Article
Medicine, Research & Experimental
Meiyun Zheng, Jinyu Yan, Lingling Jiang, Zhenzhen Dai, Xiang Liu
Summary: This study found that the M1/M2 haplotypes in the ANXA5 gene are associated with an increased risk of recurrent pregnancy loss (RPL), and carriers of the M2 haplotype have decreased ANXA5 expression.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Oncology
Zhuhua Cai, Xiuying Zheng, Yan Chen, Fengdan Chen, Liangmiao Chen, Xiaohui Deng
Summary: The M2 haplotype of ANXA5 is associated with an increased risk of recurrent pregnancy loss (RPL), as it affects the activity of ANXA5 and leads to decreased levels of Anxa5 mRNA and protein expression in RPL patients.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Genetics & Heredity
Nina Rogenhofer, Arseni Markoff, Xenia Ennerst, Nadja Bogdanova, Christian Thaler
Summary: Carriage of the M2/ANXA5 haplotype is associated with a significantly increased risk of recurrent implantation failure (RIF) for both maternal and paternal carriers, providing new insights into the pathogenesis of RIF and identifying relevant risk groups.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Immunology
Liying Peng, Wanli Yang, Xujing Deng, Shihua Bao
Summary: This review summarizes the research progress on the correlation between SNPs in ANXA5 and RPL, revealing that certain SNPs in the promoter region of ANXA5 may be associated with the occurrence of RPL.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Chemistry, Physical
Anna Mularski, Stine Lauritzen Sonder, Anne Sofie Busk Heitmann, Jesper Nylandsted, Adam Cohen Simonsen
Summary: The study reveals that ANXA4 and ANXA5 colocalize at the damage site of MCF7 cells during repair, with their (1:1) mixture inducing membrane rolling with an intermediate time constant. Unlike the crystal lattices formed by pure annexins, the (1:1) mixture generates a random arrangement of trimers, showing that curvature induction is the functional property of annexin mixtures in PMR rather than crystal formation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Immunology
Senjuti Dasgupta, Priyanka Maity, Uma Banerjee, Partha Mukhopadhyay, Saswata Saha, Biplab Das
Summary: The study revealed significantly reduced levels of ANXA5 and apelin in the placentae of patients with pre-eclampsia compared to controls. Furthermore, the expression levels of these markers were significantly associated with neonatal resuscitation and the requirement of treatment in the neonatal care unit for sick infants.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Oncology
Alexis Woodward, Gabriela N. F. Faria, Roger G. Harrison
Summary: Identifying a universal biomarker for cancer treatment remains a major challenge. Phosphatidylserine is highly expressed in cancer cells and the vasculature, and the native binding partner ANXA5 can deliver chemotherapies to the tumor microenvironment.
Article
Biochemistry & Molecular Biology
Hejun Zhang, Yalong Gao, Tuo Li, Fanjian Li, Ruilong Peng, Cong Wang, Shu Zhang, Jianning Zhang
Summary: The study found that ANXA5 protects against TBI-induced intestinal injury by inhibiting oxidative stress and inflammatory responses. ANXA5 improves body weight, reduces cell apoptosis and matrix metalloproteinase-9 levels, inhibits the degradation of tight-junction-associated protein, and improves intestinal inflammation by regulating inflammation-associated factors.
Article
Engineering, Biomedical
Sung Eun Lee, Chan Mi Lee, Ji Eun Won, Gun-Young Jang, Ju Hyeong Lee, Sang Hyeon Park, Tae Heung Kang, Hee Dong Han, Yeong-Min Park
Summary: This study demonstrates a selective nanocarrier system that enhances cytotoxic T cell immunity against tumor-specific antigens, increases survival rates of immune-activating cells, and reduces tumor mass by decreasing immune-suppressive cells and anti-inflammatory cytokines. Combining the nanocarrier system with other ICIs further amplifies the anticancer immunity of interferon gamma+ (IFN-gamma) CD8+ T cells.
Article
Chemistry, Medicinal
Brent J. Tschirhart, Xiangru Lu, Janice Gomes, Arundhasa Chandrabalan, Gillian Bell, David A. Hess, Guangxin Xing, Hong Ling, Dylan Burger, Qingping Feng
Summary: Sepsis is a dysregulated immune response to infection and a leading cause of mortality. Recombinant human Annexin A5 (Anx5) treatment has been shown to inhibit pro-inflammatory cytokine production and improve survival in sepsis models. It blocks the inflammatory response induced by activated platelets and microvesicles in endothelial cells through phosphatidylserine binding.
Article
Obstetrics & Gynecology
Xiaojie Wang, Yarui Dai, Jialu Zhang, Xin Li
Summary: This study found that ANXA5 can inhibit proliferation and metastasis of cervical cancer cells by regulating the PI3K/Akt signaling pathway.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Immunology
Yalong Gao, Hejun Zhang, Jiwei Wang, Fanjian Li, Xiaotian Li, Tuo Li, Cong Wang, Lei Li, Ruilong Peng, Li Liu, Weiyun Cui, Shu Zhang, Jianning Zhang
Summary: In this study, we investigated whether inhibiting ferroptosis and neuroinflammation using A5 could ameliorate traumatic brain injury. The results showed that A5 improved neurological deficits, brain edema, blood-brain barrier disruption, and reduced neuronal apoptosis and ferroptosis. It also regulated the NF-kB/HMGB1 pathway and the Nrf2/HO-1 antioxidant system to decrease neuroinflammation and oxidative stress damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Claire Hogan, Anthony V. Perkins
Summary: Selenium is an essential trace element for human health, and deficiency can lead to various diseases. Selenium is incorporated into selenoproteins, which play important roles in antioxidant defense, signaling, hormone production, DNA synthesis, and protein response. This review highlights the importance of selenium for a healthy pregnancy and the role of placental selenoproteins in early life development.
Review
Immunology
Ellen Menkhorst, Nandor Gabor Than, Udo Jeschke, Gabriela Barrientos, Laszlo Szereday, Gabriela Dveksler, Sandra M. Blois
Summary: Lectin-glycan interactions, particularly those mediated by the galectin family, play crucial roles in regulating processes necessary for a successful pregnancy. Galectins specifically bind to intracellular and membrane bound carbohydrate ligands, influencing angiogenesis, immune-cell adaptations, and embryogenesis. They contribute to fetal development and placental health, with implications for pathological conditions like preeclampsia.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Xiaotong Yang, Paula A. Benny, Elorri Cervera-Marzal, Biyu Wu, Cameron B. Lassiter, Joshua Astern, Lana X. Garmire
Summary: Variations in telomere length have been linked to aging, stress, and diseases. This study investigated the association between placental telomere length and preeclampsia. The results suggest that placental telomere length is not significantly different between severe preeclampsia cases and healthy controls, but it is negatively correlated with gestational age and influenced by race.
Article
Obstetrics & Gynecology
A. D. Makatsariya, E. Slukhanchuk, V. O. Bitsadze, J. K. H. Khizroeva, M. Tretyakova, V. Tsibizova, I Elalamy, J-C Gris, E. Grandone, N. A. Makatsariya, T. Mashkova
Summary: The severe complications of COVID-19 infection involve various conditions, including thrombotic microangiopathy (TMA). This article summarizes the main types, pathogenesis, and treatment principles of TMA, and discusses the possible pathological models in patients with COVID-19.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Letter
Obstetrics & Gynecology
Elvira Grandone, Gregory Piazza
HUMAN REPRODUCTION
(2022)
Article
Hematology
Alessandro Squizzato, Daniela Poli, Doris Barcellona, Antonio Ciampa, Elvira Grandone, Cesare Manotti, Marco Moia, Vincenzo Toschi, Alberto Tosetto, Sophie Testa
Summary: Patients on anticoagulant treatment often need to temporarily interrupt their medication for surgeries or invasive procedures. The Italian Federation of Centers for the diagnosis of thrombotic disorders and the Surveillance of the Antithrombotic therapies (FCSA) provides practical guidance and expert opinions on assessing risks, testing, using heparin, restarting medication after high-risk bleeding surgery, and nonpharmacological suggestions for perioperative management. FCSA also suggests forming a multidisciplinary anticoagulation team for optimal management.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Walter Ageno, Jan Beyer Westendorf, Laura Contino, Eugenio Bucherini, Maria Teresa Sartori, Marco Senzolo, Elvira Grandone, Rita Santoro, Marc Carrier, Aurelien Delluc, Valerio De Stefano, Fulvio Pomero, Marco Paolo Donadini, Alberto Tosetto, Cecilia Becattini, Ida Martinelli, Barbara Nardo, Laurent Bertoletti, Marcello Di Nisio, Alejandro Lazo-Langner, Alessandro Schenone, Nicoletta Riva
Summary: This study evaluated the safety and efficacy of rivaroxaban as a potential alternative to standard anticoagulation for the treatment of splanchnic vein thrombosis (SVT) in non-cirrhotic patients. The results showed that rivaroxaban appeared to be a promising option for the treatment of SVT in this patient population.
Article
Hematology
Gualtiero Palareti, Daniela Poli, Walter Ageno, Cristina Legnani, Emilia Antonucci, Eugenio Bucherini, Sophie Testa, Oriana Paoletti, Antonio Chistolini, Alessandra Serrao, Ida Martinelli, Paolo Bucciarelli, Anna Falanga, Alberto Tosetto, Luca Sarti, Daniela Mastroiacovo, Benilde Cosmi, Adriana Visona, Rita Carlotta Santoro, Nello Zanatta, Elvira Grandone, Lorenza Bertu, Vittorio Pengo, Lucia Caiano, Paolo Prandoni
Summary: This study evaluated the value of serial D-dimer testing and reduced-dose apixaban treatment in patients with unprovoked VTE. The results showed that using D-dimer testing as a basis for extending anticoagulation treatment is not accurate, and reduced-dose apixaban demonstrated high efficacy and safety in preventing recurrences.
Article
Biology
Pierpaolo Di Micco, Vladimir Rosa Salazar, Carmen Fernandez Capitan, Francesco Dentali, Covadonga Gomez Cuervo, Jose Luis Fernandez Torres, Jose Antonio Porras, Angeles Fidalgo, Elvira Grandone, Manuel Lopez Meseguer, Manuel Monreal
Summary: The use of rivaroxaban off-label and at low doses is associated with higher risks of major bleeding and death compared to labeled therapy, but no significant difference in venous thromboembolism recurrence was observed. Delayed initiation of rivaroxaban treatment is common in patients with severe pulmonary embolism.
Article
Environmental Sciences
Felice Sorrentino, Lorenzo Vasciaveo, Vincenzo De Feo, Erika Zanzarelli, Elvira Grandone, Guglielmo Stabile, Luigi Nappi
Summary: Interstitial pregnancy is a rare type of ectopic pregnancy, with diagnosis made by ultrasound and treatment options including medical or surgical intervention. This case report highlights the effectiveness of medical treatment, particularly for women seeking to preserve fertility. Further research is needed to establish standardized protocols and clinical scores for predicting successful outcomes in medical therapy.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Hematology
Elvira Grandone, Doris Barcellona, Mariano Intrieri, Giovanni Tiscia, Luigi Nappi, Maha Othman
Summary: This review discusses the risk of venous thromboembolism during pregnancy following ART, focusing on general and ART-specific risk factors, and provides suggestions for clinical practice based on available data and studies conducted outside ART.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Editorial Material
Hematology
Elvira Grandone, Walter Ageno
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Clinical Neurology
Redoy Ranjan, Gie Ken-Dror, Ida Martinelli, Elvira Grandone, Sini Hiltunen, Erik Lindgren, Maurizio Margaglione, Veronique Le Cam Duchez, Aude Bagan Triquenot, Marialuisa Zedde, Michelangelo Mancuso, Ynte M. Ruigrok, Brad Worrall, Jennifer J. Majersik, Jukka Putaala, Elena Haapaniemi, Susanna M. Zuurbier, Matthijs C. Brouwer, Serena M. Passamonti, Maria Abbattista, Paolo Bucciarelli, Robin Lemmens, Emanuela Pappalardo, Paolo Costa, Marina Colombi, Diana Aguiar de Sousa, Sofia Rodrigues, Patricia Canhao, Aleksander Tkach, Rosa Santacroce, Giovanni Favuzzi, Antonio Arauz, Donatella Colaizzo, Kostas Spengos, Amanda Hodge, Reina Ditta, Thang S. Han, Alessandro Pezzini, Jonathan M. Coutinho, Vincent Thijs, Katarina Jood, Turgut Tatlisumak, Jose M. Ferro, Pankaj Sharma
Summary: This study aimed to determine the impact of age, gender, and risk factors on the onset of cerebral venous thrombosis (CVT). The results showed that women develop CVT 9 years earlier than men, and female patients with multiple risk factors develop CVT 12 years earlier compared to those with no identifiable risk factors.
EUROPEAN STROKE JOURNAL
(2023)
Article
Hematology
Doris Barcellona, Francesco Marongiu, Elvira Grandone
Summary: The development of oral contraceptives (OCs) started in 1921 and faced challenges in understanding and managing the risk of venous thrombosis. Second-generation and later third-generation OCs were found to have increased thrombotic risk. In the 2000s, fourth-generation OCs with natural estrogens and a progestin were introduced. Research also provided insights into risk factors associated with OCs use.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Hematology
Behnood Bikdeli, Alfonso Muriel, Yun Wang, Gregory D. Piazza, Candrika P. Khairani, Rachel Rosovsky, Ghazaleh L. Mehdipoor, Michelle O'Donoghue, Olga Madridano, Juan Bosco Lopez-Saez, Meritxell Mellado, Ana Maria Diaz Brasero, Elvira A. Grandone, Primavera Spagnolo, Yuan Lu, Laurent Bertoletti, Luciano Lopez-Jimenez, Manuel Jesus Nunez, Angeles Blanco-Molina, Marie Z. Gerhard-Herman, Samuel M. Goldhaber, Shannon Bates, David M. Jimenez, Harlan Krumholz, Manuel Monreal
Summary: Sex-specific factors play a role in the presentation of pulmonary embolism (PE) in young patients, but it is unclear if there are sex differences in older adults. Data from international and national registries show that PE is more common in elderly women. Women with PE in older age less frequently have certain comorbidities but more often have other risk factors compared to men. They also have different symptomatology, with women presenting less often with chest pain or hemoptysis but more often with dyspnea. Further investigation is needed to determine if these differences correlate with disparities in treatment and clinical outcomes.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Hematology
Elvira Grandone, Emilia Antonucci, Donatella Colaizzo, Antonio De Laurenzo, Benilde Cosmi, Michela Cini, Cristina Legnani, Sophie Testa, Maurizio Margaglione, Gualtiero Palareti
Summary: This study investigated the impact of risk factors on pregnancy- or combined oral contraceptive (COC)-associated venous thromboembolism (VTE). Results showed that family history was a significant and independent risk factor for COC-VTE and pregnancy-associated VTE. Therefore, family history plays a crucial role in predicting the occurrence of VTE in the context of pregnancy or COC use.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, General & Internal
Carlo Rostagno, Gaia Rubbieri, Mattia Zeppa, Alessandro Cartei, Alice Ceccofiglio, Giulio Maria Mannarino, Gualtiero Palareti, Elvira Grandone
Summary: This study aimed to investigate the perioperative management and long-term prognosis of elderly patients undergoing urgent hip surgery while receiving antithrombotic treatment. The study found that anticoagulants may delay surgery, but a delay of more than 48 hours does not have a significant impact on prognosis. Patients receiving warfarin had a lower one-year survival rate, potentially due to their higher risk profile at the time of trauma.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hematology
Elvira Grandone, Mario Mastroianno, Lazzaro di Mauro, Antonella Caroli, Giovanni Tiscia, Angelo Ostuni
Summary: During the COVID-19 pandemic in 2020 in Italy, there was a significant decrease in blood donations and transfusions, along with an increase in fatality rate among male patients. Patterns of blood transfusion and mortality among COVID-19 patients show certain trends that require attention and management.
