A fusion protein derived from plants holds promising potential as a new oral therapy for type 2 diabetes

Is Incretin-Based Therapy Ready for the Care of Hospitalized Patients With Type 2 Diabetes?: The time has come for GLP-1 receptor agonists!

(2013) S. Schwartz et al.   DIABETES CARE

Downregulation of Fas activity rescues early onset of diabetes in c-KitWv/+ mice

(2012) Zhi-Chao Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The incretin hormones: from scientific discovery to practical therapeutics

(2012) S. Mudaliar et al.   DIABETOLOGIA

Critical role of c-Kit in beta cell function: increased insulin secretion and protection against diabetes in a mouse model

(2012) Z. C. Feng et al.   DIABETOLOGIA

Inhibition of Gsk3β activity improves β-cell function in c-KitWv/+ male mice

(2012) Zhi-Chao Feng et al.   LABORATORY INVESTIGATION

Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery

(2012) C. E. Bobst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exendin-4 Protects MIN6 Cells from t-BHP-Induced Apoptosis via IRE1-JNK-Caspase-3 Signaling

(2012) Wen-Jia Chen et al.   International Journal of Endocrinology

Developing risk prediction models for type 2 diabetes: a systematic review of methodology and reporting

(2011) Gary S Collins et al.   BMC Medicine

Cardiovascular Complications in Diabetes: Lessons from Animal Models

(2011) M. A. Potenza et al.   CURRENT MEDICINAL CHEMISTRY

Long-Acting Glucagon-Like Peptide 1 Receptor Agonists: A review of their efficacy and tolerability

(2011) A. J. Garber   DIABETES CARE

Effects of Receptor Binding on Plasma Half-Life of Bifunctional Transferrin Fusion Proteins

(2011) Xiaoying Chen et al.   MOLECULAR PHARMACEUTICS

Endocrine disruptors in the etiology of type 2 diabetes mellitus

(2011) Paloma Alonso-Magdalena et al.   Nature Reviews Endocrinology

Incretin-based therapy: a powerful and promising weapon in the treatment of type 2 diabetes mellitus

(2011) Chrysi Koliaki et al.   Diabetes Therapy

Recombinant human transferrin: Beyond iron binding and transport

(2010) Martin E. Brandsma et al.   BIOTECHNOLOGY ADVANCES

Global healthcare expenditure on diabetes for 2010 and 2030

(2010) Ping Zhang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Transferrin Fusion Technology: A Novel Approach to Prolonging Biological Half-Life of Insulinotropic Peptides

(2010) B.-J. Kim et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Plant-derived recombinant human serum transferrin demonstrates multiple functions

(2010) Martin E. Brandsma et al.   PLANT BIOTECHNOLOGY JOURNAL

Expression, purification, and characterization of recombinant human transferrin from rice (Oryza sativa L.)

(2010) Deshui Zhang et al.   PROTEIN EXPRESSION AND PURIFICATION

High-yield expression of recombinant soybean agglutinin in plants using transient and stable systems

(2010) Reynald Tremblay et al.   TRANSGENIC RESEARCH

A review of exenatide as adjunctive therapy in patients with type 2 diabetes

(2010) Gisela Robles   Drug Design Development and Therapy

Tobacco, a highly efficient green bioreactor for production of therapeutic proteins

(2009) Reynald Tremblay et al.   BIOTECHNOLOGY ADVANCES

Protein and peptide drug delivery: Oral approaches

(2009) Jessy Shaji et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Human growth hormone–transferrin fusion protein for oral delivery in hypophysectomized rats

(2009) Nurmamet Amet et al.   JOURNAL OF CONTROLLED RELEASE

Incretin-based therapies for type 2 diabetes mellitus

(2009) Julie A. Lovshin et al.   Nature Reviews Endocrinology

A novel platform for biologically active recombinant human interleukin-13 production

(2008) David J. Wang et al.   PLANT BIOTECHNOLOGY JOURNAL

Exendin-4 Modulates Diabetes Onset in Nonobese Diabetic Mice

(2007) Irene Hadjiyanni et al.   ENDOCRINOLOGY