期刊
PLANTA MEDICA
卷 77, 期 8, 页码 845-848出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1250633
关键词
steroidal saponin; Dioscorea bulbifera L.; Dioscoreaceae; cytotoxicity
资金
- National Natural Science Foundation of China (NSFC) [30701082]
- National Basic Research Program of China [2006CB504704]
Two new steroidal saponins, diosbulbisides D (1) and E (2), along with five known saponins (3-7) were isolated from the rhizomes of Dioscorea bulbifera L. Their structures were elucidated on the basis of spectral data. Compounds 6 and 7, two 3-O-trisaccharides of diosgenin spirostanes, showed moderate cytotoxic activity against human hepatocellular carcinoma cells, with IC50 values of 3.89 mu M and 7.47 mu M on SMMC7721, and 10.87 mu M and 19.10 mu M on Bel-7402 cell lines, respectively.
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