期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 21, 期 24, 页码 7436-7442出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v21.i24.7436
关键词
Bile acids; Chronic idiopathic constipation; Ileal bile acid transporter
资金
- Iuventus Plus program of the Polish Ministry of Science and Higher Education [0107/IP1/2013/72]
- Medical University of Lodz [503/1-156-04/503-01]
Chronic idiopathic constipation is a common disorder of the gastrointestinal tract that encompasses a wide profile of symptoms. Current treatment options for chronic idiopathic constipation are of limited value; therefore, a novel strategy is necessary with an increased effectiveness and safety. Recently, the inhibition of the ileal bile acid transporter has become a promising target for constipation-associated diseases. Enhanced delivery of bile acids into the colon achieves an accelerated colonic transit, increased stool frequency, and relief of constipation-related symptoms. This article provides insight into the mechanism of action of ileal bile acid transporter inhibitors and discusses their potential clinical use for pharmacotherapy of constipation in chronic idiopathic constipation.
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