Article
Chemistry, Multidisciplinary
Austin Sun, Joanne Wang
Summary: This study investigates the functional activity of P-gp and Bcrp at the murine blood-cerebrospinal fluid barrier (BCSFB) using live tissue imaging. The results show that Bcrp has functional activity at the apical membrane of the BCSFB, and P-gp may also have additional contributions.
PHARMACEUTICAL RESEARCH
(2023)
Article
Plant Sciences
Haihua Shang, Yinghui Sun, Ze Wang, Ying Zhou, Huajiao Yang, Xiaoyan Ci, Tao Cui, Yuanyuan Xia, Yuan Gu, Maoliang Liao, Quansheng Li, Duanyun Si, Changxiao Liu
Summary: This study investigates the oral absorption mechanism of rotundic acid (RA), a major compound in Ilicis Rotundae Cortex, and suggests that it may involve multiple transport pathways and paracellular pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Applied
Ruimin Wang, Linling Yao, Tingyu Meng, Congfa Li, Lu Wang
Summary: In this study, the researchers investigated the mitigative effect of Rhodomyrtus tomentosa fruit extract rich in phenolic compounds on high fat diet-induced intestinal barrier dysfunction. The results showed that the extract improved gut microbiota dysbiosis, reduced harmful bacteria, and increased beneficial bacteria. Additionally, it helped to improve intestinal barrier function and reduce inflammation by regulating protein expression levels and suppressing proinflammatory cytokines. These findings suggest that Rhodomyrtus tomentosa fruit extract supplementation may be an effective way to protect the intestine in obese individuals on a high fat diet.
Article
Chemistry, Multidisciplinary
Severin Mairinger, Irene Hern, Thomas Filip, Michael Sauberer, Mathilde Lobsch, Johann Stanek, Thomas Wanek, Johannes A. Sake, Thomas Pekar, Carsten Ehrhardt, Oliver Langer
Summary: This study used positron emission tomography (PET) imaging to investigate the influence of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) on the pulmonary distribution of inhaled drugs. The results showed functional activity of P-gp and BCRP in the lungs and suggested that these transporters play a role in limiting the uptake of drugs in the lungs, similar to the blood-brain barrier. The study highlights the importance of pulmonary efflux transporters in the efficacy and safety of inhaled drugs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Immunology
Xiaogang Chen, Wenjing Sun, Baichang Xu, Enyun Wu, Yao Cui, Kaiyuan Hao, Geyin Zhang, Congcong Zhou, Yanping Xu, Jiang Li, Hongbin Si
Summary: The polysaccharides from the roots of Millettia Speciosa Champ exhibit immunomodulatory effects in cyclophosphamide-induced mice by improving immune organ indices, cytokine secretion, intestinal morphology, and microbial diversity. These findings suggest that Millettia Speciosa Champ polysaccharide holds promise as an immunostimulant in functional foods and drugs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jessica Chu, Erika Panfen, Linna Wang, Anthony Marino, Xue-Qing Chen, R. Marcus Fancher, Raviraj Landage, Omprakash Patil, Salil Dileep Desai, Devang Shah, Yongjun Xue, Michael Sinz, Hong Shen
Summary: The aim of this study was to evaluate the differences between intestinal and systemic P-gp and BCRP in drug disposition. The results showed that ECD is a potent inhibitor of intestinal P-gp and BCRP. The inhibition potential of ECD towards human and animal P-gp and BCRP was assessed in vitro and in vivo.
PHARMACEUTICAL RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
Lei Jiang, Kuiliang Zhang, Mingcong Fan, Wei Pan, Haifeng Qian, Li Wang, Yan Li
Summary: 5-Heptadecylresorcinol (AR-C17) is an important active monomer with various health benefits. However, its low water solubility restricts its application. This study found that the transport of AR-C17 is influenced by transporters, temperature, pH, and quercetin as a P-glycoprotein (P-gp) inhibitor can promote its transport.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Medicine, General & Internal
Caiyun Ge, Dan Xu, Pengxia Yu, Man Fang, Juanjuan Guo, Dan Xu, Yuan Qiao, Sijia Chen, Yuanzhen Zhang, Hui Wang
Summary: This study revealed that P-gp plays a critical role in mediating the placental glucocorticoid barrier, with its expression inhibited in IUGR cases. The epigenetic regulation mechanism of P-gp was also explored, providing new insights into early warning, prevention, and treatment strategies for IUGR.
Article
Chemistry, Multidisciplinary
Hyung Shik Kim, Dong Yun Lee
Summary: Gold nanoparticles (AuNPs) with unique characteristics are considered promising candidates for improving drug bioavailability. Developing an effective oral drug delivery system requires a profound understanding of the GI tract microenvironment and mechanisms of nanoparticle transportation through the intestinal epithelium, taking into account the physicochemical properties of AuNPs.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Jennifer Lang, Ludwig Vincent, Marylore Chenel, Kayode Ogungbenro, Aleksandra Galetin
Summary: The study developed a joint DABE-dabigatran PBPK model which successfully predicted the differences in P-gp DDI magnitude between a microdose and a therapeutic dose of DABE, providing valuable model-based guidance.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Peter Szatmari, Eszter Ducza
Summary: ABC transporters are essential for drug efflux in the human body, with significant impact on pharmacokinetics and pharmacologic properties of drugs. P-gp and BCRP transporters, in particular, play a crucial role in barrier tissues. During pregnancy, placental and intestinal ABC transporters are of great importance for drug absorption and distribution. Their expression changes with gestational age and can affect the efficacy of various therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Mohd Norfaizal Ghazalli, Muhammad Shafie Md Sah, Mazidah Mat, Khadijah Awang, Mohd Azwan Jaafar, Razali Mirad, Ahmad Zaki Zaini, Anuar Rasyidi Mohd Nordin, Nurshahidah Mohd Rusli, Siti Sofiah Mohamad, Ahmad Syahman Mohd Dalee
Summary: This study characterized the leaf anatomy and micromorphology features of Mitragyna speciosa, providing additional systematic information for this species. The results revealed unique morphological characteristics that could aid in the classification of Mitragyna speciosa.
TROPICAL LIFE SCIENCES RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Maciej J. Zamek-Gliszczynski, Mitesh Patel, Xinning Yang, Justin D. Lutz, Xiaoyan Chu, Kim L. R. Brouwer, Yurong Lai, Caroline A. Lee, Sibylle Neuhoff, Mary F. Paine, Yuichi Sugiyama, Kunal S. Taskar, Aleksandra Galetin
Summary: The increasing interest in transporter induction highlights the importance of P-glycoprotein and OATP1B in drug absorption and disposition, as well as the potential for drug-drug interactions. Further research is needed to fully understand the clinical relevance and mechanisms of these interactions in order to inform drug development strategies.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Sarfaraz Ahmad Ejazi, Rebecca Louisthelmy, Katharina Maisel
Summary: Oral drug administration is popular but faces challenges in the harsh gastrointestinal environment. Nanoparticles can enhance drug bioavailability by protecting against degradation, promoting absorption, and facilitating drug transport across the intestinal epithelium. This review focuses on the components of intestinal barriers, various nanoparticles developed for oral delivery, and the intracellular pathways involved in nanoparticle internalization and transport. Understanding these factors may lead to the development of more effective nanoparticles for drug delivery.
Article
Nanoscience & Nanotechnology
David Esseni, Daniel Lizzit, Pedram Khakbaz, Francesco Driussi, Marco Pala
Summary: High contact resistance between metallic conductors and 2D semiconductors is a major challenge in nanoscale electronic devices. This study investigates the physical properties and electrical resistance of various metal contacts to monolayer MoS2 and WSe2. The interaction between metal and semiconductor orbitals can induce gap states, increase the Schottky barrier height, and degrade contact resistance.
ACS APPLIED NANO MATERIALS
(2023)