Review
Chemistry, Organic
Lu Guo, Pingping Tang
Summary: Schisandraceae, a traditional Chinese herb known for its anti-hepatitis bioactivity, has diverse and unique structures that have caught the interest of synthetic chemists. Recent efforts towards the total synthesis of schisandra triterpenoid have been summarized.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Oncology
Maobo Huang, Yuanfei Zhou, Dongzhu Duan, Chuanyu Yang, Zhongmei Zhou, Fubing Li, Yanjie Kong, Yi-Ching Hsieh, Ruihan Zhang, Wenping Ding, Weilie Xiao, PemaTenzin Puno, Ceshi Chen
Summary: The study reveals the important role of ubiquitin enzymes in therapeutic resistance in TNBC cells, suggesting that small molecule inhibitors can restore sensitivity to treatment. Specifically, PC3-15 was found to block auto-ubiquitination of HECTD3/UbcH5b and inhibit UbcH5b-mediated p62 ubiquitination, leading to increased sensitivity to lapatinib in TNBC.
Article
Chemistry, Applied
Nguyen Thi Mai, Vu Van Doan, Hoang Thi Tuyet Lan, Bui Thi Mai Anh, Nguyen Huy Hoang, Bui Huu Tai, Nguyen Xuan Nhiem, Pham Hai Yen, Seon Ju Park, Yohan Seo, Wan Namkung, Seung Hyun Kim, Phan Van Kiem
Summary: Phytochemical investigation of Schisandra sphenanthera leaves led to the isolation of new compounds, with schirubrisin B showing strong cytotoxic effects on prostate and breast cancer cells.
NATURAL PRODUCT RESEARCH
(2021)
Article
Food Science & Technology
Zhou Si, Haoxiang Chen, Chensi Gu, Tingting Wang, Ziluan Fan
Summary: Schisandra chinensis extract (SCE) has significant anti-fatigue effects in mice by prolonging swimming time, increasing levels of hepatic and muscular glycogen, reducing levels of lactic acid, blood urea nitrogen, and malondialdehyde, enhancing activities of antioxidant enzymes, and activating the AMPK/PGC-1 alpha signaling pathway.
Article
Food Science & Technology
Lijia Zhang, Mengzhou Yin, Xi Feng, Salam A. Ibrahim, Ying Liu, Wen Huang
Summary: Triterpenoid compounds from Poriae Cutis were separated and identified, with poricoic acid B showing higher anti-inflammatory activity compared to poricoic acid A, while dehydrotrametenolic acid and dehydroeburicoic acid had no anti-inflammatory properties. In addition, in vitro experiments demonstrated that poricoic acid B could decrease the production of cytokines in a dose-dependent manner.
Article
Gastroenterology & Hepatology
Armando A. Roca A. Suarez, Enkhtuul Batbold, Birke Bartosch, Naranjargal Dashdorj, Barbara Testoni, Fabien Zoulim
Summary: Hepatitis delta virus (HDV) is a satellite RNA virus that requires hepatitis B virus (HBV) for replication. Co-infection with HDV/HBV leads to faster disease progression compared to HBV mono-infection. Developing antiviral therapies targeting HDV is crucial. Evaluating promising HDV-specific drugs and combination therapies, as well as exploring anti-HBV drugs with potential effects against HDV, are key areas of research.
LIVER INTERNATIONAL
(2023)
Article
Plant Sciences
Ju-Hsin Cheng, Ho-Cheng Wu, Chia-Hung Yen, Tsong-Long Hwang, Horng-Huey Ko, Hsun-Shuo Chang
Summary: Non-alcoholic fatty liver disease (NAFLD) is a liver disease caused by the accumulation of excess lipids. The research aimed to investigate the bioactive components of Formosan plants that could reduce lipid droplet accumulation. The study found that the methanolic extract of Elaeagnus glabra Thunb. showed excellent anti-LD accumulation activity and isolated several compounds with potential therapeutic effects.
Article
Food Science & Technology
Yuan Fu, Liwen Wang, Guochuan Jiang, Lili Ren, Liyan Wang, Xuejun Liu
Summary: Auricularia cornea var. Li. polysaccharide (ACP) has potential application value in food engineering, pharmaceutical science, and health care due to its important biological activities. The extraction rate and purity of ACP are relatively high, and it has significant effects on reducing blood lipids and glucose, as well as enhancing antioxidant capacity. Moreover, ACP does not have significant adverse effects on organs and tissues.
Article
Biochemistry & Molecular Biology
Yeon Woo Jung, Jung A. Lee, Ji Eun Lee, Hanna Cha, Yun-Hyeok Choi, Wonsik Jeong, Chun Whan Choi, Joa Sub Oh, Eun-Kyung Ahn, Seong Su Hong
Summary: This study extracted 19 secondary metabolites, including a new alpha-hydroxy acid derivative and two new lanostane-type triterpenoids, from the Smilacaceae plant. These compounds showed inhibitory effects on fat accumulation, with compounds 4, 7, 9, and 19 reducing lipid content by 37.05%, 8.60%, 15.82%, and 17.73%, respectively, at a concentration of 100 μM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jiao-Jiao Cui, Ying-Shan Han, Bin Zhou, Jian-Min Yue
Summary: Investigations on Antirhea chinensis led to the discovery of two new pentacyclic triterpenoids and nine known analogs. One of the new compounds showed potent anti-HIV activity and high selectivity.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Medicinal
Tingxu Yan, Nizhi Wang, Bing Liu, Bo Wu, Feng Xiao, Bosai He, Ying Jia
Summary: The study found that lignans in Schisandra chinensis are effective in ameliorating depressive disorders by inhibiting inflammation and regulating gut microbiota balance.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Medicinal
Chao Wang, Quan-Hao Wei, Zhen-Qiang Xin, Lin -Lin Tian, Jun-Sheng Zhang, Hua Zhang
Summary: This study reported new compounds from the root extract of Morinda officinalis and determined their structures and absolute configurations using spectroscopic analysis and computational methods. These compounds showed moderate inhibitory activity against nitric oxide production in murine macrophage cells, and compound 3b also inhibited the secretion of two inflammatory cytokines.
Article
Biochemistry & Molecular Biology
Zhuorui Song, Chengfeng Gao, Qinghua Jiang, Jinyu Xu, Liangliang Xiong, Kexin Liu, Dejuan Sun, Hua Li, Lixia Chen
Summary: Six new diterpenoid alkaloids were isolated from Delphinium forrestii var. vride, with forrestline F showing the strongest anti-inflammatory activity. It acted through multiple mechanisms by suppressing inflammatory cytokines, modulating NF-kappa B/MAPK and Nrf2/HO-1 signaling pathways.
Article
Engineering, Chemical
Mohammed Helmy Faris Shalayel, Ghassab M. M. Al-Mazaideh, Abdulkareem A. A. Alanezi, Afaf F. F. Almuqati, Meshal Alotaibi
Summary: The extract of P. amygdalus var. amara has health benefits, such as lowering diabetes and heart disease risks. It demonstrated potent anti-cancer activity against multiple human tumor cell lines. The treatment significantly decreased cancer cell growth in most cell lines.
Article
Agriculture, Multidisciplinary
Bin Li, Qi Xiao, Jiushi Liu, Xinlu Mu, Jianuo Zhang, Yaodong Qi, Bengang Zhang, Peigen Xiao, Haitao Liu
Summary: The study found that PET2, a subfraction of the extract from Schisandra chinensis fruit, exhibited significant anti-inflammatory effects and potential anti-asthma properties. Six compounds from PET2 were identified to have good anti-inflammatory properties, possibly through the involvement of specific signaling pathways.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
