Article
Cell Biology
Sandra M. Blois, Paula D. Prince, Sophia Borowski, Monica Galleano, Gabriela Barrientos
Summary: Utilizing the SHRSP model, this study investigated placental mechanisms promoting superimposed preeclampsia in women with chronic hypertension. The findings revealed sustained activation of cellular stress response in SHRSP placentas, leading to redox imbalance and significant alterations in placental glycocode. The study highlights the potential role of glycoredox balance as a promising target for interventions in hypertensive disorders of pregnancy.
Article
Biochemistry & Molecular Biology
Hamid-Reza Kohan-Ghadr, Brooke Armistead, Mikaela Berg, Sascha Drewlo
Summary: Irisin is a newly discovered exercise-mediated polypeptide hormone. Studies have shown that Irisin protects against cell death by reducing pro-apoptotic signaling cascades, inducing DNA repair pathways, and inhibiting Caspase 3 activity. Additionally, Irisin acts through the Akt signaling pathway to prevent apoptosis, increase levels of anti-apoptotic BCL2, and reduce ROS levels. These findings provide new insights into the role of Irisin in promoting cell survival and preventing apoptosis in the human placenta under pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Yung-Fang Hsiao, Shao-Bin Cheng, Chia-Yu Lai, Hsiao-Tien Liu, Shih-Chien Huang, Yi-Chia Huang
Summary: This study compared the changes in oxidative stress and GSH-related antioxidant capacities before and after tumor resection in HCC patients, showing a decrease in plasma malondialdehyde level and varying increases in GSH and related enzyme activities. The findings suggest a potential therapeutic use of GPx or GR as targets for reducing HCC recurrence.
Review
Biochemistry & Molecular Biology
Ramana Vaka, Evangeline Deer, Babbette LaMarca
Summary: Despite extensive research, the pathogenesis of preeclampsia (PE) remains unclear and lacks FDA-approved treatments. Mitochondrial oxidative stress has been identified as a crucial factor in PE development and holds potential as a target for therapy.
Article
Nanoscience & Nanotechnology
Wei Wang, Jinyang Zheng, Hao Zhou, Qiang Liu, Li Jia, Xiuming Zhang, Dongtao Ge, Wei Shi, Yanan Sun
Summary: Overproduction of ROS and cumulative oxidative stress contribute to the degeneration of dopaminergic neurons in PD patients. Polydopamine (PDA), with its redox property, has been studied for its antioxidant enzyme mimetic activities. By co-synthesizing PDA with selenocystine, a nanocomposite (PDASeCys) with GPx-like activity was prepared. The PDASeCys nanocomposite showed better free radical scavenging efficiency and additional GPx enzymatic activity compared to PDA. In vitro and in vivo experiments demonstrated the protective effect of PDASeCys on neuronal cells and its ability to inhibit Parkinson-related symptoms in mice.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Environmental Sciences
Eman A. Abdelfattah, David Renault
Summary: Research investigated the physiological effects of different concentrations of epinephrine on larvae of the flesh fly Sarcophaga dux, revealing significant differences among different body compartments and epinephrine concentrations. Epinephrine treatments did not increase reactive oxygen species production except for gut tissues.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Reproductive Biology
Barbara Denkl, Nada Cordasic, Hanna Huebner, Carlos Menendez-Castro, Marius Schmidt, Alexander Mocker, Joachim Woelfle, Andrea Hartner, Fabian B. Fahlbusch
Summary: The study investigates the roles of placental UPR and oxidative stress in IUGR and PE, finding that placental ER stress is not induced in rat and mouse models, while oxidative stress is significantly increased in female IUGR rat placentas.
BIOLOGY OF REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Lingyu Ye, Yujia Huang, Xueqing Liu, Xinyu Zhang, Yang Cao, Xiangju Kong, Xiaolei Yuan, Jie Xu, Hui Zhu
Summary: The study revealed that women with preeclampsia had increased maternal apelin concentration but reduced APJ expression in the placenta. Treatment with apelin-13 could attenuate oxidative stress injury in placental trophoblasts through the activation of the PI3K/AKT signaling pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Anne Negre-Salvayre, Audrey Swiader, Robert Salvayre, Paul Guerby
Summary: This article summarizes the current knowledge on premature placental senescence and the role of oxidative stress and lipid oxidation-derived aldehydes in this process, as well as their links with preeclampsia (PE) pathogenesis. The interest of developing new therapeutic strategies targeting lipid peroxidation is discussed in order to better understand accelerated placental aging in PE pathophysiology and prevent adverse outcomes of PE.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Zahra Masoumi, Lena Erlandsson, Eva Hansson, Mattias Magnusson, Eva Mezey, Stefan R. Hansson
Summary: The study found that in preeclampsia (PE) pregnancies, there was no impact on placental hematopoietic stem and progenitor cells homing and erythropoiesis. Non-erythroid alpha-globin mRNA and protein were detected in syncytiotrophoblasts and stroma of PE placenta samples, while normal placenta explants cultured in hypoxia showed upregulation of alpha-globin protein and mRNA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Yu Zhang, Qian Guo, Xiaowei Fang, Mei Yuan, Wenjie Hu, Xiongyan Liang, Jing Liu, Yuying Yang, Chun Fang
Summary: In this study, the unusual roles of Listeria monocytogenes glutathione peroxidase (GSH-Px) in bacterial antioxidants and pathogenicity were revealed. Deletion of the GSH-Px gene increased glutathione concentrations and enhanced resistance to oxidative stress in L. monocytogenes. Additionally, the absence of GSH-Px significantly improved the adhesion and invasion efficiency of L. monocytogenes and enhanced its pathogenicity by increasing the expression of virulence factors.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Obstetrics & Gynecology
Philippe Vangrieken, Salwan Al-Nasiry, Aalt Bast, Pieter A. Leermakers, Christy B. M. Tulen, Paul M. H. Schiffers, Frederik J. van Schooten, Alex H. V. Remels
Summary: Preeclamptic placentae exhibit oxidative stress, mitochondrial abnormalities, and inflammation, leading to decreased mitochondrial content and dysregulation of molecular pathways, which may contribute to the pathophysiology of preeclampsia.
REPRODUCTIVE SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Jun Pei, Xingyu Pan, Guanghui Wei, Yi Hua
Summary: Maintaining the balance of a cell's redox function is crucial for determining cell fate, and the GPX family of proteins, such as GPX1-GPX8, plays a significant role in combating oxidative stress and maintaining redox balance. Each member of the GPX family has a distinct mechanism of action and site of action in maintaining redox balance. Understanding the expression and regulatory mechanism of each member in the redox process is important for further clarifying the functional core of the GPX family.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zongli Ren, Ning Cui, Minglin Zhu, Raouf A. Khalil
Summary: The study suggests that placental ischemia-induced proinflammatory cytokines may be one of the causes of preeclampsia. Modulating cytokines and metalloproteinases can improve vascular and uteroplacental remodeling, alleviating symptoms of preeclampsia.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mi Yang, Xiaofei Zhou, Xi Tan, Xincheng Huang, Lu Yuan, Zipeng Zhang, Yan Yang, Min Xu, Ying Wan, Zezhi Li
Summary: Alcohol dependence leads to oxidative stress in the body, as evident from the changes observed in the levels of oxidative stress biomarkers. This meta-analysis highlights the decreased activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzymes and lower levels of albumin, along with increased levels of malondialdehyde (MDA), vitamin B12, homocysteine, and bilirubin in patients with alcohol dependence.
Article
Endocrinology & Metabolism
James M. Law, David E. Morris, Lindsay Robinson, Tabitha Randell, Louise Denvir, Michael E. Symonds, Helen Budge
Summary: Type 1 diabetes affects the activity of brown adipose tissue, as shown by lower supraclavicular temperatures in children with diabetes compared to controls. Insulin delivery method may significantly impact the response of BAT to stimulation. Further research is needed to fully understand the glucose-insulin-BAT relationship.
PEDIATRIC DIABETES
(2021)
Article
Biochemistry & Molecular Biology
Paula J. Scaife, Amy Simpson, Lesia O. Kurlak, Louise Briggs, David S. Gardner, Fiona Broughton Pipkin, Carolyn J. P. Jones, Hiten D. Mistry
Summary: The study found that markers of placental oxidative stress and senescence increase in post-term pregnancies and cases of pre-eclampsia. As gestational age increases, antioxidant defenses decrease, providing insight into placental health and potentially aiding in determining the optimal gestational age for delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Peter Aldiss, Jo E. Lewis, Irene Lupini, Ian Bloor, Ramyar Chavoshinejad, David J. Boocock, Amanda K. Miles, Francis J. P. Ebling, Helen Budge, Michael E. Symonds
Summary: This study demonstrates that chronic suppression of adaptive thermogenesis leads to weight gain and increased fat mass in rodents. Living in a cool environment (20 degrees C) and treatment with a β3-adrenoreceptor agonist (YM-178) had minimal effects on metabolic health in obese rats raised at thermoneutrality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Eun D. Lee, Hiten D. Mistry
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Hiten D. Mistry, Rahel Klossner, Sampada Kallol, Michael P. Luthi, Ruedi Moser, Henning Schneider, Edgar C. Ontsouka, Lesia O. Kurlak, Markus G. Mohaupt, Christiane Albrecht
Summary: This study used an ex vivo placenta perfusion model to demonstrate that increasing aldosterone can promote the release of anti-inflammatory and pro-angiogenic factors, which may have a positive impact on pregnancy outcomes.
Article
Cell Biology
Barbara Fuenzalida, Sampada Kallol, Jonas Zaugg, Martin Mueller, Hiten D. Mistry, Jaime Gutierrez, Andrea Leiva, Christiane Albrecht
Summary: This study used a primary human trophoblast cell model to mimic the characteristics of preeclampsia (PE) under hypoxic conditions. The results showed that this cell model reflected important pathological processes occurring in PE, making it suitable for in vitro studies of PE.
Article
Biology
Benedikt Gasser, Johann Kurz, Genevieve Escher, Hiten D. Mistry, Markus G. Mohaupt
Summary: Evidence suggests that there are alterations in progesterone metabolites in individuals with autism, especially in boys. This indicates a changed routing of steroid metabolites, which may be related to dysregulation of the HPAG axis.
Article
Obstetrics & Gynecology
Terteel Elawad, Georgia Scott, Jeffrey N. Bone, Helen Elwell, Cristina Escalona Lopez, Veronique Filippi, Marcus Green, Asma Khalil, Mai-Lei W. Kinshella, Hiten D. Mistry, Kelly Pickerill, Reshma Shanmugam, Joel Singer, Rosemarie Townsend, Eleni Z. Tsigas, Marianne Vidler, Marie-Laure Volvert, Peter von Dadelszen, Laura A. Magee
Summary: The pre-eclampsia risk factors identified by clinical practice guidelines are inconsistent with the evidence, particularly for the strongest risk factor of obesity. There is a lack of distinction between risk factors identifiable in early pregnancy and those arising later. An update of the recommended strategies is needed.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lesia O. O. Kurlak, Paula J. J. Scaife, Louise V. V. Briggs, Fiona Broughton Pipkin, David S. S. Gardner, Hiten D. D. Mistry
Summary: This study aimed to investigate the relationship between the concentrations of trace elements and angiogenic markers in women with pre-eclampsia and their fetuses. The results showed that pregnant women with pre-eclampsia had lower levels of selenium, zinc, and manganese, and higher levels of copper. Additionally, maternal plasma zinc concentration was positively correlated with plasma sFlt-1 concentration, suggesting an imbalance in antioxidant status.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Laura A. Magee, Erika Molteni, Vicky Bowyer, Jeffrey N. Bone, Harriet Boulding, Asma Khalil, Hiten D. Mistry, Lucilla Poston, Sergio A. Silverio, Ingrid Wolfe, Emma L. Duncan, Peter von Dadelszen
Summary: Among women of reproductive age, older age, White ethnicity, and being in the least-deprived index of multiple deprivation are independently associated with higher vaccine uptake. Ethnicity has the strongest influence, while multiple deprivation has the weakest. These findings are crucial for informing future vaccination policies and public messaging.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Benedikt Gasser, Genevieve Escher, Anca-Elena Calin, Michael Deppeler, Miriam Marchon, Hiten D. Mistry, Johann Kurz, Markus G. Mohaupt
Summary: Background: Previous research has shown that metformin has significant effects on steroid hormone concentrations. This study aimed to investigate the specific enzymatic activities affected by metformin treatment before initial intake and after a period of treatment. Material and Methods: Twelve male and seven female subjects were recruited based on their indication for metformin. Urine collections were performed before the first intake of metformin and after 24 hours. Results: Metformin treatment resulted in a substantial average reduction in steroid hormone concentrations, with a particular decrease of almost three hundred percent in dehydroepiandrosterone. The sum of all cortisol metabolites and 18-OH cortisol, indicative of oxidative stress, were also lower after metformin treatment. Additionally, significant inhibition of 3 ss-HSD activity was detected. Discussion: The findings of this study align with previous research, demonstrating the inhibitory effect of metformin on 3 ss-HSD activity. The reduction in glucocorticoids and 18-OH cortisol following metformin treatment further supports its impact on oxidative stress. However, the complex pattern of the enzymes involved in steroid hormone metabolism is not fully understood, necessitating further studies for improved understanding.
Editorial Material
Biochemistry & Molecular Biology
Eun D. Lee, Hiten D. Mistry
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Multidisciplinary Sciences
Laura A. Magee, Erika Molteni, Vicky Bowyer, Jeffrey N. Bone, Harriet Boulding, Asma Khalil, Hiten D. Mistry, Lucilla Poston, Sergio A. Silverio, Ingrid Wolfe, Emma L. Duncan, Peter von Dadelszen, Debra Bick
NATURE COMMUNICATIONS
(2023)
Review
Multidisciplinary Sciences
Mousa Khalafi, Michael E. Symonds, Mohammad Hossein Sakhaei, Faeghe Ghasemi
Summary: The meta-analysis showed that exercise training reduces sICAM-1 but does not significantly affect sVCAM-1 in adults. Both aerobic and resistance training are effective in decreasing sICAM-1 in adults with metabolic disorders and cardiovascular diseases.