Article
Surgery
Hao Xing, Li-Yang Sun, Wen-Tao Yan, Bing Quan, Lei Liang, Chao Li, Ya-Hao Zhou, Hong Wang, Jian-Hong Zhong, Wei-Min Gu, Ting-Hao Chen, Ming-Da Wang, Han Wu, Timothy M. Pawlik, Wan Yee Lau, Meng-Chao Wu, Feng Shen, Tian Yang
Summary: The study showed that patients who underwent repeat hepatectomy for early recurrence of hepatocellular carcinoma had worse overall survival and disease-free survival compared to those with late recurrence. These findings can provide guidance for physicians in selecting patients for repeat hepatectomy.
Article
Oncology
Chenwei Wang, Kai Li, Zhenkun Huang, Yichuan Yuan, Wei He, Yun Zheng, Ruhai Zou, Binkui Li, Yunfei Yuan, Jiliang Qiu
Summary: This study compared the treatment efficacy of repeat hepatectomy (RH) and percutaneous ablation (PA) in early-stage rHCC patients with early or late recurrence. The results showed that both RH and PA can offer comparable survival rates and recurrence rates for early-stage rHCC patients, regardless of whether they experience early or late recurrence.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Chenwei Wang, Kai Li, Zhenkun Huang, Yichuan Yuan, Wei He, Yun Zheng, Ruhai Zou, Binkui Li, Yunfei Yuan, Jiliang Qiu
Summary: This study aimed to compare the treatment efficacy of repeat hepatectomy (RH) and percutaneous ablation (PA) in early-stage recurrent hepatocellular carcinoma (rHCC) patients with early or late recurrence. The results showed that RH and PA had similar 5-year overall survival (OS) and repeat recurrence-free survival (rRFS) rates for both early and late recurrence patients. Therefore, both RH and PA are feasible treatment options for early-stage rHCC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Riccardo Nevola, Rachele Ruocco, Livio Criscuolo, Angela Villani, Maria Alfano, Domenico Beccia, Simona Imbriani, Ernesto Claar, Domenico Cozzolino, Ferdinando Carlo Sasso, Aldo Marrone, Luigi Elio Adinolfi, Luca Rinaldi
Summary: Hepatocellular carcinoma (HCC) is the most common liver neoplasm with increasing incidence rates. Long-term outcomes of potentially curative treatments are affected by high recurrence rates, with early recurrence being caused by the spread of the primary neoplasm and related to tumor burden, and late recurrence being independent of the primary neoplasm. Early HCC recurrence has a poorer prognosis than late recurrence, and different predictors exist for each type of recurrence. Understanding predictive factors and recurrence risk stratification is important for guiding treatment strategies and post-treatment surveillance.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Wen-Tao Yan, Chao Li, Lan-Qing Yao, Hai-Bo Qiu, Ming-Da Wang, Xin-Fei Xu, Ya-Hao Zhou, Hong Wang, Ting-Hao Chen, Wei-Min Gu, Jian-Hong Zhong, Han Wu, Timothy M. Pawlik, Wan Yee Lau, Feng Shen, Tian Yang
Summary: This study identified predictors and long-term prognosis of early and late recurrence after hepatic resection for hepatocellular carcinoma (HCC). Results showed that there were different independent predictors associated with early and late recurrence, with patients experiencing early recurrence having poorer long-term survival compared to those with late recurrence.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Article
Oncology
Wen-Qiang Wang, Xing Lv, Jian Li, Jiang Li, Jin-Lin Wang, Tong Yuan, Jun-Jie Liu, Rong-Hua Zhu, Zhi-Yong Huang, Er-Lei Zhang
Summary: This study compared the long-term outcomes of repeat hepatectomy (RH) and microwave ablation (MWA) for recurrent hepatocellular carcinoma (HCC) and found that RH had significantly better recurrence-free survival (RFS) and overall survival (OS) rates than MWA. Early recurrence, cirrhosis, and high AFP level were identified as independent risk factors for poor prognoses of recurrent HCC. Both MWA and RH had similar long-term outcomes in patients with early recurrence, whereas RH had better RFS and OS than MWA in patients with late recurrence.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ying Zhao, Jingjun Wu, Qinhe Zhang, Zhengyu Hua, Wenjing Qi, Nan Wang, Tao Lin, Liuji Sheng, Dahua Cui, Jinghong Liu, Qingwei Song, Xin Li, Tingfan Wu, Yan Guo, Jingjing Cui, Ailian Liu
Summary: Radiomics analysis based on multiparametric MRI can predict early recurrence of hepatocellular carcinoma, providing important support for individualized treatment planning and risk stratification.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Oncology
Nikolaos Machairas, Dimitrios Papaconstantinou, Panagiotis Dorovinis, Diamantis I. Tsilimigras, Myrto D. Keramida, Stylianos Kykalos, Dimitrios Schizas, Timothy M. Pawlik
Summary: In patients with recurrent hepatocellular carcinoma (HCC), both repeat hepatectomy (RH) and radiofrequency ablation (RFA) are viable treatment options. This systematic review and meta-analysis aimed to compare the outcomes of patients undergoing RH versus RFA for recurrent HCC. The results showed that both treatments had comparable overall and disease-free survival rates, but patients undergoing RH were less likely to develop a second recurrence. However, RH was associated with higher overall and major morbidity rates. Despite this, repeat resection remains the preferred option due to its better disease control.
Article
Oncology
Yun-Le Linn, Darren W. Chua, Ye-Xin Koh, Ek-Khoon Tan, Jin-Yao Teo, Peng-Chung Cheow, Prema Raj Jeyaraj, Pierce K. H. Chow, London L. P. J. Ooi, Alexander Y. F. Chung, Chung-Yip Chan, Brian K. P. Goh
Summary: This study evaluated the outcomes of 235 patients post resection of T4 HCC and found that vascular invasion was a significant predictor of early recurrence within 12 months post resection. Patients who experienced early recurrence had significantly shorter overall survival.
SURGICAL ONCOLOGY-OXFORD
(2021)
Article
Surgery
YiFeng Wu, ChaoYong Tu, ChuXiao Shao
Summary: This study found that monocyte to lymphocyte ratio (MLR), tumor size, tumor differentiation, and BCLC stage are all risk factors for early recurrence and recurrence-free survival of hepatocellular carcinoma. Combining these factors can better predict the occurrence of early recurrence.
Article
Oncology
Lin-Qiang Li, Lei Liang, Li-Yang Sun, Chao Li, Han Wu, Yao-Ming Zhang, Wan-Guang Zhang, Hong Wang, Ya-Hao Zhou, Wei-Min Gu, Ting-Hao Chen, Jie Li, Ying-Jian Liang, Qiu-Ran Xu, Yong-Kang Diao, Hang-Dong Jia, Ming-Da Wang, Cheng-Wu Zhang, Feng Shen, Dong-Sheng Huang, Tian Yang
Summary: This study found that postoperative morbidity following hepatectomy for hepatocellular carcinoma (HCC) is an independent risk factor affecting long-term survival and recurrence. Patients with postoperative morbidity had higher rates of both early and late recurrence compared to those without, and experienced decreased overall survival and time-to-recurrence.
Article
Oncology
Xiao-Hui Wang, Qing-Bo Liu, Cai-Ling Xiang, Xian-Hai Mao, Bing Yang, Qiang Li, Qun-Fang Zhou, Shao-Qiang Li, Zhong-Guo Zhou, Min-Shan Chen
Summary: The study aimed to develop novel models to predict the long-term outcomes of patients with huge hepatocellular carcinoma (H-HCC) without portal vein tumor thrombus after hepatectomy. The novel models, based on independent preoperative and postoperative predictors, showed significantly higher predictive accuracy for postsurgical recurrence and mortality compared to conventional HCC staging systems.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Rong-yun Mai, Jie Zeng, Wei-da Meng, Hua-ze Lu, Rong Liang, Yan Lin, Guo-bin Wu, Le-qun Li, Liang Ma, Jia-zhou Ye, Tao Bai
Summary: The study found that an artificial neural network model can predict PHER for HCC patients more accurately, aiding in determining postoperative treatment and monitoring.
Article
Gastroenterology & Hepatology
Boram Lee, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Jun Suh Lee, Moonhwan Kim, Yeongsoo Jo
Summary: This study compared the clinical outcomes of laparoscopic anatomical resection (LAR) and laparoscopic non-anatomical resection (LNAR) for hepatocellular carcinoma (HCC) located in the posterosuperior (PS) segments. LNAR was found to have shorter operation time, lower blood loss, lower transfusion rate, and shorter hospital stay compared to LAR. Overall survival rates and recurrence-free survival rates were similar between the two groups, but LNAR had a higher intrahepatic recurrence rate. LNAR is considered safe and feasible for HCC located in PS segments when LAR is not feasible.
HEPATOBILIARY SURGERY AND NUTRITION
(2022)
Article
Oncology
Pinxiong Li, Lei Wu, Zhenhui Li, Jiao Li, Weitao Ye, Zhenwei Shi, Zeyan Xu, Chao Zhu, Huifen Ye, Zaiyi Liu, Changhong Liang
Summary: The study explored the usefulness of spleen radiomics features on predicting early and late recurrences of HCC patients after curative resection. The spleen radiomics signature was identified as an independent risk factor for early recurrence and the mixed model integrating various factors showed improved predictive performance. In late recurrence analysis, the spleen radiomics signature was found to be the only prognostic factor associated with late recurrence of HCC.
FRONTIERS IN ONCOLOGY
(2021)