Article
Immunology
Adrian Esqueda, Haiyan Sun, James Bonner, Huafang Lai, Collin Jugler, Karen V. V. Kibler, Herta Steinkellner, Qiang Chen
Summary: The development of glycovariants of 7D11, a neutralizing monoclonal antibody, produced in plants, shows promise as a potential therapeutic against the current monkeypox virus (MPXV) outbreak. The plant-made 7D11 antibody quickly accumulates to high levels and can be easily purified. It retains specific binding to its antigen and displays strong neutralization activity against MPXV, similar to its activity against vaccinia virus.
Article
Chemistry, Multidisciplinary
Vidya S. S. Shivatare, Po-Kai Chuang, Tzu-Hao Tseng, Yi-Fang Zeng, Han-Wen Huang, Gannedi Veeranjaneyulu, Han-Chung Wu, Chi-Huey Wong
Summary: A comprehensive structure-activity relationship study on antibody Fc-glycosylation was conducted using a chimeric anti-SSEA4 antibody chMC813-70 as a model. The α-2,6 sialylated biantennary complex type glycan was identified as the optimal Fc-glycan, which significantly enhanced antibody effector functions, including binding to different Fc receptors and ADCC.
CHEMICAL COMMUNICATIONS
(2023)
Article
Immunology
Haiyan Sun, Dhiraj Acharya, Amber M. Paul, Huafang Lai, Junyun He, Fengwei Bai, Qiang Chen
Summary: Researchers have developed a plant-based vaccine candidate that provides protective immunity against lethal West Nile virus and minimizes the risk of infection by Zika and dengue viruses.
Article
Immunology
Anne di Tommaso, Matthieu O. Juste, Zineb Lakhrif, Marie-Noelle Mevelec, Coraline Borowczyk, Pierre Hammeni, Guillaume Desoubeaux, Nathalie Van Langendonck, Francoise Debierre-Grockiego, Nicolas Aubrey, Isabelle Dimier-Poisson
Summary: Research shows that antibody fragments targeting the major surface protein SAG1 have the potential to inhibit the proliferation of Toxoplasma gondii, providing a promising avenue for specific treatment against congenital toxoplasmosis in the future.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Carmen Reitinger, Andrea Ipsen-Escobedo, Chiara Hornung, Lukas Heger, Diana Dudziak, Anja Lux, Falk Nimmerjahn
Summary: Checkpoint control and immunomodulatory antibodies are important tools for modulating tumor or self-reactive immune responses. However, severe side effects limit their full potential. Choosing IgG subclasses with low Fc-γR interaction and glycoengineering can reduce these side effects and improve therapeutic window.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Kristina Zlatina, Sebastian P. Galuska
Summary: This review discusses the impact of glycosylation on the function of antibodies, specifically Ig, and how changes in glycosylation affect their functionality. It also explores the functionality of IgG glycosylation in different physiological states, such as aging, lactation, and pathophysiological processes. Additionally, it points out the current knowledge about Ig glycosylation in farm animals and the potential contributions of new advancements in vaccination to animal welfare.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Kai-Thomas Schneider, Toni Kirmann, Esther Veronika Wenzel, Jan-Hendrik Grosch, Saskia Polten, Doris Meier, Marlies Becker, Paul Matejtschuk, Michael Hust, Giulio Russo, Stefan Duebel
Summary: Generation of sequence defined antibodies from universal libraries by phage display has been established as a robust method. ScFv-Fcs can be effective as neutralizing antibodies against a panel of pathogens and toxins, but may have variable stability. A generic lyophilization protocol has been developed to improve their shelf life, showing preservation of initial properties without compromising binding activity after storage.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Plant Sciences
Naphatsamon Uthailak, Hiroyuki Kajiura, Ryo Misaki, Kazuhito Fujiyama
Summary: This research successfully produced functional recombinant GCase with a mannosidic-type N-glycan structure in Nicotiana benthamiana plants with downregulated N-acetylglucosaminyltransferase I gene. The glycoengineered plant line offers a promising alternative for producing therapeutic proteins targeted at the mannose receptor.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Immunology
Xing Zhou, Francesca Motta, Carlo Selmi, William M. Ridgway, M. Eric Gershwin, Weici Zhang
Summary: Research focuses on the impact of Ig glycosylation in autoimmunity, describing its modulation of immune responses and the potential use of glycome profiles as biomarkers of disease activity. Antibody glycosylation in human autoimmune and chronic inflammatory conditions demonstrates specific features, with different patterns associated with disease severity and treatment options.
AUTOIMMUNITY REVIEWS
(2021)
Review
Immunology
Ruth A. Purcell, Robert M. Theisen, Kelly B. Arnold, Amy W. W. Chung, Kevin J. Selva
Summary: The efficacy of vaccines determined in clinical trials is usually higher than their real-world effectiveness due to reduced protection in vulnerable populations. Tailored immunisation schedules are recommended for high-risk groups, and considerations of immune response variations are needed for future vaccine design. Recent studies have highlighted the importance of balanced and diverse antibody functions for vaccine-induced protection, especially in immunologically vulnerable populations. This knowledge can be utilized to improve vaccine design for better public health outcomes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Alex W. Wessel, Michael P. Doyle, Taylor B. Engdahl, Jessica Rodriguez, James E. Crowe, Michael S. Diamond
Summary: This study isolated human monoclonal antibodies from individuals previously infected with WNV, mapped their epitopes, and evaluated their efficacy in vivo against lethal WNV challenge. The most protective epitopes clustered at three antigenic sites on extracellular NS1 forms. This information may aid in the development of NS1-based countermeasures against flaviviruses.
Review
Biochemistry & Molecular Biology
Maxime Fieux, Sandra Le Quellec, Sophie Battier, Andre Coste, Bruno Louis, Caroline Giroudon, Mikail Nourredine, Emilie Bequignon
Summary: FcRn has been shown to efficiently transport biologics across the nasal epithelial barrier in multiple studies reviewed. Limited studies have evaluated the potential toxicity of intranasal delivery of biologics, but they all indicate its safety. Further research is needed to fully understand the pharmacokinetic and pharmacodynamic properties of biologics after intranasal delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Immunology
Gino Arcilla, Antoine Nguyen, Antonio Liu
Summary: We encountered a patient with HIV who showed rapid deterioration in mental status and was positive for both acute West Nile encephalitis and amphiphysin antibodies. After reviewing the literature, we found Dr. Moutsopoulos's paper from your journal highly interesting (Karagianni et al., 2019 [1]). Although autoimmune encephalitis following West Nile encephalitis is not uncommon, there are several intriguing aspects in our patient's case. Firstly, the coexistence of amphiphysin antibodies with West Nile encephalitis has not been reported before. Secondly, the monophasic clinical course suggests that autoimmune encephalitis triggered by or coexisting with West Nile encephalitis may be significantly underrecognized. Lastly, our patient was HIV positive but not severely immunocompromised, which may have contributed to the autoimmune status.
CLINICAL IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yaqi Yang, Siji Nian, Lin Li, Xue Wen, Qin Liu, Bo Zhang, Yu Lan, Qing Yuan, Yingchun Ye
Summary: Enhanced EphA2 expression is a crucial target for anti-tumor therapy, with high affinity scFvs against EphA2 successfully screened from an immune library constructed using PBMCs from cancer patients. Modified antibodies showed improved affinity and the ability to bind to EphA2, tumor cells, and tissues, inhibiting tumor growth to some extent. This study highlights the potential of immune libraries from cancer patients in screening for high-affinity antibodies with therapeutic effects.
Article
Veterinary Sciences
Umberto Molini, Giovanni Franzo, Hannah Nel, Siegfried Khaiseb, Charles Ntahonshikira, Bernard Chiwome, Ian Baines, Oscar Madzingira, Federica Monaco, Giovanni Savini, Nicola D'Alterio
Summary: The study revealed the exposure of WNV in Namibian donkeys, indicating its circulation throughout the country with regional differences, and the effectiveness of donkeys as sentinels for infection surveillance.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Elisabetta Cameroni, John E. Bowen, Laura E. Rosen, Christian Saliba, Samantha K. Zepeda, Katja Culap, Dora Pinto, Laura A. VanBlargan, Anna De Marco, Julia di Iulio, Fabrizia Zatta, Hannah Kaiser, Julia Noack, Nisar Farhat, Nadine Czudnochowski, Colin Havenar-Daughton, Kaitlin R. Sprouse, Josh R. Dillen, Abigail E. Powell, Alex Chen, Cyrus Maher, Li Yin, David Sun, Leah Soriaga, Jessica Bassi, Chiara Silacci-Fregni, Claes Gustafsson, Nicholas M. Franko, Jenni Logue, Najeeha Talat Iqbal, Ignacio Mazzitelli, Jorge Geffner, Renata Grifantini, Helen Chu, Andrea Gori, Agostino Riva, Olivier Giannini, Alessandro Ceschi, Paolo Ferrari, Pietro E. Cippa, Alessandra Franzetti-Pellanda, Christian Garzoni, Peter J. Halfmann, Yoshihiro Kawaoka, Christy Hebner, Lisa A. Purcell, Luca Piccoli, Matteo Samuele Pizzuto, Alexandra C. Walls, Michael S. Diamond, Amalio Telenti, Herbert W. Virgin, Antonio Lanzavecchia, Gyorgy Snell, David Veesler, Davide Corti
Summary: The Omicron variant of SARS-CoV-2 has raised concerns due to its 37 amino acid substitutions in the spike protein, particularly in the receptor-binding domain (RBD), leading to increased binding affinity with human ACE2. Neutralizing activity against Omicron was greatly reduced in convalescent and vaccinated individuals compared to the ancestral virus, but this decrease was less significant after a third vaccine dose. Broadly neutralizing monoclonal antibodies recognizing conserved RBD epitopes may be crucial in combating the Omicron variant and future zoonotic transmissions.
Article
Microbiology
Michael P. Doyle, Joseph R. Genualdi, Adam L. Bailey, Nurgun Kose, Christopher Gainza, Jessica Rodriguez, Kristen M. Reeder, Christopher A. Nelson, Prashant N. Jethva, Rachel E. Sutton, Robin G. Bombardi, Michael L. Gross, Justin G. Julander, Daved H. Fremont, Michael S. Diamond, James E. Crowe
Summary: Yellow fever virus (YFV) is a mosquito-borne virus that occasionally causes outbreaks of severe infection in South America and sub-Saharan Africa. Effective vaccines have been developed, but recent production and distribution issues have left many people vulnerable. This study aimed to isolate an antibody from individuals who had received the YFV vaccine for future use as a biologic drug. The most powerful antiviral antibody was found to be effective in animal models of human infection. These studies provide insights into the human immune response to YFV and offer a potential therapeutic antibody candidate for inhibiting highly virulent strains of the virus.
Article
Biochemistry & Molecular Biology
Suzanne M. Scheaffer, Diana Lee, Bradley Whitener, Baoling Ying, Kai Wu, Chieh-Yu Liang, Hardik Jani, Philippa Martin, Nicholas J. Amato, Laura E. Avena, Daniela Montes Berrueta, Stephen D. Schmidt, Sijy O'Dell, Arshan Nasir, Gwo-Yu Chuang, Guillaume Stewart-Jones, Richard A. Koup, Nicole A. Doria-Rose, Andrea Carfi, Sayda M. Elbashir, Larissa B. Thackray, Darin K. Edwards, Michael S. Diamond
Summary: Bivalent vaccines induce broad immune responses against SARS-CoV-2 and its variants, offering a customizable approach to protect against COVID-19 as new strains emerge.
Article
Biochemistry & Molecular Biology
Vikas Chonira, Young D. Kwon, Jason Gorman, James Brett Case, Zhiqiang Ke, Rudo Simeon, Ryan G. Cosner, Darcy R. Harris, Adam S. Olia, Tyler Stephens, Lawrence Shapiro, Michael F. Bender, Hannah Boyd, I-Ting Teng, Yaroslav Tsybovsky, Florian Krammer, Ningyan Zhang, Michael S. Diamond, Peter D. Kwong, Zhiqiang An, Zhilei Chen
Summary: We report the engineering and selection of two synthetic proteins, FSR16m and FSR22, for the potential treatment of SARS-CoV-2 infection. These proteins exhibit broad-spectrum neutralization of SARS-CoV-2 strains and show promising results in mice, reducing viral burden and weight loss.
NATURE CHEMICAL BIOLOGY
(2023)
Review
Microbiology
Arthur S. Kim, Michael S. Diamond
Summary: This Review provides an overview of the global epidemics caused by arthropod-transmitted RNA viruses known as alphaviruses. It highlights the host factors required for alphavirus entry, the mechanisms by which protective antibodies inhibit alphavirus infection, and the progress of clinical evaluation of candidate vaccines focusing on humoral immunity.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Haiyan Sun, Collin Jugler, Katherine Nguyen, Herta Steinkellner, Qiang Chen
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Collin Jugler, Haiyan Sun, Katherine Nguyen, Roman Palt, Mitchell Felder, Herta Steinkellner, Qiang Chen
Summary: This study describes the discovery of a new, neutralizing monoclonal antibody (mAb), 11D7, against the Wuhan-Hu-1 RBD of SARS-CoV-2. The mAb was developed into a chimeric human IgG and expressed in plants to produce a mAb with human-like glycan structure, potentially increasing its therapeutic potency and safety. 11D7 recognizes and neutralizes the Omicron variant and may provide additional synergy when used in combination with established antibody cocktails.
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Immunology
Haiyan Sun, Dhiraj Acharya, Amber M. Paul, Huafang Lai, Junyun He, Fengwei Bai, Qiang Chen
Summary: Researchers have developed a plant-based vaccine candidate that provides protective immunity against lethal West Nile virus and minimizes the risk of infection by Zika and dengue viruses.
Article
Virology
Haiyan Sun, Ming Yang, Huafang Lai, Biswas Neupane, Audrey Y. -H. Teh, Collin Jugler, Julian K. -C. Ma, Herta Steinkellner, Fengwei Bai, Qiang Chen
Summary: This study demonstrates a two-tier approach for eliminating antibody-dependent enhancement (ADE) while preserving Fc effector functions in the treatment of Dengue virus and Zika virus infections. The selection of virus/serotype-specific antibodies and modulation of Fc glycosylation can effectively prevent ADE. The findings suggest that glycovariants with modified Fc glycans can abrogate ADE and retain antibody-dependent cellular cytotoxicity.
Article
Cell Biology
Glennys Reynoso, David N. Gordon, Anurag Kalia, Cynthia C. Aguilar, Courtney S. Malo, Maya Aleshnick, Kimberly A. Dowd, Christian R. Cherry, John P. Shannon, Sophia M. Vrba, Autumn C. Holmes, Yael Alippe, Sonia Maciejewski, Kenichi Asano, Michael S. Diamond, Theodore C. Pierson, Heather D. Hickman
Summary: To understand the initial steps in Zika virus (ZIKV) transmission, researchers investigated the virus's movement from the skin to the lymph nodes. Contrary to previous beliefs, migratory immune cells were not necessary for the virus to reach the lymph nodes or the bloodstream. Instead, a specific subset of macrophages in the lymph nodes, called CD169+ macrophages, were found to be rapidly infected by ZIKV and release the virus to infect other lymph nodes. These findings improve our understanding of ZIKV dissemination and identify a potential target for antiviral intervention.
Article
Immunology
Somanath Kallolimath, Roman Palt, Esther Foederl-Hoebenreich, Lin Sun, Qiang Chen, Florian Pruckner, Lukas Eidenberger, Richard Strasser, Kurt Zatloukal, Herta Steinkellner
Summary: This study successfully produced pentameric IgM antibodies in glycoengineered plants that carry a highly reproducible human-type N-glycosylation profile. The pentameric IgMs showed increased antigen binding and virus neutralization potency, up to 390-fold, compared to the parental IgG1.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Samantha R. Mackin, Pritesh Desai, Bradley M. Whitener, Courtney E. Karl, Meizi Liu, Ralph S. Baric, Darin K. Edwards, Taras M. Chicz, Ryan P. McNamara, Galit Alter, Michael S. Diamond
Summary: Fc-Fc gamma receptor interactions and alveolar macrophages play a crucial role in controlling infection with SARS-CoV-2 variants in mice vaccinated with ancestral vaccines. While the spike protein antigenic changes in SARS-CoV-2 variants reduce the neutralizing efficiency of legacy vaccine-induced antibodies, vaccines like mRNA-1273 and BNT162b2 still protect against severe disease and death, indicating the involvement of other aspects of immunity in controlling lung infection. Antibodies elicited by vaccines can bind Fc gamma receptors and exert effector functions against SARS-CoV-2 variants, and this property is associated with improved clinical outcomes. However, the causal relationship between Fc effector functions and vaccine-induced protection against infection needs further investigation.
NATURE MICROBIOLOGY
(2023)
Article
Immunology
Ming Yang, Haiyan Sun, Huafang Lai, Biswas Neupane, Fengwei Bai, Herta Steinkellner, Qiang Chen
Summary: Monoclonal antibodies have great potential as therapeutics against Zika virus, but may enhance infection by dengue virus. This study demonstrates the possibility of reducing the risk of dengue virus infection by modifying antibody glycosylation.
Article
Immunology
Adrian Esqueda, Haiyan Sun, James Bonner, Huafang Lai, Collin Jugler, Karen V. V. Kibler, Herta Steinkellner, Qiang Chen
Summary: The development of glycovariants of 7D11, a neutralizing monoclonal antibody, produced in plants, shows promise as a potential therapeutic against the current monkeypox virus (MPXV) outbreak. The plant-made 7D11 antibody quickly accumulates to high levels and can be easily purified. It retains specific binding to its antigen and displays strong neutralization activity against MPXV, similar to its activity against vaccinia virus.
Meeting Abstract
Immunology
Tiantian Liu, Sunkyung Kim, Pritesh Desai, Do-Hyun Kim, Xiao Huang, Stephen T. Ferris, Renee Wu, Feiya Ou, Takeshi Egawa, Steven J. Van Dyken, Michael S. Diamond, Masato Kubo, Theresa L. Murphy, Kenneth M. Murphy
JOURNAL OF IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xue-Mei Yang, Jing-Hao Zhao, Xiao-Yu Xiong, Zhang-Wei Hu, Ji-Fen Sun, Hao Su, Yan-Jing Liu, Ling Xiang, Yong Zhu, Jin-Lu Li, Sadam Hussain Bhutto, Guo-Bang Li, Shi-Xin Zhou, Chi Li, Mei Pu, He Wang, Zhi-Xue Zhao, Ji-Wei Zhang, Yan-Yan Huang, Jing Fan, Wen-Ming Wang, Yan Li
Summary: The Arabidopsis RPW8.1 gene enhances disease resistance but compromises plant growth. It has been found that RPW8.1 constitutively enhances the expression of WRKY51 transcription factor and activates salicylic acid and ethylene signaling pathways. WRKY51, in turn, suppresses RPW8.1 expression, forming a feedback regulation loop.
PLANT BIOTECHNOLOGY JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Hannes Claeys, Eveline Neyrinck, Lies Dumoulin, Anne Pharazyn, Arne Verstichele, Laurens Pauwels, Michael L. Nuccio, Frederic Van Ex
PLANT BIOTECHNOLOGY JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Melanie Ormancey, Bruno Guillotin, Camille Ribeyre, Clemence Medina, Nathanael Jariais, Helene San Clemente, Patrice Thuleau, Serge Plaza, Martina Beck, Jean-Philippe Combier
PLANT BIOTECHNOLOGY JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Edgar Perez-Matas, Diego Hidalgo-Martinez, Elisabeth Moyano, Javier Palazon, Mercedes Bonfill
Summary: In this study, the production of paclitaxel was enhanced by overexpressing the bottleneck genes BAPT and DBTNBT in Taxus baccata cells. The transgenic cells showed significantly higher expression of these genes and improved taxane production compared to the wild type. Transcriptional profiling revealed that the GGPPS, TXS, and DBAT genes were most responsive to DBTNBT overexpression and the dual elicitation treatment.
PLANT BIOTECHNOLOGY JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Biying Dong, Dong Meng, Zhihua Song, Hongyan Cao, Tingting Du, Meng Qi, Shengjie Wang, Jingyi Xue, Qing Yang, Yujie Fu
Summary: This study identified the involvement of the citrate transporter CcMATE35 and the long noncoding RNA CcLTCS in aluminum stress response in pigeon pea. These findings suggest that the modules CcNFYB3-CcMATE35 and CcLTCS-CcCS jointly regulate the efflux and synthesis of citrate to enhance the resistance of pigeon pea under aluminum stress.
PLANT BIOTECHNOLOGY JOURNAL
(2024)
Review
Biotechnology & Applied Microbiology
Tien V. Vu, Ngan Thi Nguyen, Jihae Kim, Jong Chan Hong, Jae-Yean Kim
Summary: Prime editing technology uses an extended guide RNA to direct a fusion peptide to a specific location in the genome, enabling precise gene editing. This groundbreaking tool has potential in improving crop varieties, but efficiency limitations exist in certain plants.
PLANT BIOTECHNOLOGY JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Yan Xu, Jinyi Tan, Junxing Lu, Yuelin Zhang, Xin Li
Summary: Sclerotinia sclerotiorum causes white mold in economically important plants, and the discovery of SsGAP1 and SsRAS1/SsRAS2 genes as essential regulators of fungal development and virulence provides potential targets for controlling the disease.
PLANT BIOTECHNOLOGY JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Xiaoyang Chen, Chen Liu, Hailin Wang, Qi Liu, Yaping Yue, Yuhang Duan, Zhaoyun Wang, Lu Zheng, Xiaolin Chen, Yaohui Wang, Junbin Huang, Qiutao Xu, Yuemin Pan
Summary: This study identified a secreted protein, Uv1809, as a key virulence factor in Ustilaginoidea virens-rice interactions. Uv1809 inhibits rice immunity and promotes infection by targeting and enhancing rice histone deacetylase OsSRT2-mediated histone deacetylation. CRISPR-Cas9 edited ossrt2 mutants showed broad-spectrum resistance to rice pathogens, indicating its potential as a genetic resource for breeding disease resistance.
PLANT BIOTECHNOLOGY JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Weishuai Bi, Jing Liu, Yuanyuan Li, Ziwei He, Yongming Chen, Tingting Zhao, Xiangxiu Liang, Xiaodan Wang, Xiangzong Meng, Daolong Dou, Guangyuan Xu
PLANT BIOTECHNOLOGY JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Shengjie You, Yu Wu, Wen Li, Xiaofeng Liu, Qinlan Tang, Fengkun Huang, Yan Li, Hsihua Wang, Mingchun Liu, Yang Zhang
Summary: In this study, a transcription factor called SlERF.G3-Like in tomato was found to play a role in regulating ethylene synthesis, cell wall degradation, and the flavonoid pathway. The researchers also discovered the interaction between SlERF.G3-Like and the master ripening regulator SlRIN, and increased the production of resveratrol derivatives through genetic manipulation. These findings provide insights into the coordination of fruit maturation and metabolic changes in tomatoes, and have implications for metabolic engineering.
PLANT BIOTECHNOLOGY JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Thomas R. Aalders, Mara de Sain, Fleur Gawehns, Nina Oudejans, Yoran D. Jak, Henk L. Dekker, Martijn Rep, Harrold A. van den Burg, Frank L. W. Takken
Summary: The TPL1 and TPL2 genes in tomato are closely associated with susceptibility to Fusarium wilt disease, and mutating these genes can enhance plant resistance to the disease.
PLANT BIOTECHNOLOGY JOURNAL
(2024)