Article
Chemistry, Inorganic & Nuclear
Aziz Ullah Khan, Hidayat Ullah Khan, Munirah Sulaiman Othman Alhar, Shahnaz, Kamran Tahir, Zainab M. Almarhoon, Magdi E. A. Zaki, Salman Latif, Afzal Shah, Afaq Ullah Khan
Summary: In this study, Fe2O3 and ZnO nanoparticles were synthesized from an aqueous extract of T. glabra. The nanoparticles exhibited antimicrobial and antioxidant activities, as well as antileishmanial effects.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Thayllan Teixeira Bezerra, Mayara Oliveira de Almeida, Nayane Maria de Amorim Lima, Naya Lucia de Castro Rodrigues, Viviane Gomes Pereira Ribeiro, Maria Jania Teixeira, Luigi Carbone, Giuseppe Mele, Diego Lomonaco, Selma Elaine Mazzetto
Summary: This study prepared green-based silver nanoparticles with cashew nutshell liquid and characterized their properties. The in vitro antileishmanial activity tests showed that cardol had high selectivity towards killing the parasite and should be further explored as a promising non-toxic treatment for cutaneous leishmaniasis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Medicinal
Yuan-E Lee, Takeshi Kodama, Hiroyuki Morita
Summary: Investigations found that adding longer alkyl chains to the C-6 position in resorcylic acid conferred antibacterial properties against Staphylococcus aureus and Bacillus subtilis. Olivetolic acid (OA) derivatives with n-undecyl and n-tridecyl side-chains, even without the hydrophobic geranyl moiety at their C-3 positions, exhibited strong antibacterial activities against B. subtilis at a MIC value of 2.5 μM. Furthermore, modifying the C-6 position of cannabigerolic acid (CBGA) with an n-heptyl alkyl chain effectively enhanced the activity against B. subtilis, demonstrating the importance of the alkyl side-chain in modulating bioactivity.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Chemistry, Applied
Akshay Singhal, Deepika Malwal, Shankar Thiyagarajan, Indranil Lahiri
Summary: The development of antibacterial and antibiofilm composites using graphene nanoplatelets offers an effective solution to prevent biofilm formation and reduce the risk of biofilm-associated infections. This innovative strategy combines the hydrophobicity of graphene, tannic acid, silver, and epoxy to enhance the antibiofilm efficiency of coatings on surfaces, demonstrating promising potential in combating biofilm-related issues.
PROGRESS IN ORGANIC COATINGS
(2021)
Article
Chemistry, Applied
Kun Huang, Xuetong Fan, Richard Ashby, Helen Ngo
Summary: The study investigated the structure-activity relationship of antibacterial bio-based epoxy polymers made from phenolic branched fatty acids by preparing curing agents from phenolic BCFAs and polyamines. The bio-epoxy polymers, especially phenol-BCFA (EDA) and creosote BCFA (EDA), demonstrated significant antimicrobial activity against a broad range of bacteria, indicating their potential as inherently antibacterial materials. The study also highlighted the importance of amphiphilicity in contributing to the antimicrobial activity of the bio-epoxy polymers.
PROGRESS IN ORGANIC COATINGS
(2021)
Article
Chemistry, Applied
Daniela Ailincai, Irina Rosca, Simona Morariu, Liliana Mititelu-Tartau, Luminita Marin
Summary: The paper discusses the preparation and characterization of hydrogels from chitooligosaccharides crosslinked with 2-formylphenylboronicacid, showing promising properties in terms of biodegradability and antimicrobial activity. The results indicate that hydrogels with lower polymerization degrees exhibit higher biodegradation rates and remarkable antimicrobial properties against various strains. Further in vivo and in vitro biocompatibility tests on experimental mice demonstrate no cytotoxic effects, highlighting the potential applications of these hydrogels in the biomedical field.
CARBOHYDRATE POLYMERS
(2022)
Article
Immunology
Joao Paulo Araujo de Sousa, Julyanne Maria Saraiva de Sousa, Raiza Raianne Luz Rodrigues, Thais Amanda de Lima Nunes, Yasmim Alves Aires Machado, Alexandre Carvalho de Araujo, Ingrid Gracielle Martins da Silva, Karine Brenda Barros-Cordeiro, Sonia Nair Bao, Michel Mualem de Moraes Alves, Francisco Jaime Bezerra Mendonca-Junior, Klinger Antonio da Franca Rodrigues
Summary: Leishmaniasis, one of the most serious Neglected Tropical Diseases (NTDs), requires urgent therapeutic alternatives due to the problems with currently available drugs. This study found that a thiophene derivative, SB-200, showed promising anti-leishmanial activity and low toxicity in mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Raiza Raianne Luz Rodrigues, Thais Amanda Lima Nunes, Alyne Rodrigues de Araujo, Jose Delano Barreto Marinho Filho, Marcos Vinicius da Silva, Fernando Aecio de Amorim Carvalho, Otilia Deusdenia Loiola Pessoa, Hozana Patricia Silva Freitas, Klinger Antonio da Franca Rodrigues, Ana Jersia Araujo
Summary: The study demonstrated that CORe from Cordia polycephala has antileishmanial activity, being effective against the parasite while non-toxic to host cells. It showed greater efficacy in inhibiting amastigote growth and higher selectivity indexes compared to reference drugs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Judson Vincent Edwards, Nicolette T. Prevost, Dorne Yager, Robert Mackin, Michael Santiago, SeChin Chang, Brian Condon, Joseph Dacorta
Summary: The development of affordable and environmentally friendly barrier fabrics with antimicrobial properties is a current focus in textile research. This study demonstrates the antimicrobial and antiviral properties of spunlaced griege cotton nonwovens treated with ascorbic acid formulations. By promoting enhanced hydrogen peroxide activity, these fabrics show efficacy against both Gram-negative and Gram-positive bacteria, as well as MS2 bacteriophages. A low-cost method for covalent attachment of ascorbic acid to cellulose is also discussed. These findings suggest a simple approach to producing antimicrobial and antiviral cotton-based nonwovens for various applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Amrita Chakrabarti, Chintam Narayana, Nishant Joshi, Swati Garg, Lalit C. Garg, Anand Ranganathan, Ram Sagar, Soumya Pati, Shailja Singh
Summary: This study chemically synthesized a library of glycoside derivatives and evaluated their inhibitory efficacy against Leishmania donovani. The results showed that Gly2 had the highest inhibitory activity against promastigotes and strong binding affinity towards Gp63. In addition to its lethal effects on infectivity and multiplication, Gly2 also enhanced complement-mediated lysis and showed effectiveness against PKDL strain.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Fabiola Suelen dos Santos, Rossimiriam Pereira de Freitas, Camila Simoes de Freitas, Debora Vasconcelos Costa Mendonca, Daniela Pagliara Lage, Grasiele de Sousa Vieira Tavares, Amanda Sanchez Machado, Vivian Tamieti Martins, Adilson Vidal Costa, Vagner Tebaldi de Queiroz, Mariana Belizario de Oliveira, Fabricio Marques de Oliveira, Luciana Maria Ribeiro Antinarelli, Elaine Soares Coimbra, Eduardo Jorge Pilau, Geovane Perez da Silva, Eduardo Antonio Ferraz Coelho, Robson Ricardo Teixeira
Summary: This study synthesized 24 methoxylated cinnamides containing 1,2,3-triazole fragments and evaluated their antileishmanial activity. One of the synthetic compounds, compound 28, demonstrated significant antileishmanial activity with low toxicity in murine cells, making it a potential candidate for the treatment of Leishmaniasis.
Article
Infectious Diseases
Kaio Maciel De Santiago-Silva, Bruna Taciane da Silva Bortoleti, Laudicea do Nascimento Oliveira, Fernanda Lima de Azevedo Maia, Joyce Cristina Castro, Ivete Conchon Costa, Danielle Bidoia Lazarin, James L. Wardell, Solange M. S. Wardell, Magaly Girao Albuquerque, Camilo Henrique da Silva Lima, Wander Rogerio Pavanelli, Marcelle de Lima Ferreira Bispo, Raoni Schroeder B. Goncalves
Summary: Leishmaniasis is a neglected tropical disease with limited therapeutic options. In this study, new compounds were synthesized and evaluated for their biological activity against different forms of Leishmania parasites. Compound 4f showed the most promising results, exhibiting potent inhibitory effects on promastigotes and low toxicity to cells.
Article
Chemistry, Multidisciplinary
Souvik Misra, Soumyajit Mukherjee, Anamika Ghosh, Pijush Singh, Sanjoy Mondal, Debes Ray, Gourav Bhattacharya, Debabani Ganguly, Alok Ghosh, V. K. Aswal, Ajit K. Mahapatra, Biswarup Satpati, Jayanta Nanda
Summary: The flexibility and aromatic functionality of phenylalanine were found not to be essential for the gel formation of model gelator Fmoc-Phe-OH, as demonstrated by the formation of hydrogels by three new analogues with slightly varied structures. These analogues also showed promising antimicrobial activity and biocompatibility with human blood cells, suggesting the potential for developing new injectable biomaterials with improved properties through minor alterations in amino acid side chains.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Applied
Moses Andima, Albert Ndakala, Solomon Derese, Sarkar Biswajyoti, Aabid Hussain, Li Jun Yang, Otieno Elsie Akoth, Paolo Coghi, Chiranjib Pal, Matthias Heydenreich, Vincent Kam-Wai Wong, Abiy Yenesew
Summary: The study investigated the antileishmanial and cytotoxic activities of secondary metabolites from three plant species. Voacristine and aloenin showed strong activity against Leishmania donovani, while ursolic acid exhibited significant inhibition of lung cancer cells. Other compounds were inactive in the tests.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ran Tao, Yin Lu, Wubing Xia, Changwei Zhang, Chengzhang Wang
Summary: This study successfully prepared a ruthenium coordination polymer composite with chitosan quaternary ammonium polymers and shikimic acid. The composite showed good antibacterial properties, with a strong inhibitory effect against S. aureus and the ability to disrupt their biofilm formation. Further mechanism studies revealed that the composite influenced the cell membrane integrity and intracellular Ca2+ levels of S. aureus.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Meirambek Ospanov, Suresh P. Sulochana, Jason J. Paris, John M. Rimoldi, Nicole Ashpole, Larry Walker, Samir A. Ross, Abbas G. Shilabin, Mohamed A. Ibrahim
Summary: Modulating the endocannabinoid system holds therapeutic potential in various pathophysiological processes. Novel Pyrrolo[2,1-c][1,4]benzodiazepines tricyclic compounds with high conformational similarity to the CB2 active site were designed for precise modulation. By synthesizing analogs and conducting binding assays, two potent and selective CB2 ligands were identified. Compound 4k exhibited oral bioavailability and favorable pharmacokinetic properties.
Article
Biochemistry & Molecular Biology
Ahmed I. Foudah, Mohammad H. Alqarni, Aftab Alam, Mohammad Ayman Salkini, Samir A. Ross, Hasan S. Yusufoglu
Summary: In this study, the leaves of Petroselinum crispum were collected from Saudi Arabia and the essential oil isolated from the leaves showed excellent antimicrobial and anti-inflammatory potential. The main constituent, myristicin, could be valuable for the development of anti-inflammatory and antimicrobial drugs.
Article
Biochemistry & Molecular Biology
Anjela Manandhar, Mona H. Haron, Samir A. Ross, Michael L. Klein, Khaled M. Elokely
Summary: This study investigates the interaction between vitamin E and the membrane-bound cannabinoid 2 receptor (CB2R), and its impact on the binding affinity of tetrahydrocannabinol (THC) to CB2R. Results show that vitamin E reduces THC binding to CB2R by widening the binding cavity and forming stable interactions. This study highlights the role of vitamin E in limiting the effect of THC and its implications on EVALI pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agronomy
Ahmed Foudah, Prawez Alam, Faiyaz Shakeel, Aftab Alam, Mohammad A. Salkini, Sultan Alshehri, Mohammed M. Ghoneim, Samir A. Ross
Summary: A simple, cost-effective, and green HPTLC method was developed for estimating ascorbic acid in plant extracts. The method showed excellent green profile and outperformed in extracting ascorbic acid.
Article
Chemistry, Multidisciplinary
Shimaa M. Abdelgawad, Mona H. Hetta, Mohamed A. Ibrahim, Premalatha Balachandran, Jin Zhang, Mei Wang, Wagdy M. Eldehna, Ghada A. Fawzy, Hesham I. El-Askary, Samir A. Ross
Summary: The study identified compounds from the extract of Sesbania sesban L. Merr. leaves with inhibitory effects on leukemia cells, some of which showed high antiproliferative effects. These compounds had impacts on various cancer-related signaling pathways and exhibited strong binding affinities to specific targets in K562 cell line, indicating their potential for cancer treatment.
JOURNAL OF CHEMISTRY
(2022)
Article
Plant Sciences
Aizhan Zhussupova, Gaziza Zhumaliyeva, Vyacheslav Ogay, Assel Issabekova, Samir A. Ross, Galiya E. Zhusupova
Summary: The study evaluated the immunomodulatory effects of extracts from Salvia deserta and Salvia sclarea plants, showing significant influences on the immune responses of macrophages and lymphocytes, either stimulating or inhibiting inflammatory reactions.
Article
Chemistry, Multidisciplinary
Ahmed I. Foudah, Mohammed H. Alqarni, Samir A. Ross, Aftab Alam, Mohammad Ayman Salkini, Piyush Kumar
Summary: This study provides a comprehensive evaluation of dendrimer G4 poloxamer nanoparticles loaded with bioactive coumarin against MRSA. The results showed that these newly developed nanoparticles have lower levels of hemolysis and cytotoxicity, and coumarin released from the nanoparticles at a slower rate, potentially enhancing its defense against MRSA.
Article
Biochemistry & Molecular Biology
Mamdouh Nabil Samy, Basma Khalaf Mahmoud, Nourhan Hisham Shady, Usama Ramadan Abdelmohsen, Samir Anis Ross
Summary: Bioassay-guided fractionation technique of roots of Paeonia officinalis led to the isolation and structure elucidation of seven known compounds, which showed antimicrobial and antimalarial activities.
Article
Biochemistry & Molecular Biology
Nurlen Manassov, Mamdouh Nabil Samy, Ubaidilla Datkhayev, Bharathi Avula, Sebastian John Adams, Kumar Katragunta, Vijayasankar Raman, Ikhlas A. Khan, Samir A. Ross
Summary: The lichen Cetraria islandica (L.) Ach. has been extensively studied for its various biological properties and chemical composition. This study focused on profiling the morpho-anatomical features, elemental analysis, and phytochemical analysis of C. islandica. A total of 37 compounds were identified and characterized, and nine compounds were isolated and structurally elucidated.
Article
Biochemistry & Molecular Biology
Umit Mukatay, Mamdouh Nabil Samy, Bharathi Avula, Kumar Katragunta, Moldir Kemelbek, Azhar Zhubanova, Ikhlas A. Khan, Samir Anis Ross
Summary: Phytochemical investigation of Artemisia heptapotamica Poljak led to the isolation of ten known compounds, including alkyl p-coumarates, sesquiterpene lactone, flavonoids, and phenolic acid derivative. The structures of the compounds were identified using spectroscopic analyses. The antimicrobial activity of the extracts and fractions was tested, and no inhibition of the growth of various pathogens was observed at the tested concentrations.
Review
Chemistry, Medicinal
Emad H. M. Hassanein, Mostafa S. Abd El-Maksoud, Islam M. Ibrahim, Esraa K. Abd-alhameed, Hanan S. Althagafy, Nesma M. Mohamed, Samir A. Ross
Summary: Galangin, a naturally occurring flavonoid, has many biological activities including anti-inflammatory effects. Its mechanism of action involves suppressing p38 MAPK, NF-kB, and NLRP3 signaling pathways, which has been confirmed by molecular docking. Clinical translational research is needed to determine if galangin can be used as a safe natural source of anti-inflammatory medication for humans.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Analytical
Ghada Abdel-Moez, Bharathi Avula, Hanaa Sayed, Azza Khalifa, Samir Ross, Kumar Katragunta, Ikhlas Khan, Shaymaa Mohamed
Summary: In this study, the chemical characteristics of three edible Amaranthus species were analyzed using non-targeted liquid chromatography-tandem mass spectrometry technique. Forty-one compounds were identified, with amino acids and flavonoid glycosides being the most prevalent. The identified compounds varied in distribution and abundance across the investigated species, providing chemotaxonomic identities.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Medicinal
Ahmed I. Foudah, Aftab Alam, Mohammad Ayman Salkini, Samir A. Ross, Piyush Kumar, Mohammed F. Aldawsari, Mohammed H. Alqarni, Sherouk Hussein Sweilam
Summary: The LTZ-BBR@AA-AuNPs is a novel drug delivery system that effectively combines LTZ and BBR, providing stability and high efficiency. It demonstrates potent cytotoxicity against breast cancer cells and has sustained and controlled drug release to minimize negative side effects.
Article
Chemistry, Medicinal
Shaymaa M. Mohamed, Samir A. Ross, Mai A. M. Ahmed
Summary: This study conducted phytochemical investigation of Gardenia latifolia Aiton and found compounds with anti-influenza activity. Canthoside C and ecdysanrosin A showed high anti-influenza activity and low cytotoxicity to host cells, indicating their potential as antiviral agents.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)
Article
Chemistry, Medicinal
Shimaa M. Abdelgawad, Mona H. Hetta, Mohamed A. Ibrahim, Premalatha Balachandran, Jin Zhang, Mei Wang, Ghada A. Fawzy, Hesham El-Askary, Samir A. Ross
Summary: Spinach leaves cultivated in Egypt have shown potential anti-leukemia activity against K562 cell line. Phytochemical investigation revealed seventeen known compounds with antiproliferative activity. In silico and molecular dynamics studies indicated strong binding affinity of specific compounds towards topoisomerase and Abl kinase. Further in vivo and preclinical studies are recommended to evaluate the potential benefits for chronic myeloid leukemia patients.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)
