Article
Biochemistry & Molecular Biology
Yuka Takahashi, Chikara Abe, Masaya Hane, Di Wu, Ken Kitajima, Chihiro Sato
Summary: Schizophrenia is a severe psychiatric disorder influenced by genetic and environmental factors. Changes in polysialylation of neural cell adhesion molecules have been found in the brains of patients with psychiatric disorders. This study investigates the effects of genetic (G) and environmental (E) factors on polysialylated NCAM expression using a schizophrenia mouse model and acute stress conditions. The study discovers differences in polysialylation and NCAM responses to stress in different brain regions, suggesting the vulnerability of the schizophrenia mouse model to stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Yu-Ming Chen, Chieh-Hsin Lin, Hsien-Yuan Lane
Summary: The study found that patients with schizophrenia had lower levels of DISC1 mRNA compared to healthy individuals, and that patients with lower DISC1 mRNA levels were more likely to exhibit more severe symptoms, including positive, negative, and depressive symptoms.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Psychiatry
Asbjorn Holmgren, Lars Hansson, Kristine Bjerkaas-Kjeldal, Agata Antonia Rita Impellizzeri, Gregor D. Gilfillan, Srdjan Djurovic, Timothy Hughes
Summary: The study identified a splice form associated with BD, which showed significant expression differences in different brain regions. This suggests a potential role of this splice form in myelin maturation in the human brain.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Medicine, Research & Experimental
Ingrid Fricke-Galindo, Blanca E. Perez-Aldana, Luis R. Macias-Kauffer, Susana Gonzalez-Arredondo, David Davila-Ortiz De Montellano, Carlos L. Avina-Cervantes, Marisol Lopez-Lopez, Yaneth Rodriguez-Agudelo, Nancy Monroy-Jaramillo
Summary: This study evaluated the association of genetic variants in COMT, PRODH, and DISC1 with cognitive performance in Mexican-Mestizo adult patients with schizophrenia. The results showed that COMT rs4633 was related to overall cognitive assessment, while PRODH rs2870984 was associated with processing speed, working memory, verbal learning, and social cognition.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Review
Medicine, General & Internal
Lorena Carrascal-Laso, Maria Isidoro-Garcia, Ignacio Ramos-Gallego, Manuel A. Franco-Martin
Summary: Current research has summarized the influence of different CYP450 gene polymorphisms on the metabolism of second-generation antipsychotic drugs, particularly olanzapine, clozapine, aripiprazole, risperidone, and quetiapine. Although significant differences in pharmacokinetic parameters between different phenotypes have been observed, more comprehensive studies describing pharmacokinetic interactions and environmental conditions among other variables are needed to fully understand these pharmacogenetic interactions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Gijsje J. L. J. Snijders, Welmoed van Zuiden, Marjolein A. M. Sneeboer, Amber Berdenis van Berlekom, Astrid T. van der Geest, Tatiana Schnieder, Donald J. MacIntyre, Elly M. Hol, Rene S. Kahn, Lot D. de Witte
Summary: The density and morphology of microglial cells in schizophrenia patients were found to be unchanged, while the expression of several microglial-specific genes was decreased. This indicates a change in microglial phenotype rather than density, which could provide a crucial molecular hallmark for future research into the role of microglia in schizophrenia and other psychiatric disorders.
Article
Neurosciences
Xin Gao, Li Yao, Fei Li, Chengmin Yang, Fei Zhu, Qiyong Gong, Su Lui
Summary: In first-episode antipsychotic-naive schizophrenia patients, widespread cortical local gyrification index (LGI) alterations were found, and specific risk genes associated with LGI deficits were identified. Lower LGI values were observed in frontotemporal and limbic regions. These findings may contribute to understanding the neurobiological basis of cortical impairments in early-stage schizophrenia.
Article
Biochemistry & Molecular Biology
Saba Habibi, Mohammad Yaghoubzad-Maleki, Emran Heshmati, Khosrow Khalifeh
Summary: The development of schizophrenia and some other psychiatric disorders is related to defects in the normal functioning of DISC1. DISC1 is a large-sized protein that interacts with various proteins. Ndel1, on the other hand, interacts with DISC1 and plays a role in nervous system development. Mutations on DISC1 have clinical implications.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Chuan-Ching Lai, Rathinasamy Baskaran, Chih-Yu Tsao, Li-Heng Tuan, Pei-Fen Siow, Mahalakshmi Palani, Lukas Jyuhn-Hsiarn Lee, Chih-Min Liu, Hai-Gwo Hwu, Li-Jen Lee
Summary: Schizophrenia usually manifests during adolescence to young adulthood, providing an opportunity for early intervention. This study investigated the preventive effect of chronic N-acetylcysteine (NAC) treatment on the outbreak of psychosis in Disc1 Het mice and found that NAC can normalize biochemical and morphological features in the striatum. The findings not only support the use of NAC as a dietary supplement for schizophrenia prodromes, but also contribute to our understanding of potential therapeutic targets for treating mental disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Zhijun Li, Xinwei Li, Mengdi Jin, Yang Liu, Yang He, Ningning Jia, Xingyao Cui, Yane Liu, Guoyan Hu, Qiong Yu
Summary: This study identified 15 key genes potentially associated with schizophrenia through analyzing multiple gene expression datasets using various bioinformatics algorithms. The study also found correlations between the expression of these hub genes and immune infiltrating cells. Furthermore, a risk prediction model based on these genes and immune cells achieved high accuracy in early diagnosis of schizophrenia.
PSYCHIATRY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Evan J. Brettrager, Arthur W. Meehan, Charles N. Falany, Robert C. A. M. van Waardenburg
Summary: Through the yeast model system, it has been found that ectopic expression of SULT4A1 leads to correct subcellular localization and functional activity. The expression of SULT4A1 promotes colony formation and protects cells from oxidative stress, which is dependent on the presence of extracellular sulfate.
SCIENTIFIC REPORTS
(2022)
Review
Genetics & Heredity
Vipul Vilas Wagh, Parin Vyas, Suchita Agrawal, Tejaswini A. Pachpor, Vasudeo Paralikar, Satyajeet P. Khare
Summary: Schizophrenia is characterized by delusions, hallucinations, and impaired socio-occupational function. Identifying biomarkers through blood-based gene expression studies can aid in early diagnosis and effective treatment strategies. The overlap of genetic, epigenetic, and gene expression changes suggests an interplay of genetic and environmental factors in schizophrenia.
FRONTIERS IN GENETICS
(2021)
Article
Neurosciences
Yong Wu, Xiao-Lin Yu, Xiao Xiao, Ming Li, Yi Li
Summary: A transcriptome-wide association study identified 144 genes whose mRNA levels were related to genetic risk of schizophrenia, with enrichment in dopamine-related pathways. These genes showed opposite expression trends in prenatal and postnatal brain tissues and were found to be enriched in glutamatergic excitatory neurons and cycling progenitors. This suggests the polygenic nature of schizophrenia and involvement of early neurodevelopment aberrations in the disorder. Further investigations using advanced algorithms are necessary to characterize transcriptomic features of schizophrenia pathogenesis along brain development.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Trang T. T. Truong, Chiara C. Bortolasci, Srisaiyini Kidnapillai, Briana Spolding, Bruna Panizzutti, Zoe S. J. Liu, Jee Hyun Kim, Olivia M. Dean, Mark F. Richardson, Michael Berk, Ken Walder
Summary: There is little understanding of the molecular mechanism behind the efficacy of antipsychotics for schizophrenia. This study integrated transcriptional data from schizophrenia patients with gene expression profiles induced by antipsychotic drugs to identify potential therapeutic targets. The results showed common regulation of genes involved in Wnt signaling and action potential regulation, suggesting these pathways as potential treatment targets for schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Laramie Duncan, Hanyang Shen, Anton Schulmann, Tayden Li, Bhaskar Kolachana, Ajeet Mandal, Ningping Feng, Pavan Auluck, Stefano Marenco
Summary: The development of 'omics technologies has brought about a new era in human postmortem tissue research, allowing for detailed measurement of genes, proteins, and spatial parameters. This study focuses on the clinical, educational, and brain gene expression correlates of polygenic scores in ancestrally diverse samples. The findings highlight the importance of understanding genetic risk and gene expression in psychiatric disorders, and provide valuable resources for future research.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Developmental
Aline Romani-Sponchiado, Pablo Vidal-Ribas, Rodrigo Affonseca Bressan, Jair de Jesus Mari, Euripedes Constantino Miguel, Ary Gadelha, Luis Augusto Paim Rohde, Sara Evans-Lacko, Giovanni Abrahao Salum, Mauricio Scopel Hoffmann
Summary: Psychopathology and positive attributes mutually influence each other over the long term and have interactive effects on educational outcomes.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Cezar H. Lorenzi, Douglas Teixeira Leffa, Rodrigo Bressan, Sintia Belangero, Ary Gadelha, Marcos L. Santoro, Giovanni A. Salum, Luis Augusto Rohde, Arthur Caye
Summary: This study validates the performance of an ADHD predictive model, showing it to be effective in developed countries but not in a developing country. The findings suggest that the model can be used in different clinical and research settings.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Psychology, Developmental
Luiza K. Axelrud, Mauricio S. Hoffmann, Daniel E. Vosberg, Marcos Santoro, Pedro M. Pan, Ary Gadelha, Sintia Belangero, Euripedes C. Miguel, Jean Shin, Anita Thapar, Jordan W. Smoller, Zdenka Pausova, Luis A. Rohde, Matthew C. Keller, Tomas Paus, Giovanni A. Salum
Summary: This study aimed to investigate the influence of parental genetics on offspring cognition, educational attainment, and psychopathology. The findings suggest that parental genetics influence offspring outcomes through genetic and phenotypic pathways, and multiple mediations may be an effective approach for understanding intergenerational transmission of behavioral traits.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Nynke A. Groenewold, Janna Marie Bas-Hoogendam, Alyssa R. Amod, Max A. Laansma, Laura S. Van Velzen, Moji Aghajani, Kevin Hilbert, Hyuntaek Oh, Ramiro Salas, Andrea P. Jackowski, Pedro M. Pan, Giovanni A. Salum, James R. Blair, Karina S. Blair, Joy Hirsch, Spiro P. Pantazatos, Franklin R. Schneier, Ardesheer Talati, Karin Roelofs, Inge Volman, Laura Blanco-Hinojo, Narcis Cardoner, Jesus Pujol, Katja Beesdo-Baum, Christopher R. K. Ching, Sophia Thomopoulos, Andreas Jansen, Tilo Kircher, Axel Krug, Igor Nenadic, Frederike Stein, Udo Dannlowski, Dominik Grotegerd, Hannah Lemke, Susanne Meinert, Alexandra Winter, Michael Erb, Benjamin Kreifelts, Qiyong Gong, Su Lui, Fei Zhu, Benson Mwangi, Jair C. Soares, Mon-Ju Wu, Ali Bayram, Mesut Canli, Rasit Tukel, P. Michiel Westenberg, Alexandre Heeren, Henk R. Cremers, David Hofmann, Thomas Straube, Alexander G. G. Doruyter, Christine Lochner, Jutta Peterburs, Marie-Jose Van Tol, Raquel E. Gur, Antonia N. Kaczkurkin, Bart Larsen, Theodore D. Satterthwaite, Courtney A. Filippi, Andrea L. Gold, Anita Harrewijn, Andre Zugman, Robin Buelow, Hans J. Grabe, Henry Voelzke, Katharina Wittfeld, Joscha Boehnlein, Katharina Dohm, Harald Kugel, Elisabeth Schrammen, Peter Zwanzger, Elisabeth J. Leehr, Lisa Sindermann, Tali M. Ball, Gregory A. Fonzo, Martin P. Paulus, Alan Simmons, Murray B. Stein, Heide Klumpp, K. Luan Phan, Tomas Furmark, Kristoffer N. T. Mansson, Amirhossein Manzouri, Suzanne N. Avery, Jennifer Urbano Blackford, Jacqueline A. Clauss, Brandee Feola, Jennifer C. Harper, Chad M. Sylvester, Ulrike Lueken, Dick J. Veltman, Anderson M. Winkler, Neda Jahanshad, Daniel S. Pine, Paul M. Thompson, Dan J. Stein, Nic J. A. Van der Wee
Summary: Limited convergence exists in neuroimaging investigations of subcortical brain region volumes in social anxiety disorder (SAD). Variations in methodological approaches and sample selection based on age and clinical characteristics may contribute to inconsistent findings. A global mega-analysis initiated by the ENIGMA-Anxiety Working Group revealed subtle volumetric alterations in subcortical regions in SAD patients. Differences were found in putamen and pallidum volumes, with additional factors such as comorbid anxiety disorders and age of SAD onset influencing these volumetric differences.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Jessica Honorato-Mauer, Gabriela Xavier, Vanessa Kiyomi Ota, Samar Nasser Chehimi, Fernanda Mafra, Cassia Cuoco, Lucas Toshio Ito, Rafaella Ormond, Paula Fontes Asprino, Adrielle Oliveira, Amanda Victoria Gomes Bugiga, Ana Claudia Torrecilhas, Rodrigo Bressan, Gisele Gus Manfro, Euripedes Constantino Miguel, Luis Augusto Rohde, Pedro Mario Pan, Giovanni Abrahao Salum, Renata Pellegrino, Sintia Belangero, Marcos Leite Santoro
Summary: This study analyzed the expression of microRNAs (miRNAs) in serum extracellular vesicles (EVs) from adolescents and found a correlation between miRNA expression and mental health disorders. The results provide support for further research on utilizing EVs miRNAs as biomarkers for mental health disorders.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Matheus Ghossain Barbosa, Viviane Machado, Carolina Ziebold, Tais Moriyama, Rodrigo A. Bressan, Pedro Pan, Luis Augusto Rohde, Euripedes Constantino Miguel, Lais Fonseca, Jim Van Os, Ary Gadelha
Summary: The Brazilian High-Risk Cohort study examined the measurement invariance of the CAPE-positive scale in children and adolescents over a three-year period. The results show that the scale is not invariant over time, indicating the need for further investigation into the factors influencing its results.
SCHIZOPHRENIA RESEARCH
(2023)
Correction
Multidisciplinary Sciences
Sergio Leonardo Mendes, Walter Hugo Lopez Pinaya, Pedro Mario Pan, Andrea Parolin Jackowski, Rodrigo Affonseca Bressan, Joao Ricardo Sato
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Sergio Leonardo Mendes, Walter Hugo Lopez Pinaya, Pedro Mario Pan, Andrea Parolin Jackowski, Rodrigo Affonseca Bressan, Joao Ricardo Sato
Summary: Recently, studies have investigated the neurodevelopment of psychiatric disorders using structural magnetic resonance imaging (sMRI) data. This study explores the reliability and consistency of a model trained on different datasets with varying stages of neurodevelopment and mental health conditions. The models used 3D convolutional neural networks (CNN) to assess autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), brain age, and dimensional psychopathology. Despite demographic and phenotypic differences, the models showed significant age estimations within and between datasets, with moderate to high correlation. The findings provide insights into youth neurodevelopmental structural changes and highlight the importance of less confounded training datasets for model generalization.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Rodolfo Furlan Damiano, Cristiana Castanho de Almeida Rocca, Antonio de Padua M. Serafim, Jennifer Loftis, Leda Leme Talib, Pedro Mario Pan, Edecio Cunha-Neto, Jorge Kalil, Gabriela Salim de Castro, Marilia F. Seelaender, Bruno K. Guedes, Suely K. Nagahashi Marie, Heraldo Possolo de Souza, Ricardo Nitrini, Euripedes Constantino Miguel, Geraldo Busatto, Orestes Forlenza
Summary: This study analyzed the potential impact of sociodemographic, clinical, and biological factors on the long-term cognitive outcome of patients who survived moderate and severe forms of COVID-19. The results found that although some sociodemographic characteristics may protect against cognitive impairment following SARS-CoV-2 infection, the data do not support a prominent role for clinical status and inflammatory background in explaining the cognitive deficits that can follow COVID-19 infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Psychiatry
Ana Paula Aguiar, Angel Olider Rojas Vistorte, Henrique Teruo Akiba, Paula Oliveira, Deise Palermo Puertas Ruiz, Ary Gadelha, Rodrigo Affonseca Bressan, Pedro Mario Pan
Summary: Methods to prospectively identify individuals at high risk of developing psychosis have been proposed, and this study translated and adapted two screening tools (PQ-16 and PRIME-Screen) into Brazilian Portuguese. After translation and cross-cultural adaptation, these new instruments can be used to screen Brazilian Portuguese-speaking patients who are at risk of psychosis in primary care.
TRENDS IN PSYCHIATRY AND PSYCHOTHERAPY
(2023)
Correction
Psychiatry
David Mongan, Melanie Focking, Colm Healy, Subash Raj Susai, Meike Heurich, Kieran Wynne, Barnaby Nelson, Patrick D. McGorry, Paul Amminger, Merete Nordentoft, Marie-Odile Krebs, Anita Riecher-Rossler, Rodrigo A. Bressan, Neus Barrantes-Vidal, Stefan Borgwardt, Stephan Ruhrmann, Gabriele Sachs, Christos Pantelis, Mark van der Gaag, Lieuwe de Haan, Lucia Valmaggia, Thomas A. Pollak, Matthew J. Kempton, Bart P. F. Rutten, Robert Whelan, Mary Cannon, Stan Zammit, Gerard Cagney, David R. Cotter, Philip McGuire
Article
Substance Abuse
Renata Faro Guerra, Ilza Rosa Batista, Hyoun S. Kim, Marcelo Queiroz Hoexter, Ming Chi Shih, Rodrigo Affonseca Bressan, Hermano Tavares
Summary: The aim of this research was to investigate the association between dopamine transporter (DAT) density in the ventral striatum and gambling disorder (GD). The results suggest that DAT density in the striatum is associated with recent gambling activity and gambling expectation.
JOURNAL OF GAMBLING STUDIES
(2023)
