Article
Food Science & Technology
Feng Gao, Shihai Yan, Zheng Sun, Jia Wang
Summary: This study aimed to determine the effects and mechanism of action of muscone on the biological activity of gastric cancer cell lines SGC-7901 and MGC-803, and found that muscone can suppress the biological activity of SGC-7901 and MGC-803 gastric cancer cells in vitro by regulating miRNA-145.
FOOD SCIENCE & NUTRITION
(2021)
Article
Oncology
Xiaoqing Qian, Feng Xie, Huabing Wei, Daxiang Cui
Summary: Exosomal miRNAs are potential biomarkers for predicting gastric cancer development. This study identified differentially expressed miRNAs in serum and urine exosomes of GC patients, with specific up-regulated miRNAs identified. The interaction network of these miRNAs' targets may provide insights into molecular mechanisms of GC development.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Xiaosheng Wu, Hao Wang, Danping Zhu, Yixia Chai, Jing Wang, Weiyu Dai, Yizhi Xiao, Weimei Tang, Jiaying Li, Linjie Hong, Miaomiao Pei, Jieming Zhang, Zhizhao Lin, Jide Wang, Aimin Li, Side Liu
Summary: This study reveals the mechanism of how deubiquitinating enzyme USP3 promotes tumor progression and metastasis in gastric cancer. The downstream targets of USP3, COL9A3 and COL6A5, are identified using isobaric tags technique. The results show that USP3 interacts with and stabilizes COL9A3 and COL6A5 through deubiquitination, playing a crucial role in the oncogenic activity of USP3 both in vitro and in vivo.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Mengyao Lin, Shun Hu, Tianyi Zhang, Jiezhen Li, Feng Gao, Zhenzhen Zhang, Ke Zheng, Guoping Li, Caihong Ren, Xiangna Chen, Fang Guo, Sheng Zhang
Summary: This study investigates the role of exosomes in the intercellular transmission of EBV-miRNA-BART and their effect on tumor cell proliferation and invasion. The study characterizes exosomes secreted by EBV-positive and negative gastric cancer cells and identifies their miRNA expression profiles. Co-culture experiments demonstrate that miR-BART1-3p transmitted through exosomes can significantly influence the growth of gastric cancer cells by targeting genes such as FAM168A, MACC1, CPEB3, ANKRD28, and USP37.
Article
Chemistry, Medicinal
Beiwei Liang, Chunlai Li, Zhan Zhou, Yubo Xie
Summary: This study aimed to investigate the effect of hydromorphone on the growth of human gastric cancer cells. The results showed that within a certain concentration range, hydromorphone can suppress the growth of human gastric cancer cells, and the inhibitory effect is enhanced with longer incubation time and higher concentrations. Hydromorphone inhibits the growth of human gastric cancer cells through cell cycle arrest and induction of apoptosis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Cheng Yan, Huijie Yang, Peng Su, Xin Li, Zhongbo Li, Dehai Wang, Yifeng Zang, Tianshi Wang, Ziping Liu, Zhuocong Bao, Shuxiao Dong, Ting Zhuang, Jian Zhu, Yinlu Ding
Summary: Gastric cancer is a deadly disease and recent studies have shown that abnormality in the Hippo/YAP axis plays a critical role in its development. Inhibiting the deubiquitination of YAP protein could be a potential new therapeutic target for gastric cancer.
Article
Biotechnology & Applied Microbiology
Xuehe Wang, Huaqin Sun, Simin Zhu
Summary: The study demonstrated that an aberrant upregulation of PTAR in cervical cancer tissues and cell lines promotes proliferation, migration, and invasion of HeLa cells, while inhibiting apoptosis and downregulating miR-101 expression through direct binding. These findings suggest that PTAR plays a crucial role and may serve as a promising target for cervical cancer diagnosis and therapy.
Article
Biotechnology & Applied Microbiology
Zhi Chen, Mei-Xiang Sang, Cui-Zhi Geng, Hui-Qun Jia
Summary: This study determines the role of miR-409 in breast cancer by targeting SATB1 and highlights its potential as a therapeutic target for the treatment of breast cancer.
Article
Biotechnology & Applied Microbiology
Sihan Lin, Zhiyong Yan, Qiaofei Tang, Shuang Zhang
Summary: UBAP2L is found to be highly expressed in gastric cancer and plays a role in promoting malignant behavior through activation of the Wnt/beta-catenin signaling pathway, affecting the survival of gastric cancer patients. Silencing UBAP2L inhibits proliferation, migration, and invasion of tumor cells, induces apoptosis, while overexpression has opposite effects.
Article
Biochemistry & Molecular Biology
Guo-Dian Zheng, Zhi-Yuan Xu, Can Hu, Hang Lv, Hua-Xia Xie, Ting Huang, Yan-Qiang Zhang, Gui-Ping Chen, Yu-Fei Fu, Xiang-Dong Cheng
Summary: The study found that the expression of exosomal miR-590-5p is associated with the clinical stage, infiltration depth, and ki-67 expression level of GC. A decrease in exosomal miR-590-5p expression is correlated with a decrease in overall survival rate. As an independent predictor, miR-590-5p may inhibit cell migration and invasion, potentially serving as a biomarker for early detection and prediction of GC.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Immunology
Sen Zhang, Huangfu Hui, Qinli Zhao, Yujun Li, Lina Wu
Summary: This study revealed that the long noncoding RNA HCP5 is highly expressed in laryngeal squamous cell carcinoma (LSCC) and plays a role in promoting cancer cell growth, migration, and invasion. HCP5 interacts with miR-216a-5p, and its knockdown inhibits the malignant biological function of LSCC cells. Moreover, miR-216a-5p downregulates the expression of ZEB1, a target gene involved in LSCC progression. These findings suggest that targeting HCP5 may be a potential therapeutic strategy for LSCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Xuefeng Yang, Shuang Cai, Yue Shu, Xun Deng, Yuanwei Zhang, Nian He, Lei Wan, Xu Chen, Yan Qu, Shouyang Yu
Summary: The study showed an increase in the proportion of M2 macrophages in gastric cancer tissues, where M2 macrophages promoted cell proliferation and tumorigenesis through exosomal miR-487a targeting TIA1. These findings may contribute to the development of novel diagnostic and therapeutic methods for gastric cancer.
Article
Biochemistry & Molecular Biology
Dongbao Li, Yuhong Wang, Chao Dong, Tao Chen, Anqi Dong, Jiayu Ren, Weikang Li, Gege Shu, Jiaoyang Yang, Wenhao Shen, Lei Qin, Lin Hu, Jin Zhou
Summary: This study revealed that CST1 promotes gastric cancer metastasis and progression by regulating GPX4 and inhibiting ferroptosis. High CST1 expression is associated with poor prognosis, and it inhibits ferroptosis by stabilizing GPX4 and reducing intracellular ROS levels, enhancing migration, invasion, and epithelial-mesenchymal transition of gastric cancer cells. CST1 may serve as a new oncological marker and therapeutic target for gastric cancer metastasis.
Article
Oncology
Houxiang Jiang, Yinhua Liu, Kaifeng Hu, Yabin Xia, Linhu Liang, Xiaoli Zhu, Xianfeng Cheng
Summary: miRNA-339 inhibits the proliferation and invasion of GC cells by targeted regulation of ZNF689 expression, showing potential therapeutic value. Additionally, the expression level of miRNA-339 can serve as a biomarker for prognosis.
TRANSLATIONAL CANCER RESEARCH
(2021)
Review
Cell Biology
Fang Liu, Yanfen Shi, Zuolong Liu, Ziyi Li, Wei Xu
Summary: Evidence has shown that miRNAs are crucial in the tumorigenesis and progression of various cancers, including gastric cancer, with miR-10a and miR-10b identified as key players in gastric carcinogenesis. Targeting the miR-10 family could be a promising approach for treating gastric cancer, as it regulates multiple aspects of cancer cell behavior and various compounds have shown antitumor activity by targeting these miRNAs.