期刊
PLACENTA
卷 34, 期 11, 页码 1095-1098出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2013.09.001
关键词
Maternal diabetes; Oxidative stress; Placenta
资金
- Fundacao para a Ciencia e a Tecnologia (FCT)
- COMPETE
- QREN
- FEDER [PTDC/SAU-OSM/102239/2008, SFRH/BD/63086/2009, SFRH/BPD/40170/2007]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/63086/2009] Funding Source: FCT
We aimed to determine the oxidative stress status in placentas obtained from gestational (GDM) and type 1 (T1D) diabetic pregnancies. Malonaldehyde and protein carbonyls, two biomarkers of oxidative damage, were higher in T1D but not in GDM placentas. Also, higher reduced glutathione and lower oxidized glutathione levels and higher glutathione peroxidase activity were found in T1D but not in GDM placentas. These results suggest that T1D placentas may develop a protective antioxidant mechanism to overcome higher oxidative stress levels. (C) 2013 Elsevier Ltd. All rights reserved.
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