Article
Medicine, General & Internal
Heiner Wedemeyer, Soo Aleman, Maurizia Rossana Brunetto, Antje Blank, Pietro Andreone, Pavel Bogomolov, Vladimir Chulanov, Nina Mamonova, Natalia Geyvandova, Viacheslav Morozov, Olga Sagalova, Tatyana Stepanova, Annemarie Berger, Dmitry Manuilov, Vithika Suri, Qi An, Ben Da, John Flaherty, Anu Osinusi, Yang Liu, Uta Merle, Julian Schulzezur Wiesch, Stefan Zeuzem, Sandra Ciesek, Markus Cornberg, Pietro Lampertico
Summary: In this study, it was found that bulevirtide is effective in inhibiting the entry of hepatitis D virus and reducing the progression of liver disease in patients with chronic hepatitis B. The recommended dosage of bulevirtide is 2 mg or 10 mg per day.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Heiner Wedemeyer, Soo Aleman, Maurizia Rossana Brunetto, Antje Blank, Pietro Andreone, Pavel Bogomolov, Vladimir Chulanov, Nina Mamonova, Natalia Geyvandova, Viacheslav Morozov, Olga Sagalova, Tatyana Stepanova, Annemarie Berger, Dmitry Manuilov, Vithika Suri, Qi An, Ben Da, John Flaherty, Anu Osinusi, Yang Liu, Uta Merle, Julian Schulze zur Wiesch, Stefan Zeuzem, Sandra Ciesek, Markus Cornberg, Pietro Lampertico
Summary: Bulevirtide treatment reduces HDV RNA and ALT levels in patients with chronic hepatitis D, with a dose-dependent effect.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Medicine, General & Internal
Zhijiang Miao, Zhenrong Xie, Li Ren, Qiuwei Pan
Summary: HDV infection can cause severe hepatitis leading to cirrhosis and hepatocellular carcinoma, requiring advanced scientific knowledge and joint efforts from multi-stakeholders to combat effectively.
CHINESE MEDICAL JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Mojisola Ogunnaike, Srijanee Das, Samiksha S. Raut, Ashrafi Sultana, Mohammad Ullah Nayan, Murali Ganesan, Benson J. Edagwa, Natalia A. Osna, Larisa Y. Poluektova
Summary: Chronic hepatitis B virus (HBV) infection can lead to the development of cirrhosis and hepatocellular carcinoma. Lifelong treatment with nucleotides/nucleoside antiviral agents is effective but adherence can be challenging. This review discusses recent advances in the development of long-acting formulations and curative strategies for HBV treatment, highlighting promising antivirals and genome editing approaches.
Review
Gastroenterology & Hepatology
Zhongren Ma, Robert A. de Man, Nassim Kamar, Qiuwei Pan
Summary: The understanding and management of chronic hepatitis E have made some progress, but there are still many unanswered questions and challenges that require further advancement in research and patient care.
JOURNAL OF HEPATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Zhe Dong, Jiang-Rong Li, Zhi-Xian Zhao, Lin Xu, Wen Yu, Wen-Yu Kang, Qiong-Fen Li
Summary: The study investigated the distribution of HBV genotypes and subgenotypes in ethnic minorities in Yunnan province, finding variations in genotype and subgenotype distribution among the 20 ethnic groups, with geographical and ethnic factors influencing genotype distribution.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Gastroenterology & Hepatology
Erkin Musabaev, Chris Estes, Shakhlo Sadirova, Shokhista Bakieva, Krestina Brigida, Rick Dunn, Shyamasundaran Kottilil, Poonam Mathur, Ameer Abutaleb, Kathryn Razavi-Shearer, Tim Anstiss, Bakhodir Yusupaliev, Homie Razavi
Summary: Chronic infection with HBV and HCV is a major cause of liver disease and mortality in Uzbekistan. This study demonstrated the feasibility of large-scale simplified testing and treatment to implement a national viral hepatitis elimination program.
LIVER INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Iain A. Gillespie, K. Arnold Chan, Yunhao Liu, Shu-Feng Hsieh, Christian Schindler, Wendy Cheng, Rose Chang, Elisabeth Kap, Eleonora Morais, Mei Sheng Duh, Suna Park, Miriam Ketz, Sarah Jenner, Naomi Boxall, Stuart Kendrick, Dickens Theodore
Summary: This study provides a comprehensive analysis of the prevalence, characteristics, treatment patterns, and long-term clinical outcomes of patients with chronic HBV infection in the US, Germany, and Taiwan. The study highlights the need for effective treatments and suggests differences in treatment patterns and outcomes among the three countries.
ADVANCES IN THERAPY
(2023)
Article
Gastroenterology & Hepatology
Feng Tian, Jordan J. Feld, Zeny Feng, Beate Sander, William W. L. Wong
Summary: The study suggests that the current strategies for vaccination, screening, and treatment are inadequate to achieve WHO's goal of eliminating chronic hepatitis B. Even with extensive integrated scale-up, the morbidity and mortality targets may not be reachable.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Po-Yao Hsu, Yu-Ju Wei, Po-Cheng Liang, Jia-Jung Lee, Sheng-Wen Niu, Jiun-Chi Huang, Cheng-Ting Hsu, Tyng-Yuan Jang, Ching- Huang, Yi-Hung Lin, Ming-Yen Hsieh, Meng-Hsuan Hsieh, Szu-Chia Chen, Chia-Yen Dai, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Jer-Ming Chang, Ming-Lun Yeh, Chung-Feng Huang, Yi-Wen Chiu, Shang-Jyh Hwang, Wan-Long Chuang, Ming-Lung Yu
Summary: Hemodialysis patients are at increased risk of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. This study found that hemodialysis patients with HCV exhibited a higher burden of comorbidities, especially in ischemic heart diseases, respiratory disorders, and mental/behavioral disorders, compared to patients with HBV and those without viral hepatitis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Immunology
Shuling Wu, Wei Yi, Yuanjiao Gao, Wen Deng, Xiaoyue Bi, Yanjie Lin, Liu Yang, Yao Lu, Ruyu Liu, Min Chang, Ge Shen, Leiping Hu, Lu Zhang, Minghui Li, Yao Xie
Summary: Functional cure is considered achieved when chronic hepatitis B patients achieve HBsAg seroclearance after treatment. Clearing the virus is challenging due to the difficulty in clearing both cccDNA and integrated dslDNA. High levels of HBsAg in the serum lead to immune system failure, making it unable to produce an effective antiviral response. Only less than 1% of chronic hepatitis B patients are cured annually with antiviral treatment. Coinfection with other viruses such as HIV, HCV, and HDV makes it even more difficult to cure. However, it has been found that patients with coinfection have a higher probability of achieving HBsAg seroclearance, especially those with HBV/HIV coinfection with up to 36% 5-year seroclerance rate. This interesting phenomenon is related to the functional reconstruction of the immune system after antiretroviral therapy (ART).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Shih-Han Hung, Tzong-Hann Yang, Yen-Fu Cheng, Chin-Shyan Chen, Herng-Ching Lin
Summary: This case-control study investigates the associations between head and neck cancer (HNC), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection, and suggests a potential association between HBV and HCV infections and the risk of HNC.
Article
Public, Environmental & Occupational Health
Samina Ejaz, Iqra Abdullah, Waqas Nazir Malik, Shazia Anjum, Muhammad Ashraf, Naveed Akhtar, Aurangzeb Khan, Yasir Hameed, Muhammad Usman, Usman Cheema, Safeena Sidiq
Summary: This study aims to investigate the prevalence and associated risk factors of hepatitis among students and employees in Pakistan and implement measures to make IUB hepatitis free. The study found that hepatitis is more prevalent in men and is associated with sharing of needles and certain behavioral and medical factors.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Immunology
Siyu Li, Na Li, Shanru Yang, Haiyan Deng, Yanguo Li, Yixuan Wang, Jiaqiang Yang, Jiaxin Lv, Lan Dong, Guansen Yu, Xin Hou, Geng Wang
Summary: This review introduces the mechanisms, immune checkpoint expression, and current treatments of chronic hepatitis B (CHB), and discusses the possibilities of using immune checkpoint inhibitors to treat CHB.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Health Policy & Services
Ermias Diro, Maria A. Corcorran, Kristine Lan, Ayushi Gupta, H. Nina Kim
Summary: An assessment was conducted on the adherence to the CDC guideline for screening hepatitis B virus infection in non-U.S. born individuals. The study found that only 26.5% of eligible individuals were screened, with a high prevalence of infection among those screened. This suggests a significant number of hepatitis B cases may be missed. Urgent efforts are needed to promote and consistently implement HBV screening in primary care clinics.
JOURNAL OF COMMUNITY HEALTH
(2022)
Article
Surgery
D. Cuccurullo, L. Guerriero, G. Mazzoni, C. Sagnelli, E. Tartaglia
Summary: This study presents an innovative robotic approach for the treatment of rectus diastasis with concurrent primary or incisional ventral hernias. The results demonstrate that the operative time and hospital stay were relatively long, while complications and recurrence rate were low.
Review
Infectious Diseases
Caterina Sagnelli, Margherita Macera, Clarissa Camaioni, Annabella Salvati, Nicola Coppola, Evangelista Sagnelli
Summary: The COVID-19 pandemic has had a detrimental impact on screening and treatment for chronic hepatitis patients, as well as liver transplantation. It has also caused delays or suspensions in HBV infection screening and treatment, as well as universal hepatitis B vaccination programs. The WHO's goal of eliminating HCV infection as a global public-health issue by 2030 has become unattainable due to the pandemic.
Article
Medicine, General & Internal
Armando Calogero, Caterina Sagnelli, Gaia Peluso, Antonello Sica, Maria Candida, Silvia Campanile, Gianluca Minieri, Paola Incollingo, Massimiliano Creta, Luigi Pelosio, Vincenzo Tammaro, Alessandro Scotti, Akbar Jamshidi, Marcello Caggiano, Evangelista Sagnelli, Concetta A. Dodaro, Nicola Carlomagno, Michele Santangelo
Summary: The study found that kidneys with vascular abnormalities can be successfully transplanted, with similar rates of surgical complications and 5-year survival rates in both the SRA and MRA groups. Individualized physical activity programs also yielded comparable excellent results in improving physical capacities, arterial pressure, lipid metabolism, insulin sensitivity, quality of life, and physical and mental status for both groups.
Article
Multidisciplinary Sciences
Alessia Lai, Annalisa Bergna, Stefano Toppo, Marina Morganti, Stefano Menzo, Valeria Ghisetti, Bianca Bruzzone, Mauro Codeluppi, Vito Fiore, Emmanuele Venanzi Rullo, Guido Antonelli, Loredana Sarmati, Gaetano Brindicci, Annapaola Callegaro, Caterina Sagnelli, Daniela Francisci, Ilaria Vicenti, Arianna Miola, Giovanni Tonon, Daniela Cirillo, Ilaria Menozzi, Sara Caucci, Francesco Cerutti, Andrea Orsi, Roberta Schiavo, Sergio Babudieri, Giuseppe Nunnari, Claudio M. Mastroianni, Massimo Andreoni, Laura Monno, Davide Guarneri, Nicola Coppola, Andrea Crisanti, Massimo Galli, Gianguglielmo Zehender
Summary: This study characterized new SARS-CoV-2 genomes sampled in Italy and investigated the origin and evolutionary dynamics of the virus in Italy and Europe. The findings suggest that China and Italy played significant roles in the widespread transmission of the virus in Europe during the early phase of the pandemic.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Nicola Longo, Giuseppe Celentano, Luigi Napolitano, Roberto La Rocca, Marco Capece, Gianluigi Califano, Claudia Colla Ruvolo, Francesco Mangiapia, Ferdinando Fusco, Simone Morra, Carmine Turco, Francesco Di Bello, Giovanni Maria Fusco, Luigi Cirillo, Crescenzo Cacciapuoti, Lorenzo Spirito, Armando Calogero, Antonello Sica, Caterina Sagnelli, Massimiliano Creta
Summary: Patients with oligometastatic urothelial carcinoma represent a challenging subset to manage. Metastasis-directed radiation therapy has the potential to facilitate local disease control and overall survival, but definitive recommendations cannot be provided due to the lack of high-quality trials.
Review
Microbiology
Caterina Sagnelli, Antonello Sica, Massimiliano Creta, Alessandra Borsetti, Massimo Ciccozzi, Evangelista Sagnelli
Summary: Onco-hematologic patients are highly susceptible to SARS-CoV-2 infection and may experience HBV reactivation during the COVID-19 pandemic. Vaccination and adherence to social distancing measures are crucial for these patients, and healthcare facilities should be adequately equipped and staffed.
Article
Medicine, General & Internal
Vincenzo Tammaro, Nicola Carlomagno, Michele Santangelo, Armando Calogero, Concetta A. Dodaro, Antonio Vernillo, Antonello Sica, Gaia Peluso, Silvia Campanile, Evangelista Sagnelli, Caterina Sagnelli
Summary: The one-stage resection of colorectal cancer and hepatic metastases using the Habib 4X(R) device has shown excellent results, with minimal complications and a low rate of recurrence.
Article
Microbiology
Beatrice Leonardi, Caterina Sagnelli, Giovanni Natale, Francesco Leone, Antonio Noro, Giorgia Opromolla, Damiano Capaccio, Francesco Ferrigno, Giovanni Vicidomini, Gaetana Messina, Rosa Maria Di Crescenzo, Antonello Sica, Alfonso Fiorelli
Summary: This study evaluated the impact of recent COVID-19 infection on the outcomes of patients undergoing thoracoscopic lobectomy for lung cancer. The results showed that COVID-19 infection did not increase postoperative complications or 90-day mortality. However, patients with recent COVID-19 infection had a higher incidence of pleural adhesions. Therefore, the treatment of lung cancer patients with recent COVID-19 infection should not be delayed and should not differ from that of the general population.
Correction
Infectious Diseases
Mariantonietta Pisaturo, Loredana Alessio, Alessandra Di Fraia, Margherita Macera, Carmine Minichini, Emanuele Cordua, Lorenzo Onorato, Gaetano Scotto, Giovanni Di Caprio, Federica Calo, Caterina Sagnelli, Nicola Coppola
Article
Virology
Mariantonietta Pisaturo, Loredana Alessio, Mario Starace, Margherita Macera, Laura Occhiello, Emanuele Cordua, Salvatore Capuano, Lorenzo Onorato, Gaetano Scotto, Giovanni Di Caprio, Federica Calo, Caterina Monari, Caterina Sagnelli, Nicola Coppola
Summary: A study on immigrants in southern Italy revealed a significant proportion of them had co-infections of hepatitis B and hepatitis C viruses, which were associated with the development of liver disease.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Health Care Sciences & Services
Paola Vitiello, Caterina Sagnelli, Andrea Ronchi, Renato Franco, Stefano Caccavale, Maria Mottola, Francesco Pastore, Giuseppe Argenziano, Massimiliano Creta, Armando Calogero, Alfonso Fiorelli, Beniamino Casale, Antonello Sica
Summary: Mycosis fungoides is a common primary cutaneous T-cell lymphoma characterized by skin-homing CD4+ T cells. It has an indolent course and low-grade malignancy. Diagnosis is difficult due to the absence of specific features and lesional polymorphism. Treatment requires staging and a multidisciplinary team approach is needed for advanced stage diseases.
Article
Infectious Diseases
Giuseppe Pipitone, Marta Camici, Guido Granata, Adriana Sanfilippo, Francesco Di Lorenzo, Calogero Buscemi, Antonio Ficalora, Daria Spicola, Claudia Imburgia, Ilenia Alongi, Francesco Onorato, Caterina Sagnelli, Chiara Iaria
Summary: The aim of this study is to evaluate the alveolar-arterial oxygen gradient (D(A-a)O-2) as a marker for predicting severe pneumonia in COVID-19 patients, in comparison to the PaO2/FiO(2). The results show that D(A-a)O-2 is more appropriate than PaO2/FiO(2) to identify COVID-19 patients at risk of developing severe pneumonia early.
INFECTIOUS DISEASE REPORTS
(2022)
Article
Health Care Sciences & Services
Beatrice Leonardi, Caterina Sagnelli, Alfonso Fiorelli, Francesco Leone, Rosa Mirra, Davide Gerardo Pica, Vincenzo Di Filippo, Francesca Capasso, Gaetana Messina, Giovanni Vicidomini, Antonello Sica, Mario Santini
Summary: This retrospective study evaluated the application of an adapted ERAS protocol for immunocompromised patients undergoing empyema surgery. The results showed that the ERAS group had shorter post-operative length of stay, chest tube duration, blood loss, and a lower rate of certain complications.
Article
Health Care Sciences & Services
Fabrizio Schonauer, Annachiara Cavaliere, Giuseppe Pezone, Armando Calogero, Caterina Sagnelli, Antonello Sica, Luca D'Andrea, Antonello Baldo
Summary: Epithelioid hemangioma is a rare reactive vasoproliferative disease characterized by painless vascular nodules in the dermal and subcutaneous tissues of the head and neck. Diagnosis can be challenging, as the main symptom is progressively tender swelling next to a vessel course. There have been few reported cases of epithelioid hemangioma localized to the nose. This article presents a case of a 47-year-old woman with a nose lesion, discussing its diagnosis and treatment.
Article
Health Care Sciences & Services
Pasquale Verolino, Caterina Sagnelli, Roberto Grella, Giovanni Francesco Nicoletti, Antonello Sica, Mario Faenza
Summary: This study evaluated the use of rivaroxaban and enoxaparin for thrombo-prophylaxis in female patients with thrombophilia undergoing abdominoplasty. The results showed that both medications were effective in preventing VTE, with a moderate risk of clinically relevant bleeding.