Sesquiterpene Lactone 12,8-Eudesmanolides from the Fungus Xylaria ianthinovelutina

The investigation of Xylaria ianthinovelutina (Mont.) led to the isolation of four new 12,8-eudesmanolides (1-4). Their structures were determined by spectroscopy and the relative stereochemistry was assigned based on NOESY and CD spectral data. Compounds 1-4 exhibited biological activity against Plasmodium falciparum K-I strain, NCI-H187, KB, MCF-7 with IC(50) values varying in the range 0.78-19.15 mu g/mL.