Article
Pharmacology & Pharmacy
Felipe Fagundes Leao, Ana Paula Farias Waltrick, Waldiceu Aparecido Verri Jr, Joice Maria da Cunha, Janaina Menezes Zanoveli
Summary: The study found that a specialized pro-resolving lipid mediator called Resolvin D5 (RvD5) can prevent depression and anxiety symptoms associated with Type 1 diabetes mellitus (T1DM) and significantly improve blood glucose levels. Furthermore, RvD5 also reduces inflammation in the hippocampus and prefrontal cortex of experimental-T1DM rats. These findings suggest that RvD5 has potential preventive and therapeutic effects on emotional complications resulting from T1DM, possibly through its action on neuroinflammation.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Neurosciences
Utkarsha D. Kulkarni, Meena Kumari Kamalkishore, Amberkar Mohanbabu Vittalrao, Praveen Kumar Siraganahalli Eshwaraiah
Summary: This study demonstrates the cognitive enhancing abilities of vitamin D and epalrestat, both individually and in combination, in diabetic rats.
COGNITIVE NEURODYNAMICS
(2022)
Article
Behavioral Sciences
Beatriz Moreno-Santos, Camila Marchi-Coelho, Willian Costa-Ferreira, Carlos C. Crestani
Summary: This study demonstrates the presence of different angiotensinergic mechanisms within the MeA controlling behavioral responses in the forced swimming test and elevated plus-maze.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Jiwon Lee, Shinhui Lee, Woonhee Jo, Hwee Won Ji, Minsu Pyeon, Myungmi Moon, Jihwon Yun, Junho H. Lee, Sung-Oh Sohn
Summary: This study investigated the effects of a herbal mixture containing Sage and St. John's Wort on cognitive and memory impairment. Marker components were identified and quantified, and the herbal mixture showed positive effects on oxidative stress, cytokine levels, and cognitive performance in both cell and animal experiments.
ADVANCES IN TRADITIONAL MEDICINE
(2023)
Article
Chemistry, Inorganic & Nuclear
Serkan Levent, Ulviye Acar Cevik, Begum Nurpelin Saglik, Yusuf Ozkay, Ozgur Devrim Can, Umide Demir Ozkay, Umit Ucucu
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2017)
Article
Biochemistry & Molecular Biology
Nafiz Oncu Can, Ozgur Devrim Can, Derya Osmaniye, Umide Demir Ozkay
Article
Biochemistry & Molecular Biology
Ozgur Devrim Can, Umut Irfan Ucel, Umide Demir Ozkay, Emel Ulupinar
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Mustafa Burak Barbaros, Ozguer Devrim Can, Umut Irfan Ucel, Nazli Turan Yuecel, Umide Demir Ozkay
Article
Chemistry, Medicinal
Nazli Turan, Umide Demir Ozkay, Nafiz Oncu Can, Ozgur Devrim Can
LETTERS IN DRUG DESIGN & DISCOVERY
(2019)
Article
Biochemistry & Molecular Biology
Gamze Tokgoz, Umide Demir Ozkay, Derya Osmaniye, Nazli Turan Yucel, Ozgur Devrim Can, Zafer Asim Kaplancikli
Article
Clinical Neurology
Ezgi Bektur, Erhan Sahin, Emre Ceyhan, Dilek Burukoglu Donmez, Mediha Canbek, Cengiz Baycu, Ozgur Devrim Can
NEUROLOGICAL RESEARCH
(2019)
Article
Cell Biology
Erhan Sahin, Ezgi Bektur, Dilek Burukoglu Donmez, Cengiz Baycu, Ozgur Devrim Can, Varol Sahinturk
Review
Pharmacology & Pharmacy
Yusuf Ozturk, Nilgun Ozturk
CURRENT PHARMACEUTICAL DESIGN
(2019)
Article
Behavioral Sciences
Umut Irfan Ucel, Ozgur Devrim Can, Umide Demir Ozkay, Emel Ulupinar
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2020)
Article
Biochemistry & Molecular Biology
Ahmet Avci, Hayrunnisa Tasci, Ummuhan Kandemir, Ozgur Devrim Can, Nesrin Gokhan-Kelekci, Birsen Tozkoparan
BIOORGANIC CHEMISTRY
(2020)
Article
Cardiac & Cardiovascular Systems
Feyza Alyu, Yusuf Olgar, Sinan Degirmenci, Belma Turan, Yusuf Ozturk
Summary: The study demonstrated the toxic effects of sibutramine on cardiovascular system, showing alterations in intracellular Ca2+, H+, and ROS levels, as well as the mechanical activity of isolated hearts. Acute sibutramine applications induced concentration-dependent changes in action potentials and potassium channel currents, leading to negative alterations in contractility and cardiac parameters. These findings have implications for clinical approaches and drug design studies.
CARDIOVASCULAR TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nazli Turan Yucel, Ummuhan Kandemir, Umut Irfan Ucel, Umide Demir Ozkay, Ozgur Devrim Can
Summary: The therapeutic potential of vortioxetine on mechanical hyperalgesia/allodynia was investigated in rats with streptozotocin-induced diabetes, and its possible mechanism of action was elucidated in this study. The findings demonstrated that vortioxetine administration significantly improved diabetes-induced hyperalgesia and allodynia responses in the rats without affecting their motor coordination. The involvement of the catecholaminergic system, alpha(2)- and beta(2)-adrenoceptors, D-2/3 dopaminergic receptors and cholinergic muscarinic receptors in the exhibited pharmacological activity was suggested.
Article
Pharmacology & Pharmacy
Muna Cemal Hussein, Nurcan Bektas, Yusuf Ozturk, Rana Arslan
Summary: This study investigated the antinociceptive effect and mechanisms of action of Moringa stenopetala leaves methanol extract in mice. The extract showed significant antinociceptive effect in various tests, and the involvement of specific receptors was identified.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Oezguer Devrim Can, Umut Irfan Uecel, Uemide Demir Oezkay, Miris Dikmen
CUKUROVA MEDICAL JOURNAL
(2017)