Article
Health Care Sciences & Services
Tingting Zhao, Yiming Zhang, Joochul Lee, Angela R. Starkweather, Erin E. Young, Xiaomei Cong
Summary: This study found that certain genetic polymorphisms are associated with the risk and symptoms of irritable bowel syndrome, including abdominal pain, sleep disturbance, and fatigue. These findings contribute to the understanding of how genetic variations influence the development and changes of IBS symptoms over time.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zijuan Bi, Shisheng Zhang, Yangyang Meng, Ya Feng, Yinshu Wang, Enkang Wang, Xiangxue Pan, Ruixin Zhu, Haiting Fan, Shuhua Pang, Lixin Zhu, Jianye Yuan
Summary: The knockout of the SERT gene may lead to changes in the serotonin system, causing VH and accelerated gastrointestinal motility in female rats, which can be used as an animal model of IBS.
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Nutrition & Dietetics
Cezary Chojnacki, Aleksandra Blonska, Paulina Konrad, Marcin Chojnacki, Marcin Podogrocki, Tomasz Poplawski
Summary: This study aimed to evaluate the urinary excretion of selected tryptophan metabolites in patients with IBS-C and IBS-D. It was found that changes in tryptophan metabolism occurred in both groups of IBS patients compared to the control group. The 5-HIAA level was correlated with abdominal symptoms and anxiety in IBS-D patients, while the concentration of kynurenines (KYN, QA) in urine was higher in IBS-C patients and correlated with depression.
Article
Gastroenterology & Hepatology
Bin Liu, Ding Ye, Hong Yang, Jie Song, Xiaohui Sun, Zhixing He, Yingying Mao, Guifeng Hao
Summary: This study used a Mendelian randomization (MR) approach to evaluate the potential causal relationships between gut microbiota and the risk of irritable bowel syndrome (IBS). The findings suggest there may be a causal relationship between certain gut microbiota taxa and the risk of IBS.
BMC GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Jonas Schmidt, Sandro Berghaus, Frithjof Blessing, Holger Herbeck, Josef Blessing, Peter Schierack, Stefan Rodiger, Dirk Roggenbuck, Folker Wenzel
Summary: Nanopore sequencing has great potential for clinical diagnostics, but further validation and certification are required.
Article
Gastroenterology & Hepatology
Sabrina Berens, Yuanjun Dong, Nikola Fritz, Jutta Walstab, Mauro D'Amato, Tenghao Zheng, Verena Wahl, Felix Boekstegers, Justo Lorenzo Bermejo, Cristina Martinez, Stefanie Schmitteckert, Egbert Clevers, Felicitas Engel, Annika Gauss, Wolfgang Herzog, Robin Spiller, Miriam Goebel-Stengel, Hubert Moennikes, Viola Andresen, Frieling Thomas, Jutta Keller, Christian Pehl, Christoph Stein-Thoeringer, Gerard Clarke, Timothy G. Dinan, Eamonn M. Quigley, Gregory Sayuk, Magnus Simren, Jonas Tesarz, Gudrun Rappold, Lukas van Oudenhove, Rainer Schaefert, Beate Niesler
Summary: This study provides evidence that HTR3C c.489C > A is involved in depressive and anxiety symptoms in individuals with IBS. The SNP score indicates that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Physiology
Xiao-Lan Yu, Cui-Ping Li, Lian-Ping He
Summary: Several studies have shown the critical role of serotonin in the development of depression and irritable bowel syndrome. Recent research indicates that vitamin D is involved in regulating the synthesis of serotonin. This review focuses on the recent advancements in understanding the relationship between vitamin D and serotonin synthesis.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Michael Camilleri, Guy Boeckxstaens
Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.
Article
Gastroenterology & Hepatology
Zlatan Mujagic, Melpomeni Kasapi, Daisy M. A. E. Jonkers, Isabel Garcia-Perez, Lisa Vork, Zsa Zsa R. M. Weerts, Jose Ivan Serrano-Contreras, Alexandra Zhernakova, Alexander Kurilshikov, Jamie Scotcher, Elaine Holmes, Cisca Wijmenga, Daniel Keszthelyi, Jeremy K. Nicholson, Joram M. Posma, Ad A. M. Masclee
Summary: Combining microbiome and metabolome data can distinguish between irritable bowel syndrome (IBS) patients and healthy controls. Unsupervised clustering based on fecal microbiome-metabolome data revealed distinct subsets of IBS patients. The study also found associations between altered serotonin metabolism, unfavorable stress response related to gastrointestinal symptoms, and IBS, supporting the importance of the microbiome-gut-brain axis in the pathogenesis of IBS.
Article
Medicine, General & Internal
Maha Daghestani, Nashwa Othman, Mohammed A. Omair, Fahidah Alenzi, Maha A. Omair, Eman Alqurtas, Shireen Amin, Arjumand Warsy
Summary: This study conducted an investigation on the Saudi population and found that 6 single nucleotide polymorphisms (SNPs) were significantly associated with rheumatoid arthritis (RA), with 4 of them having a protective effect. Two SNPs showed significantly higher heterozygote frequencies in the control group compared to the patients. This indicates considerable heterogeneity in the genetics of RA in different populations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Yu-Ting Hsiao, Feng-Chih Shen, Shao-Wen Weng, Pei-Wen Wang, Yung-Jen Chen, Jong-Jer Lee
Summary: This study identified genetic determinants of increased risk of diabetic retinopathy (DR) in individuals with type 2 diabetes mellitus (T2DM), focusing on FTO (rs8050136) and PSMD6 (rs831571) genetic variations. By combining genetic and nongenetic risk factors, the predictive model showed improved accuracy in predicting DR risk, especially in patients with poor glycemic control or severe microalbuminuria.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Nayoung Kwak, Hankil Lee, Beom Kyung Kim, Yun Mi Yu, Hye-Young Kang
Summary: This study found that the risk of subsequent IBS occurrence following SSRI use was high in patients who initially took a heavy SSRI dose and those who did not have a history of psychiatric drug use.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cezary Chojnacki, Marta Medrek-Socha, Aleksandra Blonska, Radoslaw Zajdel, Jan Chojnacki, Tomasz Poplawski
Summary: This study evaluates the effect of a tryptophan-lowering diet on abdominal and mental symptoms in patients with irritable bowel syndrome and finds that reducing dietary intake of tryptophan can reduce abdominal discomfort.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Mihaela Fadgyas Stanculete, Abdulrahman Ismaiel, Stefan-Lucian Popa, Octavia Oana Capatina
Summary: Irritable bowel syndrome (IBS) is a disorder characterized by altered gut-brain interaction and dysfunction of the brain-gut-microbiota axis. Prior studies have shown significant impairments in the health-related quality of life of patients with IBS. Resilience, as a psychosocial ability, plays a crucial role in promoting health and enhancing stress response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Jasbir Makker, Hassan Tariq, Kishore Kumar, Madhavi Ravi, Danial Haris Shaikh, Vivien Leung, Umar Hayat, Muhammad T. Hassan, Harish Patel, Suresh Nayudu, Sridhar Chilimuri
Summary: The study revealed that a significant number of patients with type-2 diabetes mellitus have nonalcoholic fatty liver disease, grade 3 steatosis, and advanced hepatic fibrosis, even when their alanine aminotransferase levels are normal.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Endocrinology & Metabolism
Jasbir Makker, Haozhe Sun, Harish Patel, Nikhitha Mantri, Maleeha Zahid, Sudharsan Gongati, Sneha Galiveeti, Sharon W. Renner, Sridhar Chilimuri
Summary: In older patients aged 55 years and above, the type of diabetes does not affect mortality. On the other hand, in younger patients aged less than 55 years, the presence of type-2 diabetes is associated with higher mortality. Newly diagnosed type-2 diabetes patients may have better survival compared to previously known patients. Prediabetes does not impact outcomes in patients with COVID-19 infection.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Gastroenterology & Hepatology
Harish K. Patel, Jasbir Makker, Ahemd Alemam, Sridhar Chilimuri
Summary: Infection with novel coronavirus SARS-CoV-2 can lead to gastrointestinal symptoms such as diarrhea, possibly due to viral invasion of enterocytes and exocrine pancreatic insufficiency. This was demonstrated in a case series of three patients with predominant respiratory symptoms developing diarrhea, where fecal analysis revealed exocrine pancreatic insufficiency as the underlying mechanism.
CASE REPORTS IN GASTROINTESTINAL MEDICINE
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Danial H. Shaikh, Haozhe Sun, Harish Patel, Dongmin Shin, Ahmed Baiomi, Shehriyar Mehershahi, Madhavi Ravi, Jasbir Makker, Bhavna Balar, Suresh Kumar Nayudu
Meeting Abstract
Gastroenterology & Hepatology
Suresh Kumar Nayudu, Jasbir Makker, Haozhe Sun, Dongmin Shin, Sharon Renner, Syeda H. Salman, Nikhitha Mantri, Maleeha Zahid, Sudharshan Reddy Gongati, Sridhar Chilimuri
Article
Medicine, General & Internal
Ahmed Alemam, Subhan Ata, Danial Shaikh, Bianca Leuzzi, Jasbir Makker
Summary: Syphilitic hepatitis is a rare manifestation of treponemal infection, with diagnosis achieved through characteristic signs, positive serological markers, elevated liver enzymes, and excluding other causes of hepatobiliary insult. This case highlights the importance of considering syphilis as a potential cause of acute liver injury, given the increasing incidence of venereal diseases in the United States.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Harish Patel, Kishore Kumar, Rajesh Kumar Essrani, Masooma Niazi, Jasbir Makker, Suresh Kumar Nayudu
Summary: Viral infections, alcohol, hepatic steatosis, autoimmunity medications, and herbal supplements are common causes of hepatitis. Khat, a recreational substance in East African and Middle Eastern countries, has been associated with hepatotoxicity. Liver injury from Khat may be due to its biochemical components or additives, with a potential autoimmune mechanism.
CLINICS AND PRACTICE
(2021)
Review
Medicine, General & Internal
Danial H. Shaikh, Harish Patel, Jasbir Makker, Kanthi Badipatla, Sridhar Chilimuri
Summary: COVID-19 infection causing isolated colonic dilatation is rare and requires prompt recognition and treatment to prevent thrombosis. Treatment options include COVID-19-targeted medications and surgical intervention, with further research and clinical practice needed for better understanding and management.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Gastroenterology & Hepatology
Jasbir Makker, Danial Shaikh, Harish Patel, Siddarth Hanumanthu, Haozhe Sun, Bushra Zaidi, Madhavi Ravi, Bhavna Balar
Summary: The study highlights that unplanned visits within 7 days of colonoscopy are not necessarily related to the procedure, with those that are tend to be due to unavoidable patient factors. Therefore, the CMS measure may not accurately determine the quality of care delivered by the procedure or facility.
CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Haozhe Sun, Jasbir Makker, Harish Patel, Nikhitha Mantri, Ali N. Hussain, Naeem Abbas
CASE REPORTS IN GASTROINTESTINAL MEDICINE
(2020)
Review
Medicine, General & Internal
Danial H. Shaikh, Kishore Kumar, Harish Patel, Shehriyar Mehershanhi, Jasbir Makker
CUREUS JOURNAL OF MEDICAL SCIENCE
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Kishore Kumar, Jasbir Makker, Muhammad Hassan, Chime Chukwunonso, Hassan Tariq, Harish Patel, Bhavna Balar
Meeting Abstract
Gastroenterology & Hepatology
Kishore Kumar, Jasbir Makker, Muhammad Hassan, Chukwunonso Chime, Hassan Tariq, Harish Patel, Bhavna Balar
Article
Gastroenterology & Hepatology
Harish Patel, Bhavna Balar, Maheswara Irigela, Vamshidhar Vootla, Chaitanya Chandrala, Hafiz Hashmi, Molham Abdulsamad, Jasbir Makker
GASTROENTEROLOGY RESEARCH
(2020)
Article
Gastroenterology & Hepatology
Hassan Tariq, Harish Patel, Muhammad Umar Kamal, Naeem Abbas, Muhammad Ameen, Sara Azam, Kishore Kumar, Madhavi Ravi, Vamshidhar Vootla, Danial Shaikh, Vamsi Amanchi, Ali N. Hussain, Jasbir Makker
CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY
(2020)