Article
Pharmacology & Pharmacy
Xiangyu Zhang, Xinran Wang, Tianxiao Wu, Wenbo Yin, Jiangkun Yan, Yixiang Sun, Dongmei Zhao
Summary: This study provides an extensive review of LSD1 as an important histone demethylase in cancer and its potential applications. The aberrant overexpression of LSD1 in tumor cells is associated with tumor growth, invasion, and metastasis, making it a promising target for cancer therapy. The review summarizes recent advances in LSD1 inhibitors, including their structural characteristics, screening methods, and future directions for development.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Chang-Yun Li, Yan-Jun Liu, Fan Tao, Ru-Yi Chen, Jin-Jin Shi, Jian-Fei Lu, Guan -Jun Yang, Jiong Chen
Summary: This article discusses the important role of lysine-specific demethylase 7A (KDM7A) in biological regulation and disease development, as well as its structure, function, and potential drug treatments. KDM7A is not only crucial for normal development but also associated with various diseases.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Agronomy
Maximilian M. Muellender, Anne-Katrin Mahlein, Gerd Stammler, Mark Varrelmann
Summary: This study identified mutations associated with reduced sensitivity in C. beticola isolates collected from different European countries. The experiment showed that some mutations were related to lower EC50 values, indicating a possible correlation between target site mutations and reduced sensitivity.
PEST MANAGEMENT SCIENCE
(2021)
Article
Energy & Fuels
Ahmed Tijjani Dahiru, Chee Wei Tan, Abba Lawan Bukar, Kwan Yiew Lau
Summary: The proposed method in this study introduces a time-of-use fitness approach in a grid connected photovoltaic/wind/battery nanogrid for reducing energy costs and maintaining customer comforts. By considering three different configurations of the nanogrid optimized through nested integer linear programming, the method applies fitness functions to either critical or flexible demands based on real-time residential consumption, renewable generation, and main grid imported power.
JOURNAL OF ENERGY STORAGE
(2021)
Article
Plant Sciences
Michael G. Palmer, Gerald J. Holmes
Summary: Field observations indicate reduced fungicide sensitivity in field populations of Podosphaera aphanis, the causal agent of strawberry powdery mildew (SPM). This study characterizes the sensitivity of 19 P. aphanis isolates to common fungicides used against SPM in California, revealing resistance to most fungicides and the first ever reported resistance to penthiopyrad and quinoxyfen worldwide in P. aphanis.
Review
Immunology
Kai Wang, Chao Yang, Haibin Li, Xiaoyan Liu, Meiling Zheng, Zixue Xuan, Zhiqiang Mei, Haiyong Wang
Summary: JMJD6 is a histone demethylase belonging to the Jumonji domain family, involved in the regulation of transcription, chromatin structure, epigenetics, and genome integrity. Abnormal expression of JMJD6 is associated with various tumors and it also regulates the immune response. Targeting the JMJD6 gene may be a promising strategy for cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hannah Prensky, Angela Gomez-Simmonds, Anne-Catrin Uhlemann, Allison J. Lopatkin
Summary: The process of plasmid acquisition during conjugation results in immediate but transient metabolic perturbation. This study found that newly acquired transconjugants exhibit slower growth and prolonged lag times compared to cells that have been replicating for several generations, indicating the presence of a plasmid acquisition cost. The short-term effects of plasmid acquisition have been shown to play a critical role in both short- and long-term plasmid prevalence, particularly in microbiomes with high plasmid/strain diversity.
MOLECULAR SYSTEMS BIOLOGY
(2021)
Article
Engineering, Environmental
Wanting Zhao, Chunlei Wei, Yuandong Cui, Junqing Ye, Bin He, Xiaomin Liu, Jian Sun
Summary: This study successfully utilizes low-cost bifunctional protic ionic liquids (PILs) for dissolving and demethylating lignin, providing a new approach for improving the valorization of lignin.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Physics, Fluids & Plasmas
Jacob Moran, Devon Finlay, Mikhail Tikhonov
Summary: The expression level and the rate of protein evolution are strongly related, forming a potential feedback loop of improvement or loss. Studies have shown that in a changing environment, systems with higher expression levels are more likely to improve fitness.
Article
Microbiology
Fredrika Rajer, Linus Sandegren
Summary: Multiresistance plasmids have evolutionary advantage in antibiotic treatment environments and impose fitness costs on bacteria. This study investigates the contribution of plasmid-borne resistance genes to bacterial fitness and finds that particular resistance genes are responsible for the cost of the plasmid.
Article
Microbiology
Fredrika Rajer, Linus Sandegren
Summary: Multiresistance plasmids provide bacterial cells with protection against multiple antibiotics, but can also reduce the fitness of bacterial cells. Some resistance genes carried by plasmids incur costs on bacterial cells, while others are cost-free.
Article
Polymer Science
Alexandre Lancelot, Amelia A. Putnam-Neeb, S. Lee Huntington, Jennifer M. Garcia-Rodriguez, Nevin Naren, Cindy L. Atencio-Martinez, Jonathan J. Wilker
Summary: This study presents a biomimetic polymer that achieves adhesive bonding in wet environments and improves bonding performance through modified synthesis methods.
Article
Microbiology
Pedro Dorado-Morales, M. Pilar Garcillan-Barcia, Inigo Lasa, Cristina Solano
Summary: Plasmids play a major role in the spread of antibiotic resistance genes among bacterial strains. This study demonstrates that the initial fitness cost of plasmids in Staphylococcus aureus can be alleviated over time through plasmid rearrangements mediated by insertion sequences, leading to the loss of antimicrobial resistance genes. The results suggest the potential benefits of reducing antibiotic use in both animal and clinical settings to prevent the spread of clinical multidrug resistance plasmids.
Article
Agronomy
Dengke Hua, Xiaoyu Li, Jiangjiang Yuan, Min Tao, Kun Zhang, Xiaobin Zheng, Yanran Wan, Lianyou Gui, Youjun Zhang, Qingjun Wu
Summary: This study compared the reproductive capacities, ovary development, and vitellogenin (Vg) gene expression in spinosad-susceptible and -resistant western flower thrips to investigate the reason for the fitness cost in spinosad resistance. The results showed that the spinosad-resistant strain exhibited a decrease in fecundity and shortened ovariole length compared to the susceptible strain. The downregulated expression of Vg was found to contribute to these phenotypic changes and the fitness cost.
PEST MANAGEMENT SCIENCE
(2023)
Article
Agronomy
Tim Birr, Mario Hasler, Joseph-Alexander Verreet, Holger Klink
Summary: The study found that the sensitivity of wheat septoria tritici blotch to specific fungicides has changed over different time periods, with sensitivity remaining stable or decreasing for most fungicides except for a slight increase in sensitivity for one. Over the past 21 years, complete resistance of Z. tritici to quinone outside inhibitors has developed, and resistance to two other fungicides has gradually increased, posing a major challenge for future wheat cultivation.
Article
Virology
John P. Carr, Trisna Tungadi, Ruairi Donnelly, Ana Bravo-Cazar, Sun-Ju Rhee, Lewis G. Watt, J. Musembi Mutuku, Francis O. Wamonje, Alex M. Murphy, Warren Arinaitwe, Adrienne E. Pate, Nik J. Cunniffe, Christopher A. Gilligan
Article
Plant Sciences
Francis O. Wamonje, Ruairi Donnelly, Trisna D. Tungadi, Alex M. Murphy, Adrienne E. Pate, Christine Woodcock, John Caulfield, J. Musembi Mutuku, Toby J. A. Bruce, Christopher A. Gilligan, John A. Pickett, John P. Carr
FRONTIERS IN PLANT SCIENCE
(2020)
Article
Multidisciplinary Sciences
Ruairi Donnelly, Christopher A. Gilligan
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2020)
Article
Plant Sciences
Francis O. Wamonje, Trisna D. Tungadi, Alex M. Murphy, Adrienne E. Pate, Christine Woodcock, John C. Caulfield, J. Musembi Mutuku, Nik J. Cunniffe, Toby J. A. Bruce, Christopher A. Gilligan, John A. Pickett, John P. Carr
FRONTIERS IN PLANT SCIENCE
(2020)
Article
Plant Sciences
Anna Maria Szyniszewska, Patrick Chiza Chikoti, Mathias Tembo, Rabson Mulenga, Christopher Aidan Gilligan, Frank van den Bosch, Christopher Finn McQuaid
Summary: A survey in Zambia revealed that 90% of growers used planting materials from their own or nearby fields, and only 48% of them received information on cassava diseases and clean seed, with nearby friends, family, and neighbors being the main sources of information.
Article
Entomology
Yevhen F. Suprunenko, Matthew D. Castle, Cerian R. Webb, Julia Branson, Andrew Hoppit, Christopher A. Gilligan
Summary: The expansion of oak processionary moth (OPM) in South-East England has been accelerating since 2015, with potential factors including the species' natural dispersal capabilities and environmental heterogeneity.
AGRICULTURAL AND FOREST ENTOMOLOGY
(2022)
Article
Multidisciplinary Sciences
Jean B. Ristaino, Pamela K. Anderson, Daniel P. Bebber, Kate A. Brauman, Nik J. Cunniffe, Nina Fedoroff, Cambria Finegold, Karen A. Garrett, Christopher A. Gilligan, Christopher M. Jones, Michael D. Martin, Graham K. MacDonald, Patricia Neenan, Angela Records, David G. Schmale, Laura Tateosian, Qingshan Wei
Summary: The global increase in plant disease outbreaks poses a threat to food security for vulnerable populations, while a human pandemic is also threatening the health of millions worldwide. To address these challenges, new tools such as disease surveillance and improved detection technologies are needed to prevent future outbreaks, as well as an integrated research agenda to mitigate future plant disease pandemics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Plant Sciences
Ruairi Donnelly, Christopher A. Gilligan
Summary: Cassava is an important crop for food security, and its emergence of severe cassava mosaic disease in East Africa has been linked to a superabundance of Bemisia tabaci whitefly. The study proposes that pathogenic modification of infected plants may contribute to the growth of insect vector colonies. Through landscape-scale modeling, the role of pathogen-mediated insect superabundance in plant disease invasion is demonstrated.
JOURNAL OF ECOLOGY
(2022)
Article
Agronomy
Renata Retkute, Rebekah G. K. Hinton, Keith Cressman, Christopher A. Gilligan
Summary: The research found that around 16.1% of grid cells with locust presence and 14.9% of grid cells with control operations had a proportion of rangeland higher than 0.75, while approximately 13.3% of grid cells with locust presence and 13.2% of grid cells with control operations had a proportion of croplands higher than 0.75, highlighting the presence of locusts and control operations in both rangeland and cropland. Control operations are used to reduce locust numbers and protect crops, with wheat production being particularly vulnerable during periods of increased locust infestations.
Article
Environmental Sciences
Catherine D. Bradshaw, William Thurston, David Hodson, Tamas Mona, Jacob W. Smith, Sarah C. Millington, Gerald Blasch, Yoseph Alemayehu, Kitessa Gutu, Matthew C. Hort, Christopher A. Gilligan
Summary: Wheat stem rust epidemics caused by Puccinia graminis f.sp. tritici pose serious threats to global wheat production. Highly virulent variants, such as Ug99 and TTKTT, have rapidly spread in recent years, highlighting the importance of surveillance and mitigation strategies.
ENVIRONMENTAL RESEARCH LETTERS
(2022)
Correction
Multidisciplinary Sciences
Jean B. Ristaino, Pamela K. Anderson, Daniel P. Bebber, Kate A. Brauman, Nik J. Cunniffe, Nina V. Fedoroff, Cambria Finegold, Karen A. Garrett, Christopher A. Gilligan, Christopher M. Jones, Michael D. Martin, Graham K. MacDonald, Patricia Neenan, Angela Records, David G. Schmale, Laura Tateosian, Qingshan Wei
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biodiversity Conservation
Cerian R. Webb, Tamas Mona, Christopher A. Gilligan
Summary: The emerald ash borer has caused immense economic and social costs in North America and European Russia, with potential rapid spread in southern England if not controlled. Differences in climate may limit spread in parts of Great Britain, but early surveillance and control measures are essential to minimize human-mediated spread of this destructive pest.
PLANTS PEOPLE PLANET
(2021)
Article
Multidisciplinary Sciences
Yevhen F. Suprunenko, Stephen J. Cornell, Christopher A. Gilligan
Summary: Computer simulations of individual-based models are used to compare strategies for controlling epidemics in spatially distributed populations. However, simulations can be slow and may not immediately give general insights. By applying an analytical approximation to a spatially explicit SIR(S) model, this study identifies conditions for pathogen invasion and persistence, quantifies the impact of control interventions on the epidemic, and considers the socio-economic cost of these interventions. A trade-off between control measures and a vaccination strategy is shown, along with the optimal strategy to minimize socio-economic costs for controlling invading and endemic diseases.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2021)
Article
Multidisciplinary Sciences
R. N. Thompson, C. A. Gilligan, N. J. Cunniffe
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2020)
Review
Ecology
Michaela Roberts, Christopher A. Gilligan, Adam Kleczkowski, Nick Hanley, A. E. Whalley, John R. Healey
FRONTIERS IN FORESTS AND GLOBAL CHANGE
(2020)