期刊
PLANTA MEDICA
卷 78, 期 1, 页码 39-45出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1280266
关键词
Arnebia euchroma; Boraginaceae; hydroquinone terpenoids; monoterpenylbenzenoid; anti-HCV activity; antibacterial activity
资金
- National Natural Science Foundation of China [21062008, 20862011]
- Foundation for the Author of National Excellent Doctoral Dissertation of P.R. China [200780]
- Fok Ying Tong Education Foundation [111040]
- Specialized Research Fund for the Doctoral Program of Higher Education [20095314110001]
Three new hydroquinone terpenoids with benzogeijerene skeletons, euchroquinols A-C (1-3), and a new monoterpenylbenzenoid, 9,17-epoxyarnebinol (4), along with five known compounds were isolated from the stem bark of Arnebia euchroma. Shikonin (6) exhibited potent anti-HCV activity with a selective index of 43.56, and compounds 1, 6, and des-O-methyllasiodiplodin (7) showed anti-Staphylococcus aureus activity with MICs of 0.5, 0.125, and 0.125 mg/mL, respectively.
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