Article
Obstetrics & Gynecology
Ameer Abdallah, Mohammed Khairy, Mohamed Tawfik, Safaa Mohamed, Mazen Abdel-Rasheed, Sondos Salem, Eissa Khalifa
Summary: Assessment of first-trimester 3D placental volume and power Doppler of placental vascular indices, especially when combined with uterine artery Doppler assessment, can enhance the accuracy of early detection of women at risk for developing pre-eclampsia.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Developmental Biology
J. Y. Chen, M. Chen, X. J. Wu, J. M. Sun, Y. Zhang, Y. F. Li, L. Y. Zhong, B. L. Yu, J. Luo, J. H. Liu
Summary: The study found that the placental vascularization indices (PVIs) at 32-36 weeks of gestation have good value in predicting preeclampsia and fetal growth restriction, while their predictive ability is poor before 32 weeks.
Article
Acoustics
E. Gibbone, A. Wright, R. Vallenas Campos, A. Sanchez Sierra, K. H. Nicolaides, M. Charakida
Summary: The study examined the impact of various factors on maternal cardiovascular indices during 19-23 weeks' gestation, finding that peripheral vascular resistance was the only index significantly affected by the subsequent development of PE, while other indices showed weak correlations with PE. Although maternal cardiovascular indices provide insights into the pathophysiology of PE, they are not useful for predicting PE.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Endocrinology & Metabolism
Zhenyan Han, Yuan Zhang, Xuelan Li, Wei-Hsiu Chiu, Yuzhu Yin, Hongying Hou
Summary: This study compared placental volume (PV) and vascular indices between pregnant women with and without gestational diabetes mellitus (GDM) using three-dimensional (3D) Power Doppler ultrasound. Results showed significant differences in PV, vascularization index (VI), flow index (FI), and vascularization flow index (VFI) between the two groups. Combining maternal age, gravida, PV, and VFI may be a more accurate marker for detecting GDM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Jessica Schuster, Shi-Bin Cheng, James Padbury, Surendra Sharma
Summary: Pre-eclampsia is a hypertensive disease of pregnancy with mechanisms centered around abnormal placentation, inadequate spiral-artery remodeling, and deficiency in trophoblast invasion. Extracellular vesicles (EVs) are suggested to play a crucial role in pre-eclampsia, potentially influencing immune responses, inflammation, altered angiogenesis, and endothelial dysfunction.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Hong Cui, Leilei Yu, Hua Li, Hongling Wang, Wenwen Liang, Huige Wang, Huifeng Wang
Summary: This study found that decreased placental growth potential and low placental bed perfusion in early second trimester have the potential to predict early-onset preeclampsia.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Pharmacology & Pharmacy
Michelle Broekhuizen, Rene de Vries, Marja A. W. Smits, Willem A. Dik, Sam Schoenmakers, Birgit C. P. Koch, Daphne Merkus, Irwin K. M. Reiss, A. H. Jan Danser, Sinno H. P. Simons, Emilie Hitzerd
Summary: This study investigated the placental transfer, vascular effects, and anti-inflammatory actions of pentoxifylline in healthy and pre-eclamptic human placentas. The results showed that while pentoxifylline had beneficial effects on vasodilation and inflammation in healthy placentas, these effects were not retained in pre-eclamptic placentas. This limits the application of pentoxifylline in the treatment of pre-eclampsia, but it may still have value for other placenta-related disorders.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Chiara Tersigni, Donatella Lucchetti, Rita Franco, Filomena Colella, Caterina Neri, Laura Crispino, Alessandro Sgambato, Antonio Lanzone, Giovanni Scambia, Manu Vatish, Nicoletta Di Simone
Summary: PE is a common pregnancy disorder characterized by hypertension and proteinuria, with aberrant expression of HLA-DR in STBEVs specifically associated with PE. Further studies are needed to define the role of abnormal placental HLA-DR expression in PE pathogenesis and evaluate the potential application of detecting circulating HLA-DR positive STBEVs in diagnosing and predicting PE in early and mid-pregnancy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Anesthesiology
R. Bala, D. Budhwar, V. Kumar, S. Singhal, P. Kaushik, J. Sharma
Summary: The aim of this study was to assess airway indices using both routinely used clinical methods and ultrasound. The study found that the routinely used clinical methods lack sensitivity and specificity in airway assessment, while ultrasound can visualize anatomical structures in the supraglottic and subglottic views and is encouraging as an airway assessment tool.
INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA
(2023)
Article
Computer Science, Artificial Intelligence
Maximilian Pietsch, Alison Ho, Alessia Bardanzellu, Aya Mutaz Ahmad Zeidan, Lucy C. Chappell, Joseph Hajnal, Mary Rutherford, Jana Hutter
Summary: The study proposes a fully automatic pipeline for predicting the biological age and health of the placenta from rapid MRI scans. Automatic segmentation shows lower performance than manual segmentation but is sufficient for estimating placental mean T2*. The prediction of placental health is able to differentiate cases of placental insufficiency between 27 and 33 weeks.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Acoustics
L. Saleh, M. M. Alblas, D. Nieboer, R. I. Neuman, Y. Vergouwe, I. A. Brusse, J. J. Duvekot, E. W. Steyerberg, H. J. Versendaal, A. H. J. Danser, A. H. Van den Meiracker, K. Verdonk, W. Visser
Summary: A clinical prediction model was developed and internally validated to predict the risk of pre-eclampsia (PE)-related maternal and fetal complications within 7, 14 and 30 days. The model showed good discriminative performance and awaits further investigation and external validation for clinical use.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Alejandra Chaparro, Maximiliano Monckeberg, Ornella Realini, Marcela Hernandez, Fernanda Param, Daniela Albers, Valeria Ramirez, Juan Pedro Kusanovic, Roberto Romero, Gregory Rice, Sebastian E. Illanes
Summary: This study evaluated the performance of a model combining GCF-PLAP concentration and systolic blood pressure in predicting the risk of developing pre-eclampsia (PE). The model showed potential utility in identifying pre-symptomatic women who may later develop PE, with GCF-PLAP concentrations showing an association with the likelihood of developing the condition.
Article
Biochemistry & Molecular Biology
Ilinca T. Mihai, Jeannette Rudzitis-Auth, Michael D. Menger, Matthias W. Laschke
Summary: This study reveals that the presence of pre-existing endometriotic lesions promotes the growth of new lesions, not through cell exchange, but rather through peritoneal inflammation induced by established lesions. These findings indicate that the chronic nature of endometriosis may be driven by a lesion-induced inflammatory milieu in the peritoneal cavity, creating favorable conditions for the development of new lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Reproductive Biology
Isabela S. Campos, Guillerme N. de Souza, Gustavo Mendes Gomes, Aline E. Pinna, Ana M. R. Ferreira
Summary: The aim of this study was to investigate the correlation between the spectral index of uterine arteries and equine placental development in mares with advanced pregnancies. The results showed that the combined uteroplacental thickness was correlated with gestational time, and significant differences were observed from the sixth month onwards. There was a negative correlation between combined uteroplacental thickness and resistance index, but no correlation with pulsatility index. The resistance index differed significantly among age groups, with a tendency of decrease in the left uterine artery.
Article
Cell Biology
Lina Bergman, Karl Bergman, Eduard Langenegger, Ashley Moodley, Stephanie Griffith-Richards, Johan Wikstrom, David Hall, Lloyd Joubert, Philip Herbst, Sonja Schell, Teelkien van Veen, Michael Belfort, Stephen Y. C. Tong, Susan Walker, Roxanne Hastie, Catherine Cluver
Summary: This project aims to establish a pre-eclampsia biobank in South Africa, focusing on phenotyping severe disease and improving understanding, prediction, and potential drug evaluation of organ complications associated with the condition.
Article
Nutrition & Dietetics
Amy Wotherspoon, Sarah Elshahat, Nicholas McAlinden, Katrina Dean, Ian S. Young, Peter C. Sharpe, Stefan Blankenburg, Chris C. Patterson, Michelle C. McKinley, Alun Evans, Jayne Woodside
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
(2020)
Article
Medical Laboratory Technology
Kelly-Ann Eastwood, Alyson J. Hunter, Christopher C. Patterson, David R. Mc Cance, Ian S. Young, Valerie A. Holmes
ANNALS OF CLINICAL BIOCHEMISTRY
(2020)
Article
Endocrinology & Metabolism
Naomi Todd, Ross McNally, Abdelrahim Alqudah, Djurdja Jerotic, Sonja Suvakov, Danilo Obradovic, Denise Hoch, Jose R. Hombrebueno, Guillermo Lopez Campos, Chris J. Watson, Miroslava Gojnic-Dugalic, Tatjana P. Simic, Anna Krasnodembskaya, Gernot Desoye, Kelly-Ann Eastwood, Alyson J. Hunter, Valerie A. Holmes, David R. McCance, Ian S. Young, David J. Grieve, Louise C. Kenny, Vesna D. Garovic, Tracy Robson, Lana McClements
Summary: The FKBPL-CD44 pathway plays a central role in the pathogenesis of preeclampsia, showing promising utilities for early diagnostic and therapeutic purposes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Abdelrahim Alqudah, Kelly-Ann Eastwood, Djurdja Jerotic, Naomi Todd, Denise Hoch, Ross McNally, Danilo Obradovic, Stefan Dugalic, Alyson J. Hunter, Valerie A. Holmes, David R. McCance, Ian S. Young, Chris J. Watson, Tracy Robson, Gernot Desoye, David J. Grieve, Lana McClements
Summary: The study indicates that the downregulation of FKBPL and SIRT-1 in diabetic pregnancies may play a key role in the development of vascular dysfunction and associated complications. The expression of these proteins is regulated under high glucose conditions and can affect endothelial cell function and placental angiogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Siang Ing Lee, Amaya Azcoaga-Lorenzo, Utkarsh Agrawal, Jonathan Kennedy, Adeniyi Francis Fagbamigbe, Holly Hope, Anuradhaa Subramanian, Astha Anand, Beck Taylor, Catherine Nelson-Piercy, Christine Damase-Michel, Christopher Yau, Francesca Crowe, Gillian Santorelli, Kelly-Ann Eastwood, Zoe Vowles, Maria Loane, Ngawai Moss, Peter Brocklehurst, Rachel Plachcinski, Shakila Thangaratinam, Mairead Black, Dermot O'Reilly, Kathryn M. Abel, Sinead Brophy, Krishnarajah Nirantharakumar, Colin McCowan
Summary: This study investigated the prevalence of pre-existing multimorbidity in pregnant women in the United Kingdom and found that it is a common occurrence. The study also identified older age, multiple pregnancies, higher body mass index, and preconception smoking as factors associated with a higher risk of multimorbidity in pregnant women.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Medicine, General & Internal
Siang Ing Lee, Kelly-Ann Eastwood, Ngawai Moss, Amaya Azcoaga-Lorenzo, Anuradhaa Subramanian, Astha Anand, Beck Taylor, Catherine Nelson-Piercy, Christopher Yau, Colin McCowan, Dermot O'Reilly, Holly Hope, Jonathan Ian Kennedy, Kathryn Mary Abel, Louise Locock, Peter Brocklehurst, Rachel Plachcinski, Sinead Brophy, Utkarsh Agrawal, Shakila Thangaratinam, Krishnarajah Nirantharakumar, Mairead Black
Summary: This study aims to develop a core outcome set for maternal and offspring outcomes in pregnant women with pre-existing multimorbidity. The study design includes systematic literature search, focus groups, Delphi surveys, and consensus group meetings, intended for broad application in various pregnancy settings.
Article
Primary Health Care
Lisa Kent, Christopher Cardwell, Ian Young, Kelly-Ann Eastwood
Summary: The study found a high prevalence and increasing trend of maternal overweight and obesity in Northern Ireland, with obesity being associated with older age, number of previous pregnancies, unemployment, and comorbidities. Maternal obesity prevalence was also related to deprivation levels.
FAMILY MEDICINE AND COMMUNITY HEALTH
(2021)
Article
Nutrition & Dietetics
Alyson J. Hill, C. C. Patterson, I. S. Young, V. A. Holmes, D. R. McCance
Summary: This study explored the relationships between carbohydrate intake, BMI, and glycaemic control in pregnant women with type 1 diabetes. The findings suggest that the average quantity of dietary carbohydrate influences HbA1c, while BMI has less impact. Additionally, differences were observed in fibre and glycaemic index in relation to glycaemic control.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Review
Biotechnology & Applied Microbiology
Katrina Z. Freimane, Lauren Kerrigan, Kelly-Ann Eastwood, Chris J. Watson
Summary: This study aimed to identify the most promising biomarker candidates for clinical implementation in existing pre-eclampsia (PE) models among women with type 1 diabetes mellitus (T1DM). The study found that higher levels of HbA1c and urinary albumin in the first trimester were associated with an increased risk of PE development in women with T1DM. Additionally, urinary neutrophil gelatinase-associated lipocalin and adipokines were identified as novel biomarkers with moderate predictive ability before 15 weeks of gestation. Furthermore, two T1DM-specific PE prediction models were proposed, which measured adipokines or urinary neutrophil gelatinase-associated lipocalin along with maternal clinical characteristics. Contradicting previous literature, the study found correlations between PE risk in women with T1DM and vitamin D levels and atherogenic lipid profile in the context of haptoglobin phenotype 2-2.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Megha Singh, Francesca Crowe, Shakila Thangaratinam, Kathryn Mary Abel, Mairead Black, Kelvin Okoth, Richard Riley, Kelly-Ann Eastwood, Holly Hope, Steven Wambua, Jemma Healey, Siang Ing Lee, Katherine Phillips, Zoe Vowles, Neil Cockburn, Ngawai Moss, Krishnarajah Nirantharakumar
Summary: This study aims to summarize the association between pregnancy complications and five groups of long-term health conditions, and develop prediction models for the risk of developing these health conditions following a pregnancy complication.
Article
Medicine, Research & Experimental
K. A. Eastwood, V. A. Allen-Walker, M. Maxwell, M. C. McKinley
Summary: This study assessed the feasibility of raising awareness of pre-conception care in community pharmacies in Northern Ireland and found that community pharmacies can effectively provide information on pre-conception care to couples planning a pregnancy. The results of the study suggest that improving staff training and support, as well as exploring incentives for pharmacies to prioritize pre-conception care, are key to enhancing the effectiveness of pre-conception care interventions in this setting.
PILOT AND FEASIBILITY STUDIES
(2022)
Meeting Abstract
Nutrition & Dietetics
J. McClelland, L. McGowan, D. Gallagher, S. E. Moore, R. J. Beeken, C. R. Cardwell, H. Croker, K. A. Eastwood, C. O'Neill, R. F. O'Neill, J. V. Woodside, M. C. McKinley
PROCEEDINGS OF THE NUTRITION SOCIETY
(2021)
Article
Ophthalmology
Nicola B. Quinn, David H. Steel, Usha Chakravarthy, Tunde Peto, Barbra Hamill, Alyson Muldrew, Katie Graham, David Elliott, Riona Hennessy, Sharon Cruise, Bernadette McGuinness, Ian S. Young, Frank Kee, Ruth E. Hogg
OPHTHALMOLOGY RETINA
(2020)
Article
Cardiac & Cardiovascular Systems
Gavin Robertson, Alan Fleming, Michelle Claire Williams, Emanuele Trucco, Nicola Quinn, Ruth Hogg, Gareth J. Mckay, Frank Kee, Ian Young, Enrico Pellegrini, David E. Newby, Edwin J. R. van Beek, Tunde Peto, Baljean Dhillon, Jano van Hemert, Thomas J. MacGillivray