & Cardiovascular Systems
Umut Serhat Sanri, Kadir Kaan Ozsin, Faruk Toktas, Senol Yavuz
Summary: The study showed that Del Nido cardioplegia (DNC) can be safely used in adult coronary bypass surgery, reducing the development of postoperative atrial fibrillation (PoAF), while also decreasing the aortic cross-clamp time and the volume of cardioplegia delivered during surgery.
BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
(2021)
Article
Nutrition & Dietetics
Asli Ozkok, Esin Akbay, Asli Elif Tanugur Samanci, Nazli Mayda, Mehmet Ali Onur
Summary: This study evaluated the cell proliferation potentials of different royal jelly samples collected from 5 different regions in Turkey. The results showed that the samples from different regions varied in their effects on stem cell growth, with RJ5 at the lowest concentration showing the best growth-stimulating activity and RJ1 and RJ3 at the highest dilutions leading to more cell death. These findings highlight the potential differences of royal jelly samples on stem cell growth stimulation.
PROGRESS IN NUTRITION
(2021)
Article
Medicine, General & Internal
Kadir Kaan Ozsin, Abdullah Burak Balci, Umut Serhat Sanri, Orhan Guvenc, Senol Yavuz
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2020)
Article
Medicine, General & Internal
Arda Aybars Pala, Temmuz Taner, Ahmet Burak Tatli, Kadir Kaan Ozsin, Senol Yavuz
CUREUS JOURNAL OF MEDICAL SCIENCE
(2020)
Article
Cardiac & Cardiovascular Systems
Umut Serhat Sanri, Kadir Kaan Ozsin, Faruk Toktas, Senol Yavuz
BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
(2019)
