期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 21, 期 27, 页码 8340-8351出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v21.i27.8340
关键词
Inflammation; Probiotics; Oxidative stress; Clostridium butyricum; Gastric ulcer
资金
- National Key Basic Research (973) Program of China [2010CB529704]
- National Natural Science Foundation of China [81030055, 81372030]
- Guangdong Provincial Natural Science Foundation [S2013010014422]
- Program of Wenzhou Sci-tech Museum [Y20130215]
AIM: To investigate the effects of Clostridium butyricum (C. butyricum) on experimental gastric ulcers (GUs) induced by alcohol, restraint cold stress, or pyloric ligation in mice, respectively. METHODS: One hundred and twenty mice were randomly allocated into three types of gastric ulcer models (n = 40 each), induced by alcohol, restraint cold stress, or pyloric ligation. In each GU model, 40 mice were allocated into four groups (n = 10 each): the sham control group; model group (GU induction without pretreatment); C. butyricum group (GU induction with C. butyricum pretreatment); and Omeprazole group (GU induction with Omeprazole pretreatment). The effects of C. butyricum were evaluated by examining the histological changes in the gastric mucosal erosion area, the activities of superoxide dismutase (SOD) and catalase (CAT), the level of malondialdehyde (MDA), and the contents of interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha, leukotriene B-4 (LTB4) and 6-keto-PGF-1 alpha (degradation product of PGI(2)) in the gastric tissue. RESULTS: Our data showed that C. butyricum significantly reduced the gastric mucosal injury area and ameliorated the pathological conditions of the gastric mucosa. C. butyricum not only minimized the decreases in activity of SOD and CAT, but also reduced the level of MDA in all three GU models used in this study. The accumulation of IL1-beta, TNF-alpha and LBT4 decreased, while 6-keto-PGF-1 alpha increased with pretreatment by C. butyricum in all three GU models. CONCLUSION: Our data demonstrated the protective effects of pretreatment with C. butyricum on antioxidation and anti-inflammation in different types of GU models in mice. Further studies are needed to explore its potential clinical benefits.
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