期刊
PLASMA PROCESSES AND POLYMERS
卷 8, 期 7, 页码 599-606出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppap.201000160
关键词
antibacterial coatings; drug release; hydrolysis; infection; plasma polymerization
资金
- Spanish Ministry for Science and Innovation [PSS-300100-2006-1, PSS-300100-2007-4]
Locally applied antibiotics under temporally controlled release present many advantages over systemic clinical treatments, e. g. efficiency and side effects. This can be achieved by a coating on top of the medical device, in which the antibiotic is stored. This study presents the use of plasma polymerization to produce such a coating using N, O-bis-tert-butyldimethylsilylated ciprofloxacin (silylciprofloxacin) as a precursor. Once exposed to physiological media, the outer layers of the coating release the antibiotic by a hydrolysis reaction. Thus, the plasma process parameters can control the speed of liberation through the coating polymerization. Besides, this study shows that the release products present antibiotic activity against a number of bacteria: E. coli, P. aeruginosa, and S. aureus.
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