Article
Marine & Freshwater Biology
Gilles Tinant, Melusine Van Larebekea, Benjamin Lemaire, Marine Courteille, Cecile Gardin, Ineke Neefs, Krishna Das, Melissa M. Page, Jean-Francois Rees, Yvan Larondelle, Cathy Debier
Summary: This study investigated the impacts of dietary MeHg and fatty acids on lipid metabolism in rainbow trout. The results showed that a diet enriched in linoleic acid (LA) increased the overall lipid content, while the addition of MeHg significantly reduced the lipid content. The size of adipocytes was influenced by both LA and MeHg. The fatty acid composition of adipose tissue and liver was significantly altered by the dietary fatty acids. Exposure to MeHg led to a release of n-6 PUFA from the hepatic membranes. This study highlights the important impact of MeHg exposure and dietary fatty acids on lipid metabolism in fish.
AQUATIC TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Welma Stonehouse, Domenico Sergi, Bianca Benassi-Evans, Genevieve James-Martin, Nathan Johnson, Campbell H. Thompson, Mahinda Abeywardena
Summary: In this study, the effects of diets enriched in different types of fats on liver fat concentration and adipose tissue in healthy adults were investigated. The results showed that the quality of dietary fats did not significantly impact liver fat concentration and adipose tissue amounts, although effects on serum lipids were inconsistent across different lipid profiles. Further research is needed to confirm these findings in individuals with metabolic impairments before making recommendations.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Yusuke Igarashi, Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Muneaki Kumagai, Miyoko Yamaoka, Hiromi Nishimura, Michiaki Fukui
Summary: This study found that both the quantity and density of visceral adipose tissue (VAT) were associated with the prevalence and incidence of nonalcoholic fatty liver disease (NAFLD). Visceral fat density (VFD) may be more related to the incidence of NAFLD than visceral fat area (VFA) index.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Fan Yang, Nan Zhou, Xiaolei Zhu, Cuiting Min, Wei Zhou, Xiaonan Li
Summary: Early-life nutrition has a significant impact on adult metabolism. This study found that postnatal overnutrition increases the risk of NAFLD and decreases Nrg4 expression, while a postweaning n-3 PUFA diet enhances Nrg4 expression in adipose tissues and helps attenuate NAFLD induced by overnutrition. Additionally, external NRG4 reduces lipogenesis in hepatocytes and n-3 PUFAs may promote NRG4 production through the PPARG pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Helene Salaun, Mathilde Poisson, Adeline Dolly, Flavie Arbion, Stephane Servais, Jean Francois Dumas, Caroline Goupille, Lobna Ouldamer
Summary: Prognostic factors for epithelial ovarian cancers (EOCs) include clinical factors such as FIGO stages, genetic mutation, and histological phenotypes. This study found that FIGO stage, tumor residue after surgery, and body mass index were predictors of recurrence-free survival (RFS). Additionally, the study revealed that total long-chain polyunsaturated fatty acids (PUFAs) were positively associated with RFS in EOC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yuko Akazawa, Tomohito Morisaki, Hiroko Fukuda, Kiyuu Norimatsu, Junya Shiota, Keiichi Hashiguchi, Maiko Tabuchi, Moto Kitayama, Kayoko Matsushima, Naoyuki Yamaguchi, Hisayoshi Kondo, Fumihiko Fujita, Hiroaki Takeshita, Kazuhiko Nakao, Fuminao Takeshima
Summary: This study investigated the significance of palmitoleic acid (PO) levels in the serum of patients with ulcerative colitis (UC) and Crohn's disease (CD). The results showed that serum PO levels were significantly higher in CD patients compared to controls, and were associated with CD activity index and increased risk of surgical intervention requirement during follow-up. Elevated serum PO levels might serve as a marker for local inflammation and prognosis in patients with CD.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Marta Lopez-Yus, Silvia Lorente-Cebrian, Raquel Del Moral-Bergos, Carlos Horndler, Maria Pilar Garcia-Sobreviela, Carmen Casamayor, Alejandro Sanz-Paris, Vanesa Bernal-Monterde, Jose M. Arbones-Mainar
Summary: This study investigated the molecular mechanisms of subcutaneous white adipose tissue (scWAT) in the progression of nonalcoholic fatty liver disease (NAFLD). Through RNA sequencing analysis and in vitro experiments, potential key genes related to NAFLD progression were identified. These findings provide new potential targets for future therapies against liver steatosis.
Article
Biochemical Research Methods
Minghui Ou, Qian Zhang, Huidong Zhao, Chang Shu
Summary: The study revealed that PUFAs and LXA4 have an impact on PE by regulating LOX and inflammatory responses.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Food Science & Technology
Jiahui Wang, Zhixin Zhang, Yan Lin, Juan Chen, Fangbin Wang, Lu Wang, Jian Liu, Xian Zhang
Summary: Dietary luteolin inhibits the lipolysis induced by 5-HT, preventing the development of obesity-related complications. In high-fat diet-fed mice, luteolin supplementation alleviates the occurrence of fatty liver. However, luteolin has no significant effect on body weight.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Medicine, General & Internal
Carolina M. Perdomo, Jorge M. Nunez-Cordoba, Ana Ezponda, Francisco J. Mendoza, Javier Ampuero, Gorka Bastarrika, Gema Fruhbeck, Javier Escalada
Summary: The study found that patients with MAFLD-T2D and MAFLD-OW phenotypes have a significantly increased risk of cardiovascular disease. The new MAFLD criteria emphasized the importance of identifying metabolic phenotypes in populations, as it may help identify patients with a higher risk of CVD and provide personalized therapeutic management in primary prevention settings.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Andrea Barrientos-Riosalido, Laia Bertran, Merce Vilaro-Blay, Carmen Aguilar, Salome Martinez, Marta Paris, Fatima Sabench, David Riesco, Jessica Binetti, Daniel Del Castillo, Cristobal Richart, Teresa Auguet
Summary: The objective of this study was to assess the involvement of OLFM2 in NAFLD mediated by the adipose-tissue-liver axis. OLFM2 expression in SAT was enhanced in MO individuals and in the presence of NAFLD. Additionally, OLFM2 expression in VAT decreased in the presence of NASH and exhibited a positive correlation with adiponectin levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Xuefeng Ni, Li Jiao, Ye Zhang, Jin Xu, Yunqing Zhang, Xiaona Zhang, Yao Du, Zhaoyong Sun, Shitian Wang
Summary: The study shows a significant relationship between non-alcoholic fatty liver disease (NAFLD) and abdominal and pericardial adipose tissue, with an increase in abdominal visceral adipose tissue correlating with a higher risk of developing NAFLD.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Jihong Dong, Kaiming Yue, Juan J. Loor, Ahmad Aboragah, Guojin Li, Linfang Chen, Yuxiang Song, Xiliang Du, Guowen Liu, Zhe Wang, Xiaobing Li, Xinwei Li
Summary: Increased lipolysis in cows with fatty liver during the transition period is associated with enhanced autophagy, but the specific molecular mechanisms linking lipolysis and autophagy still need further investigation.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jesus Fernandez-Felipe, Adrian Plaza, Gema Dominguez, Javier Perez-Castells, Victoria Cano, Francesco Cioni, Nuria Del Olmo, Mariano Ruiz-Gayo, Beatriz Merino
Summary: High-fat diets enriched with lauric acid do not increase leptin production and reduce the effect of leptin on kinase phosphorylation. Both high-fat diets affect adipocyte-size distribution and gene expression related to adipogenesis and inflammation. The composition of white adipose tissue is different between the two diets, which may impact the biophysical properties and signaling of leptin receptor.
Article
Nutrition & Dietetics
Evelyn Nunes Goulart da Silva Pereira, Beatriz Peres de Araujo, Karine Lino Rodrigues, Raquel Rangel Silvares, Carolina Souza Machado Martins, Edgar Eduardo Ilaquita Flores, Caroline Fernandes-Santos, Anissa Daliry
Summary: Simvastatin plays an important role in the treatment of nonalcoholic liver disease by modulating microcirculation, improving metabolic and oxidative stress parameters, and reducing tissue damage and inflammation.
Review
Obstetrics & Gynecology
Anne Cathrine Staff, Heidi E. Fjeldstad, Ingrid Knutsdotter Fosheim, Kjartan Moe, Gitta Turowski, Guro Mork Johnsen, Patji Alnaes-Katjavivi, Meryam Sugulle
Summary: Physiological transformation and remodeling of uteroplacental spiral arteries play a key role in successful placentation and normal placental function. Poor remodeling is associated with early-onset preeclampsia and other major obstetrical syndromes. Acute atherosis, a foam cell lesion, is linked to poor remodeling and may be triggered by inflammatory stimulation. Understanding this uteroplacental interface is crucial for understanding the pathophysiology of preeclampsia and its short- and long-term effects on pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Cell Biology
Rahul Mallick, Asim K. Duttaroy
Summary: The endothelium acts as a barrier to prevent circulating lipids from entering the arterial wall and regulates various responses and signals in the circulatory system. Increased levels of plasma free fatty acids are associated with atherosclerosis and cardiovascular diseases, and are considered essential in the onset of endothelial dysfunction. FFA-mediated endothelial dysfunction involves multiple mechanisms, and modulation of these pathways may help prevent complications associated with cardiovascular disease risk.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Correction
Developmental Biology
Ingrid Knutsdotter Fosheim, Guro Mork Johnsen, Patji Alnaes-Katjavivi, Gitta Turowski, Meryam Sugulle, Anne Cathrine Staff
Article
Cell & Tissue Engineering
Ganesan Jothimani, Surajit Pathak, Suman Dutta, Asim K. Duttaroy, Antara Banerjee
Summary: This study identified that primary human MSCs release miRNAs and growth factors via exosomes, which have a critical influence in regulating cell death and apoptosis of cancer cells.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Vilasagaram Srinivas, Archana Molangiri, Saikanth Varma, Aswani Mallepogu, Suryam Reddy Kona, Ahamed Ibrahim, Asim K. Duttaroy, Sanjay Basak
Summary: Maternal omega-3 (n-3) polyunsaturated fatty acids (PUFAs) deficiency can affect offspring's adiposity and metabolism by modulating lipid and glucose metabolism. The study found that n-3 PUFA deficiency affects the development of fetal interscapular brown adipose tissue (iBAT) and the expression of thermogenesis-related proteins. Additionally, the expression of insulin growth factor-1 (IGF-1) and glucose transporters (GLUTs) in the offspring is also altered.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Obstetrics & Gynecology
Heidi E. Fjeldstad, Daniel P. Jacobsen, Guro M. Johnsen, Meryam Sugulle, Angel Chae, Sami B. Kanaan, Hilary S. Gammill, Anne Cathrine Staff
Summary: Changes in placental-associated markers may increase fetal cell transfer and contribute to fetal microchimerism. Our findings suggest that underlying placental dysfunction potentially drives increased fetal microchimerism.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Immunology
Meenu Bhatiya, Surajit Pathak, Ganesan Jothimani, Asim K. Duttaroy, Antara Banerjee
Summary: The study aimed to investigate the anticancer and anti-aging effects of quercetin in colon cancer cell lines. The results showed that quercetin inhibited cell proliferation by modulating the expression of aging proteins and inhibiting telomerase activity. Additionally, quercetin provided DNA damage protection by reducing proteasome 20S levels. Moreover, the miRNA expression profiling revealed differential expression of miRNA involved in the regulation of cell cycle, proliferation, and transcription in colon cancer cells. These findings provide a better understanding of quercetin's potential use in colon cancer treatment.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2023)
Article
Biochemistry & Molecular Biology
Saikanth Varma, Archana Molangiri, Suryam Reddy Kona, Ahamed Ibrahim, Asim K. Duttaroy, Sanjay Basak
Summary: Daily exposure to bisphenols can affect reproductive functions due to their pseudo-estrogenic and/or anti-androgenic effects. Whether prenatal exposure to bisphenols alters testicular fatty acid metabolism in adult offspring is unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Luis Alberto Bravo-Vazquez, Erick Octavio Mora-Hernandez, Alma L. L. Rodriguez, Padmavati Sahare, Anindya Bandyopadhyay, Asim K. K. Duttaroy, Sujay Paul
Summary: Neurodegenerative diseases (NDDs) are a major global health issue characterized by the loss of neurons in the central nervous system. Immunotherapeutic approaches using plant-based antigen expression systems have shown promising results in treating NDDs such as Alzheimer's, Parkinson's, and multiple sclerosis. These plant-made vaccines induce significant immune responses and offer advantages like scalability, absence of human pathogens, cold chain-free production, and lower costs. This article provides an overview of the progress and future prospects of plant-manufactured vaccines for NDDs.
Article
Cell Biology
Alakesh Das, Surajit Pathak, Madhavi Premkumar, Chitra Veena Sarpparajan, Esther Raichel Balaji, Asim K. Duttaroy, Antara Banerjee
Summary: The COVID-19 pandemic has caused significant morbidity and mortality worldwide, with a diverse range of symptoms and a cytokine surge that worsens the severity of the disease. Efforts to reduce the cytokine surge and its complications have focused on treatment strategies like corticosteroids, chloroquine, and intravenous immunoglobulin. Comprehensive post-COVID-19 management strategies, including nutritional guidance and multidisciplinary care, have also become increasingly important.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Food Science & Technology
Agnese Barin, Ranjit K. Das, Nasser E. Bastani, Per Ole Iversen, Asim K. Duttaroy
Summary: Hyperactive platelets contribute to atherosclerosis and new research shows that sugar-free extracts of tamarillo, horned melon, and raspberry can inhibit platelet aggregation and contain antiplatelet compounds.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Editorial Material
Nutrition & Dietetics
Asim K. Duttaroy
Review
Nutrition & Dietetics
Antara Banerjee, Indumathi Somasundaram, Diptimayee Das, Samatha Jain Manoj, Husaina Banu, Pavane Mitta Suresh, Sujay Paul, Atil Bisgin, Hong Zhang, Xiao-Feng Sun, Asim K. Duttaroy, Surajit Pathak
Summary: Natural herbs and functional foods can boost the immune system and fight against viruses. Functional foods like prebiotics, probiotics, and dietary fibers have positive effects on gut microbiota and immune function. The gut microbiota plays a critical role in overall health and immune function, and disruptions to its balance have been linked to health problems. This review article explores the potential use of functional foods in mitigating the impact of SARS-CoV-2 variants on gut microbiota diversity and combating the effects of the virus.
Review
Genetics & Heredity
Javier A. Benavides-Aguilar, Andrea Torres-Copado, Jose Isidoro-Sanchez, Surajit Pathak, Asim K. Duttaroy, Antara Banerjee, Sujay Paul
Summary: Obesity is a major health concern worldwide and can lead to various chronic diseases. MiRNAs play a significant role in the onset and progression of obesity and related ailments, and their expression can be influenced by chemical compounds in food and treatments.
Article
Biochemistry & Molecular Biology
Rahul Mallick, Asim K. Duttaroy
Summary: Changes in gene expression play a role in brain functions, and epigenetic processes have a crucial role in modulating gene expression. Understanding the impact of various factors on the brain's epigenome can help unravel the mysteries of brain function.
NEUROCHEMISTRY INTERNATIONAL
(2023)
