Article
Biotechnology & Applied Microbiology
Shanmukh S. Salimath, Trevor B. Romsdahl, Anji Reddy Konda, Wei Zhang, Edgar B. Cahoon, Michael K. Dowd, Thomas C. Wedegaertner, Kater D. Hake, Kent D. Chapman
Summary: Upland cotton is an economically important crop globally cultivated for various purposes. Transgenic cotton lines expressing a barley gene showed increased accumulation of vitamin E without negative impacts on plant performance; in fact, it enhanced antioxidant activity and oxidative stability of cottonseed oil, potentially providing new opportunities for improved cottonseed co-products.
PLANT BIOTECHNOLOGY JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
M. Vidya Muthulakshmi, Aparajitha Srinivasan, Smita Srivastava
Summary: Vitamin E is essential for human well-being and efforts to enhance its production using plant in vitro cultures have gained traction. This review discusses the structure, biosynthesis, and important roles of vitamin E in human health and industrial applications. It highlights the advantages of in vitro plant cell/tissue culture as an alternative to current commercial production platforms. The review also covers strategies for metabolic pathway engineering, bioprocess optimization, and sustainable green extraction methods of vitamin E.
Article
Plant Sciences
Zhanghui Zeng, Yong Jia, Xiaoping Huang, Zhehao Chen, Taihe Xiang, Ning Han, Hongwu Bian, Chengdao Li
Summary: The study explored the molecular function and transcriptional profiles of HPT1 and HPT2 in different tissues and stages of barley, wheat, and oat. It revealed that HPT1s were ubiquitously transcribed in various tissues, while HPT2s were highly expressed in specific stages and tissues, suggesting a tissue-specific pattern. Protein structural analysis identified putative catalytic amino acid residues for HPT1 and HPT2, supporting their role in tocopherol production in Triticeae.
Article
Food Science & Technology
Aleksander Siger, Pawel Gornas
Summary: The tocopherol and tocotrienol profiles were studied in 418 plant oil samples, representing 31 families, 82 species, and 5 cross-species. Tocotrienols dominated in 15 species, while tocopherols dominated in 67 species. Gamma-T accounted for almost half (49.3%) of the total tocochromanol content, while alpha-T constituted one quarter (25.0%), and other tocochromanols were minor constituents. The presence of characteristic tocochromanol profiles in oils was related to the taxonomic plant origin. This study also demonstrated that both monocotyledonous and dicotyledonous families can be rich in tocotrienols. The usefulness of statistical tools such as PCA and HCA for differentiating plant samples based on their tocochromanol profile was shown.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Zhimin Wu, Yazhi Li, Huajiao Qiu, Songhua Long, Xinlin Zhao, Yufu Wang, Xinbo Guo, Aliya Baitelenova, Caisheng Qiu
Summary: This study aimed to investigate the relationship between different flaxseed varieties, their agronomic traits, and seed quality. The study found that fiber flax variety had the highest lignan content, while oil flax variety had the highest levels of vitamins and carotenoids. The study also observed correlations between seed yield, seed type, plant height, and fiber content with seed quality.
Article
Pharmacology & Pharmacy
Mohd Saufi Harun, Tin Wui Wong, Chee Wai Fong
Summary: The study investigated a combination of nanocarrier and microwave system for delivering alpha-tocopherol and gamma-tocotrienol against dermatitis without the thinning effect of steroids. By formulating vitamin E into water-rich/water-poor nanoemulsions and pre-treating the skin with precision microwave, the research found that the approach promoted therapeutic accumulation in the skin epidermis, leading to an alleviation of dermatitis without the skin thinning effect. The combination of microwave and nanotechnology offers a promising strategy for enhancing vitamin delivery and improving dermatitis treatment outcomes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Plant Sciences
Estanislao Burgos, Maria Belen De Luca, Isidore Diouf, Luis A. de Haro, Elise Albert, Christopher Sauvage, Zhao J. Tao, Luisa Bermudez, Ramon Asis, Adriano N. Nesi, Michel Matringe, Claire Brehelin, Thomas Guiraud, Carine Ferrand, Isabelle Atienza, Joana Jorly, Jean P. Mauxion, Pierre Baldet, Alisdair R. Fernie, Leandro Quadrana, Christophe Rothan, Mathilde Causse, Fernando Carrari
Summary: By studying the genetic determinants of tocochromanol accumulation in tomato fruits and genetically engineering their biosynthetic pathway, a total of 25 quantitative trait loci were identified across the genome. By bypassing specific pathway points, the engineered tomatoes showed increased tocopherols and tocotrienols content, indicating a trade-off between VTE and natural variation in chorismate metabolism.
Article
Plant Sciences
Min Deng, Hao Chen, Wei Zhang, Edgar B. Cahoon, Yongming Zhou, Chunyu Zhang
Summary: Tocotrienols and tocopherols, which function as potent antioxidants in plants, are synthesized in plastids of plant cells. This study successfully increased the total tocochromanol content in canola seeds by transforming the barley HGGT gene. The transgenic canola plants showed no negative impact on important agronomic traits and their oil exhibited enhanced oxidative stability, indicating the potential application of the HvHGGT gene in improving tocochromanol content in canola.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biology
Yong Jia, Mingrui Xu, Haifei Hu, Brett Chapman, Calum Watt, B. Buerte, Ning Han, Muyuan Zhu, Hongwu Bian, Chengdao Li, Zhanghui Zeng
Summary: Using genomic data from Triticeae, this study explored gene retention in the process of gene duplication, and found that gene dosage constraint and environmental adaption are associated with the retention of HPT2 gene in barley, wild emmer, and bread wheat. Comparative gene retention analysis revealed that HPT2 duplicates are mainly small-scale duplicates, experiencing relaxed selection pressure and transcriptional divergence. These duplicates are enriched with molecular-binding and defense response functions, and larger gene families are more prone to gene loss. Overall, gene dosage constraint, environmental adaption, and species-specific selection are three factors affecting gene retention after gene duplication.
Article
Plant Sciences
Devanshi Chandel Upadhyaya, Deepak Singh Bagri, Chandrama Prakash Upadhyaya, Ashwani Kumar, Muthu Thiruvengadam, Subodh Kumar Jain
Summary: Genetic engineering has successfully increased the content of vitamin E in potato by overexpressing genes related to the biosynthetic pathway, leading to enhanced tolerance to salt and heavy metal stresses. This approach holds great promise for improving crop yields and human health benefits under adverse environmental conditions.
PHYSIOLOGIA PLANTARUM
(2021)
Review
Biochemistry & Molecular Biology
Atsuki Suzuki, Yasuomi Urano, Tomohisa Ishida, Noriko Noguchi
Summary: 24S-OHC and 25OHC induced the same type of cell death in each of the cell types examined, and the inhibitory effect varied depending on the type of cell death for alpha-Toc and alpha-Toc3.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Nur Amira Md Amin, Siti Hamimah Sheikh Abdul Kadir, Akmal Hisyam Arshad, Norhaslinda Abdul Aziz, Nurul Alimah Abdul Nasir, Normala Ab Latip
Summary: Vitamin E has been shown to play a crucial role in female reproductive processes, but its benefits for female fertility and gynecological health are still unclear. This paper summarizes the known effects of vitamin E supplementation on women's gynecological health and reproductive-related diseases, and explores future research directions.
Article
Biochemistry & Molecular Biology
Na-Young Park, Suji Im, Qing Jiang
Summary: The study revealed that vitamin E forms and 13'-COOHs have inhibitory effects on COX-1 activity and thromboxane formation in platelets, and elucidated the mechanisms underlying their inhibition of 5-LOX. These observations are useful for understanding the role of these compounds in disease prevention and therapy.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Chemistry, Applied
Alexander Montoya-Arroyo, Jose David Alfaro-Solis, Patricia Esquivel, Victor M. Jimenez, Jan Frank
Summary: The study found significant differences in vitamin E content and composition of Acrocomia aculeata fruits from different regions in Costa Rica. The mesocarp was dominated by tocotrienols, while no tocopherols were found in the endosperm. The region with the most tropical climatic conditions had the highest vitamin E content observed.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Yoshiro Saito
Summary: Vitamin E is a potent lipid-soluble antioxidant, consisting of tocopherol and tocotrienol. They have different isoforms which exhibit similar radical scavenging abilities, but offer unique cytoprotective effects in cells. The review focuses on the actions of vitamin E against oxidative stress and its relation to cellular uptake and distribution, as well as its role in preventing lipid peroxidation and ferroptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)