Article
Obstetrics & Gynecology
Kelsey McLaughlin, Sebastian R. Hobson, Anjana Ravi Chandran, Swati Agrawal, Rory C. Windrim, W. Tony Parks, Adrian W. Bowman, Ulla Sovio, Gordon C. Smith, John C. Kingdom
Summary: The study established a gestational age-specific reference range for placental growth factor levels and showed that low-molecular-weight heparin therapy can increase circulating placental growth factor levels in patients, prolonging pregnancy and reducing adverse pregnancy outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Samprikta Manna, Colm J. J. Mc Elwain, Gillian M. M. Maher, Marta Giralt Martin, Andrea Musumeci, Fergus P. P. McCarthy, Cathal McCarthy
Summary: This study investigated the cellular senescence phenotypes of pre-eclampsia and intrauterine growth restriction (IUGR) pregnancies by measuring multiple biomarkers of senescence. The results showed signs of premature senescence in IUGR pregnancies, while pre-eclampsia activated cell cycle checkpoint regulators but with a phenotype of cell repair and proliferation rather than senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Acoustics
C. A. Cluver, L. Bergman, J. Bergkvist, H. Imberg, L. Geerts, D. R. Hall, B. W. Mol, S. Tong, S. P. Walker
Summary: This study assessed whether coexisting fetal growth restriction (FGR) influences pregnancy latency and maternal and perinatal outcomes in women with preterm pre-eclampsia. The results showed that FGR is associated with shorter pregnancy latency, more emergency Cesarean deliveries, fewer successful inductions of labor, and increased rates of neonatal morbidity and mortality.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Barbara Gardella, Mattia Dominoni, Camilla Caporali, Stefania Cesari, Giacomo Fiandrino, Stefania Longo, Giovanni Battista De Vito, Cecilia Naboni, Davide Tonduti, Gianfranco Perotti, Simona Orcesi, Arsenio Spinillo
Summary: The study found that in pregnancies complicated by intrauterine growth restriction, both maternal and fetal vascular malperfusion are associated with an increased risk of abnormal infant neurodevelopmental outcomes at 2 years of age. Specifically, fetal vascular malperfusion has a more significant impact on infant neurodevelopment, highlighting the importance of attention to this issue in clinical practice.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Stefano Fruci, Silvia Salvi, Sascia Moresi, Francesca Gallini, Marco Dell 'Aquila, Vincenzo Arena, Enrico Di Stasio, Sergio Ferrazzani, Sara De Carolis, Antonio Lanzone
Summary: This study describes the perinatal outcomes and placental histopathological findings in a small series of pregnant women with severe preeclampsia (PE) and intrauterine growth restriction (IUGR) treated with pravastatin on compassionate grounds. The two-year follow-up of these infants did not show significant differences.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Acoustics
Farah Deeba, Ricky Hu, Victoria Lessoway, Jefferson Terry, Denise Pugash, Jennifer Hutcheon, Chantal Mayer, Septimiu Salcudean, Robert Rohling
Summary: Pregnancy complications such as pre-eclampsia (PE) and intrauterine growth restriction (IUGR) are associated with changes in the structure and function of the placenta. Elastography techniques can assess the mechanical properties of the placenta and be used for detecting placenta abnormalities and predicting pregnancy outcomes.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Computer Science, Information Systems
Lola Gomez-Jemes, Andreea Madalina Oprescu, Angel Chimenea-Toscano, Lutgardo Garcia-Diaz, Maria del Carmen Romero-Ternero
Summary: The use of artificial intelligence in healthcare, especially in obstetrics and gynecology, has great potential. This study proposes a machine learning model to predict risk events in pregnancy, specifically pre-eclampsia and intrauterine growth restriction, using specific measurements. The variation of the decision tree classifier was found to be the best performing model.
Article
Public, Environmental & Occupational Health
Daina B. Esposito, Brian Bateman, Martha Werler, Loreen Straub, Helen Mogun, Sonia Hernandez-Diaz, Krista Huybrechts
Summary: Opioids may have an impact on placental abruption, preterm delivery, and small for gestational age, while showing no association with preeclampsia, according to a study using data from the US nationwide Medicaid Analytic Extract.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Developmental Biology
A. Arias, J. A. Schander, M. Bariani, F. Correa, A. P. Dominguez Rubio, M. Cella, C. B. Cymeryng, M. L. Wolfson, A. M. Franchi, J. Aisemberg
Summary: Maternal dexamethasone administration during late gestation results in fetal and placental growth restriction, potentially due to altered placental angiogenesis.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Thi Truong, Alexandra J. Harvey, David K. Gardner
Summary: This study investigated the effect of combined antioxidants on mouse fetal gene expression. The results showed that both in-vitro culture in the presence of 20% oxygen and vitrification of blastocysts significantly perturbed fetal liver and placental gene expression. However, supplementation with A3 reduced the number of differentially expressed genes and altered biological processes, establishing a more in-vivo-like gene expression profile, particularly in the placenta. Additionally, A3 supplementation significantly reduced the expression of genes associated with pre-eclampsia and intrauterine growth restriction.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Adi Goldbart, Gali Pariente, Eyal Sheiner, Tamar Wainstock
Summary: This study aims to identify the association between first pregnancy and subsequent placental abruption. The results show that complications during first pregnancy are associated with an increased risk of placental abruption, and the risk further increases with multiple complications. This suggests that the first pregnancy may serve as an opportunity to identify women at risk for future placental abruption.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Laura D. Brown, Claire Palmer, Lucas Teynor, Brit H. Boehmer, Jane Stremming, Eileen Chang, Alicia White, Amanda K. Jones, Sarah N. Cilvik, Stephanie R. Wesolowski, Paul J. Rozance
Summary: The study found that fetal sex does not have a widespread impact on experimental insults, with most outcomes showing no gender-based differences. The only exceptions were higher hormone concentrations in female fetuses.
REPRODUCTIVE SCIENCES
(2022)
Article
Immunology
Jessica Schuster, Shi-Bin Cheng, James Padbury, Surendra Sharma
Summary: Pre-eclampsia is a hypertensive disease of pregnancy with mechanisms centered around abnormal placentation, inadequate spiral-artery remodeling, and deficiency in trophoblast invasion. Extracellular vesicles (EVs) are suggested to play a crucial role in pre-eclampsia, potentially influencing immune responses, inflammation, altered angiogenesis, and endothelial dysfunction.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Cell Biology
Carter Norton, Derek Clarke, Joshua Holmstrom, Isaac Stirland, Paul R. Reynolds, Tim G. Jenkins, Juan A. Arroyo
Summary: The objective of this study was to analyze methylation patterns in placental DNA from normal pregnancies, preeclampsia (PE) and intrauterine growth restriction (IUGR) affected pregnancies. DNA was extracted, bisulfite converted and hybridized for methylation array. Differentially methylated regions were identified using the USEQ program, and gene promoters were identified using UCSC's Genome browser and Stanford's GREAT analysis. Western blot confirmed differential protein expression of commonly regulated genes. The study found some common methylation alterations between PE and IUGR, which may explain the clinical similarities observed with these obstetric complications.
Article
Immunology
Yang Liu, Jin Liu, Anguo Liu, Hillary Yin, Irina Burd, Jun Lei
Summary: This study investigates the involvement of SAA isoforms in the mechanism of spontaneous PTB and identifies SAA2 as a novel therapeutic target. Maternal inhibition of Saa2 using siRNA shows promise in alleviating PTB.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Pediatrics
Maria Ann Mannion, Brendan Fitzgerald, Peter Filan
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2016)
Article
Medicine, Research & Experimental
Cassie Fives, Andreea Nae, Phoebe Roche, Gerard O'Leary, Brendan Fitzgerald, Linda Feeley, Patrick Sheahan
Article
Otorhinolaryngology
Nicola M. Hughes, Andreea Nae, Josephine Barry, Brendan Fitzgerald, Linda Feeley, Patrick Sheahan
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2017)
Review
Immunology
Brendan Fitzgerald
Article
Developmental Biology
L. K. Proctor, B. Fitzgerald, W. L. Whittle, N. Mokhtari, E. Lee, G. Machin, J. C. P. Kingdom, S. J. Keating
Article
Otorhinolaryngology
Patrick Sheahan, Mohamed Mohamed, Carmel Ryan, Linda Feeley, Brendan Fitzgerald, Julie McCarthy, Antoinette Tuthill, Matthew S. Murphy
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2014)
Article
Obstetrics & Gynecology
Khadijah I. Ismail, Ailish Hannigan, Peter Kelehan, Brendan Fitzgerald, Keelin O'Donoghue, Amanda Cotter
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2020)
Article
Developmental Biology
Grace Neville, Noirin Russell, Keelin O'Donoghue, Brendan Fitzgerald
Review
Developmental Biology
Laura Linehan, Keelin O'Donoghue, Susan Dineen, Jessica White, John R. Higgins, Brendan Fitzgerald
Summary: SARS-CoV-2 infection during pregnancy can lead to placental infection, posing a threat to the fetus, though this situation is relatively rare.
Article
Medical Laboratory Technology
David A. Schwartz, Marcella Baldewijns, Alexandra Benachi, Mattia Bugatti, Gaetano Bulfamante, Ke Cheng, Rebecca R. J. Collins, Larisa Debelenko, Daniele De Luca, Fabio Facchetti, Brendan Fitzgerald, Daniel Levitan, Rebecca L. Linn, Lukas Marcelis, Denise Morotti, Raffaella Morotti, Luisa Patane, Sophie Prevot, Bianca Pulinx, Ali G. Saad, Sam Schoenmakers, David Strybol, Kristen Thomas, Delfina Tosi, Valentina Toto, Lotte E. Van der Meeren, Robert M. Verdijk, Alexandre J. Vivanti, Mehreen Zaigham
Summary: The study found that SARS-CoV-2 can extend beyond the syncytiotrophoblast to enter other villous stromal cells in the placenta, including Hofbauer cells and capillary endothelial cells. Infection of Hofbauer cells and villous capillary endothelial cells in the placenta is uncommon.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Medical Laboratory Technology
David A. Schwartz, Elyzabeth Avvad-Portari, Pavel Babal, Marcella Baldewijns, Marie Blomberg, Amine Bouachba, Jessica Camacho, Sophie Collardeau-Frachon, Arthur Colson, Isabelle Dehaene, Joan Carles Ferreres, Brendan Fitzgerald, Marta Garrido-Pontnou, Hazem Gergis, Beata Hargitai, A. Cecilia Helguera-Repetto, Sandra Holmstrom, Claudine Liliane Irles, Asa Leijonhfvud, Sasha Libbrecht, Tamas Marton, Noel McEntagart, James T. Molina, Raffaella Morotti, Alfons Nadal, Alexandra Navarro, Maria Nelander, Angelica Oviedo, Andre Ricardo Oyamada Otani, Nikos Papadogiannakis, Astrid C. Petersen, Drucilla J. Roberts, Ali G. Saad, Anna Sand, Sam Schoenmakers, Jennifer K. Sehn, Preston R. Simpson, Kristen Thomas, M. Yolotzin Valdespino-Vazquez, Lotte E. van der Meeren, Jo Van Dorpe, Robert M. Verdijk, Jaclyn C. Watkins, Mehreen Zaigham
Summary: This study evaluated the mechanism of stillbirth and neonatal death following maternal infection with COVID-19. The findings suggest that placental abnormalities caused by SARS-CoV-2 infection result in placental malperfusion and insufficiency, leading to fetal hypoxic-ischemic injury and perinatal death.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2022)
Article
Medical Laboratory Technology
Brendan Fitzgerald, Keelin O'Donoghue, Noel McEntagart, John E. Gillan, Peter Kelehan, John O'Leary, Paul Downey, Jonathan Dean, Cillian F. De Gascun, John Bermingham, Fionnvola Armstrong, Attia Al Fathil, Nicola Maher, Cliona Murphy, Louise Burke
Summary: A severe third wave of COVID-19 in Ireland resulted in 1 second-trimester miscarriage and 6 stillbirths due to SARS-CoV-2 placentitis. The presence of SARS-CoV-2 alpha in all cases suggests an increased risk of fetal death compared to the original virus. Maternal thrombocytopenia may serve as a potential clinical marker of placentitis, and there may be a window for intervention in some cases.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2022)
Review
Pathology
Carla Bartosch, Alfons Nadal, Ana C. Braga, Angela Salerno, Anne-Laure Rougemont, Anne-Sophie Van Rompuy, Brendan Fitzgerald, Caroline Joyce, Fabienne Allias, Geoffrey J. Maher, Gitta Turowski, Jean-Christophe Tille, Kinan Drak Alsibai, Koen van de Vijver, Lesley Mcmahon, Lone Sunde, Michal Pyzlak, Paul Downey, Sandra Wessman, Sophie Patrier, Baljeet Kaur, Rosemary Fisher
Summary: Hydatidiform moles are rare and require prompt and accurate identification due to their potential premalignant nature. Diagnosis can be improved through the use of standardized diagnostic criteria and algorithms.
Article
Obstetrics & Gynecology
Abi Merriel, Brendan Fitzgerald, Keelin O'Donoghue
Summary: SARS-CoV-2 has had a significant impact on pregnancy outcomes, with a clear link between the virus and poor fetal outcome observed during the Alpha and Delta waves. Some women who contract COVID-19 develop SARS-CoV-2 placentitis, which has been associated with intrauterine fetal death. Surprisingly, SARS-CoV-2 placentitis is often not associated with severe maternal COVID-19 infection, making prediction difficult.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
D. Nuzum, B. Fitzgerald, M. J. Evans, K. O'Donoghue
Summary: Perinatal autopsy rates have significantly declined in recent decades, but there is a lack of consensus on the potential religious influences in decision making. Most chaplains reported being asked about post-mortem by parents, but only a minority felt adequately prepared.
JOURNAL OF RELIGION & HEALTH
(2021)