期刊
PLANTA MEDICA
卷 77, 期 7, 页码 726-U52出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1250500
关键词
pristimerol; 8-epi-6-deoxoblepharodol; Celastraceae; Staphylococcus epidermidis; antibacterial activity; membrane disruption
资金
- Government of Canarias [SolSubC200801000049]
Two phenolic triterpenoids, pristimerol (30 mu g/mL) and 8-epi-6-deoxoblepharodol (20 mu g/mL), obtained by catalytic reduction of pristimerin, exhibited bacteriostatic action against Staphylococcus epidermidis. This activity was not dependent on the inoculum size and the growth phase although it showed a stronger effect when cells were growing actively. Addition of phenolic triterpenoids to S. epidermidis cultures in the log-phase of growth led to an inhibitory effect on incorporation and uptake of radiolabeled precursors thymidine, uridine, leucine, and N-acetyl-glucosamine after 30 min of treatment. Furthermore, a clear release of UV-absorbing material and leakage of intracellular potassium were also detected. These findings, coupled with the high lipophilicity of these molecules, shown by high ClogP values, suggest that 8-epi and pristimerol are able to interact within the lipid bilayer and as a consequence cause functional alterations on the cytoplasmic membrane of S. epidermidis cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据