Article
Biochemistry & Molecular Biology
Yuan Gao, Jun-Su Zhou, Hong-Chun Liu, Yan Zhang, Wei-Hang Yin, Qun-Fang Liu, Guan-Wu Wang, Jin-Xin Zhao, Jian-Min Yue
Summary: A chemical investigation on the aerial parts of Euphorbia neriifolia led to the discovery of thirteen undescribed diterpenoids, including phorneroid A, which features a unique structure. These compounds exhibited moderate cytotoxicity against two human tumor cell lines.
Article
Biochemistry & Molecular Biology
Stephen S. Chang, Hung-Tse Huang, Yu-Chi Lin, Chih-Hua Chao, Geng-You Liao, Zhi-Hu Lin, Hui-Chi Huang, Jenny Chun-Ling Kuo, Chia-Ching Liaw, Chen-Jei Tai, Yao-Haur Kuo
Summary: Euphorbia neriifolia L. is a widely distributed plant with various medicinal properties. This study isolated 11 triterpenes from the plant and determined their structures. Additionally, the anti-inflammatory and antiproliferative effects of these compounds were evaluated, revealing a potential structure-activity relationship.
Article
Chemistry, Multidisciplinary
Stephen S. S. Chang, Hung-Tse Huang, Wen-Chi Wei, I-Wen Lo, Yu-Chi Lin, Chih-Hua Chao, Geng-You Liao, Yuh-Chiang Shen, Jih-Jung Chen, Tsung-Lin Li, Liang-Tzung Lin, Chen-Jei Tai, Yao-Haur Kuo, Chia-Ching Liaw
Summary: The Euphorbia neriifolia plant, widely found in India, Thailand, Southeastern China, and Taiwan, has anti-inflammatory properties and is used to treat inflammation-related diseases. In this study, additional triterpenes with potential anti-inflammatory effects were isolated from the plant. The chemical structures of these compounds were determined through spectroscopic data analysis, and their anti-inflammatory activity was evaluated. The study found that certain triterpenes showed inhibitory effects on IL-6 and TNF-a, indicating their potential as anti-inflammatory agents.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kaicheng Du, Zhiqi Zhang, Di Jing, Yumeng Wang, Xingyao Li, Dali Meng
Summary: The phytochemical study on Euphorbia fischeriana, a folk medicinal plant in China, led to the isolation of eight undescribed glycosides, including two diterpene glycosides, three acetophenone glycosides and three tannins together with eight known ones. The structures of these glycosides were determined through extensive analysis using 1D, 2D NMR experiments and HRESIMS. Two of the diterpene glycosides showed cytotoxic activity against several human cancer cell lines, while the tannins exhibited significant antibacterial activity.
Article
Chemistry, Applied
Liping He, Daili Yuchen, Shangzhi Zhang, Yangyang Hui, Namei Wei, Yangqing He
Summary: The chemical constituents of Euphorbia sikkimensis roots were investigated, resulting in the isolation of twelve known compounds. Five of these compounds were isolated from Euphorbia sikkimensis for the first time. The agonistic activity of peroxisome proliferator-activated receptor gamma (PPARγ) was evaluated for several compounds, and compound 1 showed moderate agonistic activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Agricultural Engineering
Meixiang Chen, Mei Tian, Fei Liu, Wanli Zhao, Jian Peng, Li Linwei, Min Yin, Yonghua Gu, Xu Feng, Yu Chen
Summary: Resource discovery for producing biologically active phytochemicals is crucial in the field of industrial crops. This study utilized UHPLC-MS to analyze the free ingenol content in 61 selected plant species from the Euphorbiaceae family, revealing varying levels of ingenol derivatives and identifying high-ingenol plant species. The research also confirmed the impact of greenhouse covering materials on the production of ingenol esters in Euphorbia plants.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Review
Biochemistry & Molecular Biology
Longfei Deng, Xuan Zhai, Ping Liang, Hongjuan Cui
Summary: TRAIL holds therapeutic potential in cancer treatment, but many cancers, including GBM, exhibit resistance. Recent studies have identified new mechanisms in regulating TRAIL-induced apoptosis in GBM and effective combinatorial strategies. The TRAIL/TRAIL death receptor axis may have future clinical applications for GBM treatment.
Review
Biochemistry & Molecular Biology
Yang Xu, Peiyu Tang, Man Zhu, Yali Wang, Dejuan Sun, Hua Li, Lixia Chen
Summary: A large number of previously undescribed diterpenoids have been isolated from Euphorbia plants, showing various biological activities such as neuroprotection and antimalarial effects. These diterpenoids have been classified into 26 normal classes and 37 novel skeleton types based on their structure types.
Article
Chemistry, Applied
Minli Zhang, Qinwen Yang, Xiaofeng Zhang, Haifeng Wu
Summary: A new cyclotane triterpene bisdesmoside, soulieoside T, and a known compound, oleanolic acid, were isolated from the ethanolic extract of Actaea vaginata rhizomes. Compound 1 was evaluated for cytotoxic activities against three human cancer cell lines.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Newsha Motinia, Mustafa Ghannadian, Behzad Zolfaghari, Zeinab Yazdiniapour
Summary: The study aimed to investigate the presence and structural determination of secondary metabolites, particularly terpenoid compounds, in Euphorbia tucomanica. Through purification and identification, the chemical structures of nine known terpenoids were determined for the first time from E. tucomanica. E. tucomanica, with a rich terpenoid profile, could serve as a valuable resource for drug development.
Article
Chemistry, Applied
Haifeng Wu, Qinwen Yang, Xiangyuan Li, Yindi Zhu, Zhengqi Dong, Guoxu Ma, Xudong Xu, Gui Chen, Xiaokang Ai, Qiongyu Zou, Xing Hu, Xianjin Wu
Summary: A new cycloartane triterpene bisdesmoside, soulieoside U, was isolated from the rhizomes of Actaea vaginata. Its structure was determined by extensive analysis of NMR and MS data. Soulieoside U was evaluated for cytotoxic activities against three human cancer cell lines.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Organic
Yuan Gao, Jun-Su Zhou, Hong-Chun Liu, Yan Zhang, Wei-Hang Yin, Qun-Fang Liu, Guan-Wu Wang, Jin-Xin Zhao, Jian-Min Yue
Summary: A phytochemical study of the aerial parts of Euphorbia neriifolia led to the isolation of new ingenane-type and ingol-type diterpenoids. The structures and absolute configurations of these compounds were determined, and their biological evaluation revealed cytotoxic effects against human tumor cell lines.
Review
Plant Sciences
Rania Benjamaa, Abdelkarim Moujanni, Neha Kaushik, Eun Ha Choi, Abdel Khalid Essamadi, Nagendra Kumar Kaushik
Summary: The genus Euphorbia includes plants with toxic milky fluid or latex widely found in temperate and tropical zones. These plants have been used in traditional and complementary medicine for various health issues, and their medicinal properties are attributed to the presence of various compounds, with the focus on their latex. This review summarizes the current knowledge on the chemical composition and biological activities of latex from Euphorbia species, aiming to explore its medical applications and assess its ethnopharmacological potential.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Marcia Maria de Souza, Luiz G. R. D. Chagas, Ana Elisa Goncalves, Marcelo Tomczak, Simone Reichert, Ivania T. A. Schuquel, Valdir Cechinel-Filho, Christiane Meyre-Silva
Summary: The study showed that the hydroethanolic extract of Aleurites moluccanus bark has significant analgesic and anti-inflammatory properties, with AMC90 performing the best. Specific compounds such as acetyl aleuritolic acid, atraric acid, and (5 beta ,10 alpha )-12-hydroxy-13-methoxy-8,11,13-podocarpatrien-3-one were found to contribute to these effects.
Article
Biochemistry & Molecular Biology
Jia Meng, Bo-Ting Li, Gang Sheng, An-Ling Zhang, Xing-Cong Li, Jun-Mian Tian
Summary: Five new diterpenoids, named euphorfischerins A-E, were isolated from the roots of Euphorbia fischeriana. Euphorfischerin A and euphorfischerin B showed cytotoxicity against human cancer cell lines.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Chemistry, Medicinal
Yasinjan Hashim, Kazufumi Toume, Shusaku Mizukami, Toshinori Kitami, Mayumi Taniguchi, Awet Alem Teklemichael, Yuki Tayama, Nguyen Tien Huy, Jose Nzunzu Lami, Joseph M. Bodi, Kenji Hirayama, Katsuko Komatsu
Summary: Various phenylpropanoid-conjugated iridoid glucosides were isolated from Morinda morindoides and evaluated for their anti-trypanosomal activity and cytotoxicity. Two compounds showed potential anti-trypanosomal effects.
JOURNAL OF NATURAL MEDICINES
(2022)
Article
Chemistry, Medicinal
Yoshinori Makita, Shun Saito, Anna Tsuchiya, Masami Ishibashi, Midori A. Arai
Summary: Notch signaling pathway is crucial in cell differentiation and proliferation, but abnormal activation can lead to tumorigenesis. Compound 1 beta,2 alpha-epoxytagitinin C (2) was discovered to inhibit Notch signaling and exhibit strong cytotoxicity against the Notch-activated leukemia cell line HPB-ALL.
JOURNAL OF NATURAL MEDICINES
(2022)
Article
Chemistry, Multidisciplinary
Simplice Joel Tatsimo Ndendoung, Jean-De-Dieu Tamokou, Kazufumi Toume, Leopold Havyarimana, Steve Endeguele Ekom, Katsuko Komatsu
Summary: The investigation of the non-polar and polar fractions of ethyl acetate extract from Gymnosporia senegalensis leaves resulted in the isolation of nine compounds, including a new megastigmane derivative and known derivatives of galloyl, chlorophyll, and fatty acid. The compounds were tested for their antibacterial, antifungal, and antioxidant activities, showing various levels of effectiveness.
JOURNAL OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Organic
Yasumasa Hara, Keiichiro Watanabe, Akiko Takaya, Teruhisa Manome, Takashi Yaguchi, Masami Ishibashi
Summary: Two new peptides named uniformides A and B (1 and 2) were isolated from the cultured extracts of Nocardia uniformis IFM0856(T) in the presence of mouse macrophage-like cell line J774.1, showing high cytotoxicity against J774.1 and inhibiting the production of nitric oxide, IL-6, and IL-1 beta through the suppression of the NF-kappa B pathway. These compounds were only produced in cultures containing J774.1.
Correction
Chemistry, Organic
Yasumasa Hara, Keiichiro Watanabe, Akiko Takaya, Itsuki Ebihara, Teruhisa Manome, Midori A. Arai, Takashi Yaguchi, Masami Ishibashi
Article
Chemistry, Medicinal
Teruhisa Manome, Yasumasa Hara, Masami Ishibashi
Summary: A new 1,2-diketone physalin, physalin XII (1), and 13 known compounds were isolated from Physalis minima whole plant collected in Thailand. Among them, physalin F (3) showed the strongest activity against TRAIL-induced apoptosis by suppressing anti-apoptotic proteins c-FLIP and Bcl-2.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Chemistry, Medicinal
Qundong Liu, Katsuko Komatsu, Kazufumi Toume, Shu Zhu, Ken Tanaka, Shigeki Hayashi, Naoko Anjiki, Nobuo Kawahara, Akihito Takano, Katsunori Miyake, Norio Nakamura, Suchada Sukrong, Mangestuti Agil, Indira Balachandra
Summary: This study aimed to characterize the essential oil compositions of 12 Curcuma species and detect the compositional variation among different species, as well as between plant specimens and genetically validated crude drug samples. The results showed that plant specimens of the same species exhibited similar essential oil patterns regardless of their geographical sources. Marker compounds identified through orthogonal partial least squares-discriminant analysis were able to distinguish each group or species.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Biochemistry & Molecular Biology
Teruhisa Manome, Yasumasa Hara, Masami Ishibashi
Summary: Eighteen compounds, including fourteen flavonoids, one steroid, two fatty acids, and one nitrogen-containing compound, were isolated from the whole Blumea lacera plant collected in Thailand. Compounds 1-11 and 15-17 showed activity in overcoming tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance. Among them, bonanzin (2) and cirsilineol (7) exhibited particularly strong TRAIL resistance-overcoming activity, with IC50 values of 10.7 μM and 5.9 μM, respectively, against the human gastric adenocarcinoma cell line AGS in the presence of TRAIL (100 ng/mL).
Article
Plant Sciences
Kritamorn Jitrangsri, Yasumasa Hara, Akiko Takaya, Masami Ishibashi
Summary: Bioactivity-guided isolation of Uvaria rufa leaves and Nephelium hypoleucum bark led to the discovery of nine compounds with a new polyoxygenated cyclohexene scaffold. These compounds exhibited TRAIL resistance-overcoming activity and increased inhibition of gastric cancer cell line. Compounds 3 and 9 were found to sensitize AGS cells to apoptosis via both extrinsic and intrinsic pathways.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Chemistry, Organic
Yasumasa Hara, Teruhisa Manome, Wataru Suehiro, Shinji Harada, Yoshikazu Yamagishi, Akiko Takaya, Yasumitsu Ogra, Masami Ishibashi
Summary: Two new octadeca-peptibols, trichorzin PAX and XI (1 and 2), were isolated from the fungus Trichoderma harzianum IFM 66736, obtained from the soil in Aobanomori Park, Chiba City, Japan. The structures of the compounds were determined through spectral studies, X-ray crystallographic analysis, and MS/MS analysis. Compound 1 and 2 exhibited cytotoxicity against human colon cancer cell lines HCT116.
TETRAHEDRON LETTERS
(2023)
Article
Chemistry, Medicinal
Yuzhuo Dong, Kazufumi Toume, Shu Zhu, Yanhong Shi, Takayuki Tamura, Kayo Yoshimatsu, Katsuko Komatsu
Summary: H-1 NMR-based metabolomics analysis was used to evaluate peony roots with different botanical origins, producing areas, and post-harvest processing. Five types of monoterpenoids and six other compounds were detected in the extracts of peony root samples. The quantitative H-1 NMR analysis showed that certain compounds had different contents in different types of peony root samples.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Chemistry, Medicinal
Yuzhuo Dong, Kazufumi Toume, Shin Kimijima, Hanpei Zhang, Shu Zhu, Yumin He, Shaoqing Cai, Takuro Maruyama, Katsuko Komatsu
Summary: Drynariae Rhizoma, a traditional medicine used for treating bone diseases and kidney deficiency, has recently been found to enhance memory function. The study used NMR-based metabolite profiling and HPLC analysis to distinguish the botanical origin of Drynariae Rhizoma and verify the validity of its uses. The results showed that samples derived from different botanical origins and stir-fried samples cannot substitute for the genuine Drynariae Rhizoma.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Tropical Medicine
Yuki Tayama, Shusaku Mizukami, Kazufumi Toume, Katsuko Komatsu, Tetsuo Yanagi, Takeshi Nara, Paul Tieu, Nguyen Tien Huy, Shinjiro Hamano, Kenji Hirayama
Summary: In this study, traditional medicinal herb formulations were screened for potential anti-Chagas disease drugs. Three protoberberine-type alkaloids showed strong anti-T. cruzi activity with low cytotoxicity. Among them, coptisine chloride exhibited the most significant effect in the acute infection model.
TROPICAL MEDICINE AND HEALTH
(2023)
Article
Chemistry, Medicinal
Kazuki Fujii, Yasumasa Hara, Midori A. Arai, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi
Summary: A new coumarin derivative and 30 known compounds were isolated from Mammea siamensis and Andrographis paniculata. These compounds exhibited BMI1 promoter inhibitory activity, and one compound showed high cytotoxicity against DU145 cells.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Integrative & Complementary Medicine
Zitai Wang, Kayu Okutsu, Yumiko Yoshizaki, Taiki Futagami, Hisanori Tamaki, Takuro Maruyama, Kazufumi Toume, Katsuko Komatsu, Fumio Hashimoto, Kazunori Takamine
Summary: The study found that microbial fermentation contributes to increased enzyme activity and changes in MMF volatiles. MMF prepared with different microbes showed different characteristics. Thus, microbial control in the production of commercial MMF is crucial for maintaining its quality.
TRADITIONAL & KAMPO MEDICINE
(2022)
