期刊
PLACENTA
卷 70, 期 -, 页码 50-52出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2018.09.004
关键词
Bovine foetal growth restriction; miRNA expression; Placenta; Mammals
资金
- National Science Centre, Poland [2013/09/B/NZ9/03160, 2016/23/N/NZ9/00232]
Intrauterine growth restriction (IUGR) is a serious pregnancy complication caused by placental insufficiency. We previously reported that truncation of MIMT1 gene exons 3 and 4 (MIMT1(Del)) causes IUGR in cattle. Here we investigated miRNA expression in the foetal and maternal placenta tissues of MIMT1(Del/WT) foetuses. Small RNA next generation sequencing and quantitative PCR revealed placental tissue-specific expression of the miR-4321, known to regulate many genes involved in early foetal development. This study also indicated that maternal and foetal components of the placenta respond differently to a deleterious conceptus mutation.
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